Simvastatin combined with Tiotropium Bromide

Reports:

Reaction Outcome Event Date Age Sex Weight Reported Reporter Country Treatment
Role Name
Inappropriate Antidiuretic Hormone Secretion Life Threatening 12/7/2005 83 Male 1/13/2006 United Kingdom
Primary
Concomitant
Arrhythmia Supraventricular Hospitalization 12/12/2005 67 Male 1/30/2006 Other Health Professional Germany
Primary
Secondary
Concomitant
Aortic Dissection Death 4/5/2005 Male 2/1/2006 Consumer United Kingdom
Primary
Secondary
Aortic Dissection Death 4/5/2005 Male 2/1/2006 Consumer United Kingdom
Primary
Secondary
Arrhythmia Supraventricular Hospitalization 12/12/2005 67 Male 3/14/2006 Other Health Professional Germany
Primary
Secondary
Concomitant
Pneumonia Staphylococcal Hospitalization 8/22/2005 80 Male 191 lb 12/27/2005 Consumer United States
Primary
Concomitant
Death Death 3/29/2006 67 Female 6/14/2006 Other Health Professional Denmark
Primary
Concomitant
Death Death 3/29/2006 67 Female 6/28/2006 Other Health Professional Denmark
Primary
Concomitant
Total Lung Capacity Decreased Other Serious 9/1/2005 79 Female 6/29/2006 Other Health Professional United States
Primary
Secondary
Concomitant
Arrhythmia Supraventricular Hospitalization 12/12/2005 67 Male 7/5/2006 Other Health Professional Germany
Primary
Secondary
Concomitant
Thrombocytopenia Hospitalization 7/19/2006 77 Male 8/3/2006 Other Health Professional Germany
Primary
Secondary
Concomitant
Visual Acuity Reduced Other Serious 1/1/1997 52 Female 143 lb 9/7/2006 Physician Austria
Primary
Concomitant
Stevens-johnson Syndrome Hospitalization 5/11/2006 79 Female 154 lb 10/3/2006 Other Health Professional United Kingdom
Primary
Concomitant
Panic Attack Hospitalization 9/3/2006 63 Male 258 lb 10/5/2006 Germany
Primary
Concomitant
Panic Attack Hospitalization 8/15/2006 63 Male 258 lb 10/5/2006 Other Health Professional Germany
Primary
Concomitant
Skin Lesion Other Serious 7/23/2006 72 Female 11/10/2006 United Kingdom
Primary
Secondary
Concomitant
Death Life Threatening 10/1/2006 81 Female 11/21/2006 Physician Canada
Primary
Concomitant
Retinal Artery Occlusion Disability 10/23/2006 75 Male 174 lb 12/14/2006 Other Health Professional United Kingdom
Primary
Concomitant
Arrhythmia Supraventricular Hospitalization 12/12/2005 67 Male 1/4/2007 Other Health Professional Germany
Primary
Secondary
Concomitant
Urticaria Other Serious 7/23/2006 72 Female 154 lb 12/28/2006 United Kingdom
Primary
Secondary
Concomitant
Visual Acuity Reduced Other Serious 1/1/1997 52 Female 143 lb 1/3/2007 Physician Austria
Primary
Concomitant
Visual Acuity Reduced Other Serious 1/1/1997 52 Female 143 lb 3/13/2007 Physician Austria
Primary
Concomitant
Insomnia 11/1/2006 85 Male 162 lb 1/12/2007 Consumer United States
Primary
Concomitant
Pallor Hospitalization 5/11/2006 79 Female 154 lb 5/18/2007 Other Health Professional United Kingdom
Primary
Concomitant
Left Ventricular Failure Hospitalization Male 6/26/2007 Germany
Primary
Concomitant
Insomnia 4/1/2007 64 Male 240 lb 7/10/2007 Consumer United States
Primary
Concomitant
Swelling Face Other Serious 3/4/2007 64 Male 9/5/2007 Consumer United Kingdom
Primary
Concomitant
Mouth Ulceration Disability 5/8/2007 89 Female 9/10/2007 Other Health Professional United Kingdom
Primary
Concomitant
Rhabdomyolysis Hospitalization 5/7/2007 60 Male 234 lb 8/15/2007 Physician United States
Primary
Secondary
Concomitant
Swelling Face Other Serious 3/4/2007 64 Male 11/28/2007 Consumer United Kingdom
Primary
Concomitant
Vomiting Hospitalization 5/27/2006 89 Male 12/3/2007 Pharmacist United Kingdom
Primary
Concomitant
Vomiting Hospitalization 5/27/2006 89 Male 12/6/2007 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Vomiting Hospitalization 5/27/2006 89 Male 12/6/2007 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Syncope Other Serious 10/1/2007 Female 120 lb 2/4/2008 Physician United States
Primary
Concomitant
Pancreatitis Acute Hospitalization 1/25/2008 63 Female 2/12/2008 Physician Italy
Primary
Concomitant
Loss Of Consciousness Life Threatening 6/9/2006 76 Male 168 lb 3/11/2008 Other Health Professional United Kingdom
Primary
Concomitant
Pulmonary Embolism Other Serious 2/25/2008 71 Female 161 lb 3/19/2008 Other Health Professional United Kingdom
Primary
Concomitant
Prothrombin Level Decreased Hospitalization 2/14/2008 67 Female 4/9/2008 Other Health Professional Sweden
Primary
Concomitant
Interacting
Pulmonary Embolism Other Serious 2/25/2008 71 Female 161 lb 4/11/2008 Other Health Professional United Kingdom
Primary
Concomitant
Pancreatitis Acute Hospitalization 1/25/2008 63 Female 5/29/2008 Physician Italy
Primary
Concomitant
Retinal Artery Occlusion Disability 10/23/2006 75 Male 174 lb 6/10/2008 Other Health Professional United Kingdom
Primary
Concomitant
Myocardial Infarction Hospitalization 12/1/2006 Female 130 lb 6/13/2008 Consumer United States
Primary
Concomitant
Rash Hospitalization 6/15/2008 63 Female 7/7/2008 Other Health Professional United Kingdom
Primary
Concomitant
Myalgia Other Serious 6/1/2008 7/11/2008 Other Health Professional United Kingdom
Primary
Concomitant
Ulcer 6/15/2008 63 Female 7/10/2008 Other Health Professional United Kingdom
Primary
Concomitant
Polyarthritis Other Serious 72 Male 194 lb 7/18/2008 Other Health Professional United Kingdom
Primary
Concomitant
Injection Site Pain 1/1/2007 Male 230 lb 9/12/2008 United States
Primary
Concomitant
Ulcer Hospitalization 63 Female 10/10/2008 Other Health Professional United Kingdom
Primary
Concomitant
Myalgia Other Serious 6/1/2008 69 Female 121 lb 11/6/2008 Other Health Professional United Kingdom
Primary
Concomitant
Myalgia Other Serious 6/1/2008 69 Female 121 lb 11/11/2008 Consumer United Kingdom
Primary
Concomitant
Atrial Flutter Other Serious 10/10/2008 69 Male 267 lb 11/19/2008 Physician United Kingdom
Primary
Concomitant
Feeling Abnormal Other Serious 70 Male 238 lb 11/24/2008 Physician
Primary
Secondary
Concomitant
Feeling Abnormal Other Serious Male 238 lb 11/26/2008 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Transient Ischaemic Attack Other Serious 7/1/2008 76 Male 12/1/2008 Physician United Kingdom
Primary
Secondary
Transient Ischaemic Attack Other Serious 7/1/2008 76 Male 12/1/2008 Other Health Professional United Kingdom
Primary
Secondary
Renal Failure Death 77 Female 12/1/2008 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Transient Ischaemic Attack Other Serious 7/1/2008 76 Male 12/1/2008 Physician United Kingdom
Primary
Secondary
Renal Failure Death 77 Female 12/4/2008 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Transient Ischaemic Attack Other Serious 7/1/2008 76 Male 12/4/2008 Physician United Kingdom
Primary
Secondary
Transient Ischaemic Attack Other Serious 7/1/2008 76 Male 12/9/2008 Physician United Kingdom
Primary
Secondary
Rhabdomyolysis Death 77 Female 12/8/2008 Other Health Professional United Kingdom
Primary
Concomitant
Transient Ischaemic Attack Other Serious 7/1/2008 76 Male 11/30/2008 Consumer United Kingdom
Primary
Secondary
Transient Ischaemic Attack Other Serious 7/1/2008 76 Male 12/17/2008 Other Health Professional
Primary
Secondary
Pancreatitis Acute Other Serious 1/1/2008 75 Male 213 lb 12/17/2008 Physician United Kingdom
Primary
Concomitant
Restlessness Other Serious 11/24/2008 12/30/2008 Other Health Professional United Kingdom
Primary
Concomitant
Pancreatitis Acute Other Serious 1/1/2008 75 Male 213 lb 1/12/2009 Physician United Kingdom
Primary
Concomitant
Pancreatitis Acute Other Serious 1/1/2008 75 Male 213 lb 1/12/2009 Physician United Kingdom
Primary
Concomitant
Pancreatitis Other Serious 1/1/2008 75 Male 213 lb 1/16/2009 Physician United Kingdom
Primary
Concomitant
Oesophagitis Other Serious 10/1/2008 77 Female 146 lb 1/26/2009 Other Health Professional United Kingdom
Primary
Concomitant
Renal Impairment Hospitalization 12/21/2008 82 Male 1/30/2009 Other Health Professional United Kingdom
Primary
Concomitant
Pancreatitis Other Serious 1/1/2008 Male 213 lb 2/6/2009 Physician United Kingdom
Primary
Concomitant
Renal Failure Death 2/10/2009 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Pancreatitis Acute Other Serious 1/1/2008 75 Male 213 lb 2/12/2009 Physician United Kingdom
Primary
Concomitant
Strangury Hospitalization 10/1/2007 Female 2/13/2009 Physician
Primary
Concomitant
Hypoglycaemia Life Threatening 11/14/2008 83 Male 3/10/2009 Pharmacist Germany
Primary
Concomitant
Interacting
Ulcer Other Serious 65 Male 3/9/2009 Other Health Professional France
Primary
Concomitant
Ulcer Other Serious 65 Male 2/12/2009 Other Health Professional United Kingdom
Primary
Concomitant
Weight Decreased Hospitalization 3/9/2009 60 Male 4/1/2009 Physician United Kingdom
Primary
Concomitant
Hypoglycaemia Life Threatening 11/14/2008 83 Male 4/7/2009 Pharmacist Germany
Primary
Concomitant
Interacting
Restlessness Other Serious 11/24/2008 4/10/2009 Other Health Professional United Kingdom
Primary
Concomitant
Neutropenia Life Threatening 4/21/2009 53 6/1/2009 Other Health Professional United Kingdom
Primary
Concomitant
Gout Other Serious 3/12/2009 72 Female 6/25/2009 Physician United Kingdom
Primary
Concomitant
Gout Other Serious 3/12/2009 72 Female 7/2/2009 Other Health Professional United Kingdom
Primary
Concomitant
Gout Required Intervention 3/12/2009 72 Female 6/30/2009 Other Health Professional United Kingdom
Primary
Concomitant
Oesophagitis Other Serious 10/1/2008 77 Female 7/28/2009 United Kingdom
Primary
Concomitant
International Normalised Ratio Increased Other Serious 7/6/2009 83 Male 8/4/2009 Other Health Professional United Kingdom
Primary
Concomitant
Interacting
Peripheral Sensory Neuropathy Hospitalization 5/28/2009 Female 8/7/2009 Physician United Kingdom
Primary
Secondary
Concomitant
Peripheral Sensory Neuropathy Hospitalization 5/28/2009 Female 8/18/2009 Physician United Kingdom
Primary
Secondary
Concomitant
Syncope Other Serious 4/15/2009 8/19/2009 Other Health Professional United States
Primary
Secondary
Concomitant
Surgery Hospitalization 64 Male 8/20/2009 United States
Primary
Concomitant
Perforated Duodenal Ulcer Repair Hospitalization 8/25/2009 61 Male 9/17/2009 Physician United Kingdom
Primary
Concomitant
Psychotic Disorder Hospitalization 3/22/2009 68 Female 172 lb 9/19/2009 Other Health Professional United Kingdom
Primary
Concomitant
Duodenal Ulcer Perforation Hospitalization 8/25/2009 61 Male 9/19/2009 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Psychotic Disorder Hospitalization 3/1/2009 68 Female 172 lb 9/14/2009 United Kingdom
Primary
Concomitant
Tachycardia Hospitalization 64 Male 10/18/2009 Lawyer United States
Primary
Concomitant
Pneumonia Death 2/1/2009 62 Male 10/28/2009 Other Health Professional United States
Primary
Concomitant
Myalgia Hospitalization 2/27/2008 63 Male 10/23/2009 United Kingdom
Primary
Concomitant
Tachycardia Hospitalization 64 Male 201 lb 10/26/2009 United States
Primary
Concomitant
Drug Toxicity Life Threatening 1/2/2009 72 Male 240 lb 11/9/2009 Pharmacist Germany
Primary
Concomitant
Interacting
Oesophageal Ulcer Haemorrhage Hospitalization 5/9/2009 76 Male 11/23/2009 Other Health Professional Netherlands
Primary
Concomitant
Interacting
Pseudoporphyria Other Serious 65 Male 12/10/2009 United Kingdom
Primary
Concomitant
Cytolytic Hepatitis Other Serious 11/13/2009 67 Male 1/14/2010 Other Health Professional France
Primary
Secondary
Concomitant
Drug Toxicity Life Threatening 1/2/2009 72 Male 240 lb 1/25/2010 Pharmacist Germany
Primary
Concomitant
Interacting
Drug Withdrawal Syndrome Hospitalization 1/19/2010 Male 2/10/2010 Physician
Primary
Secondary
Concomitant
Drug Withdrawal Syndrome Hospitalization 1/19/2010 Male 2/18/2010 Physician
Primary
Secondary
Concomitant
Electrocardiogram Qt Prolonged Other Serious 1/19/2010 Male 2/22/2010 Physician
Primary
Secondary
Concomitant
Left Ventricular Failure Hospitalization 8/15/2009 Female 214 lb 2/23/2010 Other Health Professional United Kingdom
Primary
Concomitant
Chronic Obstructive Pulmonary Disease Hospitalization 2/18/2010 Male 159 lb 2/26/2010
Primary
Secondary
Concomitant
Electrocardiogram Qt Prolonged Other Serious 1/19/2010 65 Male 4/6/2010 Physician
Primary
Secondary
Concomitant
Renal Failure Acute Other Serious 66 Male 4/8/2010 Other Health Professional United Kingdom
Primary
Concomitant
Prothrombin Time Prolonged Other Serious 2/5/2010 77 Male 185 lb 4/15/2010 Physician Germany
Primary
Concomitant
Chronic Obstructive Pulmonary Disease Hospitalization 2/18/2010 54 Male 159 lb 4/20/2010
Primary
Secondary
Concomitant
Thrombocytopenia Other Serious 2/6/2010 86 Female 4/20/2010 Other Health Professional United Kingdom
Primary
Concomitant
Electrocardiogram Qt Prolonged Other Serious 1/19/2010 65 Male 5/24/2010 Physician
Primary
Secondary
Concomitant
Ventricular Tachycardia Other Serious 2/1/2008 73 Male 5/24/2010 Lawyer United States
Primary
Concomitant
Delirium Hospitalization 8/18/2009 75 Female 168 lb 6/23/2010 Other Health Professional United Kingdom
Primary
Concomitant
Renal Failure Acute Other Serious 66 Male 6/24/2010 Other Health Professional United Kingdom
Primary
Concomitant
Lung Disorder Hospitalization 6/12/2010 73 Male 6/25/2010 Physician United States
Primary
Secondary
Concomitant
Delirium Hospitalization 8/18/2009 75 Female 168 lb 6/25/2010 Other Health Professional United Kingdom
Primary
Concomitant
Delirium Hospitalization 8/18/2009 75 Female 168 lb 6/29/2010 Other Health Professional United Kingdom
Primary
Concomitant
Electrocardiogram Qt Prolonged Other Serious 1/19/2010 65 Male 6/30/2010 Physician
Primary
Secondary
Concomitant
Delirium Hospitalization 8/18/2009 75 Female 165 lb 6/30/2010 Consumer United Kingdom
Primary
Concomitant
Renal Failure Acute Other Serious 66 Male 6/21/2010 United Kingdom
Primary
Concomitant
Vomiting Hospitalization 60 Female 6/28/2010 Other Health Professional Denmark
Primary
Concomitant
Osteonecrosis Of Jaw Other Serious 8/15/2005 68 Female 7/20/2010 Physician United Kingdom
Primary
Concomitant
Electrocardiogram Qt Prolonged Other Serious 1/19/2010 65 Male 7/23/2010 Physician
Primary
Secondary
Concomitant
Mucosal Inflammation Hospitalization 5/7/2010 68 Male 168 lb 8/3/2010 Physician Germany
Primary
Secondary
Concomitant
Total Lung Capacity Decreased Hospitalization 5/10/2010 73 Male 208 lb 8/3/2010 Physician United States
Primary
Secondary
Concomitant
Renal Failure Acute Hospitalization 7/27/2010 70 Female 8/4/2010 Other Health Professional United Kingdom
Primary
Concomitant
Neck Pain Hospitalization 5/2/2010 80 Female 8/5/2010 Other Health Professional Sweden
Primary
Secondary
Concomitant
Renal Failure Acute Hospitalization 8/2/2010 86 Male 132 lb 9/22/2010 Physician Germany
Primary
Concomitant
Respiratory Failure Other Serious 12/1/2007 71 Male 192 lb 10/15/2010 Lawyer United States
Primary
Concomitant
Varicose Vein Other Serious 1/1/2009 11/4/2010 Physician Germany
Primary
Secondary
Concomitant
Renal Failure Other Serious 78 Male 11/10/2010 Other Health Professional United Kingdom
Primary
Concomitant
Thrombocytopenia Other Serious 11/1/2007 50 Female 282 lb 11/24/2010 Other Health Professional United States
Primary
Concomitant
Troponin Increased Hospitalization 11/9/2010 70 Male 11/24/2010 Other Health Professional United Kingdom
Primary
Concomitant
Rhabdomyolysis Hospitalization 11/4/2010 86 Male 146 lb 11/30/2010 Other Health Professional Netherlands
Primary
Secondary
Concomitant
Troponin Increased Hospitalization 11/9/2010 70 Male 12/2/2010 Other Health Professional United Kingdom
Primary
Concomitant
Rash Generalised Hospitalization 11/2/2010 80 Female 12/8/2010 Pharmacist United Kingdom
Primary
Concomitant
Skin Haemorrhage Other Serious 9/26/2010 48 Female 115 lb 9/27/2010 Pharmacist United States
Primary
Secondary
Concomitant
Productive Cough 9/26/2009 12/19/2010 Consumer United States
Primary
Concomitant
Vaginitis Bacterial 6/8/2010 12/22/2010 Physician United States
Primary
Concomitant
Injection Site Reaction 2/1/2010 12/22/2010 Consumer United States
Primary
Concomitant
Somnolence Disability 1/24/2011 77 Female 187 lb 2/4/2011 Other Health Professional United Kingdom
Primary
Concomitant
Right Ventricular Failure Other Serious 1/1/2009 71 Female 207 lb 2/8/2011 Consumer Germany
Primary
Secondary
Concomitant
Pericardial Effusion Hospitalization 1/22/2011 55 Female 134 lb 2/10/2011 Consumer United States
Primary
Secondary
Concomitant
Somnolence Disability 1/24/2011 77 Female 187 lb 2/16/2011 Other Health Professional United Kingdom
Primary
Concomitant
Dyspnoea Disability 10/21/2010 77 Female 2/17/2011 Other Health Professional United Kingdom
Primary
Concomitant
Pericardial Effusion Hospitalization 1/22/2011 55 Female 134 lb 2/22/2011 Other Health Professional United States
Primary
Secondary
Concomitant
Dyspnoea Disability 10/21/2010 77 Female 2/28/2011 Other Health Professional United Kingdom
Primary
Concomitant

Drug Data