Simvastatin combined with Theophylline

Reports:

Reaction Outcome Event Date Age Sex Weight Reported Reporter Country Treatment
Role Name
Gynaecomastia Other Serious 72 Male 1/24/2006 Spain
Primary
Secondary
Concomitant
Pneumonia Hospitalization 1/1/2004 84 Male 130 lb 4/11/2005 Consumer United States
Primary
Secondary
Concomitant
Renal Function Test Abnormal Hospitalization 7/20/2005 82 Male 3/21/2006 Physician Sweden
Primary
Secondary
Concomitant
Acute Myocardial Infarction Death 2/25/2006 62 Male 256 lb 3/30/2006 Physician Australia
Primary
Concomitant
International Normalised Ratio Increased Hospitalization 4/25/2006 Male 203 lb 4/26/2006 Pharmacist United States
Primary
Concomitant
Stevens-johnson Syndrome Hospitalization 5/11/2006 79 Female 154 lb 10/3/2006 Other Health Professional United Kingdom
Primary
Concomitant
Upper Limb Fracture Required Intervention 9/13/2006 62 Female 214 lb 9/28/2006 Physician Germany
Primary
Concomitant
Hypertension Other Serious 8/18/2006 72 Male 10/26/2006 Germany
Primary
Concomitant
Vomiting Required Intervention 9/13/2006 62 Female 214 lb 10/31/2006 Physician Germany
Primary
Concomitant
Oedema Peripheral Other Serious 3/1/2006 72 Male 12/6/2006 Physician United States
Primary
Secondary
Concomitant
Pallor Hospitalization 5/11/2006 79 Female 154 lb 5/18/2007 Other Health Professional United Kingdom
Primary
Concomitant
Weight Decreased Other Serious 1/1/2006 67 Male 196 lb 12/13/2006 Consumer United States
Primary
Concomitant
Insomnia Other Serious 3/15/2007 6/7/2007 Consumer United Kingdom
Primary
Concomitant
Left Ventricular Failure Hospitalization Male 6/26/2007 Germany
Primary
Concomitant
Drug Ineffective 2/1/2007 74 Female 9/6/2007 Consumer United States
Primary
Concomitant
Tongue Disorder Hospitalization 4/26/2007 78 Male 375 lb 9/10/2007 Pharmacist United States
Primary
Secondary
Concomitant
Personality Disorder Other Serious 7/1/2007 Female 129 lb 9/17/2007 United States
Primary
Concomitant
Renal Failure Hospitalization 70 Female 84 lb 9/25/2007 Consumer Germany
Primary
Secondary
Concomitant
Tremor Other Serious 9/14/2007 75 Male 146 lb 11/9/2007 Consumer United Kingdom
Primary
Secondary
Concomitant
Dizziness Male 11/13/2007 Consumer United States
Primary
Concomitant
Tremor Life Threatening 9/14/2007 75 Male 146 lb 11/15/2007 Pharmacist United Kingdom
Primary
Concomitant
Interacting
Angioedema 10/15/2007 54 Male 228 lb 11/16/2007 Consumer United States
Primary
Secondary
Concomitant
Tremor Life Threatening 9/14/2007 11/22/2007 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Obstructive Airways Disorder Life Threatening 9/14/2007 75 Male 146 lb 11/16/2007 United Kingdom
Primary
Secondary
Concomitant
Tremor Life Threatening 9/14/2007 75 Male 11/16/2007 United Kingdom
Primary
Secondary
Concomitant
Malaise Hospitalization 9/8/2007 75 Female 12/17/2007 United Kingdom
Primary
Concomitant
Pruritus 10/12/2007 80 Male 12/27/2007 Other Health Professional United States
Primary
Concomitant
Skin Laceration Hospitalization 12/23/2007 71 Male 160 lb 12/27/2007 Other Health Professional United States
Primary
Concomitant
Pneumonia Hospitalization Female 1/16/2008 Consumer United States
Primary
Concomitant
Sinus Tachycardia Hospitalization 3/27/2007 66 Male 1/22/2008 Germany
Primary
Concomitant
Stent Occlusion Other Serious 1/1/2004 80 Male 11/30/2007 Physician United States
Primary
Secondary
Concomitant
Infection Hospitalization 1/31/2008 50 Female 3/3/2008 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Pyrexia Hospitalization 71 Male 159 lb 3/14/2008 Other Health Professional United States
Primary
Secondary
Concomitant
Pyrexia Hospitalization 3/10/2008 71 Male 159 lb 3/18/2008 Other Health Professional United States
Primary
Secondary
Concomitant
Myalgia Hospitalization 2/27/2008 63 Male 3/27/2008 United Kingdom
Primary
Concomitant
Hepatitis Acute Hospitalization 10/30/2007 59 Female 165 lb 4/29/2008 Germany
Primary
Secondary
Concomitant
Oedema Peripheral Hospitalization 59 5/6/2008 Physician United States
Primary
Concomitant
Supraventricular Tachycardia Hospitalization 2/29/2008 Male 5/15/2008 Other Health Professional United Kingdom
Primary
Concomitant
Liver Function Test Abnormal Hospitalization 10/30/2007 59 Female 165 lb 5/21/2008 Germany
Primary
Secondary
Concomitant
Pain In Extremity Other Serious 2/25/2008 Male 220 lb 5/29/2008 Physician United States
Primary
Concomitant
Oedema Peripheral Hospitalization 59 6/11/2008 Physician United States
Primary
Concomitant
Tachycardia Hospitalization 6/4/2008 72 Male 159 lb 6/6/2008 Other Health Professional United States
Primary
Secondary
Concomitant
Myocardial Infarction Death 57 Female 131 lb 6/30/2008 Austria
Primary
Concomitant
Heart Rate Increased Other Serious 12/1/2007 62 Male 7/3/2008 Consumer United States
Primary
Secondary
Concomitant
Pneumonia Hospitalization 7/12/2008 79 Female 8/8/2008 Physician
Primary
Concomitant
Pneumonia Hospitalization 7/12/2008 79 Female 8/13/2008 Physician
Primary
Concomitant
Leukocytosis Hospitalization 7/7/2008 74 Male 123 lb 8/25/2008 United States
Primary
Secondary
Concomitant
Pneumonia Hospitalization 7/12/2008 79 Female 8/26/2008 Physician
Primary
Concomitant
Urticaria Female 8/29/2008 United States
Primary
Concomitant
Increased Tendency To Bruise Other Serious 8/1/2008 64 Male 140 lb 9/2/2008 Consumer United Kingdom
Primary
Concomitant
Transient Ischaemic Attack Other Serious 7/1/2008 76 Male 9/9/2008 Consumer United Kingdom
Primary
Secondary
Pneumonia Hospitalization 7/12/2008 79 Female 10/2/2008 Other Health Professional
Primary
Concomitant
Accidental Drug Intake By Child Other Serious 2 Male 11/6/2008 Other Health Professional Germany
Primary
Secondary
Accidental Drug Intake By Child Other Serious 2 Male 11/6/2008 Other Health Professional Germany
Primary
Secondary
Transient Ischaemic Attack Other Serious 7/1/2008 76 Male 11/17/2008 Physician United Kingdom
Primary
Secondary
Disorientation Hospitalization 9/10/2008 Male 222 lb 11/19/2008 United States
Primary
Secondary
Concomitant
Transient Ischaemic Attack Other Serious 7/1/2008 76 Male 12/1/2008 Physician United Kingdom
Primary
Secondary
Transient Ischaemic Attack Other Serious 7/1/2008 76 Male 12/1/2008 Other Health Professional United Kingdom
Primary
Secondary
Memory Impairment Other Serious 7/1/2008 76 Male 12/1/2008 Other Health Professional
Primary
Secondary
Transient Ischaemic Attack Other Serious 7/1/2008 76 Male 12/1/2008 Physician United Kingdom
Primary
Secondary
Transient Ischaemic Attack Other Serious 7/1/2008 76 Male 12/2/2008 Other Health Professional United Kingdom
Primary
Secondary
Accidental Drug Intake By Child Other Serious 2 Male 11/24/2008 Other Health Professional Germany
Primary
Secondary
Accidental Drug Intake By Child Other Serious 2 Male 11/24/2008 Other Health Professional Germany
Primary
Secondary
Concomitant
No Adverse Event Other Serious 2 Male 11/24/2008 Other Health Professional Germany
Primary
Secondary
Transient Ischaemic Attack Other Serious 7/1/2008 76 Male 12/4/2008 Physician United Kingdom
Primary
Secondary
Transient Ischaemic Attack Other Serious 7/1/2008 76 Male 12/9/2008 Physician United Kingdom
Primary
Secondary
Transient Ischaemic Attack Other Serious 7/1/2008 76 Male 12/5/2008 United Kingdom
Primary
Secondary
Transient Ischaemic Attack Other Serious 7/1/2008 76 Male 11/30/2008 Consumer United Kingdom
Primary
Secondary
Transient Ischaemic Attack Other Serious 7/1/2008 76 Male 12/9/2008 Other Health Professional United Kingdom
Primary
Secondary
Transient Ischaemic Attack Other Serious 7/1/2008 76 Male 12/17/2008 Other Health Professional
Primary
Secondary
Tongue Haemorrhage Hospitalization 10/20/2007 Female 12/26/2008 Consumer United States
Primary
Secondary
Concomitant
Vomiting Hospitalization 12/1/2008 Female 126 lb 1/23/2009 Consumer United States
Primary
Secondary
Concomitant
Dysuria Other Serious 12/18/2008 83 Male 170 lb 2/12/2009 Other Health Professional United States
Primary
Concomitant
Tachycardia Other Serious 71 Female 179 lb 3/11/2009 Other Health Professional Germany
Primary
Secondary
Concomitant
Lower Respiratory Tract Infection Other Serious 71 Female 3/23/2009 Consumer United Kingdom
Primary
Secondary
Weight Decreased Hospitalization 3/9/2009 60 Male 4/1/2009 Physician United Kingdom
Primary
Concomitant
Weight Decreased Other Serious 8/12/2003 60 Male 216 lb 4/3/2009 United States
Primary
Concomitant
Hypomagnesaemia Other Serious 78 Female 170 lb 4/10/2009 Physician United Kingdom
Primary
Concomitant
Productive Cough Other Serious 78 Female 170 lb 4/10/2009 Other Health Professional United Kingdom
Primary
Concomitant
Tongue Haemorrhage Hospitalization 10/20/2007 Female 4/16/2009 Consumer Germany
Primary
Secondary
Concomitant
Insomnia 4/8/2008 59 Male 226 lb 12/29/2008 Pharmacist United States
Primary
Concomitant
Sputum Discoloured Other Serious 78 Female 4/12/2009 United Kingdom
Primary
Secondary
Concomitant
Hypomagnesaemia Other Serious 78 Female 170 lb 4/20/2009 Other Health Professional United Kingdom
Primary
Concomitant
White Blood Cell Count Increased Other Serious 78 Female 4/24/2009 United Kingdom
Primary
Concomitant
Laboratory Test Abnormal Other Serious 78 Female 5/22/2009 United Kingdom
Primary
Concomitant
Trigeminal Neuralgia Other Serious 7/1/2005 35 6/4/2009 Physician Germany
Primary
Concomitant
Transient Ischaemic Attack Hospitalization 10/11/2008 Male 7/8/2009 Other Health Professional Switzerland
Primary
Concomitant
Product Quality Issue Female 6/25/2009 Consumer United States
Primary
Concomitant
Trigeminal Neuralgia Other Serious 7/1/2005 35 7/10/2009 Physician Germany
Primary
Concomitant
Death Death Male 156 lb 7/14/2009 Consumer United States
Primary
Concomitant
Respiratory Failure Death 3/1/2009 72 Male 7/16/2009 Physician Brazil
Primary
Secondary
Concomitant
Death Death Male 156 lb 8/4/2009 Physician United States
Primary
Concomitant
Drug Interaction Hospitalization 6/3/2009 74 8/4/2009 Japan
Primary
Concomitant
Interacting
Drug Interaction Hospitalization 6/3/2009 74 8/5/2009 Japan
Primary
Concomitant
Interacting
Pseudomembranous Colitis Hospitalization 11/7/2008 Male 129 lb 8/6/2009 Physician Belgium
Primary
Concomitant
Transient Ischaemic Attack Other Serious 7/1/2008 76 Male 7/31/2009 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Flushing 6/1/2009 Female 8/29/2009 United States
Primary
Concomitant
Drug Interaction Hospitalization 5/19/2009 78 Female 130 lb 9/11/2009 Other Health Professional Germany
Primary
Secondary
Concomitant
Drug Interaction Hospitalization 5/19/2009 78 Female 130 lb 9/11/2009 Other Health Professional Germany
Primary
Concomitant
Interacting
Drug Interaction Hospitalization 1/1/2009 78 Female 130 lb 9/14/2009 Other Health Professional Germany
Primary
Concomitant
Interacting
Drug Ineffective 1/1/2008 60 Male 9/16/2009 Consumer United States
Primary
Concomitant
Road Traffic Accident Hospitalization 2/23/2001 59 Male 190 lb 9/23/2009 Other Health Professional United States
Primary
Concomitant
Insomnia Other Serious 3/15/2007 73 Male 9/30/2009 Other Health Professional United Kingdom
Primary
Concomitant
Pseudomembranous Colitis Hospitalization 11/7/2008 Male 129 lb 10/23/2009 Physician Belgium
Primary
Concomitant
Myalgia Hospitalization 2/27/2008 63 Male 10/23/2009 United Kingdom
Primary
Concomitant
Fatigue Disability 10/1/2009 Female 132 lb 11/3/2009 Physician Germany
Primary
Concomitant
Pseudomembranous Colitis Other Serious 11/7/2008 Male 129 lb 11/12/2009 Physician Belgium
Primary
Concomitant
Drug Interaction Hospitalization 5/19/2009 78 Female 130 lb 11/17/2009 Other Health Professional Germany
Primary
Concomitant
Interacting
Drug Interaction Hospitalization 1/1/2009 78 Female 130 lb 11/19/2009 Other Health Professional Germany
Primary
Concomitant
Interacting
Pseudomembranous Colitis Other Serious 11/7/2008 Male 129 lb 12/3/2009 Physician Belgium
Primary
Concomitant
Pseudomembranous Colitis Other Serious 11/7/2008 Male 129 lb 12/10/2009 Physician Belgium
Primary
Concomitant
Trigeminal Neuralgia Other Serious 7/1/2005 35 12/21/2009 Germany
Primary
Concomitant
Toxic Epidermal Necrolysis Other Serious 70 Female 12/23/2009 Physician Israel
Primary
Concomitant
Dyspnoea Other Serious 10/28/2009 Female 1/27/2010 Other Health Professional Switzerland
Primary
Concomitant
Weight Decreased 64 Female 1/21/2010 United States
Primary
Concomitant
Wheezing Hospitalization 2/3/2010 Female 218 lb 2/11/2010 Consumer United States
Primary
Concomitant
Toxic Epidermal Necrolysis Hospitalization 70 Female 1/29/2010 Israel
Primary
Concomitant
Dyspnoea Other Serious 10/28/2009 Female 2/17/2010 Other Health Professional Switzerland
Primary
Concomitant
Death Death 11/1/2009 Female 165 lb 2/19/2010 Consumer United Kingdom
Primary
Concomitant
Death Death Male 260 lb 3/1/2010 Consumer United States
Primary
Concomitant
Cardiac Arrest Death 2/22/2010 Male 260 lb 3/9/2010 Consumer United States
Primary
Concomitant
Renal Failure Acute Death 2/22/2010 Male 260 lb 3/16/2010 Consumer United States
Primary
Concomitant
Wheezing Hospitalization 2/3/2010 Female 218 lb 3/18/2010 Consumer United States
Primary
Concomitant
Urinary Retention Hospitalization 2/19/2010 Male 125 lb 3/29/2010 United Kingdom
Primary
Secondary
Concomitant
Renal Failure Chronic Other Serious Female 3/30/2010 United States
Primary
Concomitant
Musculoskeletal Stiffness Hospitalization 2/3/2010 43 Female 218 lb 4/16/2010 Physician United States
Primary
Concomitant
Myocardial Infarction Other Serious Male 238 lb 4/27/2010 Physician Germany
Primary
Secondary
Concomitant
Throat Tightness Hospitalization 3/21/2010 80 Male 4/26/2010 Consumer United Kingdom
Primary
Concomitant
Dyspnoea Death 4/8/2009 72 Male 238 lb 5/7/2010 Italy
Primary
Concomitant
Inappropriate Schedule Of Drug Administration Other Serious 3/1/2010 74 Male 6/4/2010 Physician Germany
Primary
Concomitant
Toxic Epidermal Necrolysis Hospitalization 70 Female 6/7/2010 Other Health Professional Israel
Primary
Secondary
Concomitant
Toxic Epidermal Necrolysis Hospitalization Female 6/10/2010 Other Health Professional Israel
Primary
Secondary
Toxic Epidermal Necrolysis Hospitalization Female 6/16/2010 Physician France
Primary
Secondary
Medication Error Female 208 lb 6/16/2010 United States
Primary
Concomitant
Thrombocytopenia Hospitalization 70 Female 6/18/2010 Other Health Professional Japan
Primary
Secondary
Concomitant
Toxic Epidermal Necrolysis Hospitalization Female 6/21/2010 Physician France
Primary
Secondary
Toxic Epidermal Necrolysis Hospitalization 70 Female 6/22/2010 Other Health Professional Germany
Primary
Secondary
Concomitant
Toxic Epidermal Necrolysis Hospitalization 70 Female 6/22/2010 Other Health Professional France
Primary
Secondary
Concomitant
Thrombocytopenia Hospitalization 70 Female 6/23/2010 Other Health Professional Japan
Primary
Secondary
Concomitant
Toxic Epidermal Necrolysis Hospitalization 70 Female 6/29/2010 Other Health Professional Germany
Primary
Secondary
Concomitant
Toxic Epidermal Necrolysis Hospitalization 70 Female 6/30/2010 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Tongue Haemorrhage Hospitalization 54 Male 6/30/2010 Consumer United States
Primary
Concomitant
Toxic Epidermal Necrolysis Hospitalization 70 Female 7/1/2010 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Toxic Epidermal Necrolysis Hospitalization Female 7/7/2010 Other Health Professional Israel
Primary
Secondary
Concomitant
Toxic Epidermal Necrolysis Hospitalization 70 Female 7/9/2010 Physician United Kingdom
Primary
Secondary
Toxic Epidermal Necrolysis Hospitalization 70 Female 7/9/2010 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Toxic Epidermal Necrolysis Hospitalization 70 Female 7/9/2010 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Toxic Epidermal Necrolysis Hospitalization 7/12/2010 Physician Israel
Primary
Secondary
Concomitant
Toxic Epidermal Necrolysis Hospitalization 70 Female 7/12/2010 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Toxic Epidermal Necrolysis Required Intervention 70 Female 7/2/2010 Physician United Kingdom
Primary
Secondary
Concomitant

Drug Data