Simvastatin combined with Spironolactone

Reports:

Reaction Outcome Event Date Age Sex Weight Reported Reporter Country Treatment
Role Name
Coronary Artery Stenosis Hospitalization 10/4/2005 70 Male 159 lb 1/12/2006 Czech Republic
Primary
Secondary
Concomitant
Stent Occlusion Hospitalization 7/25/2005 64 Male 183 lb 1/12/2006 Poland
Primary
Secondary
Concomitant
Haemothorax Life Threatening 8/17/2004 77 Male 1/20/2006 Consumer Poland
Primary
Concomitant
Hyperkalaemia Required Intervention 1/10/2006 84 Male 144 lb 1/18/2006 Pharmacist United States
Primary
Concomitant
Toe Amputation Hospitalization 10/1/2005 73 Male 1/12/2006 Physician Netherlands
Primary
Concomitant
Gynaecomastia Hospitalization 8/15/2004 70 Male 1/19/2006 Physician Sweden
Primary
Concomitant
Renal Failure Other Serious 9/1/2005 78 Male 1/19/2006 Physician Netherlands
Primary
Secondary
Concomitant
Renal Impairment Hospitalization 1/1/2005 78 Male 1/23/2006 Physician Netherlands
Primary
Secondary
Concomitant
Lethargy Other Serious 12/27/2005 64 Female 253 lb 12/30/2005 Pharmacist United States
Primary
Concomitant
Tremor Hospitalization 12/7/2005 74 Male 213 lb 12/29/2005 Pharmacist United States
Primary
Concomitant
Renal Impairment Other Serious 78 Male 2/13/2006 Netherlands
Primary
Secondary
Concomitant
Therapeutic Agent Toxicity Hospitalization 12/1/2005 Male 2/22/2006 Pharmacist United States
Primary
Secondary
Concomitant
Myocardial Ischaemia Death 62 Male 2/22/2006 Physician United Kingdom
Primary
Concomitant
Weight Decreased Other Serious 64 Male 2/28/2006 Israel
Primary
Concomitant
Coronary Artery Stenosis Hospitalization 10/4/2005 70 Male 159 lb 3/31/2006 Other Health Professional Czech Republic
Primary
Secondary
Concomitant
Hypertension Other Serious 3/1/2006 60 Female 4/7/2006 Pharmacist Canada
Primary
Concomitant
Neck Pain Death 2/16/2006 82 Male 205 lb 4/4/2006 Consumer United States
Primary
Concomitant
Urticaria Other Serious 1/2/2006 67 Male 248 lb 2/15/2006 Pharmacist United States
Primary
Concomitant
Pulmonary Toxicity Required Intervention 4/26/2005 72 Male 175 lb 4/20/2006 Pharmacist United States
Primary
Concomitant
Rhabdomyolysis Required Intervention 4/13/2006 76 Male 160 lb 4/18/2006 Pharmacist United States
Primary
Concomitant
Urinary Tract Infection Other Serious 6/22/2005 45 Female 150 lb 4/25/2006 Pharmacist United States
Primary
Concomitant
Tricuspid Valve Sclerosis Other Serious 1/1/2004 58 Male 4/25/2006 Denmark
Primary
Concomitant
Hypertension Other Serious 3/1/2006 60 Female 4/25/2006 Pharmacist Canada
Primary
Concomitant
Oedema Peripheral Other Serious 73 Male 5/5/2006 Physician United Kingdom
Primary
Secondary
Rash Maculo-papular Required Intervention 9/24/2005 76 Female 159 lb United States
Primary
Concomitant
Renal Impairment Hospitalization 1/1/2005 78 Male 5/12/2006 Physician Netherlands
Primary
Secondary
Concomitant
Thrombotic Thrombocytopenic Purpura Other Serious 2/26/2006 35 Female 220 lb 5/18/2006 Physician Canada
Primary
Secondary
Concomitant
Cardiac Failure Other Serious 73 Male 5/31/2006 Other Health Professional United Kingdom
Primary
Secondary
Rales Other Serious 73 Male 6/1/2006 Consumer United Kingdom
Primary
Secondary
Nausea 6/7/2006 58 Male 160 lb 6/15/2006 Pharmacist United States
Primary
Concomitant
Oedema Peripheral Other Serious 73 Male 6/12/2006 Other Health Professional United Kingdom
Primary
Secondary
Cardiac Failure Other Serious 1/1/2000 73 Male 6/12/2006 United Kingdom
Primary
Secondary
Liver Function Test Abnormal Other Serious 3/22/2005 57 Female 143 lb 6/23/2006 Belgium
Primary
Concomitant
Gastric Ulcer 6/21/2006 68 Male 238 lb 6/21/2006 Pharmacist United States
Primary
Concomitant
Rhabdomyolysis Other Serious 34 Male 7/21/2006 Other Health Professional Spain
Primary
Concomitant
Staphylococcal Infection Hospitalization 1/8/2001 63 Male 7/24/2006 France
Primary
Secondary
Concomitant
Periodontitis Hospitalization 71 Female 8/2/2006 Other Health Professional Sweden
Primary
Concomitant
Vomiting Life Threatening 2/1/2006 75 Male 150 lb 8/4/2006 Physician Germany
Primary
Concomitant
Thinking Abnormal 5/1/2006 64 Male 200 lb 7/12/2006 Consumer United States
Primary
Concomitant
Weight Decreased 6/1/2005 Male 215 lb 8/8/2006 Consumer United States
Primary
Concomitant
Osteonecrosis Hospitalization 71 Female 8/9/2006 Other Health Professional Sweden
Primary
Concomitant
Sepsis Other Serious 5/7/2005 71 Female 209 lb 8/10/2006 Physician United States
Primary
Concomitant
Therapeutic Agent Toxicity Hospitalization 6/28/2006 54 Male 9/1/2006 Pharmacist United States
Primary
Secondary
Concomitant
Sedation 2/1/2006 83 Male 9/6/2006 Consumer United States
Primary
Concomitant
Hyperkalaemia Hospitalization 6/20/2006 70 Male 9/13/2006 Pharmacist United States
Primary
Secondary
Concomitant
Coronary Artery Stenosis Hospitalization 5/23/2006 73 Male 176 lb 9/13/2006 Netherlands
Primary
Secondary
Concomitant
Stevens-johnson Syndrome Hospitalization 5/11/2006 79 Female 154 lb 10/3/2006 Other Health Professional United Kingdom
Primary
Concomitant
Circulatory Collapse Death 69 Male 9/30/2006 Physician Singapore
Primary
Secondary
Stevens-johnson Syndrome Hospitalization 79 Female 154 lb 9/29/2006 United Kingdom
Primary
Concomitant
Hyperkalaemia Hospitalization 78 Male 10/5/2006
Primary
Secondary
Concomitant
Hyperkalaemia Hospitalization 78 Male 10/9/2006 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Red Blood Cell Count Decreased Hospitalization 5/23/2006 73 Male 176 lb 10/3/2006 Poland
Primary
Secondary
Concomitant
Ill-defined Disorder Hospitalization 7/7/2006 82 Male 192 lb 10/4/2006 Pharmacist United States
Primary
Concomitant
Vomiting Life Threatening 2/1/2006 75 Male 148 lb 10/10/2006 Physician Germany
Primary
Concomitant
Hyperkalaemia Hospitalization 78 Male 10/10/2006 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Neutropenia Other Serious 74 Female 175 lb 10/10/2006 Physician
Primary
Secondary
Concomitant
Hyperkalaemia Hospitalization 78 Male 10/9/2006 Physician United Kingdom
Primary
Secondary
Concomitant
Neutropenia Other Serious 74 Female 10/16/2006 Physician
Primary
Secondary
Concomitant
Hyperkalaemia Hospitalization 78 Male 10/6/2006 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Hyperkalaemia Required Intervention 78 Male 10/10/2006 Other Health Professional Denmark
Primary
Concomitant
Neutropenia Other Serious 74 Female 10/23/2006 Physician
Primary
Secondary
Concomitant
Neutropenia Other Serious 74 Female 175 lb 10/18/2006 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Tachycardia Hospitalization 9/26/2006 59 Male 10/26/2006 United States
Primary
Secondary
Concomitant
Linear Iga Disease Other Serious 73 Male 10/26/2006 Physician United States
Primary
Concomitant
Renal Failure Acute Other Serious 76 Female 11/7/2006 Other Health Professional Canada
Primary
Secondary
Concomitant
Dyspnoea 6/1/2006 80 Male 11/13/2006 Consumer United States
Primary
Concomitant
Myocardial Ischaemia Death 69 Male 11/14/2006 Physician Singapore
Primary
Concomitant
Pulmonary Oedema Hospitalization 8/1/2006 81 Female 11/8/2006 United Kingdom
Primary
Concomitant
Pulmonary Oedema Hospitalization 8/1/2006 81 Female 11/13/2006 United States
Primary
Concomitant
Pulmonary Oedema Hospitalization 8/1/2006 81 Female 11/13/2006 United Kingdom
Primary
Concomitant
Speech Disorder Other Serious 7/21/2006 86 Male 164 lb 7/26/2006 Pharmacist United States
Primary
Concomitant
Rash Other Serious 8/2/2006 65 Male 185 lb 9/18/2006 Physician United States
Primary
Concomitant
Sinus Tachycardia Hospitalization 8/3/2006 65 Male 256 lb 12/1/2006 Physician United States
Primary
Secondary
Concomitant
Wheezing Hospitalization 9/15/2006 65 Male 256 lb 12/1/2006 Physician United States
Primary
Concomitant
Treatment Noncompliance Hospitalization 7/25/2006 65 Male 256 lb 12/1/2006 Physician United States
Primary
Secondary
Concomitant
Chronic Obstructive Pulmonary Disease Hospitalization 8/27/2006 65 Male 256 lb 12/1/2006 Physician United States
Primary
Concomitant
Renal Failure Death 11/30/2006 78 Male 12/15/2006 Physician Germany
Primary
Concomitant
Respiratory Failure Hospitalization 11/18/2006 62 Male 187 lb 12/18/2006 Physician Spain
Primary
Secondary
Renal Impairment Hospitalization 11/8/2006 75 Male 1/8/2007
Primary
Secondary
Concomitant
Urine Output Decreased Hospitalization 11/18/2006 62 Male 187 lb 1/3/2007 Physician Spain
Primary
Secondary
Cardiogenic Shock Death 3/11/2006 91 Male 154 lb 10/6/2006 United States
Primary
Secondary
Concomitant
Pyrexia Other Serious 8/30/2005 60 Male 134 lb 10/6/2006 United States
Primary
Secondary
Concomitant
Right Ventricular Failure Death 11/30/2006 Male 1/9/2007 Physician Germany
Primary
Concomitant
Rectal Haemorrhage Required Intervention 7/11/2006 74 Female 177 lb 7/15/2006 Pharmacist United States
Primary
Concomitant
Abdominal Pain 7/30/2006 73 Female 140 lb 10/24/2006 United States
Primary
Concomitant
Gastrointestinal Haemorrhage Hospitalization 12/3/2006 78 Male 1/9/2007 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Deep Vein Thrombosis Hospitalization 11/9/2006 73 Male 183 lb 1/19/2007 Physician Germany
Primary
Concomitant
Toe Amputation Hospitalization 10/1/2005 73 Male 1/16/2007 Netherlands
Primary
Concomitant
Urine Sodium Increased Hospitalization 78 Male 1/15/2007 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Vomiting Other Serious 4/14/2006 80 Male 240 lb 1/18/2007 Pharmacist United States
Primary
Concomitant
Hyponatraemia Other Serious 93 Female 1/16/2007 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Rash Other Serious 10/24/2006 56 Male 210 lb 10/25/2006 Pharmacist United States
Primary
Secondary
Concomitant
Gynaecomastia Other Serious 9/26/2006 64 Male 242 lb 9/26/2006 Pharmacist United States
Primary
Concomitant
Weight Increased Other Serious 1/1/1998 77 Male 209 lb 1/25/2007 Consumer Germany
Primary
Concomitant
Subdural Haematoma Life Threatening 10/18/2006 80 Male 191 lb 1/9/2007 Pharmacist United States
Primary
Secondary
Concomitant
Hyperkalaemia Hospitalization 78 Male 1/29/2007 Consumer United Kingdom
Primary
Secondary
Concomitant
Hyperkalaemia Hospitalization 78 Male 1/30/2007 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Chronic Obstructive Pulmonary Disease Hospitalization 7/25/2006 65 Male 256 lb 1/31/2007 Physician United States
Primary
Concomitant
Chronic Obstructive Pulmonary Disease Hospitalization 9/15/2006 65 Male 256 lb 2/1/2007 Physician United States
Primary
Concomitant
Chronic Obstructive Pulmonary Disease Hospitalization 8/27/2006 65 Male 256 lb 2/1/2007 Physician United States
Primary
Concomitant
Chronic Obstructive Pulmonary Disease Hospitalization 8/3/2006 65 Male 256 lb 2/1/2007 Physician United States
Primary
Secondary
Concomitant
Psychotic Disorder Other Serious 9/1/2006 77 Male 121 lb 2/14/2007 Physician Sweden
Primary
Concomitant
Myositis Life Threatening 6/1/2006 75 Male 139 lb 3/5/2007 Other Health Professional United Kingdom
Primary
Concomitant
Hypotonia Hospitalization 10/26/2006 3/6/2007 Physician United States
Primary
Secondary
Concomitant
Myositis Life Threatening 6/1/2006 75 Male 139 lb 3/1/2007 United Kingdom
Primary
Concomitant
Drug Ineffective 75 Male 3/7/2007 Consumer United States
Primary
Concomitant
Septic Shock Hospitalization 11/18/2006 62 NotSpecified 187 lb 3/6/2007 Physician Spain
Primary
Secondary
Myositis Other Serious 2/1/2007 64 Female 220 lb 3/14/2007 United Kingdom
Primary
Secondary
Concomitant
Parkinson's Disease Hospitalization 2/3/2007 Male 197 lb 4/2/2007 Other Health Professional United States
Primary
Secondary
Concomitant
Urethral Haemorrhage Other Serious 1/1/2006 Male 165 lb 4/5/2007 Physician Germany
Primary
Concomitant
Vomiting Hospitalization 76 Female 4/9/2007 Consumer Colombia
Primary
Concomitant
Pulmonary Embolism Other Serious 3/7/2007 72 Male 4/4/2007 Physician United Kingdom
Primary
Concomitant
Loss Of Consciousness Hospitalization 3/23/2007 72 Male 4/10/2007 Physician United Kingdom
Primary
Concomitant
Ventricular Fibrillation Hospitalization 12/4/2006 Female 198 lb 4/18/2007 Physician Germany
Primary
Secondary
Concomitant
Pulmonary Oedema Hospitalization 11/1/2006 78 Male 4/17/2007 Consumer United Kingdom
Primary
Concomitant
Loss Of Consciousness Hospitalization 3/23/2007 72 Male 4/16/2007 United Kingdom
Primary
Concomitant
Weight Increased Hospitalization 1/1/2006 Female 4/30/2007 Consumer United States
Primary
Secondary
Concomitant
Hypotonia Hospitalization 5/15/2006 70 Male 5/1/2007 Physician United Kingdom
Primary
Secondary
Concomitant
Breast Cancer Hospitalization 2/23/2007 68 Female 251 lb 5/2/2007 Physician United Kingdom
Primary
Concomitant
Suicidal Ideation Life Threatening 4/1/2007 65 Male 5/9/2007 Consumer United Kingdom
Primary
Concomitant
Pulmonary Embolism Other Serious 3/7/2007 72 Male 5/11/2007 Physician United Kingdom
Primary
Concomitant
Myalgia Other Serious 4/13/2007 68 Male 181 lb 5/8/2007 Physician Germany
Primary
Secondary
Concomitant
Asthenia Hospitalization 3/22/2007 Male 153 lb 5/10/2007 Pharmacist United States
Primary
Concomitant
Pallor Hospitalization 5/11/2006 79 Female 154 lb 5/18/2007 Other Health Professional United Kingdom
Primary
Concomitant
Syncope Other Serious 11/1/2006 78 Male 218 lb 5/24/2007 Consumer United Kingdom
Primary
Concomitant
Gastrointestinal Haemorrhage Hospitalization 1/28/2007 60 Female 5/25/2007 Other Health Professional Sweden
Primary
Secondary
Concomitant
Transient Ischaemic Attack Hospitalization 10/16/2006 66 Male 187 lb 2/9/2007 Physician United States
Primary
Concomitant
White Blood Cell Count Decreased Death 3/14/2007 79 Female 5/24/2007 Sweden
Primary
Concomitant
Respiratory Disorder Hospitalization Male 220 lb 6/5/2007 Consumer France
Primary
Concomitant
Ventricular Tachycardia Hospitalization 5/23/2007 72 Male 6/4/2007 United Kingdom
Primary
Concomitant
Hallucination Other Serious 3/24/2007 79 Female 117 lb 6/7/2007 Physician Japan
Primary
Concomitant
Syncope Other Serious 3/1/2007 78 Male 218 lb 6/11/2007 Consumer United Kingdom
Primary
Concomitant
Hepatic Enzyme Increased 12/12/2006 70 Female 5/17/2007 United States
Primary
Concomitant
Vasospasm Hospitalization 84 Female 6/13/2007 Other Health Professional United States
Primary
Secondary
Concomitant
Ventricular Fibrillation Hospitalization 12/4/2006 Female 198 lb 6/15/2007 Physician Germany
Primary
Secondary
Concomitant
Guillain-barre Syndrome Other Serious 58 Male 6/18/2007 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Weight Increased Other Serious 1/8/2007 71 Male 142 lb 6/28/2007 Physician United Kingdom
Primary
Concomitant
Renal Impairment Hospitalization 3/1/2005 81 Female 6/27/2007 United Kingdom
Primary
Concomitant
Sensory Loss Other Serious 58 Male 6/19/2007 United Kingdom
Primary
Secondary
Concomitant
Oral Mucosal Blistering 5/1/2007 47 Female 7/6/2007 Consumer United States
Primary
Secondary
Concomitant
Sinus Bradycardia Life Threatening 84 Female 7/6/2007 Germany
Primary
Secondary
Concomitant
Ventricular Fibrillation Hospitalization 12/4/2006 Female 198 lb 7/12/2007 Physician Germany
Primary
Secondary
Concomitant
Sinus Bradycardia Life Threatening 84 Female 7/17/2007 Other Health Professional Germany
Primary
Secondary
Concomitant
Guillain-barre Syndrome Other Serious 58 Male 7/6/2007 United Kingdom
Primary
Secondary
Concomitant
Skin Cancer Other Serious 7/1/2007 73 Male 8/2/2007 United States
Primary
Concomitant
Flatulence 6/1/2007 80 Male 8/3/2007 Consumer United States
Primary
Concomitant
Renal Failure Hospitalization 58 Male 8/16/2007 Physician United Kingdom
Primary
Secondary
Concomitant
Renal Failure Hospitalization 58 Male 8/17/2007 Physician United Kingdom
Primary
Secondary
Concomitant
Renal Failure Other Serious 58 Male 8/24/2007 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Guillain-barre Syndrome Other Serious 58 Male 8/30/2007 Other Health Professional United Kingdom
Primary
Secondary
Concomitant

Drug Data