Senna combined with Spironolactone

Reports:

Reaction Outcome Event Date Age Sex Weight Reported Reporter Country Treatment
Role Name
Tremor Other Serious 8/6/2005 59 Male 239 lb 1/19/2006 Consumer United States
Primary
Concomitant
Renal Failure Death 1/18/2006 85 Male 2/28/2006 Other Health Professional United Kingdom
Primary
Concomitant
Renal Failure Death 1/18/2006 85 Male 3/1/2006 Other Health Professional United Kingdom
Primary
Concomitant
Renal Failure Death 1/18/2006 85 Male 3/3/2006 Other Health Professional United Kingdom
Primary
Concomitant
Periarthritis Hospitalization 8/13/2001 64 Female 170 lb 5/9/2006 Physician United States
Primary
Concomitant
Rash Maculo-papular Required Intervention 9/24/2005 76 Female 159 lb United States
Primary
Concomitant
Jaundice Cholestatic Hospitalization 3/28/2006 67 Female 173 lb 5/11/2006 Pharmacist United States
Primary
Concomitant
Disease Progression Other Serious 3/22/2006 80 Female 5/1/2006 Physician United States
Primary
Concomitant
Wound Infection Other Serious 3/1/2006 60 Female 105 lb 10/30/2006 Physician United States
Primary
Concomitant
Speech Disorder Other Serious 7/21/2006 86 Male 164 lb 7/26/2006 Pharmacist United States
Primary
Concomitant
Transient Ischaemic Attack Hospitalization 12/4/2005 87 Male 168 lb 12/19/2006 United Kingdom
Primary
Concomitant
Rectal Haemorrhage Required Intervention 7/11/2006 74 Female 177 lb 7/15/2006 Pharmacist United States
Primary
Concomitant
Subdural Haematoma Life Threatening 10/18/2006 80 Male 191 lb 1/9/2007 Pharmacist United States
Primary
Secondary
Concomitant
Vomiting Death 1/1/2007 77 Female 4/13/2007 Other Health Professional United Kingdom
Primary
Concomitant
Respiratory Disorder Hospitalization Male 220 lb 6/5/2007 Consumer France
Primary
Concomitant
Renal Impairment Hospitalization 3/1/2005 81 Female 6/27/2007 United Kingdom
Primary
Concomitant
Non-cardiac Chest Pain Hospitalization 7/26/2007 62 Male 9/13/2007 United Kingdom
Primary
Concomitant
Non-cardiac Chest Pain Hospitalization 7/26/2007 62 Male 9/12/2007 Physician United Kingdom
Primary
Concomitant
Liver Function Test Abnormal Other Serious 9/7/2007 55 Male 10/11/2007 Consumer United Kingdom
Primary
Concomitant
Vomiting Hospitalization 12/21/2005 81 Female 10/25/2007 Physician United Kingdom
Primary
Secondary
Concomitant
Vomiting Hospitalization 12/21/2005 81 Female 10/26/2007 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Vomiting Hospitalization 12/21/2005 10/30/2007 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Vomiting Hospitalization 12/21/2005 81 Female 10/25/2007 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Weight Increased Hospitalization Female 203 lb 1/15/2008 Physician United States
Primary
Concomitant
Death Death 12/16/2007 Male 1/29/2008 Physician United States
Primary
Concomitant
Renal Failure Hospitalization 12/31/2007 Male 216 lb 1/31/2008 Consumer United States
Primary
Concomitant
Right Ventricular Failure Other Serious 10/1/2007 70 Female 139 lb 2/1/2008 Physician United States
Primary
Secondary
Concomitant
Urethritis Hospitalization 1/30/2008 63 Male 2/4/2008 Norway
Primary
Concomitant
Renal Failure Hospitalization 12/31/2007 Male 216 lb 2/8/2008 Consumer United States
Primary
Concomitant
Renal Failure Hospitalization 2/6/2008 76 Male 195 lb 3/7/2008 Other Health Professional United States
Primary
Concomitant
Angina Pectoris Hospitalization 3/6/2008 66 Female 251 lb 3/28/2008 Consumer United Kingdom
Primary
Concomitant
Muscular Weakness Hospitalization 3/1/2008 50 Male 163 lb 4/10/2008 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Right Ventricular Failure Other Serious 10/1/2007 70 Female 139 lb 5/23/2008 Physician United States
Primary
Secondary
Concomitant
Urethritis Hospitalization 1/30/2008 63 Male 6/5/2008 Norway
Primary
Concomitant
Upper Gastrointestinal Haemorrhage Hospitalization 6/24/2008 61 Male 7/31/2008 Other Health Professional United Kingdom
Primary
Concomitant
Vomiting Hospitalization 10/21/2008 53 Male 282 lb 10/22/2008 Physician United States
Primary
Secondary
Concomitant
Respiratory Failure Hospitalization 10/21/2008 53 Male 282 lb 11/3/2008 Physician United States
Primary
Secondary
Concomitant
Vomiting Other Serious 9/21/2008 Male 282 lb 11/17/2008 Physician United States
Primary
Secondary
Concomitant
Vomiting Other Serious 9/21/2008 Male 282 lb 12/1/2008 Physician United States
Primary
Secondary
Concomitant
Product Quality Issue Other Serious 11/20/2008 81 Female 140 lb 12/5/2008 Consumer United States
Primary
Concomitant
International Normalised Ratio Increased Other Serious 1/11/2009 Female 1/20/2009 Pharmacist United States
Primary
Concomitant
Vomiting Hospitalization 4/14/2009 63 Female 146 lb 4/23/2009 Other Health Professional United States
Primary
Concomitant
Vomiting Other Serious 4/14/2009 Female 146 lb 5/6/2009 United States
Primary
Concomitant
Neuropathy Peripheral Hospitalization 4/20/2009 Female 5/7/2009 Physician United Kingdom
Primary
Secondary
Concomitant
Vomiting Hospitalization 4/24/2009 63 Female 146 lb 5/7/2009 Other Health Professional United States
Primary
Concomitant
Vomiting Other Serious 4/1/2009 Female 146 lb 5/18/2009 United States
Primary
Concomitant
Neuropathy Peripheral Hospitalization 4/20/2009 Female 5/26/2009 Physician United Kingdom
Primary
Secondary
Concomitant
Treatment Noncompliance Hospitalization 5/1/2009 70 Female 6/25/2009 Other Health Professional United States
Primary
Concomitant
Hypoglycaemia Required Intervention 3/31/2009 Male 200 lb 4/11/2009 Pharmacist United States
Primary
Concomitant
Vomiting Other Serious 4/1/2009 Female 146 lb 6/26/2009 United States
Primary
Concomitant
Weight Increased Other Serious 1/1/2003 47 Male 283 lb 7/21/2009 United States
Primary
Concomitant
Weight Decreased Hospitalization 10/13/2006 65 Female 167 lb 8/13/2009 Lawyer United States
Primary
Concomitant
Weight Increased Other Serious 7/22/2008 69 Male 8/27/2009 Physician United States
Primary
Secondary
Concomitant
Death Death 8/13/2009 Female 8/27/2009 Other Health Professional United States
Primary
Concomitant
Tibia Fracture Required Intervention 7/12/2009 61 Male 195 lb 7/13/2009 United States
Primary
Secondary
Concomitant
Wound Infection Hospitalization 29 Female 276 lb 9/29/2009 United States
Primary
Concomitant
Nervous System Disorder Other Serious 7/22/2008 69 Male 10/6/2009 Physician United States
Primary
Secondary
Concomitant
Neuropathy Peripheral Hospitalization 4/20/2009 Female 10/7/2009 Physician United Kingdom
Primary
Secondary
Concomitant
Leukocytoclastic Vasculitis Other Serious 76 Female 10/19/2009 Pharmacist United States
Primary
Concomitant
Pneumonia Hospitalization 7/1/2009 Female 140 lb 10/22/2009 Consumer United States
Primary
Concomitant
Generalised Oedema Other Serious 2/7/2010 81 Male 3/12/2010 Other Health Professional United Kingdom
Primary
Concomitant
Generalised Oedema Other Serious 2/7/2010 81 Male 3/12/2010 Other Health Professional United Kingdom
Primary
Concomitant
Generalised Oedema Other Serious 2/7/2010 81 Male 3/18/2010 Other Health Professional United Kingdom
Primary
Concomitant
Generalised Oedema Other Serious 2/7/2010 81 Male 3/18/2010 Other Health Professional United Kingdom
Primary
Concomitant
Staphylococcal Bacteraemia Other Serious 1/1/2008 69 Male 3/19/2010 Physician United States
Primary
Secondary
Concomitant
Generalised Oedema Other Serious 2/7/2010 81 Male 3/15/2010 Other Health Professional United Kingdom
Primary
Concomitant
Injection Site Swelling 11/5/2009 Male 3/20/2010 Other Health Professional United States
Primary
Concomitant
Vision Blurred Other Serious 1/1/2001 Female 3/23/2010 United States
Primary
Concomitant
Generalised Oedema Other Serious 81 Male 3/22/2010 Other Health Professional
Primary
Concomitant
Staphylococcal Bacteraemia Other Serious 1/1/2008 69 Male 4/19/2010 Physician United States
Primary
Secondary
Concomitant
Visual Acuity Reduced Other Serious 1/1/2001 56 Female 142 lb 4/26/2010 Physician United States
Primary
Concomitant
Unresponsive To Stimuli Hospitalization 2/6/2008 76 Male 195 lb 4/23/2010 Other Health Professional United States
Primary
Concomitant
Unresponsive To Stimuli Other Serious 1/1/2005 57 Male 5/24/2010 Lawyer United States
Primary
Secondary
Concomitant
Unresponsive To Stimuli Other Serious 1/1/2005 57 Male 5/25/2010 Lawyer United States
Primary
Secondary
Concomitant
Inappropriate Antidiuretic Hormone Secretion Hospitalization 6/3/2010 Other Health Professional Italy
Primary
Concomitant
Ventricular Hypertrophy Hospitalization 49 Female 5/27/2010 United States
Primary
Concomitant
Vomiting Hospitalization 5/22/2010 63 Female 123 lb 6/11/2010 Physician United States
Primary
Secondary
Concomitant
General Physical Health Deterioration Hospitalization 6/19/2010 78 Male 142 lb 7/7/2010 Physician United Kingdom
Primary
Secondary
Concomitant
General Physical Health Deterioration Hospitalization 6/21/2010 78 Male 142 lb 7/28/2010 Physician United Kingdom
Primary
Secondary
Concomitant
Rash Maculo-papular Hospitalization 8/13/2010 47 Female 125 lb 8/14/2010 Pharmacist United States
Primary
Concomitant
Disseminated Intravascular Coagulation Hospitalization 8/18/2010 62 Male 171 lb 8/31/2010 Other Health Professional United States
Primary
Secondary
Concomitant
Weight Decreased Hospitalization 10/13/2006 65 Female 167 lb 9/3/2010 United States
Primary
Concomitant
Disseminated Intravascular Coagulation Hospitalization 8/18/2010 62 Male 171 lb 9/22/2010 Other Health Professional United States
Primary
Secondary
Concomitant
Sputum Discoloured Hospitalization 9/30/2010 80 Male 10/20/2010 Other Health Professional United Kingdom
Primary
Concomitant
Gastrointestinal Haemorrhage Hospitalization 10/28/2010 69 Male 11/11/2010 Physician United States
Primary
Concomitant
Cardiac Failure Congestive Hospitalization 11/2/2010 82 Male 168 lb 12/13/2010 Other Health Professional United Kingdom
Primary
Concomitant
Sinusitis Hospitalization 1/1/2010 42 Female 12/29/2010 Physician United States
Primary
Concomitant
Dyspnoea Other Serious 1/1/2005 57 Male 1/27/2011 Lawyer United States
Primary
Secondary
Concomitant
Asthenia Hospitalization 2/6/2008 76 Male 195 lb 1/18/2011 Other Health Professional United States
Primary
Concomitant
Adverse Drug Reaction Hospitalization 1/1/2010 42 Female 2/2/2011 Consumer United States
Primary
Concomitant
Death Death Female 2/23/2011 Physician United States
Primary
Concomitant
Conversion Disorder Hospitalization 1/1/2010 42 Female 3/4/2011 Other Health Professional United States
Primary
Concomitant
Glomerular Filtration Rate Decreased Other Serious 2/18/2011 76 Female 254 lb 3/4/2011 Other Health Professional United Kingdom
Primary
Concomitant
Sudden Death Death 2/17/2011 71 Female 3/8/2011 Physician United States
Primary
Concomitant
Glomerular Filtration Rate Decreased Other Serious 2/18/2011 76 Female 3/15/2011 Other Health Professional Denmark
Primary
Concomitant
Glomerular Filtration Rate Decreased Other Serious 2/18/2011 76 Female 254 lb 3/24/2011 Other Health Professional United Kingdom
Primary
Concomitant
Cardiac Failure Congestive Other Serious 2/18/2011 76 Female 3/31/2011 Other Health Professional Denmark
Primary
Concomitant
Intervertebral Disc Disorder Hospitalization 1/1/2010 42 Female 4/15/2011 Consumer United States
Primary
Concomitant
Glomerular Filtration Rate Decreased Other Serious 2/18/2011 76 Female 254 lb 4/28/2011 Other Health Professional United Kingdom
Primary
Concomitant
Chronic Obstructive Pulmonary Disease Other Serious 4/16/2009 74 Female 6/24/2011 Physician United Kingdom
Primary
Concomitant
Anorgasmia Other Serious 1/3/2011 64 Male 260 lb 6/24/2011 Physician United States
Primary
Concomitant
Pneumonia Hospitalization 8/10/2011 63 Female 9/22/2011 New Zealand
Primary
Concomitant
Hypotension Death 1/1/2005 57 Male 10/13/2011 Lawyer United States
Primary
Secondary
Concomitant
Respiratory Distress Death 1/1/2011 74 Female 11/9/2011 Physician United States
Primary
Concomitant
Tubulointerstitial Nephritis Hospitalization 9/3/2011 73 Male 11/23/2011 United Kingdom
Primary
Concomitant
Toxicity To Various Agents Hospitalization 12/9/2011 71 Male 220 lb 12/15/2011 Pharmacist United States
Primary
Concomitant
Disseminated Intravascular Coagulation Hospitalization 8/18/2010 62 Male 171 lb 1/31/2012 Other Health Professional United States
Primary
Secondary
Concomitant
Glomerular Filtration Rate Decreased Other Serious 2/8/2012 61 Male 278 lb 3/1/2012 Physician Japan
Primary
Secondary
Concomitant
Tremor Hospitalization 1/9/2012 59 Female 220 lb 3/5/2012 Other Health Professional United States
Primary
Secondary
Concomitant
Heart Rate Irregular Other Serious 2/16/2012 76 Female 150 lb 3/9/2012 Physician United States
Primary
Concomitant
Abdominal Distension Hospitalization 2/24/2012 48 Female 108 lb 3/21/2012 Consumer United States
Primary
Concomitant
Intestinal Ischaemia Hospitalization 2/25/2012 48 Female 108 lb 4/3/2012 Other Health Professional United States
Primary
Concomitant
Pneumonia Other Serious 8/22/2011 67 Male 5/11/2012 Other Health Professional United States
Primary
Concomitant
Pneumonia Death 8/22/2011 67 Male 5/25/2012 Other Health Professional United States
Primary
Concomitant
Non-small Cell Lung Cancer Other Serious 5/15/2012 49 Female 127 lb 7/6/2012 Physician Hong Kong
Primary
Concomitant
Tremor Hospitalization 1/9/2012 60 Female 220 lb 10/10/2012 Other Health Professional Us
Primary
Secondary
Concomitant
Tremor Hospitalization 1/9/2012 60 Female 220 lb 8/7/2013 Other Health Professional Us
Primary
Secondary
Concomitant
Stomatitis 5/12/2012 81 Female 9/27/2012 Consumer Us
Primary
Concomitant
Leukopenia Other Serious 9/7/2011 72 Female 165 lb 6/27/2013 Pharmacist Us
Primary
Concomitant
Hepatic Failure Hospitalization 9/4/2012 54 Female 164 lb 1/3/2013 Physician Us
Primary
Secondary
Concomitant
Rheumatoid Lung Hospitalization 6/18/2012 85 Female 123 lb 9/18/2012 Physician Country Not Specified
Primary
Concomitant
Haemorrhagic Stroke Hospitalization 10/5/2012 85 Female 12/26/2012 Physician Ph
Primary
Concomitant
Liver Function Test Abnormal Hospitalization 6/1/2012 45 Female 11/9/2012 Physician Gb
Primary
Secondary
Concomitant
Tremor 2007 Female 181 lb 1/24/2013 Consumer Us
Primary
Concomitant
Palpitations Other Serious 98 Female 12/19/2012 Consumer Us
Primary
Secondary
Concomitant
Head Injury Other Serious Male 1/8/2013 Physician Us
Primary
Concomitant
Cardiac Failure Death 1/4/2013 58 Male 119 lb 2/19/2013 Consumer Gb
Primary
Secondary
Concomitant
Weight Decreased Other Serious Male 5/20/2013 Consumer Country Not Specified
Primary
Concomitant
Liver Function Test Abnormal Hospitalization 45 Female 11/1/2012 Pharmacist Gb
Primary
Secondary
Concomitant
Insomnia Female 167 lb 5/10/2013 Consumer Us
Primary
Secondary
Concomitant
Tremor Other Serious 2/26/2013 56 Male 231 lb 5/20/2013 Pharmacist Gb
Primary
Concomitant
Cardiac Arrest Life Threatening 6/27/2013 70 Male 166 lb 8/12/2013 Physician Us
Primary
Secondary
Concomitant
Skin Erosion Hospitalization 4/29/2013 84 Male 110 lb 10/2/2013 Physician Gb
Primary
Concomitant
Skin Erosion Disability 4/29/2013 84 Male 110 lb 9/4/2013 Physician Gb
Primary
Concomitant
Skin Erosion Disability 4/29/2013 84 Male 110 lb 10/10/2013 Other Health Professional Gb
Primary
Concomitant
Skin Erosion Hospitalization 4/29/2013 84 Male 110 lb 9/5/2013 Physician Gb
Primary
Concomitant
Cardiac Output Decreased Death 6/19/2013 34 Female 198 lb 9/20/2013 Consumer Gb
Primary
Secondary
Concomitant
Acute Hepatic Failure Death 8/15/2013 67 Male 216 lb 9/20/2013 Other Health Professional Gb
Primary
Concomitant
Acute Hepatic Failure Death 8/15/2013 67 Male 216 lb 9/23/2013 Physician Gb
Primary
Concomitant
Skin Erosion Disability 4/29/2013 84 Male 110 lb 10/3/2013 Other Health Professional Gb
Primary
Concomitant
Disease Progression Death 53 Female 10/24/2013 Consumer Us
Primary
Concomitant
Muscle Spasms Hospitalization 10/2012 74 Female 11/7/2013 Pharmacist Us
Primary
Concomitant
Left Ventricular Dysfunction Disability 2012 27 Female 12/7/2013 Physician Gb
Primary
Concomitant
Left Ventricular Dysfunction Life Threatening 2012 27 Female 12/9/2013 Physician Gb
Primary
Concomitant
Left Ventricular Dysfunction Life Threatening 2012 27 Female 12/9/2013 Other Health Professional Gb
Primary
Concomitant
Pain 36 Female 12/16/2013 Consumer Us
Primary
Concomitant
Left Ventricular Dysfunction Disability 2012 27 Female 12/18/2013 Physician Gb
Primary
Concomitant
Left Ventricular Dysfunction Other Serious 2012 27 Female 12/18/2013 Physician Gb
Primary
Concomitant
Left Ventricular Dysfunction Hospitalization 2012 27 Female 12/19/2013 Gb
Primary
Concomitant
Stevens-johnson Syndrome Hospitalization 10/27/2009 74 Male 95 lb 12/16/2012 Pharmacist Jp
Primary
Concomitant

Drug Data