Senna combined with Simvastatin

Reports:

Reaction Outcome Event Date Age Sex Weight Reported Reporter Country Treatment
Role Name
Renal Failure Chronic Required Intervention 11/9/2005 79 Female 1/16/2006 Physician United States
Primary
Concomitant
Rales Life Threatening 11/11/2005 85 Female 1/23/2006 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Somnolence Hospitalization 6/28/2005 62 Male 141 lb 1/24/2006 Physician United Kingdom
Primary
Secondary
Concomitant
Subcutaneous Emphysema Other Serious 10/1/2003 Male 203 lb 2/9/2006 United Kingdom
Primary
Secondary
Concomitant
Loss Of Consciousness Hospitalization 11/23/2005 74 Male 209 lb 12/12/2005 Pharmacist United States
Primary
Concomitant
Gastric Ulcer Hospitalization 11/9/2005 49 Female 3/10/2006 Physician Japan
Primary
Concomitant
Dystonia 2/20/2006 54 Male 3/14/2006 United Kingdom
Primary
Concomitant
Nervous System Disorder Hospitalization 3/14/2006 77 Female 4/14/2006 Other Health Professional United Kingdom
Primary
Concomitant
Transient Ischaemic Attack Other Serious 9/1/2001 70 Female 126 lb 4/14/2006 Physician Canada
Primary
Concomitant
Stress Ulcer Hospitalization 11/8/2005 49 Female 4/18/2006 Physician Japan
Primary
Concomitant
Rash Maculo-papular Required Intervention 9/24/2005 76 Female 159 lb United States
Primary
Concomitant
Vomiting Other Serious 10/30/2004 55 Male 254 lb 6/12/2006 Physician United Kingdom
Primary
Concomitant
Weight Increased Hospitalization 4/13/2006 67 Male 6/29/2006 Physician United States
Primary
Secondary
Concomitant
Metastasis Other Serious 6/20/2006 75 Female 8/17/2006 Other Health Professional United Kingdom
Primary
Concomitant
Gastrointestinal Haemorrhage Hospitalization 1/10/2005 85 Female 8/28/2006 United Kingdom
Primary
Secondary
Concomitant
Hypoglycaemia Other Serious 6/26/2006 71 Male 9/6/2006 Other Health Professional United Kingdom
Primary
Concomitant
Knee Arthroplasty Hospitalization 8/24/2006 76 Female 9/1/2006 Pharmacist United States
Primary
Concomitant
Myalgia Other Serious 5/9/2006 79 Male 182 lb 9/19/2006 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Tremor Hospitalization 8/28/2006 Male 10/23/2006 Pharmacist United States
Primary
Concomitant
Myositis Life Threatening 7/30/2006 79 Female 110 lb 10/25/2006 United Kingdom
Primary
Concomitant
Platelet Count Decreased Hospitalization 6/8/2006 81 Female 11/7/2006 Consumer United Kingdom
Primary
Concomitant
Melaena Other Serious 10/10/2006 82 Female 11/9/2006 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Therapy Cessation Hospitalization 10/19/2006 67 Male 122 lb 11/3/2006 Physician United Kingdom
Primary
Concomitant
Speech Disorder Other Serious 7/21/2006 86 Male 164 lb 7/26/2006 Pharmacist United States
Primary
Concomitant
Vomiting Other Serious 10/21/2006 85 Female 12/6/2006 Other Health Professional United Kingdom
Primary
Concomitant
Multi-organ Failure Other Serious 10/30/2004 Male 254 lb 12/8/2006 Physician United Kingdom
Primary
Concomitant
Rectal Haemorrhage Required Intervention 7/11/2006 74 Female 177 lb 7/15/2006 Pharmacist United States
Primary
Concomitant
Paranoia Other Serious 7/24/2006 71 Female 139 lb 1/16/2007 United Kingdom
Primary
Concomitant
Immobile Hospitalization 10/26/2006 77 Female 1/18/2007 Other Health Professional United Kingdom
Primary
Concomitant
Swelling Hospitalization 1/16/2007 78 Male 194 lb 1/23/2007 Other Health Professional United States
Primary
Secondary
Concomitant
Renal Impairment Other Serious 10/11/2006 68 Male 228 lb 10/11/2006 Physician United States
Primary
Concomitant
Subdural Haematoma Life Threatening 10/18/2006 80 Male 191 lb 1/9/2007 Pharmacist United States
Primary
Secondary
Concomitant
Subcutaneous Emphysema Hospitalization 10/1/2003 66 Male 1/27/2007 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Stomatitis Hospitalization 10/18/2006 Male 122 lb 2/1/2007 United Kingdom
Primary
Concomitant
Subcutaneous Emphysema Other Serious 10/1/2003 66 Male 2/1/2007 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Vomiting Hospitalization 1/8/2007 68 Male 203 lb 2/28/2007 United Kingdom
Primary
Concomitant
Drug Interaction Life Threatening 2/8/2007 86 Female 3/1/2007 Consumer United Kingdom
Primary
Secondary
Concomitant
Drug Interaction Life Threatening 2/8/2007 86 Female 3/7/2007 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Pulmonary Embolism Hospitalization 9/15/2006 Female 176 lb 3/8/2007 Other Health Professional United Kingdom
Primary
Concomitant
Dystonia Hospitalization 1/3/2007 68 Female 4/3/2007 United Kingdom
Primary
Secondary
Concomitant
Dystonia Hospitalization 1/3/2007 68 Female 4/5/2007 United Kingdom
Primary
Secondary
Concomitant
Vomiting Hospitalization 9/1/2006 75 Male 163 lb 4/27/2007 Netherlands
Primary
Concomitant
Urinary Tract Infection Other Serious 3/15/2007 70 Female 4/30/2007 Other Health Professional United Kingdom
Primary
Concomitant
Vomiting Hospitalization 4/1/2007 Male 4/30/2007 United Kingdom
Primary
Concomitant
Vomiting Hospitalization 4/1/2007 Male 5/7/2007 United Kingdom
Primary
Concomitant
Urinary Tract Infection Other Serious 3/15/2007 70 Female 5/9/2007 Other Health Professional United Kingdom
Primary
Concomitant
Rash Macular 5/9/2007 46 Female 192 lb 5/16/2007 Pharmacist United States
Primary
Concomitant
Vomiting Hospitalization 9/1/2006 75 Male 163 lb 5/29/2007 Netherlands
Primary
Concomitant
Respiratory Disorder Hospitalization Male 220 lb 6/5/2007 Consumer France
Primary
Concomitant
Renal Impairment Hospitalization 3/1/2005 81 Female 6/27/2007 United Kingdom
Primary
Concomitant
Mania Other Serious 6/1/2007 73 Male 6/29/2007 Other Health Professional United Kingdom
Primary
Concomitant
Vomiting Hospitalization 1/1/2007 Male 7/13/2007 Other Health Professional United Kingdom
Primary
Concomitant
Pain Hospitalization 7/10/2006 47 Male 154 lb 7/23/2007 Other Health Professional United Kingdom
Primary
Concomitant
Dyspnoea Hospitalization 8/5/2007 35 Female 294 lb 8/17/2007 Consumer United Kingdom
Primary
Concomitant
Pulmonary Embolism Life Threatening 4/10/2007 55 Male 229 lb 4/17/2007 Pharmacist United States
Primary
Concomitant
Malaise Other Serious 1/1/2007 40 Male 9/18/2007 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Malaise Other Serious 1/1/2007 40 Male 9/18/2007 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Non-cardiac Chest Pain Hospitalization 7/26/2007 62 Male 9/13/2007 United Kingdom
Primary
Concomitant
Non-cardiac Chest Pain Hospitalization 7/26/2007 62 Male 9/12/2007 Physician United Kingdom
Primary
Concomitant
Fracture Other Serious 94 Female 9/28/2007 Physician United Kingdom
Primary
Concomitant
Malaise Other Serious 1/1/2007 40 Male 10/4/2007 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Vomiting Hospitalization 5/27/2006 89 Male 12/3/2007 Pharmacist United Kingdom
Primary
Concomitant
Vomiting Hospitalization 5/27/2006 89 Male 12/6/2007 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Muscular Weakness Disability 8/24/2007 12/5/2007 United Kingdom
Primary
Secondary
Concomitant
Vomiting Hospitalization 5/27/2006 89 Male 12/6/2007 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Labyrinthitis Other Serious 1/1/2001 Female 12/31/2007 Brazil
Primary
Secondary
Concomitant
Myocardial Ischaemia Other Serious 11/1/2007 72 Male 165 lb 12/28/2007 Physician United Kingdom
Primary
Concomitant
Ventricular Tachycardia Death 10/14/2007 37 Female 146 lb 11/14/2007 Pharmacist United States
Primary
Concomitant
Myocardial Ischaemia Other Serious 11/1/2007 72 Male 165 lb 1/17/2008 Physician United Kingdom
Primary
Concomitant
Serotonin Syndrome Other Serious 7/23/2007 Female 183 lb 1/24/2008 Consumer United States
Primary
Concomitant
Vomiting Hospitalization 9/1/2006 75 Male 163 lb 1/29/2008 Netherlands
Primary
Concomitant
Right Ventricular Failure Other Serious 10/1/2007 70 Female 139 lb 2/1/2008 Physician United States
Primary
Secondary
Concomitant
Pulmonary Embolism Death 2/4/2008 Female 2/20/2008 Other Health Professional United Kingdom
Primary
Concomitant
Flank Pain Hospitalization 2/22/2008 Female 153 lb 2/26/2008 Other Health Professional United States
Primary
Concomitant
Urinary Tract Infection Hospitalization 1/19/2008 83 Male 2/18/2008 Other Health Professional United Kingdom
Primary
Concomitant
Metastatic Neoplasm Hospitalization 2/22/2008 Female 153 lb 3/13/2008 Other Health Professional United States
Primary
Concomitant
Neutropenia Other Serious 2/18/2008 86 Female 3/18/2008 Other Health Professional United Kingdom
Primary
Concomitant
Fungal Peritonitis Hospitalization 3/3/2008 61 Female 4/21/2008 Other Health Professional
Primary
Secondary
Concomitant
Pulmonary Embolism Hospitalization 2/4/2008 Female 4/24/2008 Other Health Professional United Kingdom
Primary
Concomitant
Therapeutic Response Decreased Hospitalization Female 5/8/2008 Other Health Professional Australia
Primary
Concomitant
Pulmonary Embolism Hospitalization 2/4/2008 Female 5/19/2008 Other Health Professional United Kingdom
Primary
Concomitant
Right Ventricular Failure Other Serious 10/1/2007 70 Female 139 lb 5/23/2008 Physician United States
Primary
Secondary
Concomitant
Peritonitis Bacterial Other Serious 5/2/2008 29 Female 143 lb 6/23/2008 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Therapeutic Response Decreased Life Threatening Female 176 lb 7/25/2008 Other Health Professional Australia
Primary
Concomitant
Therapeutic Response Decreased Life Threatening Female 176 lb 7/29/2008 Other Health Professional Australia
Primary
Concomitant
Platelet Count Increased Hospitalization 6/19/2008 73 Female 128 lb 7/24/2008 United Kingdom
Primary
Concomitant
Therapeutic Response Decreased Life Threatening Female 176 lb 8/1/2008 Other Health Professional Australia
Primary
Concomitant
Pulmonary Embolism Hospitalization 2/4/2008 Female 8/8/2008 Physician United Kingdom
Primary
Secondary
Concomitant
Vomiting Other Serious 8/7/2008 77 Female 8/21/2008 United States
Primary
Concomitant
White Blood Cell Count Increased Life Threatening 62 Male 191 lb 9/22/2008 Other Health Professional United States
Primary
Secondary
Concomitant
Erythema Multiforme Hospitalization 8/13/2008 78 Male 9/25/2008
Primary
Concomitant
Erythema Multiforme Hospitalization 8/13/2008 78 Male 9/30/2008 Other Health Professional United Kingdom
Primary
Concomitant
Erythema Multiforme Hospitalization 8/13/2008 78 Male 10/7/2008 Other Health Professional United Kingdom
Primary
Concomitant
Erythema Multiforme Hospitalization 8/13/2008 78 Male 10/8/2008 Other Health Professional United Kingdom
Primary
Concomitant
Vomiting Other Serious 8/7/2008 Female 154 lb 10/14/2008 United States
Primary
Concomitant
Cellulitis Hospitalization 9/15/2008 60 Female 185 lb 10/17/2008 Physician Singapore
Primary
Secondary
Concomitant
Vomiting Hospitalization 10/21/2008 53 Male 282 lb 10/22/2008 Physician United States
Primary
Secondary
Concomitant
Unresponsive To Stimuli Other Serious 7/15/2008 Male 10/24/2008 Other Health Professional United Kingdom
Primary
Concomitant
Sudden Onset Of Sleep Other Serious 7/15/2008 83 Male 10/17/2008 United Kingdom
Primary
Concomitant
Respiratory Distress Other Serious 9/17/2008 63 Male 168 lb 10/28/2008 Other Health Professional United Kingdom
Primary
Concomitant
Respiratory Failure Hospitalization 10/21/2008 53 Male 282 lb 11/3/2008 Physician United States
Primary
Secondary
Concomitant
Sudden Onset Of Sleep Other Serious 7/15/2008 83 Male 10/30/2008 United Kingdom
Primary
Concomitant
Sudden Onset Of Sleep Other Serious 7/15/2008 Male 11/6/2008 Other Health Professional United Kingdom
Primary
Concomitant
Vomiting Other Serious 8/7/2008 Female 154 lb 11/11/2008 United States
Primary
Concomitant
Vomiting Other Serious 9/21/2008 Male 282 lb 11/17/2008 Physician United States
Primary
Secondary
Concomitant
Weight Decreased Hospitalization 2/1/2008 Female 235 lb 11/11/2008 Consumer United States
Primary
Concomitant
Unresponsive To Stimuli Required Intervention 10/9/2008 72 Female 10/20/2008 Pharmacist United States
Primary
Concomitant
Weight Decreased Hospitalization Male 298 lb 11/21/2008 Physician United Kingdom
Primary
Concomitant
Calciphylaxis Hospitalization 9/15/2008 60 Female 179 lb 11/24/2008 Physician Singapore
Primary
Secondary
Concomitant
Therapeutic Agent Toxicity Other Serious 10/12/2008 Female 222 lb 11/4/2008 Physician United States
Primary
Concomitant
Vomiting Other Serious 9/21/2008 Male 282 lb 12/1/2008 Physician United States
Primary
Secondary
Concomitant
Thrombocytopenia Other Serious 65 Female 12/1/2008 United States
Primary
Secondary
Concomitant
Convulsion Hospitalization 12/3/2007 Male 170 lb 12/15/2008 Physician United States
Primary
Secondary
Concomitant
Swelling Face Other Serious 11/28/2008 Female 12/18/2008 Consumer United Kingdom
Primary
Concomitant
Hepatitis Toxic Death 10/2/2008 82 Female 167 lb 12/26/2008 Other Health Professional United States
Primary
Secondary
Concomitant
Calciphylaxis Hospitalization 9/15/2008 60 Female 179 lb 1/16/2009 Physician Singapore
Primary
Secondary
Concomitant
Vomiting Hospitalization 10/2/2008 69 Female 132 lb 1/19/2009 United Kingdom
Primary
Concomitant
Weight Decreased Hospitalization 5/1/2008 66 Male 170 lb 1/26/2009 Other Health Professional United Kingdom
Primary
Concomitant
Oesophagitis Other Serious 10/1/2008 77 Female 146 lb 1/26/2009 Other Health Professional United Kingdom
Primary
Concomitant
Rhabdomyolysis Life Threatening 12/10/2008 70 Male 1/27/2009 Other Health Professional United Kingdom
Primary
Concomitant
Weight Decreased Hospitalization Male 298 lb 1/27/2009 Physician United Kingdom
Primary
Concomitant
Oesophagitis Other Serious 10/1/2008 77 Female 146 lb 1/26/2009 Other Health Professional United Kingdom
Primary
Concomitant
Staphylococcal Sepsis Other Serious 7/14/2008 Female 205 lb 2/2/2009 United States
Primary
Concomitant
Vomiting Hospitalization 10/2/2008 69 Female 132 lb 2/5/2009 United Kingdom
Primary
Concomitant
Myocardial Infarction Life Threatening 1/18/2009 65 Male 223 lb 2/9/2009 Physician United Kingdom
Primary
Concomitant
Lower Respiratory Tract Infection Other Serious 2/6/2009 Male 132 lb 3/19/2009 Physician United Kingdom
Primary
Concomitant
Rhabdomyolysis Other Serious 12/1/2008 70 Male 4/2/2009 Other Health Professional United Kingdom
Primary
Concomitant
Hypoxia Hospitalization 6/18/2008 72 Male 179 lb 4/2/2009 Other Health Professional United States
Primary
Concomitant
Oesophageal Ulcer Hospitalization 3/16/2009 81 Female 4/6/2009 Other Health Professional United Kingdom
Primary
Concomitant
Rhabdomyolysis Other Serious 1/1/2008 73 Male 4/16/2009 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Type 1 Diabetes Mellitus Other Serious 10/2/2008 82 Female 167 lb 4/27/2009 Other Health Professional United States
Primary
Secondary
Concomitant
Pancreatitis Required Intervention 2/1/2009 57 Female 163 lb 3/2/2009 Pharmacist United States
Primary
Concomitant
Cerebral Infarction Required Intervention 2/3/2009 47 Female 140 lb 2/16/2009 Pharmacist United States
Primary
Concomitant
Muscular Weakness Other Serious 3/2/2009 67 Male 185 lb 5/5/2009 Physician United Kingdom
Primary
Concomitant
Pleural Effusion Hospitalization 5/11/2009 Male 190 lb 5/26/2009 Other Health Professional United States
Primary
Secondary
Concomitant
Myocardial Ischaemia Death Male 5/27/2009 Consumer Switzerland
Primary
Concomitant
Muscular Weakness Other Serious 3/2/2009 67 Male 185 lb 5/28/2009 Physician United Kingdom
Primary
Concomitant
Vomiting Hospitalization 10/2/2008 69 Female 132 lb 6/10/2009 United Kingdom
Primary
Concomitant
Normal Pressure Hydrocephalus Required Intervention 4/7/2009 89 Male 4/8/2009 Pharmacist United States
Primary
Concomitant
Vaginal Haemorrhage Required Intervention 4/14/2009 44 Female 214 lb 4/15/2009 Pharmacist United States
Primary
Concomitant
Tumour Lysis Syndrome Other Serious 5/19/2009 Male 7/9/2009 United States
Primary
Secondary
Concomitant
Oral Candidiasis Other Serious 2/6/2009 Male 132 lb 7/13/2009 Physician United Kingdom
Primary
Concomitant
Gastric Ulcer Other Serious 77 Female 7/15/2009 Other Health Professional United Kingdom
Primary
Concomitant
Gastric Ulcer Other Serious 77 Female 7/20/2009 Other Health Professional United Kingdom
Primary
Concomitant
Pneumonia Hospitalization 5/11/2009 Male 190 lb 7/27/2009 Physician United States
Primary
Secondary
Concomitant
Lip Neoplasm Malignant Stage Unspecified Other Serious 12/7/2007 Female 137 lb 7/31/2009 Other Health Professional United Kingdom
Primary
Concomitant
Oesophagitis Other Serious 10/1/2008 77 Female 7/28/2009 United Kingdom
Primary
Concomitant
Tumour Lysis Syndrome Other Serious 5/19/2009 Male 8/4/2009 United States
Primary
Secondary
Concomitant
Stevens-johnson Syndrome Other Serious 7/8/2009 52 8/13/2009 Other Health Professional United Kingdom
Primary
Concomitant
Interacting
Stevens-johnson Syndrome Other Serious 7/8/2009 52 Female 8/7/2009 Other Health Professional United Kingdom
Primary
Secondary
Concomitant

Drug Data