Rituximab combined with Tocilizumab

Reports:

Reaction Outcome Event Date Age Sex Weight Reported Reporter Country Treatment
Role Name
Pulmonary Embolism Death 11/21/2007 Female 143 lb 1/8/2008 Physician United Kingdom
Primary
Concomitant
Aspergillosis Hospitalization 7/19/2007 65 Male 5/15/2008 Other Health Professional United Kingdom
Primary
Secondary
Sepsis Life Threatening 7/20/2009 Male 8/18/2009 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Respiratory Failure Death 11/21/2007 Female 143 lb 9/15/2009 Physician Germany
Primary
Concomitant
Respiratory Failure Hospitalization 11/21/2007 Female 10/13/2009 Germany
Primary
Concomitant
Pyrexia Hospitalization 8/1/2009 Male 154 lb 1/18/2010 Physician Brazil
Primary
Secondary
Concomitant
Pyrexia Hospitalization 8/1/2009 Male 154 lb 1/21/2010 Physician United Kingdom
Primary
Secondary
Concomitant
Pyrexia Hospitalization 1/1/2009 Male 154 lb 1/25/2010 Physician Brazil
Primary
Secondary
Concomitant
Pyrexia Hospitalization 1/1/2009 Male 154 lb 2/1/2010 Physician United Kingdom
Primary
Secondary
Concomitant
Pyrexia Hospitalization 1/1/2009 Male 154 lb 2/4/2010 Physician Brazil
Primary
Secondary
Concomitant
Pyrexia Hospitalization 1/1/2009 Male 154 lb 2/10/2010 Physician United Kingdom
Primary
Secondary
Concomitant
Pulmonary Fibrosis Hospitalization 11/21/2007 74 Female 2/10/2010 Other Health Professional Germany
Primary
Concomitant
Chronic Obstructive Pulmonary Disease Hospitalization 1/21/2010 Female 158 lb 3/4/2010 Consumer United States
Primary
Secondary
Concomitant
Chronic Obstructive Pulmonary Disease Hospitalization 1/21/2010 Female 158 lb 3/22/2010 Consumer United States
Primary
Secondary
Concomitant
Vomiting Other Serious 11/1/2008 Female 132 lb 3/29/2010 Physician Brazil
Primary
Secondary
Concomitant
Leukopenia Other Serious 46 Female 4/2/2010 Physician United Kingdom
Primary
Secondary
Chronic Obstructive Pulmonary Disease Hospitalization 1/21/2010 76 Female 158 lb 6/16/2010 Consumer United States
Primary
Secondary
Concomitant
Urticaria Hospitalization 1/1/2008 58 Female 139 lb 6/22/2010 Consumer Brazil
Primary
Secondary
Concomitant
Hypercholesterolaemia Other Serious 4/1/2009 58 Female 7/2/2010 Physician Finland
Primary
Concomitant
Interacting
Red Blood Cell Sedimentation Rate Increased Other Serious 10/1/2009 45 Female 163 lb 7/13/2010 Consumer United Kingdom
Primary
Secondary
Concomitant
Red Blood Cell Sedimentation Rate Increased Other Serious 10/1/2009 45 Female 163 lb 7/30/2010 Consumer United Kingdom
Primary
Secondary
Concomitant
Rheumatoid Factor Increased Other Serious 5/1/2010 69 Female 143 lb 8/6/2010 Consumer Brazil
Primary
Secondary
Concomitant
Urticaria Hospitalization 1/1/2008 58 Female 139 lb 8/19/2010 Consumer Brazil
Primary
Secondary
Concomitant
Rheumatoid Factor Increased Other Serious 5/1/2010 69 Female 143 lb 8/24/2010 Consumer Brazil
Primary
Secondary
Concomitant
Pain In Extremity Other Serious 1/1/2009 52 Female 141 lb 9/2/2010 Consumer Brazil
Primary
Secondary
Concomitant
Pain In Extremity Other Serious 1/1/2009 52 Female 141 lb 9/9/2010 Consumer United Kingdom
Primary
Secondary
Concomitant
Rheumatoid Factor Increased Other Serious 5/1/2010 69 Female 143 lb 9/14/2010 Consumer Brazil
Primary
Secondary
Concomitant
Rheumatoid Factor Increased Other Serious 5/1/2010 69 Female 143 lb 9/20/2010 Consumer Brazil
Primary
Secondary
Concomitant
Therapeutic Response Decreased Death 1/1/2009 50 Female 130 lb 10/7/2010 Consumer Brazil
Primary
Secondary
Concomitant
Rheumatoid Factor Increased Other Serious 5/1/2010 69 Female 143 lb 10/8/2010 Physician Brazil
Primary
Secondary
Concomitant
Therapeutic Response Decreased Death 1/1/2009 50 Female 130 lb 10/13/2010 Consumer United Kingdom
Primary
Secondary
Concomitant
Varices Oesophageal Hospitalization 3/1/2010 25 Male 139 lb 10/25/2010 Consumer Brazil
Primary
Secondary
Concomitant
Varices Oesophageal Hospitalization 3/1/2010 25 Male 139 lb 11/1/2010 Consumer United Kingdom
Primary
Secondary
Concomitant
Nasopharyngitis Other Serious 1/1/2008 44 Female 126 lb 11/2/2010 Consumer Brazil
Primary
Secondary
Concomitant
Red Blood Cell Sedimentation Rate Increased Other Serious 1/1/2010 46 Female 165 lb 11/4/2010 Physician United Kingdom
Primary
Secondary
Concomitant
Nasopharyngitis Other Serious 1/1/2008 44 Female 126 lb 11/9/2010 Consumer United Kingdom
Primary
Secondary
Concomitant
Thirst Other Serious 1/1/2010 46 Female 161 lb 11/17/2010 Consumer United Kingdom
Primary
Secondary
Concomitant
Rheumatoid Factor Increased Other Serious 5/1/2010 69 Female 143 lb 11/29/2010 Physician Brazil
Primary
Secondary
Concomitant
Varices Oesophageal Other Serious 3/1/2010 25 Male 139 lb 12/8/2010 Consumer Brazil
Primary
Secondary
Concomitant
Viral Infection Other Serious 1/1/2008 44 Female 126 lb 12/17/2010 Consumer Brazil
Primary
Secondary
Concomitant
Varices Oesophageal Other Serious 3/1/2010 25 Male 139 lb 12/17/2010 Consumer United Kingdom
Primary
Secondary
Concomitant
Thirst Other Serious 1/1/2010 46 Female 161 lb 12/20/2010 Physician United Kingdom
Primary
Secondary
Concomitant
Rheumatoid Factor Increased Other Serious 1/1/2009 68 Female 143 lb 12/21/2010 Physician Brazil
Primary
Secondary
Concomitant
Viral Infection Other Serious 1/1/2008 44 Female 126 lb 12/22/2010 Consumer United Kingdom
Primary
Secondary
Concomitant
Rheumatoid Factor Increased Other Serious 7/29/2010 69 Female 143 lb 12/27/2010 Physician Brazil
Primary
Secondary
Concomitant
Drug Ineffective Other Serious 1/1/2008 44 Female 126 lb 1/12/2011 Consumer Brazil
Primary
Secondary
Concomitant
Thirst Other Serious 1/1/2009 45 Female 161 lb 1/14/2011 Other Health Professional Brazil
Primary
Secondary
Concomitant
Therapeutic Response Decreased Other Serious 1/1/2008 44 Female 126 lb 1/19/2011 Consumer United Kingdom
Primary
Secondary
Concomitant
Pain In Extremity Other Serious 1/1/2010 46 Female 165 lb 1/21/2011 Consumer United Kingdom
Primary
Secondary
Concomitant
Hypersensitivity Other Serious 1/1/2010 46 Female 161 lb 1/21/2011 Consumer United Kingdom
Primary
Secondary
Concomitant
Hypersensitivity Other Serious 1/1/2009 50 Female 130 lb 1/25/2011 Consumer Brazil
Primary
Secondary
Concomitant
Nausea Other Serious 2/1/2010 37 Female 176 lb 1/27/2011 Consumer Brazil
Primary
Secondary
Concomitant
Cardiomyopathy Death 1/1/2009 50 Female 130 lb 2/2/2011 Consumer United Kingdom
Primary
Secondary
Concomitant
White Blood Cell Count Decreased Hospitalization 12/1/2008 82 Female 186 lb 2/8/2011 Physician Brazil
Primary
Secondary
Concomitant
Haemorrhage Hospitalization 12/1/2008 82 Female 186 lb 2/11/2011 Consumer Brazil
Primary
Secondary
Concomitant
Chills Hospitalization 12/1/2008 82 Female 186 lb 2/17/2011 Consumer United Kingdom
Primary
Secondary
Concomitant
Rheumatoid Arthritis Hospitalization 3/1/2010 25 Male 139 lb 2/18/2011 Consumer Brazil
Primary
Secondary
Concomitant
Pneumonia Other Serious 1/1/2010 46 Female 165 lb 2/18/2011 Physician United Kingdom
Primary
Secondary
Concomitant
Pustular Psoriasis Other Serious 2/1/2010 37 Female 176 lb 2/24/2011 Consumer Brazil
Primary
Secondary
Concomitant
Rheumatoid Arthritis Other Serious 3/1/2010 25 Male 139 lb 2/24/2011 Consumer United Kingdom
Primary
Secondary
Concomitant
Sepsis Hospitalization 1/1/2010 65 Female 2/24/2011 Consumer United Kingdom
Primary
Secondary
Concomitant
Neck Pain Hospitalization 1/1/2010 65 Female 2/25/2011 Physician United Kingdom
Primary
Secondary
Concomitant
Sepsis Hospitalization 1/1/2010 65 Female 3/1/2011 Consumer United Kingdom
Primary
Secondary
Concomitant
Drug Resistance Hospitalization 1/1/2010 65 Female 3/3/2011 Physician United Kingdom
Primary
Secondary
Concomitant
Rash Hospitalization 1/1/2010 65 Female 3/8/2011 Physician United Kingdom
Primary
Secondary
Concomitant
Erythema Other Serious 1/1/2010 40 Male 165 lb 3/10/2011 Consumer Brazil
Primary
Secondary
Concomitant
Malaise Other Serious 7/29/2010 69 Female 139 lb 3/16/2011 Physician Brazil
Primary
Secondary
Concomitant
Sepsis Hospitalization 1/1/2010 65 Female 3/16/2011 Physician United Kingdom
Primary
Secondary
Concomitant
Drug Resistance Hospitalization 1/1/2010 65 Female 3/16/2011 Consumer United Kingdom
Primary
Secondary
Concomitant
Neck Pain Hospitalization 1/1/2010 65 Female 3/23/2011 Consumer United Kingdom
Primary
Secondary
Concomitant
Eye Disorder Other Serious 1/1/2009 40 Male 157 lb 4/1/2011 Consumer Brazil
Primary
Secondary
Concomitant
Neutropenia Other Serious 1/1/2010 71 Female 132 lb 4/1/2011 Physician Finland
Primary
Secondary
Concomitant
Hypertension Hospitalization 1/1/2008 58 Female 139 lb 4/5/2011 Consumer Brazil
Primary
Secondary
Concomitant
Thrombocytopenia Other Serious 12/1/2010 71 Female 132 lb 4/8/2011 Consumer United Kingdom
Primary
Secondary
Concomitant
Dizziness Other Serious 1/1/2009 38 Female 148 lb 4/15/2011 Consumer Brazil
Primary
Concomitant
Interacting
Hypertension Hospitalization 12/1/2008 82 Female 187 lb 4/18/2011 Physician Brazil
Primary
Secondary
Concomitant
Joint Warmth Other Serious 1/1/2008 58 Female 143 lb 4/18/2011 Physician Brazil
Primary
Secondary
Concomitant
Dyspnoea Other Serious 11/17/2009 39 Female 148 lb 4/20/2011 Consumer Brazil
Primary
Concomitant
Interacting
Pustular Psoriasis Other Serious 2/1/2010 37 Female 176 lb 4/22/2011 Consumer Brazil
Primary
Secondary
Concomitant
Cough Hospitalization 12/1/2008 82 Female 187 lb 4/22/2011 Physician United Kingdom
Primary
Secondary
Concomitant
Pain Hospitalization 1/1/2010 63 Female 176 lb 5/17/2011 Consumer United Kingdom
Primary
Secondary
Concomitant
Vaginal Haemorrhage Other Serious 1/1/2010 46 Female 165 lb 5/18/2011 Consumer United Kingdom
Primary
Secondary
Concomitant
Pain In Extremity Other Serious 1/1/2010 46 Female 165 lb 5/31/2011 Consumer United Kingdom
Primary
Secondary
Concomitant
Ill-defined Disorder Other Serious 1/1/2009 52 Female 130 lb 6/8/2011 Consumer Brazil
Primary
Secondary
Concomitant
Rheumatoid Arthritis Disability 12/1/2010 67 Female 6/10/2011 Consumer Brazil
Primary
Secondary
Concomitant
Haemorrhage Hospitalization 12/1/2008 82 Female 187 lb 6/13/2011 Physician Brazil
Primary
Secondary
Concomitant
Drug Ineffective Other Serious 1/1/2009 52 Female 130 lb 6/15/2011 Consumer United Kingdom
Primary
Secondary
Concomitant
Pain Hospitalization 1/1/2010 63 Female 176 lb 6/15/2011 Consumer United Kingdom
Primary
Secondary
Concomitant
Rheumatoid Arthritis Disability 12/1/2010 67 Female 6/17/2011 Consumer United Kingdom
Primary
Secondary
Concomitant
Incontinence Other Serious 11/3/2009 70 Male 150 lb 6/20/2011 Physician Germany
Primary
Secondary
Concomitant
Leukaemia Other Serious 1/1/2010 71 Female 132 lb 6/20/2011 Physician Finland
Primary
Secondary
Concomitant
Renal Failure Acute Hospitalization 11/3/2009 70 Male 150 lb 6/22/2011 Consumer United Kingdom
Primary
Secondary
Concomitant
Tooth Extraction Hospitalization 9/1/2008 60 Female 6/23/2011 Physician Finland
Primary
Secondary
Concomitant
Blood Glucose Abnormal Other Serious 1/1/2009 40 Male 159 lb 6/24/2011 Consumer Brazil
Primary
Secondary
Concomitant
Neutropenia Other Serious 12/1/2010 71 Female 132 lb 6/27/2011 Physician United Kingdom
Primary
Secondary
Concomitant
Joint Injury Hospitalization 12/1/2010 67 Female 6/28/2011 Consumer Brazil
Primary
Secondary
Concomitant
Synovial Rupture Hospitalization 9/1/2008 60 Female 6/29/2011 Physician United Kingdom
Primary
Secondary
Concomitant
Feeling Hot Other Serious 1/1/2010 63 Female 143 lb 7/5/2011 Physician Brazil
Primary
Secondary
Concomitant
Pain Hospitalization 12/1/2010 67 Female 7/6/2011 Consumer United Kingdom
Primary
Secondary
Concomitant
Procedural Pain Other Serious 1/1/2010 63 Female 143 lb 7/6/2011 Consumer Brazil
Primary
Secondary
Concomitant
Sinusitis Other Serious 3/1/2010 59 Female 132 lb 7/8/2011 Physician United Kingdom
Primary
Secondary
Concomitant
Tendonitis Other Serious 1/1/2010 63 Female 143 lb 7/12/2011 Consumer Brazil
Primary
Secondary
Concomitant
Ureteric Stenosis Disability 10/1/2009 69 Male 150 lb 7/14/2011 Physician Germany
Primary
Secondary
Concomitant
Cough Hospitalization 12/1/2008 82 Female 187 lb 7/19/2011 Physician Brazil
Primary
Secondary
Concomitant
Incontinence Hospitalization 11/3/2009 70 Male 150 lb 7/19/2011 Physician United Kingdom
Primary
Secondary
Concomitant
Headache Other Serious 9/1/2009 44 Female 159 lb 8/3/2011 Consumer United Kingdom
Primary
Secondary
Concomitant
Dyspepsia Disability 12/1/2010 67 Female 8/5/2011 Consumer United Kingdom
Primary
Secondary
Concomitant
Chest Pain Other Serious 6/1/2011 65 Female 8/9/2011 Physician France
Primary
Secondary
Concomitant
Joint Swelling Other Serious 3/1/2010 59 Female 132 lb 8/11/2011 Physician Brazil
Primary
Secondary
Concomitant
Ureteric Stenosis Disability 10/1/2009 69 Male 150 lb 8/17/2011 Physician Germany
Primary
Secondary
Concomitant
Nasopharyngitis Hospitalization 12/1/2008 80 Female 176 lb 8/23/2011 Physician Brazil
Primary
Secondary
Concomitant
Renal Failure Acute Disability 11/3/2009 70 Male 150 lb 8/25/2011 Physician United Kingdom
Primary
Secondary
Concomitant
Dysphonia Life Threatening 12/1/2008 80 Female 176 lb 8/25/2011 Consumer Brazil
Primary
Secondary
Concomitant
Organising Pneumonia Disability 5/13/2011 56 Male 140 lb 8/26/2011 Physician Israel
Primary
Secondary
Concomitant
Organising Pneumonia Hospitalization 5/13/2011 56 Male 140 lb 8/31/2011 Consumer United Kingdom
Primary
Secondary
Concomitant
Hypocoagulable State Death 4/12/2010 60 Male 9/12/2011 Physician Japan
Primary
Secondary
Concomitant
Gastrointestinal Haemorrhage Hospitalization 4/12/2010 60 Male 9/13/2011 Other Health Professional Japan
Primary
Secondary
Concomitant
Iron Deficiency Anaemia Death 4/12/2010 60 Male 9/13/2011 Consumer United Kingdom
Primary
Secondary
Concomitant
Hypocoagulable State Hospitalization 4/12/2010 60 Male 9/21/2011 Other Health Professional Japan
Primary
Secondary
Concomitant
Constipation Other Serious 4/12/2010 60 Male 9/22/2011 Physician United Kingdom
Primary
Secondary
Concomitant
Iron Deficiency Anaemia Hospitalization 4/12/2010 60 Male 9/23/2011 Physician Japan
Primary
Secondary
Concomitant
Bladder Cancer Other Serious 61 Male 2/7/2012 Physician United States
Primary
Secondary
Concomitant
Urinary Tract Infection Life Threatening 9/1/2010 Female 2/13/2012 Other Health Professional Germany
Primary
Secondary
Concomitant
Shoulder Arthroplasty Hospitalization 6/15/2011 Female 2/13/2012 Physician Germany
Primary
Concomitant
Shoulder Arthroplasty Hospitalization 6/15/2011 Female 2/14/2012 Physician Germany
Primary
Concomitant
Lung Adenocarcinoma Metastatic Life Threatening 9/1/2010 Female 4/27/2012 Other Health Professional Germany
Primary
Secondary
Concomitant
Unevaluable Event Other Serious 5/1/2012 63 Female 5/11/2012 Physician Portugal
Primary
Secondary
Urinary Tract Infection Life Threatening 9/1/2010 Female 5/14/2012 Other Health Professional Germany
Primary
Secondary
Concomitant
Tachycardia Other Serious 3/2010 Female 134 lb 1/3/2013 Consumer Br
Primary
Secondary
Concomitant
Bladder Cancer Hospitalization 61 Male 6/21/2013 Physician Us
Primary
Secondary
Concomitant
Weight Increased Other Serious 6/15/2011 56 Female 148 lb 8/8/2013 Physician Gb
Primary
Secondary
Concomitant
Localised Infection Hospitalization Female 187 lb 8/5/2013 Physician Gb
Primary
Secondary
Concomitant
Pulmonary Embolism Death Female 11/21/2012 Physician Gb
Primary
Secondary
Concomitant
Vaginal Haemorrhage Other Serious 2010 Female 128 lb 1/24/2013 Consumer Br
Primary
Secondary
Concomitant
Myocardial Infarction Hospitalization 5/8/2012 17 Male 243 lb 2/22/2013 Physician De
Primary
Secondary
Staphylococcal Bacteraemia Hospitalization 2010 Female 10/22/2012 Physician Country Not Specified
Primary
Secondary
Concomitant
Therapeutic Response Decreased Other Serious 2010 Male 154 lb 11/9/2012 Consumer Br
Primary
Secondary
Concomitant
Small Intestinal Obstruction Other Serious Female 11/27/2012 Physician Gb
Primary
Secondary
Concomitant
Pain Hospitalization 10/25/2012 62 Female 146 lb 11/30/2012 Physician De
Primary
Secondary
Concomitant
Skin Cancer Other Serious 4/22/2008 67 Female 12/19/2012 Physician Gb
Primary
Secondary
Concomitant
Post Transplant Lymphoproliferative Disorder Hospitalization 9/7/2006 58 Male 207 lb 12/20/2012 Physician Be
Primary
Secondary
Concomitant
Malignant Melanoma Other Serious 3/29/2012 75 Female 1/23/2013 Physician Gb
Primary
Secondary
Concomitant
Sepsis Death 2/12/2011 61 Male 168 lb 2/28/2013 Physician De
Primary
Secondary
Concomitant
Face Oedema Hospitalization 3/21/2012 55 Female 143 lb 2/18/2013 Other Health Professional Fr
Primary
Concomitant
Dyspnoea Hospitalization Female 220 lb 3/18/2013 Physician Gb
Primary
Secondary
Concomitant
Vulval Cancer Other Serious Female 168 lb 4/3/2013 Physician Gb
Primary
Secondary
Concomitant
Vasculitis Other Serious 46 Male 5/18/2013 Other Health Professional Country Not Specified
Primary
Secondary
Pneumonia Fungal Death NotSpecified 5/23/2013 Other Health Professional De
Primary
Secondary
Suffocation Feeling Other Serious 6/2008 53 Female 134 lb 6/4/2013 Consumer Br
Primary
Secondary
Concomitant
Lung Infection Other Serious NotSpecified 6/5/2013 Other Health Professional Us
Primary
Secondary

Drug Data