Pyrazinamide combined with Rifampin

Reports:

Reaction Outcome Event Date Age Sex Weight Reported Reporter Country Treatment
Role Name
Spondylitis Other Serious 1/1/2005 Male 163 lb 1/27/2006 Physician United States
Primary
Secondary
Concomitant
Renal Failure Hospitalization 2/1/2006 Male 3/3/2006 Other Health Professional United States
Primary
Concomitant
Spondylitis Other Serious 1/1/2005 Male 163 lb 3/15/2006 Physician United States
Primary
Secondary
Concomitant
Pruritus 10/23/2005 53 Male 201 lb 10/24/2005 Pharmacist United States
Primary
Concomitant
Hyponatraemia Hospitalization 32 Male 3/30/2006 Physician Switzerland
Primary
Secondary
Concomitant
Hepatocellular Damage Death 32 Female 4/3/2006 United States
Primary
Secondary
Concomitant
Hepatocellular Damage Death 34 Male 4/3/2006 United States
Primary
Secondary
Concomitant
Hepatocellular Damage Death 35 Male 4/3/2006 United States
Primary
Secondary
Concomitant
Hepatocellular Damage Death 37 Male 4/3/2006 United States
Primary
Secondary
Concomitant
Hepatocellular Damage Death 49 Male 4/3/2006 United States
Primary
Secondary
Concomitant
Hepatocellular Damage Death 51 Male 4/3/2006 United States
Primary
Secondary
Concomitant
Hepatocellular Damage Death 53 Male 4/3/2006 United States
Primary
Secondary
Concomitant
Hepatocellular Damage Death 54 Female 4/3/2006 United States
Primary
Secondary
Concomitant
Hepatocellular Damage Death 55 Male 4/3/2006 United States
Primary
Secondary
Concomitant
Hepatocellular Damage Death 62 Female 4/3/2006 United States
Primary
Secondary
Concomitant
Hepatocellular Damage Death 66 Male 4/3/2006 United States
Primary
Secondary
Concomitant
Hyponatraemia Hospitalization 32 Male 4/14/2006 Physician Switzerland
Primary
Secondary
Concomitant
Hepatocellular Damage Death 32 Female 5/8/2006 United States
Primary
Secondary
Concomitant
Hepatocellular Damage Death 34 Male 5/8/2006 United States
Primary
Secondary
Concomitant
Hepatocellular Damage Death 35 Male 5/8/2006 United States
Primary
Secondary
Concomitant
Hepatocellular Damage Death 62 Female 5/8/2006 United States
Primary
Secondary
Concomitant
Hepatocellular Damage Death 66 Male 5/8/2006 United States
Primary
Secondary
Concomitant
Renal Failure Hospitalization 39 Male 5/11/2006
Primary
Secondary
Concomitant
Vomiting Death 32 Female 5/25/2006 United States
Primary
Secondary
Yellow Skin Death 34 Male 5/25/2006 United States
Primary
Secondary
Hepatocellular Damage Death 35 Male 5/26/2006 United States
Primary
Secondary
Concomitant
Hepatocellular Damage Death 37 Male 5/26/2006 United States
Primary
Secondary
Concomitant
Hepatocellular Damage Death 49 Male 5/26/2006 United States
Primary
Secondary
Concomitant
Nausea Death 51 Male 5/26/2006 United States
Primary
Secondary
Concomitant
Vomiting Death 53 Male 5/26/2006 United States
Primary
Secondary
Concomitant
International Normalised Ratio Increased Death 54 Female 5/26/2006 United States
Primary
Secondary
Concomitant
Pulmonary Oedema Death 55 Male 5/26/2006 United States
Primary
Secondary
Concomitant
Vomiting Death 62 Female 5/26/2006 United States
Primary
Secondary
Concomitant
Prothrombin Time Prolonged Death 66 Male 5/26/2006 United States
Primary
Secondary
Concomitant
Renal Failure Hospitalization 39 Male 5/11/2006 Other Health Professional Spain
Primary
Secondary
Concomitant
Hyperglycaemia Hospitalization 40 Male 7/31/2006 Consumer United States
Primary
Secondary
Urinary Tract Infection 1/17/2006 41 Female 4/24/2006 Physician United States
Primary
Concomitant
Renal Failure Acute Other Serious 4/1/2005 72 Male 8/10/2006 United States
Primary
Concomitant
Hyperglycaemia Hospitalization 40 Male 8/16/2006 Consumer United States
Primary
Secondary
Lethargy Life Threatening 6/2/2006 56 Female 128 lb 10/25/2006 United States
Primary
Secondary
Blood Bilirubin Increased Hospitalization 12/12/2006 Male 70 lb 12/14/2006 Pharmacist United States
Primary
Concomitant
Self-medication Other Serious 35 Male 154 lb 1/5/2007 Physician United States
Primary
Concomitant
Vomiting Hospitalization 11/14/2004 41 Female 128 lb 2/16/2007 United States
Primary
Concomitant
Tuberculosis Other Serious 1/1/2007 Female 104 lb 3/2/2007 Consumer United States
Primary
Concomitant
Vomiting Hospitalization 12/17/2006 58 Male 207 lb 3/3/2007 Pharmacist United States
Primary
Secondary
Hepatitis Hospitalization 7/30/2006 Male 127 lb 2/13/2007 Pharmacist United States
Primary
Secondary
Concomitant
Uveitis Other Serious 40 Male 6/22/2007 India
Primary
Secondary
Tendon Disorder Other Serious 6/22/2007 35 Male 209 lb 7/6/2007 Other Health Professional United States
Primary
Concomitant
Uveitis Other Serious 40 Male 8/2/2007
Primary
Secondary
Septic Shock Other Serious 42 Male 10/16/2007 Other Health Professional United States
Primary
Concomitant
Sepsis Hospitalization 18 Male 10/23/2007
Primary
Secondary
Concomitant
Uveitis Other Serious 58 Female 10/31/2007
Primary
Secondary
Concomitant
Pancytopenia Hospitalization 10/22/2007 35 Male 11/1/2007 Physician Zimbabwe
Primary
Secondary
Concomitant
Pancytopenia Hospitalization 10/22/2007 35 Male 11/15/2007 Physician Zimbabwe
Primary
Secondary
Concomitant
Stridor Hospitalization 44 Female 11/19/2007 Physician France
Primary
Secondary
Concomitant
Kaposi's Sarcoma Hospitalization 33 Female 11/19/2007 Physician France
Primary
Secondary
Concomitant
Pancytopenia Hospitalization 10/22/2007 35 Male 4/7/2008 Physician Zimbabwe
Primary
Secondary
Concomitant
Tuberculoid Leprosy Other Serious 37 Male 5/12/2008 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Hepatitis Required Intervention 2/11/2008 43 Female 4/22/2008 Pharmacist United States
Primary
Concomitant
Hepatitis Required Intervention 5/14/2008 Female 107 lb 6/6/2008 Other Health Professional United States
Primary
Secondary
Tuberculosis Death 10/1/2007 Female 146 lb 6/16/2008 Physician United States
Primary
Secondary
Concomitant
Hepatotoxicity Life Threatening 6/17/2008 37 Male 7/1/2008 Other Health Professional United States
Primary
Secondary
Concomitant
Immune Reconstitution Syndrome Hospitalization 1/1/2007 17 Male 7/24/2008 Physician United States
Primary
Secondary
Pleural Effusion Other Serious 4/28/2004 29 Female 8/29/2008 Korea, Republic Of
Primary
Secondary
Lung Adenocarcinoma Metastatic Hospitalization 50 Female 9/8/2008 Physician United Kingdom
Primary
Concomitant
Weight Decreased Other Serious 2/1/2008 Male 132 lb 9/18/2008 Physician Korea, Republic Of
Primary
Concomitant
Interacting
Weight Decreased Hospitalization 2/1/2008 Male 132 lb 10/2/2008 Physician Korea, Republic Of
Primary
Concomitant
Interacting
Vomiting Hospitalization 42 Male 10/31/2008 Consumer Korea, Republic Of
Primary
Secondary
Concomitant
Encephalitis Hospitalization 1/27/2008 Male 211 lb 11/18/2008 Physician United States
Primary
Concomitant
Pyrexia Other Serious 2/6/2008 Male 112 lb 11/20/2008 Physician United States
Primary
Concomitant
Neuroleptic Malignant Syndrome Hospitalization 1/1/2008 42 Male 11/26/2008 Other Health Professional Korea, Democratic People's Republic Of
Primary
Secondary
Concomitant
Pyrexia Other Serious 2/6/2008 Male 112 lb 12/1/2008 Physician United States
Primary
Concomitant
Protein Urine Present Hospitalization 12/3/2008 28 Male 12/12/2008 Physician United States
Primary
Concomitant
Neuroleptic Malignant Syndrome Hospitalization 42 Male 12/15/2008
Primary
Secondary
Concomitant
Hepatic Enzyme Increased Hospitalization 12/3/2008 28 Male 12/20/2008 Physician United States
Primary
Concomitant
Hepatic Enzyme Increased Hospitalization 12/3/2008 28 Male 12/23/2008 Physician United States
Primary
Concomitant
Hepatic Enzyme Increased Hospitalization 11/19/2008 28 Male 1/5/2009 Physician United States
Primary
Concomitant
Renal Failure Death 12/13/2008 29 Male 96 lb 1/8/2009 Physician United States
Primary
Secondary
Concomitant
Renal Impairment Life Threatening 12/27/2008 47 Female 1/21/2009 Other Health Professional United States
Primary
Secondary
Concomitant
Renal Impairment Life Threatening 12/27/2008 47 Female 1/27/2009 Other Health Professional United States
Primary
Secondary
Concomitant
Paradoxical Drug Reaction Hospitalization 1/1/2009 19 Female 1/28/2009 Other Health Professional Korea, Democratic People's Republic Of
Primary
Secondary
Renal Impairment Life Threatening 12/27/2008 47 Female 2/2/2009 Other Health Professional United States
Primary
Secondary
Concomitant
Renal Failure Death 12/13/2008 29 Male 96 lb 2/2/2009 United States
Primary
Secondary
Concomitant
Renal Impairment Life Threatening 12/27/2008 47 Female 2/9/2009 Other Health Professional United States
Primary
Secondary
Concomitant
Renal Impairment Life Threatening 12/27/2008 47 Female 2/25/2009 Other Health Professional United States
Primary
Secondary
Concomitant
Hepatotoxicity Death Female 3/13/2009
Primary
Secondary
Hepatotoxicity Death Female 3/13/2009
Primary
Secondary
Paradoxical Drug Reaction Other Serious 1/1/2008 11 Male 121 lb 4/23/2009 Other Health Professional China
Primary
Secondary
Respiratory Failure Life Threatening 6/12/2008 73 5/29/2009 Other Health Professional Taiwan, Province Of China
Primary
Concomitant
White Blood Cell Count Decreased Hospitalization 4/29/2009 47 Male 123 lb 6/5/2009 Physician United States
Primary
Secondary
Concomitant
Vomiting Hospitalization 42 Male 6/10/2009 Physician Korea, Republic Of
Primary
Secondary
Concomitant
Pneumonia Bacterial Hospitalization 4/29/2009 47 Male 123 lb 6/18/2009 United States
Primary
Secondary
Concomitant
Vomiting Death 5/23/2009 43 Male 119 lb 6/17/2009 Other Health Professional United States
Primary
Secondary
Concomitant
Pulmonary Tuberculosis Death 5/23/2009 43 Male 119 lb 7/9/2009 United States
Primary
Secondary
Concomitant
Lupus Nephritis Hospitalization 29 Male 7/21/2009 Physician Romania
Primary
Secondary
Concomitant
Lupus Nephritis Hospitalization 29 Male 7/24/2009 Physician Romania
Primary
Secondary
Concomitant
Lupus Nephritis Hospitalization 29 Male 8/3/2009 Physician Romania
Primary
Secondary
Concomitant
Hepatitis Fulminant Life Threatening 5/16/2009 36 Female 8/28/2009 Other Health Professional France
Primary
Secondary
Concomitant
Tachypnoea Hospitalization 19 Female 9/17/2009 Korea, Republic Of
Primary
Concomitant
Tubulointerstitial Nephritis Hospitalization 6/1/2006 26 Male 118 lb 9/21/2009 Japan
Primary
Concomitant
Systemic Inflammatory Response Syndrome Hospitalization 7/17/2009 86 Male 9/29/2009 Physician United States
Primary
Secondary
Thrombocytopenia Other Serious 10/1/2000 Male 139 lb 10/12/2009 Other Health Professional Canada
Primary
Concomitant
Hypophosphataemia Life Threatening 7/21/2009 36 Male 183 lb 10/16/2009 Consumer United States
Primary
Secondary
Concomitant
Hypophosphataemia Life Threatening 7/21/2009 36 Male 183 lb 10/26/2009 Consumer United States
Primary
Secondary
Concomitant
Ulcer Required Intervention 11 Male 121 lb 11/2/2009 China
Primary
Concomitant
Neutropenia Life Threatening 11/2/2009 32 Male 11/17/2009 Physician United States
Primary
Secondary
Concomitant
Skin Exfoliation Hospitalization 8/14/2009 33 Female 11/25/2009 Other Health Professional France
Primary
Secondary
Concomitant
Neutropenia Life Threatening 11/2/2009 32 Male 12/29/2009 Physician United States
Primary
Secondary
Concomitant
Neutropenia Life Threatening 11/2/2009 32 Male 12/31/2009 Physician United States
Primary
Secondary
Concomitant
Systemic Inflammatory Response Syndrome Hospitalization Male United States
Primary
Secondary
Concomitant
Rectal Cancer Hospitalization 66 Female 12/23/2009 Korea, Democratic People's Republic Of
Primary
Concomitant
Myocardial Infarction Hospitalization 12/31/2009 57 Female 216 lb 1/19/2010 Other Health Professional United States
Primary
Concomitant
Pyrexia Hospitalization 2 Male 2/2/2010
Primary
Secondary
Concomitant
Pain In Jaw Hospitalization 1/1/2009 57 Female 216 lb 2/4/2010 Other Health Professional United States
Primary
Concomitant
Hepatitis Fulminant Life Threatening 5/16/2009 36 Female 2/19/2010 Other Health Professional France
Primary
Secondary
Concomitant
Unresponsive To Stimuli Other Serious 50 Female 2/5/2010 Other Health Professional United Kingdom
Primary
Concomitant
Pulmonary Embolism 48 Female 10/8/2009 United States
Primary
Concomitant
Tuberculoma Of Central Nervous System Other Serious 1/1/2009 7 Male 3/19/2010 Other Health Professional India
Primary
Secondary
Liver Transplant 7/28/2008 66 Female 10/8/2008 Physician United States
Primary
Secondary
Concomitant
Nausea Hospitalization 8/17/2001 33 Female 159 lb 3/22/2010 Other Health Professional United States
Primary
Secondary
Immune Reconstitution Syndrome Other Serious 1/1/2009 70 Male 4/2/2010 Physician United States
Primary
Secondary
Hyperglycaemia Hospitalization 3/17/1994 41 Female 4/21/2010 Physician Japan
Primary
Secondary
Concomitant
Tremor Other Serious 28 Female 5/17/2010 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Pyrexia Other Serious 11/1/2008 73 Female 5/24/2010 Physician Japan
Primary
Secondary
Pyrexia Other Serious 11/1/2008 73 Female 5/28/2010 Physician Japan
Primary
Secondary
Splenic Abscess Other Serious 1/1/2010 6/4/2010 Other Health Professional India
Primary
Secondary
Sinus Tachycardia Hospitalization 6/1/2009 87 Female 6/30/2010 Physician Japan
Primary
Secondary
Concomitant
Sinus Tachycardia Hospitalization 6/1/2009 87 Female 7/2/2010 Physician Japan
Primary
Secondary
Concomitant
Renal Failure Death 12/13/2008 29 Male 96 lb 7/16/2010 United States
Primary
Secondary
Concomitant
Pyrexia Other Serious 11/1/2008 73 Female 7/27/2010 Physician Japan
Primary
Secondary
Concomitant
Tuberculosis Hospitalization 7/4/2010 55 Female 99 lb 8/6/2010 Physician Korea, Republic Of
Primary
Secondary
Syncope Hospitalization 50 Female 8/6/2010 Other Health Professional Italy
Primary
Concomitant
Tuberculosis Hospitalization 7/4/2010 55 Female 99 lb 8/16/2010 Physician Korea, Republic Of
Primary
Secondary
Concomitant
Platelet Count Decreased Other Serious 7/21/2010 21 Male 106 lb 8/17/2010 Brazil
Primary
Secondary
Concomitant
Hemiparesis Other Serious 1/1/2007 5 Female 8/17/2010 Germany
Primary
Concomitant
Leukopenia Other Serious 7/26/2010 54 Male 117 lb 8/25/2010 Brazil
Primary
Secondary
Concomitant
Leukopenia Other Serious 7/26/2010 54 Male 8/20/2010 France
Primary
Secondary
Concomitant
Leukopenia Other Serious 7/26/2010 54 Male 8/23/2010 France
Primary
Secondary
Concomitant
Neutropenia Other Serious 4/17/2010 54 Male 8/26/2010 France
Primary
Secondary
Concomitant
Paradoxical Drug Reaction Hospitalization 1/1/2010 44 Male 9/2/2010 Other Health Professional Spain
Primary
Secondary
Vomiting Death 27 Female 99 lb 9/24/2010
Primary
Secondary
Concomitant
Hepatotoxicity Other Serious 45 Female 121 lb 9/24/2010
Primary
Secondary
Tuberculosis Hospitalization 7/4/2010 55 Female 99 lb 9/28/2010 Physician Korea, Republic Of
Primary
Secondary
Concomitant
Pulmonary Tuberculosis Other Serious 44 Female 9/29/2010 Physician Korea, Republic Of
Primary
Secondary
Concomitant
Tuberculosis Hospitalization 7/4/2010 55 Female 99 lb 10/11/2010 Physician Korea, Republic Of
Primary
Secondary
Concomitant
Pulmonary Tuberculosis Required Intervention 44 Female 10/6/2010 Physician Korea, Republic Of
Primary
Secondary
Concomitant
Vomiting Death 27 Female 99 lb 11/3/2010
Primary
Secondary
Concomitant
Hepatotoxicity Other Serious 45 Female 121 lb 11/3/2010
Primary
Secondary
Neutropenia Other Serious 4/17/2010 45 Male 10/28/2010 France
Primary
Secondary
Concomitant
Drug Interaction Other Serious 7 Female 12/2/2010 Other Health Professional United States
Primary
Concomitant
Interacting

Drug Data