Pregabalin combined with Topiramate

Reports:

Reaction Outcome Event Date Age Sex Weight Reported Reporter Country Treatment
Role Name
Psychiatric Symptom Other Serious 9/22/2006 Female 137 lb 2/6/2007 Other Health Professional United Kingdom
Primary
Concomitant
Nausea Hospitalization 5/1/2007 50 Female 6/7/2007 Consumer Canada
Primary
Secondary
Concomitant
Therapy Regimen Changed Other Serious 26 Female 7/3/2007 Other Health Professional United States
Primary
Secondary
Pain In Extremity Other Serious 3/12/2007 Female 7/27/2007 Consumer United Kingdom
Primary
Concomitant
Neuroleptic Malignant Syndrome Other Serious 26 Female 8/7/2007 Physician United States
Primary
Secondary
Lethargy 7/4/2007 Male 43 lb 1/16/2008 Physician United States
Primary
Secondary
Concomitant
Weight Increased Other Serious 1/1/2006 Female 119 lb 5/2/2008
Primary
Secondary
Concomitant
Pruritus 6/1/2008 Female 282 lb 8/29/2008 United States
Primary
Concomitant
Pruritus Other Serious 2/10/2008 28 Female 9/3/2008 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Pruritus Other Serious 2/10/2008 28 Female 9/12/2008 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Pruritus Other Serious 2/10/2008 28 Female 9/19/2008 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Underdose 9/8/2008 Female 220 lb 12/12/2008 Consumer United States
Primary
Concomitant
Lethargy 7/4/2007 4 Male 43 lb 6/4/2009 Other Health Professional United States
Primary
Secondary
Concomitant
Death Death 6/10/2009 59 Female 157 lb 6/24/2009 Physician United States
Primary
Concomitant
Swelling Face Other Serious Female 8/31/2009 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Lupus-like Syndrome Other Serious 1/1/2009 Female 290 lb 9/21/2009 Other Health Professional United States
Primary
Secondary
Concomitant
Weight Decreased Other Serious 9/1/2009 29 Male 307 lb 10/20/2009 Physician United States
Primary
Concomitant
Dyspnoea 1/1/2009 Female 290 lb 12/10/2009 Other Health Professional United States
Primary
Secondary
Concomitant
Respiratory Arrest Hospitalization 1/1/2008 51 Female 1/15/2010 Physician United States
Primary
Secondary
Concomitant
Drug Toxicity Other Serious 55 Female 1/21/2010 Physician United States
Primary
Secondary
Drug Toxicity Death 55 Female 1/26/2010 Other Health Professional Germany
Primary
Secondary
Injection Site Swelling 10/1/2008 Female 1/30/2009 Other Health Professional United States
Primary
Concomitant
Hypersensitivity Other Serious 10/15/2008 Male 6/24/2009 Physician United States
Primary
Concomitant
Completed Suicide Death 55 Female 1/15/2010 Physician United States
Primary
Secondary
Drug Toxicity Death 55 Female 2/3/2010 Other Health Professional Germany
Primary
Secondary
Post Laminectomy Syndrome Other Serious 1/1/2004 56 Male 2/7/2010 Physician Spain
Primary
Concomitant
White Blood Cell Count Increased Death 12/1/2009 51 Female 2/1/2010 Physician United States
Primary
Secondary
Concomitant
Poisoning Death 1/1/2008 55 Female 2/2/2010 Physician United States
Primary
Secondary
Hypotension Other Serious 50 Female 2/18/2010
Primary
Secondary
Concomitant
Pupil Fixed Other Serious 50 Female 2/23/2010 Physician United States
Primary
Secondary
Concomitant
Completed Suicide Death 55 Female 2/23/2010 Physician United States
Primary
Secondary
Drug Toxicity Death 51 Female 2/23/2010 United States
Primary
Secondary
Drug Toxicity Other Serious 50 Female 2/25/2010 Physician United States
Primary
Concomitant
Completed Suicide Death 55 Female 3/5/2010 Other Health Professional United States
Primary
Secondary
Completed Suicide Death 55 Female 2/26/2010 Other Health Professional Denmark
Primary
Secondary
Unresponsive To Stimuli Death 55 Female 3/9/2010 Physician United States
Primary
Secondary
Death Death 1/1/2008 55 Female 3/25/2010 Other Health Professional United States
Primary
Secondary
Metabolic Acidosis Other Serious 9 Female 4/7/2010 Physician United States
Primary
Concomitant
Metabolic Acidosis Hospitalization 9 Female 4/26/2010
Primary
Secondary
Concomitant
Vertigo Other Serious 65 Female 4/27/2010 Austria
Primary
Concomitant
Metabolic Acidosis Hospitalization 9 Female 5/8/2010 Physician United States
Primary
Concomitant
Weight Decreased Hospitalization 14 Female 5/20/2010 United States
Primary
Concomitant
Urticaria Other Serious 11/1/2009 50 Female 160 lb 6/4/2010 Other Health Professional United States
Primary
Secondary
Concomitant
Somnolence Hospitalization 46 Female 6/11/2010 Other Health Professional United States
Primary
Concomitant
Somnolence Other Serious 46 Female 6/18/2010 Other Health Professional United States
Primary
Concomitant
Pancreatitis Other Serious 20 Female 7/19/2010 Other Health Professional Finland
Primary
Concomitant
Somnolence Other Serious 46 Female 8/5/2010
Primary
Secondary
Pancreatitis Other Serious 20 Female 8/9/2010 Other Health Professional Finland
Primary
Concomitant
Respiratory Arrest Hospitalization 1/1/2008 51 Female 9/16/2010 Physician United States
Primary
Secondary
Concomitant
Nausea 11/1/2009 49 Female 220 lb 9/20/2010 Other Health Professional United States
Primary
Concomitant
Therapeutic Response Decreased Other Serious 1/1/2007 10/21/2010 Other Health Professional United States
Primary
Concomitant
Ventricular Tachycardia Required Intervention 7/1/2010 56 Female 197 lb 10/18/2010 Pharmacist United States
Primary
Secondary
Concomitant
Respiratory Arrest Hospitalization 1/1/2008 51 Female 1/15/2010 Physician United States
Primary
Secondary
Concomitant
Cardiac Arrest Death 1/1/2009 38 Female 1/10/2011 Physician United States
Primary
Secondary
Completed Suicide Hospitalization 38 Female 1/12/2011 Physician United States
Primary
Secondary
Death Death 38 Female 1/18/2011 Physician United States
Primary
Secondary
Intentional Drug Misuse Death 38 Female 1/21/2011 Physician United States
Primary
Secondary
Respiratory Arrest Death 1/1/2009 38 Female 1/27/2011 Physician United States
Primary
Secondary
Cardio-respiratory Arrest Death 38 Female 2/7/2011 Other Health Professional United States
Primary
Secondary
Asthma Other Serious 71 Female 2/12/2011 Physician Colombia
Primary
Concomitant
Oropharyngeal Pain Hospitalization 9/25/2009 14 Female 95 lb 2/14/2011 United States
Primary
Secondary
Concomitant
Drug Ineffective Hospitalization 17 Male 2/16/2011 Physician United States
Primary
Secondary
Completed Suicide Death 38 Female 2/17/2011 Physician United States
Primary
Secondary
Cardio-respiratory Arrest Death Female 2/7/2011 Physician United States
Primary
Secondary
Completed Suicide Death 38 Female 3/4/2011 Other Health Professional United States
Primary
Secondary
Quadriparesis Other Serious 74 Female 3/14/2011 Other Health Professional Germany
Primary
Secondary
Concomitant
Respiratory Arrest Death 38 Female 3/24/2011 Physician United States
Primary
Secondary
Visual Acuity Reduced Disability 1/1/2011 35 Male 4/18/2011 Physician Germany
Primary
Secondary
Concomitant
Blood Homocysteine Increased Other Serious 61 Male 6/16/2011 Other Health Professional United Kingdom
Primary
Secondary
Convulsion Other Serious 11/1/2010 50 Male 6/20/2011 Physician Germany
Primary
Secondary
Concomitant
Blood Homocysteine Increased Other Serious 61 Male 6/30/2011 Other Health Professional United Kingdom
Primary
Secondary
Retinal Vein Occlusion Other Serious 61 Male 7/5/2011 Physician United Kingdom
Primary
Secondary
Retinal Vein Occlusion Other Serious 61 Male 7/5/2011 Other Health Professional United Kingdom
Primary
Secondary
Retinal Vein Occlusion Other Serious 61 Male 6/23/2011 United Kingdom
Primary
Secondary
Retinal Haemorrhage Other Serious 61 Male 7/7/2011 Other Health Professional United Kingdom
Primary
Secondary
Blood Homocysteine Increased Other Serious 7/12/2011 Other Health Professional United Kingdom
Primary
Secondary
Retinal Vein Occlusion Other Serious 61 Male 7/12/2011 Other Health Professional United Kingdom
Primary
Secondary
Product Substitution Issue Other Serious 27 Female 7/13/2011 Pharmacist United States
Primary
Concomitant
Blood Homocysteine Increased Other Serious 61 Male 7/13/2011 Other Health Professional United Kingdom
Primary
Secondary
Condition Aggravated Other Serious 61 Male 7/7/2011 United Kingdom
Primary
Secondary
Macular Oedema Other Serious 61 Male 7/5/2011 Other Health Professional United Kingdom
Primary
Secondary
Retinal Vein Occlusion Other Serious 61 Male 7/20/2011 Other Health Professional United Kingdom
Primary
Secondary
Retinal Vein Occlusion Other Serious 61 Male 7/20/2011 Other Health Professional United Kingdom
Primary
Secondary
Retinal Haemorrhage Other Serious 61 Male 7/8/2011 United Kingdom
Primary
Secondary
Retinal Vein Occlusion Other Serious 61 Male 7/13/2011 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Retinal Vein Occlusion Other Serious 61 Male 7/27/2011 Other Health Professional United Kingdom
Primary
Secondary
Blood Homocysteine Increased Other Serious 61 Male 7/15/2011 Other Health Professional United Kingdom
Primary
Secondary
Vision Blurred Other Serious 61 Male 7/28/2011 Physician United Kingdom
Primary
Secondary
Retinal Vein Occlusion Other Serious 61 Male 7/29/2011 Other Health Professional United Kingdom
Primary
Secondary
Drug Ineffective Other Serious 17 Male 8/1/2011 Physician United States
Primary
Secondary
Visual Acuity Reduced Other Serious 61 Male 8/8/2011 Other Health Professional United Kingdom
Primary
Secondary
Visual Acuity Reduced Other Serious 61 Male 8/10/2011 Other Health Professional United Kingdom
Primary
Secondary
Blood Homocysteine Increased Other Serious 61 Male 8/11/2011 Other Health Professional United Kingdom
Primary
Secondary
Retinal Haemorrhage Other Serious 61 Male 8/5/2011 Other Health Professional United Kingdom
Primary
Secondary
Retinal Vein Occlusion Other Serious 61 Male 8/12/2011 Other Health Professional United Kingdom
Primary
Secondary
Convulsion Other Serious 11/1/2010 50 Male 8/16/2011 Physician Germany
Primary
Secondary
Concomitant
Polyneuropathy Other Serious 1/1/2010 49 Male 143 lb 8/16/2011 Physician Germany
Primary
Secondary
Concomitant
Macular Oedema Other Serious 61 Male 8/17/2011 Other Health Professional United Kingdom
Primary
Secondary
Maculopathy Other Serious 61 Male 8/10/2011 Other Health Professional
Primary
Secondary
Visual Acuity Reduced Other Serious 61 Male 8/12/2011 Other Health Professional
Primary
Secondary
Retinal Vein Occlusion Other Serious 61 Male 8/16/2011 Other Health Professional United Kingdom
Primary
Secondary
Vision Blurred Other Serious 61 Male 8/25/2011 Physician United Kingdom
Primary
Secondary
Retinal Vascular Disorder Other Serious 61 Male 8/15/2011 United Kingdom
Primary
Secondary
Blood Homocysteine Increased Other Serious 61 Male 8/19/2011 Other Health Professional United Kingdom
Primary
Secondary
Condition Aggravated Other Serious 27 Female 8/19/2011 Other Health Professional United States
Primary
Secondary
Concomitant
Blood Homocysteine Increased Other Serious 61 Male 9/1/2011 Other Health Professional United Kingdom
Primary
Secondary
Constipation Other Serious 8/2/2011 32 Female 177 lb 9/2/2011 Other Health Professional United Kingdom
Primary
Concomitant
Memory Impairment Other Serious 8/2/2011 32 Female 177 lb 9/2/2011 Other Health Professional United Kingdom
Primary
Concomitant
Blood Homocysteine Increased Other Serious 61 Male 9/6/2011 Other Health Professional United Kingdom
Primary
Secondary
Condition Aggravated Other Serious 61 Male 9/6/2011 Other Health Professional United Kingdom
Primary
Secondary
Visual Impairment Other Serious 8/2/2011 32 Female 177 lb 9/6/2011 Other Health Professional United Kingdom
Primary
Concomitant
Memory Impairment Other Serious 32 Female 9/2/2011 Other Health Professional United Kingdom
Primary
Concomitant
Vomiting Other Serious 28 Female 210 lb 9/22/2011 Consumer United States
Primary
Concomitant
Dysphagia Other Serious 53 Male 10/5/2011 Physician Greece
Primary
Secondary
Somnolence Death 3/1/2009 36 Female 160 lb 10/12/2011 Lawyer United States
Primary
Secondary
Concomitant
Product Substitution Issue Other Serious 27 Female 10/12/2011 Other Health Professional United States
Primary
Secondary
Visual Impairment Other Serious 8/2/2011 32 Female 177 lb 10/24/2011 Other Health Professional United Kingdom
Primary
Concomitant
Anger Other Serious 8/2/2011 32 Female 177 lb 10/20/2011 Other Health Professional United Kingdom
Primary
Concomitant
Fatigue Other Serious 8/2/2011 32 Female 177 lb 10/20/2011 Other Health Professional United Kingdom
Primary
Concomitant
Constipation Other Serious 32 Female 10/19/2011 United Kingdom
Primary
Concomitant
Somnolence Death 3/1/2009 36 Female 160 lb 11/2/2011 Lawyer United States
Primary
Secondary
Concomitant
Somnolence Death 3/1/2009 36 Female 160 lb 11/7/2011 Consumer United States
Primary
Secondary
Concomitant
Drug Effect Decreased Other Serious 53 Male 11/22/2011 Physician Greece
Primary
Secondary
Purpura Disability 9/1/2011 62 Female 12/2/2011 Physician United Kingdom
Primary
Concomitant
Death Death 1/1/2010 45 Female 12/23/2011 Physician United States
Primary
Secondary
Respiratory Arrest Death 1/1/2010 49 Female 12/26/2011 Physician United States
Primary
Secondary
Toxicity To Various Agents Death 45 Female 12/30/2011 Physician United States
Primary
Secondary
Toxicity To Various Agents Death 45 Female 1/4/2012 Physician United States
Primary
Secondary
Speech Disorder Other Serious 7/31/2001 17 Female 1/5/2012 Other Health Professional Canada
Primary
Secondary
Death Death 45 Female 1/6/2012 Physician United States
Primary
Secondary
Toxicity To Various Agents Death 45 Female 1/9/2012 Physician United States
Primary
Secondary
Anaemia Hospitalization 11/5/2011 54 Female 162 lb 1/9/2012 Physician United States
Primary
Concomitant
Toxicity To Various Agents Death 45 Female 1/11/2012 Physician United States
Primary
Secondary
Toxicity To Various Agents Death 45 Female 1/12/2012 Physician United States
Primary
Secondary
Somnolence Death 3/1/2009 36 Female 160 lb 1/13/2012 Other Health Professional United States
Primary
Secondary
Concomitant
Toxicity To Various Agents Death 1/1/2010 45 Female 1/13/2012 Physician United States
Primary
Secondary
Death Death 45 Female 1/24/2012 Other Health Professional United States
Primary
Secondary
Anaemia Hospitalization 11/5/2011 54 Female 162 lb 1/24/2012 Physician United States
Primary
Concomitant
Death Death 45 Female 1/18/2012 Physician United States
Primary
Secondary
Poisoning Death 6/9/2009 59 Female 157 lb 1/20/2012 Physician United States
Primary
Secondary
Concomitant
Death Death 45 Female 2/2/2012 Physician United States
Primary
Secondary
Toxicity To Various Agents Death 45 Female 2/16/2012 Physician United States
Primary
Concomitant
Fall Hospitalization 1/28/2012 46 Female 165 lb 2/15/2012 Consumer United States
Primary
Concomitant
Malaise Other Serious 29 Female 220 lb 12/13/2011 Consumer United States
Primary
Concomitant
Death Death 45 Female 3/2/2012 Other Health Professional United States
Primary
Secondary
Multiple Sclerosis Relapse Hospitalization 26 Female 8/18/2011 Consumer United States
Primary
Concomitant
Death Death 45 Female 4/3/2012 Other Health Professional United States
Primary
Secondary
Incorrect Dose Administered Other Serious 37 Female 4/6/2012 Physician Canada
Primary
Concomitant
Respiratory Arrest Death 1/1/2010 49 Female 4/13/2012 Physician United States
Primary
Secondary
Fatigue Death 5/2/2012 50 Male 5/18/2012 Other Health Professional Germany
Primary
Secondary
Concomitant

Drug Data