Phenytoin combined with Zonisamide

Reports:

Reaction Outcome Event Date Age Sex Weight Reported Reporter Country Treatment
Role Name
Lymphadenopathy Hospitalization 2/18/2006 25 Female 4/28/2006 Physician Japan
Primary
Concomitant
White Blood Cell Count Decreased Hospitalization 3/25/2005 31 Female 6/15/2006 Physician Japan
Primary
Secondary
Therapy Non-responder Required Intervention 4/10/2006 38 Female 6/16/2006 Physician Japan
Primary
Concomitant
Pyrexia Hospitalization 6/18/2006 33 Female 9/1/2006 Physician Japan
Primary
Secondary
Concomitant
Rash Papular Hospitalization 6/18/2006 33 Female 9/22/2006 Physician Japan
Primary
Secondary
Concomitant
Epilepsy Life Threatening 10/5/2006 60 Female 11/20/2006 Physician Japan
Primary
Concomitant
Epilepsy Life Threatening 11/4/2006 60 Female 11/22/2006 Physician Japan
Primary
Concomitant
Hypothyroidism Required Intervention 11/14/2006 0 Female 12/1/2006 Other Health Professional Japan
Primary
Secondary
Concomitant
Hypothyroidism Required Intervention 11/14/2006 0 Female 12/7/2006 Physician Japan
Primary
Secondary
Concomitant
Pyrexia Other Serious 11/1/2006 34 Male 154 lb 3/18/2007 Physician Japan
Primary
Concomitant
Therapeutic Agent Toxicity Hospitalization 2/15/2007 Male 111 lb 3/23/2007 Physician Japan
Primary
Secondary
Pyrexia Other Serious 11/1/2006 34 Male 154 lb 4/3/2007 Physician Japan
Primary
Concomitant
Pneumonia Hospitalization 5/23/2006 5 Male 4/19/2007 Physician Japan
Primary
Concomitant
Transient Hypogammaglobulinaemia Of Infancy Other Serious 3 Male 8/28/2007
Primary
Secondary
Somnolence Hospitalization 22 Female 9/8/2007 Japan
Primary
Concomitant
Somnolence Hospitalization 22 Female 9/20/2007 Japan
Primary
Concomitant
Type 1 Diabetes Mellitus Other Serious Female 190 lb 10/5/2007 Consumer United States
Primary
Secondary
Concomitant
Drug Ineffective Other Serious 37 Female 10/15/2007
Primary
Secondary
Drug Ineffective Hospitalization 24 Female 10/15/2007
Primary
Secondary
Suicide Attempt Other Serious 36 Female 11/13/2007 Japan
Primary
Concomitant
Rash Hospitalization 10/26/2007 40 Male 11/8/2007 Physician Japan
Primary
Concomitant
Somnolence Hospitalization 24 Male 11/19/2007
Primary
Secondary
Concomitant
Drug Rash With Eosinophilia And Systemic Symptoms Life Threatening 57 Female 11/16/2007 Physician Japan
Primary
Secondary
Vomiting Hospitalization 10/25/2007 40 Male 11/16/2007 Physician Japan
Primary
Secondary
Concomitant
Drug Rash With Eosinophilia And Systemic Symptoms 57 Female 11/21/2007 Physician Japan
Primary
Secondary
Vomiting Hospitalization 10/25/2007 40 Male 11/28/2007 Physician Japan
Primary
Secondary
Concomitant
Muscular Weakness Other Serious 63 Female 12/22/2007 Japan
Primary
Concomitant
Muscular Weakness Other Serious 1/1/1981 63 Female 95 lb 12/31/2007 Japan
Primary
Concomitant
Status Epilepticus Required Intervention 3 Male 1/9/2008 Physician Japan
Primary
Secondary
Concomitant
Sequestrectomy Other Serious 1/1/1981 63 Female 95 lb 1/28/2008 Japan
Primary
Concomitant
Drug Exposure During Pregnancy Congenital Anomaly 1/18/2008 Other Health Professional Japan
Primary
Secondary
Sequestrectomy Other Serious 1/1/1981 63 Female 95 lb 2/26/2008 Japan
Primary
Concomitant
Pyrexia Other Serious 11 Male 3/25/2008 Physician Japan
Primary
Secondary
Concomitant
Drug Rash With Eosinophilia And Systemic Symptoms Other Serious 1/1/2006 34 4/8/2008 Physician Japan
Primary
Secondary
White Blood Cell Count Decreased Hospitalization 6/11/2006 33 Female 112 lb 5/15/2008 Other Health Professional Japan
Primary
Secondary
Concomitant
White Blood Cell Count Decreased Hospitalization 6/13/2006 33 Female 5/29/2008 Physician Japan
Primary
Secondary
Concomitant
Shock Death 64 Male 6/19/2008 Other Health Professional United States
Primary
Concomitant
Shock Required Intervention 64 Male 6/30/2008 Other Health Professional United States
Primary
Concomitant
Protein Total Increased Hospitalization 16 Female 7/1/2008 Other Health Professional Japan
Primary
Concomitant
Pyrexia Other Serious 11/1/2006 Male 154 lb 7/11/2008 Physician Japan
Primary
Concomitant
Protein Total Decreased Hospitalization 16 Female 7/1/2008 Japan
Primary
Secondary
Concomitant
Respiratory Distress Other Serious 11/1/2006 Male 154 lb 7/30/2008 Physician Japan
Primary
Concomitant
Drug Interaction Hospitalization 8/7/2008 25 Female 8/25/2008 Consumer United Kingdom
Primary
Secondary
Drug Interaction Hospitalization 8/7/2008 25 Female 8/26/2008 Other Health Professional United Kingdom
Primary
Interacting
Postictal State Hospitalization 8/7/2008 25 Female 8/26/2008 United Kingdom
Primary
Interacting
Drug Interaction Hospitalization 8/7/2008 25 Female 8/28/2008 Other Health Professional United Kingdom
Primary
Interacting
Drug Interaction Other Serious 25 Female 9/2/2008 Other Health Professional United Kingdom
Primary
Secondary
Convulsion Hospitalization 8/7/2008 25 Female 8/28/2008 Other Health Professional United Kingdom
Primary
Secondary
Pneumonia Hospitalization 1/11/2009 50 Male 1/19/2009 Other Health Professional Japan
Primary
Secondary
Concomitant
Status Epilepticus Other Serious 12 1/20/2009 Other Health Professional Japan
Primary
Concomitant
Pseudomonas Infection Hospitalization 1/11/2009 50 Male 1/27/2009 Other Health Professional Japan
Primary
Secondary
Concomitant
Inflammatory Carcinoma Of The Breast Life Threatening 10/4/2008 64 Female 115 lb 1/28/2009 Physician Japan
Primary
Concomitant
Pseudomonas Infection Hospitalization 1/11/2009 50 Male 2/10/2009 Other Health Professional Japan
Primary
Secondary
Concomitant
Inflammatory Carcinoma Of The Breast Life Threatening 10/4/2008 64 Female 115 lb 3/3/2009 Physician Japan
Primary
Concomitant
Vitamin B12 Deficiency Other Serious 7/1/2007 39 Male 6/10/2009 Other Health Professional Japan
Primary
Concomitant
Vitamin B12 Deficiency Other Serious 7/1/2007 39 Male 181 lb 6/25/2009 Other Health Professional Japan
Primary
Concomitant
Death Death 6/10/2009 59 Female 157 lb 6/24/2009 Physician United States
Primary
Concomitant
Haemorrhoids Hospitalization 1/4/2007 74 Male 115 lb 11/3/2009 Japan
Primary
Concomitant
Selective Mutism Other Serious 23 Male 12/30/2009 Physician Japan
Primary
Concomitant
Malignant Neoplasm Progression Other Serious 2/6/2009 47 Male 192 lb 3/9/2010 Other Health Professional Japan
Primary
Concomitant
Wrong Technique In Drug Usage Process Hospitalization 4/3/2010 57 Male 114 lb 4/16/2010 Physician Japan
Primary
Secondary
Concomitant
Hyponatraemia Other Serious 2/6/2009 47 Male 192 lb 4/23/2010 Physician Japan
Primary
Concomitant
Respiratory Distress Other Serious 11/1/2006 34 Male 154 lb 5/12/2010 Japan
Primary
Concomitant
Rash Hospitalization 33 Male 5/10/2010 Physician Japan
Primary
Concomitant
Myoclonus Other Serious 11 Male 8/6/2010 Other Health Professional Japan
Primary
Secondary
Concomitant
Status Epilepticus Hospitalization 11/1/2009 73 Male 8/16/2010 Austria
Primary
Secondary
Concomitant
Myoclonus Other Serious 11 Male 8/27/2010 Other Health Professional Japan
Primary
Secondary
Concomitant
Paranoia Other Serious 22 Female 10/21/2010 Other Health Professional Japan
Primary
Concomitant
Paranoia Other Serious 22 Female 11/8/2010 Other Health Professional Japan
Primary
Concomitant
Status Epilepticus Other Serious 38 Female 11/4/2010 Italy
Primary
Concomitant
Lennox-gastaut Syndrome Other Serious 38 Female 11/4/2010 Italy
Primary
Concomitant
Sudden Death Death 12/29/2010 15 Male 64 lb 1/14/2011 Physician India
Primary
Concomitant
Sudden Death Death 12/29/2010 15 Male 64 lb 1/19/2011 India
Primary
Concomitant
Status Epilepticus Death 12/28/2010 15 Male 64 lb 1/21/2011 Physician India
Primary
Concomitant
Status Epilepticus Death 12/28/2010 15 Male 64 lb 1/21/2011 Physician India
Primary
Concomitant
Speech Disorder Other Serious 21 Female 2/2/2011 Other Health Professional Denmark
Primary
Secondary
Concomitant
Grand Mal Convulsion Other Serious 21 Female 2/4/2011 United Kingdom
Primary
Secondary
Concomitant
Hyperkalaemia Death 12/1/2010 2/22/2011 Physician Japan
Primary
Concomitant
Drug Interaction Other Serious 36 Female 70 lb 2/28/2011 Other Health Professional Japan
Primary
Interacting
Quadriparesis Other Serious 74 Female 3/14/2011 Other Health Professional Germany
Primary
Secondary
Concomitant
Psychotic Disorder Other Serious 1/1/2009 39 Male 3/7/2011 Physician Germany
Primary
Secondary
Concomitant
Status Epilepticus Death 12/28/2010 15 Male 64 lb 3/21/2011 Physician India
Primary
Concomitant
Drug Resistance Other Serious 36 Female 3/11/2011 Other Health Professional Japan
Primary
Secondary
Concomitant
Balance Disorder Other Serious 37 Female 3/21/2011 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Status Epilepticus Death 12/28/2010 15 Male 64 lb 4/7/2011 India
Primary
Concomitant
Diplopia Other Serious 37 Female 3/28/2011 United Kingdom
Primary
Secondary
Concomitant
Hyperkalaemia Other Serious 12/1/2010 4/21/2011 Consumer Japan
Primary
Concomitant
Renal Cancer Hospitalization 11/1/2007 62 Female 145 lb 4/26/2011 Consumer United States
Primary
Concomitant
Drug Level Increased Other Serious 36 Female 70 lb 4/29/2011 Other Health Professional Japan
Primary
Interacting
Drug Ineffective Other Serious 27 Female 5/4/2011 Other Health Professional United Kingdom
Primary
Secondary
Encephalocele Other Serious 27 Female 4/28/2011 Other Health Professional United Kingdom
Primary
Secondary
Drug Ineffective Other Serious 27 Female 4/27/2011 Other Health Professional United Kingdom
Primary
Secondary
Encephalocele Other Serious 27 Female 5/3/2011 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Drug Ineffective Other Serious 27 Female 5/11/2011 Other Health Professional United Kingdom
Primary
Concomitant
Drug Ineffective 27 Female 5/3/2011 Other Health Professional United Kingdom
Primary
Secondary
Drug Effect Decreased Other Serious 36 Female 71 lb 5/23/2011 Other Health Professional Japan
Primary
Concomitant
Interacting
Rash Other Serious 1/1/2007 33 Male 5/24/2011 Other Health Professional Japan
Primary
Concomitant
Pyrexia Hospitalization 2/18/2011 33 Female 6/6/2011 Physician Japan
Primary
Concomitant
Dizziness Hospitalization 11/1/2007 62 Female 145 lb 6/13/2011 Physician United States
Primary
Concomitant
Drug Ineffective Other Serious 21 Male 6/27/2011 Other Health Professional United States
Primary
Secondary
Drug Ineffective 21 Male 6/29/2011 Other Health Professional United States
Primary
Secondary
Agranulocytosis Other Serious 50 Male 7/5/2011 Other Health Professional Japan
Primary
Secondary
Fatigue Hospitalization 3/5/2011 61 Female 95 lb 7/5/2011 Physician Japan
Primary
Secondary
Concomitant
Polydipsia Hospitalization 3/5/2011 61 Female 95 lb 7/12/2011 Physician Japan
Primary
Secondary
Concomitant
Renal Tubular Disorder Hospitalization 8 Female 51 lb 8/26/2011 Physician Japan
Primary
Concomitant
Major Depression Hospitalization 11/10/2008 46 Female 8/8/2011 Consumer United States
Primary
Secondary
Concomitant
Pyrexia Hospitalization 7/14/2011 36 Female 229 lb 9/23/2011 Consumer United States
Primary
Secondary
Concomitant
Pyrexia Hospitalization 7/14/2011 36 Female 229 lb 10/3/2011 Consumer United States
Primary
Secondary
Concomitant
Single Photon Emission Computerised Tomogram Abnormal Hospitalization 1 Female 11/8/2011 Other Health Professional Japan
Primary
Secondary
Convulsion Hospitalization 5/10/2010 15 Male 11/11/2011 Physician Japan
Primary
Concomitant
Suicidal Ideation Hospitalization 1/14/2003 34 Male 11/21/2011 Consumer United States
Primary
Concomitant
Somnolence Other Serious 2/14/2009 42 Female 11/23/2011 Consumer United States
Primary
Concomitant
Tonic Clonic Movements Hospitalization 5/10/2010 15 Male 12/22/2011 Physician Japan
Primary
Concomitant
Epidermal Necrosis Other Serious 1/9/2012 Consumer Japan
Primary
Secondary
Poisoning Death 6/9/2009 59 Female 157 lb 1/20/2012 Physician United States
Primary
Secondary
Concomitant
Drug Interaction Other Serious 9/1/2011 52 Male 150 lb 2/3/2012 Physician United States
Primary
Secondary
Concomitant
Memory Impairment Hospitalization 1/10/2000 15 Female 12/13/2011 Consumer United States
Primary
Concomitant
Malaise Other Serious 29 Female 220 lb 12/13/2011 Consumer United States
Primary
Concomitant
Infectious Pleural Effusion Hospitalization 5/12/2010 50 Female 75 lb 3/2/2012 Physician Japan
Primary
Secondary
Concomitant
Adverse Drug Reaction Hospitalization 1/1/2009 39 Female 12/13/2011 United States
Primary
Concomitant
Failure To Thrive Other Serious 9 Female 3/20/2012 Physician Japan
Primary
Concomitant
Brain Operation Hospitalization 56 Female 4/9/2012 Consumer United States
Primary
Concomitant
Hepatorenal Failure Other Serious 6/30/2009 42 Male 185 lb 4/17/2012 Physician Japan
Primary
Secondary
Concomitant
Prothrombin Time Prolonged Other Serious 4/23/2008 48 Male 138 lb 4/25/2012 Physician Japan
Primary
Secondary
Concomitant
Partial Seizures Other Serious 31 Female 6/20/2012 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Protrusion Tongue Other Serious 31 Female 7/9/2012 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Movement Disorder Other Serious 31 Female 7/10/2012 Consumer United Kingdom
Primary
Secondary
Concomitant
Mobility Decreased Other Serious 31 Female 7/10/2012 Consumer United Kingdom
Primary
Secondary
Concomitant
Fall Other Serious 6 Male 8/9/2012 Physician Japan
Primary
Secondary
Concomitant
Convulsion Other Serious 24 Male 8/9/2012 Physician Japan
Primary
Secondary
Concomitant
Drug Ineffective Other Serious 17 Female 8/9/2012 Physician Japan
Primary
Secondary
Concomitant
Convulsion Other Serious 7 Male 8/9/2012 Physician Japan
Primary
Secondary
Concomitant
Drug Ineffective Other Serious 20 Male 8/9/2012 Physician Japan
Primary
Secondary
Concomitant
Fall Other Serious 5 Male 8/9/2012 Physician Japan
Primary
Secondary
Concomitant
Fall Other Serious 6 Female 8/9/2012 Physician Japan
Primary
Secondary
Concomitant
Drug Ineffective Other Serious 6 Female 8/16/2012 Physician Japan
Primary
Secondary
Concomitant
Atonic Seizures Other Serious 6 Male 8/16/2012 Physician Japan
Primary
Secondary
Concomitant
Atonic Seizures Other Serious 17 Female 8/16/2012 Physician Japan
Primary
Secondary
Concomitant
Atonic Seizures Other Serious 7 Male 8/16/2012 Physician Japan
Primary
Secondary
Concomitant
Drug Ineffective Other Serious 20 Male 8/16/2012 Physician Japan
Primary
Secondary
Concomitant
Atonic Seizures Other Serious 5 Male 8/16/2012 Physician Japan
Primary
Secondary
Concomitant
Atonic Seizures Other Serious 24 Male 8/16/2012 Physician Japan
Primary
Secondary
Concomitant
Respiratory Depression Other Serious 6/28/2012 37 Female 8/17/2012 Physician Japan
Primary
Secondary
Concomitant
Convulsion Other Serious Male 8/6/2012 Other Health Professional Japan
Primary
Secondary
Concomitant
Convulsion Other Serious Male 8/6/2012 Other Health Professional Japan
Primary
Secondary
Concomitant
Drop Attacks Other Serious Male 8/6/2012 Other Health Professional Japan
Primary
Secondary
Concomitant
Fall Other Serious Female 8/6/2012 Other Health Professional Japan
Primary
Secondary
Concomitant
Drop Attacks Other Serious Female 8/6/2012 Other Health Professional Japan
Primary
Secondary
Concomitant
Convulsion Other Serious 6/28/2012 37 Female 8/21/2012 Physician Japan
Primary
Secondary
Concomitant
Drug Ineffective Other Serious 6 Male 10/16/2012 Physician Country Not Specified
Primary
Secondary
Concomitant

Drug Data