Phenytoin combined with Valproate Sodium

Reports:

Reaction Outcome Event Date Age Sex Weight Reported Reporter Country Treatment
Role Name
Blood Sodium Decreased Hospitalization 7/12/2005 78 Female 1/30/2006 Consumer Italy
Primary
Concomitant
Drug Interaction Hospitalization 1/1/2005 2 Female 1/25/2006 Physician United Kingdom
Primary
Secondary
Concomitant
Status Epilepticus Hospitalization 2 Female 1/31/2006 United Kingdom
Primary
Secondary
Concomitant
Tachypnoea Other Serious 2 Female 2/6/2006 Other Health Professional United Kingdom
Primary
Concomitant
Visual Field Defect Other Serious 1/26/2005 54 Male 3/13/2006 Consumer United States
Primary
Secondary
Tachypnoea Hospitalization 1 Female 4/27/2006 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Status Epilepticus Other Serious 17 Male 5/5/2006 Other Health Professional France
Primary
Secondary
Tachycardia Other Serious 4/26/2004 57 Female 6/2/2006 France
Primary
Concomitant
Interacting
Pulmonary Embolism Hospitalization 10/1/2005 49 Male 6/28/2006 United Kingdom
Primary
Concomitant
White Blood Cell Count Decreased Other Serious 48 Female 86 lb 7/19/2006 Consumer Japan
Primary
Concomitant
Hepatotoxicity Other Serious 5 Female 8/29/2006 Germany
Primary
Concomitant
Lactic Acidosis Death 5 Female 8/29/2006 Germany
Primary
Concomitant
Pneumonia Death 5 Female 8/29/2006 Germany
Primary
Concomitant
Sepsis Hospitalization 3/30/2006 5 Male 33 lb 8/23/2006 Physician Japan
Primary
Concomitant
Hepatotoxicity Hospitalization 19 Male 9/1/2006 Australia
Primary
Concomitant
Sputum Culture Positive Other Serious 46 Male 8/18/2006 Other Health Professional Spain
Primary
Concomitant
Myoclonic Epilepsy Other Serious 7 Female 10/17/2006 Japan
Primary
Concomitant
Sepsis Other Serious 18 Female 82 lb 10/20/2006 Other Health Professional United Kingdom
Primary
Concomitant
Drug Exposure During Pregnancy Congenital Anomaly 7/27/2006 NotSpecified 10/13/2006 Physician United States
Primary
Concomitant
Status Epilepticus Death 5 Female 10/27/2006 Germany
Primary
Concomitant
Somnolence Hospitalization 9/11/2006 45 Male 10/27/2006 Other Health Professional France
Primary
Secondary
Concomitant
White Blood Cell Count Decreased Other Serious 1/1/1985 47 Male 11/7/2006 Consumer Germany
Primary
Secondary
Concomitant
Dizziness Other Serious 10/31/2006 55 Female 12/29/2006 Physician Japan
Primary
Secondary
Concomitant
Grand Mal Convulsion Other Serious 3/15/2005 46 Female 1/29/2007 Physician Spain
Primary
Secondary
Concomitant
Rash Pruritic Hospitalization 11/24/2006 65 Female 1/26/2007 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Grand Mal Convulsion Other Serious 3/15/2005 46 Female 1/31/2007 Physician Spain
Primary
Secondary
Concomitant
Pyrexia Other Serious 12/18/2006 2/2/2007 Physician Japan
Primary
Concomitant
Complex Partial Seizures Other Serious Male 2/9/2007 Physician United Kingdom
Primary
Concomitant
Drug Exposure During Pregnancy Congenital Anomaly 7/27/2006 Female 2/5/2007 Other Health Professional United States
Primary
Concomitant
Rash Pruritic Hospitalization 11/24/2006 65 Female 2/16/2007 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Treatment Noncompliance Other Serious 18 Female 82 lb 3/2/2007 Other Health Professional United Kingdom
Primary
Concomitant
Supraventricular Extrasystoles Other Serious 11/4/2006 39 Female 2/26/2007 Germany
Primary
Concomitant
Head Injury Other Serious Female 3/8/2007 Hong Kong
Primary
Secondary
Thrombocytopenic Purpura Other Serious 9/1/1994 77 Female 3/25/2007 Japan
Primary
Secondary
Concomitant
Thrombocytopenic Purpura Other Serious 9/1/1994 77 Female 75 lb 3/31/2007 Japan
Primary
Secondary
Concomitant
Drug Exposure During Pregnancy Congenital Anomaly 7/27/2006 Female 3/27/2007 Physician United States
Primary
Concomitant
Tooth Injury Other Serious 1/1/1978 19 Male 4/13/2007 Australia
Primary
Concomitant
Drug Exposure During Pregnancy Congenital Anomaly 7/27/2006 Female 4/5/2007 Physician United States
Primary
Concomitant
Pneumonia Hospitalization 5/23/2006 5 Male 4/19/2007 Physician Japan
Primary
Concomitant
Somnolence Other Serious 35 Female 4/27/2007 Netherlands
Primary
Concomitant
Therapeutic Agent Toxicity Other Serious 60 Male 4/27/2007 Netherlands
Primary
Concomitant
Drug Exposure During Pregnancy Congenital Anomaly 7/27/2006 Female 4/30/2007 Physician United States
Primary
Concomitant
Convulsion Life Threatening 56 Male 5/31/2007 Pharmacist United Kingdom
Primary
Secondary
Concomitant
Suicidal Ideation Other Serious 30 Female 5/30/2007 Germany
Primary
Concomitant
Somnolence Hospitalization 9/7/2006 45 Male 6/8/2007 Other Health Professional France
Primary
Secondary
Concomitant
Haematochezia Other Serious 1/1/2003 25 Male 97 lb 6/11/2007 Japan
Primary
Concomitant
Metabolic Encephalopathy Hospitalization 4/1/2007 Male 6/15/2007 Other Health Professional France
Primary
Concomitant
Premature Baby Congenital Anomaly 7/27/2006 Female 6 lb 6/29/2007 Physician United States
Primary
Concomitant
Therapeutic Agent Toxicity Hospitalization 4/18/2004 31 Female 7/9/2007 United States
Primary
Concomitant
Vaginal Haemorrhage Other Serious 3/1/1996 Female 7/20/2007 Consumer France
Primary
Concomitant
Tachypnoea Hospitalization 2 Female 8/3/2007 United Kingdom
Primary
Concomitant
Interacting
Epilepsy Hospitalization 13 Male 8/15/2007 Japan
Primary
Concomitant
Epilepsy Hospitalization 13 Male 8/28/2007 Japan
Primary
Concomitant
Transient Hypogammaglobulinaemia Of Infancy Other Serious 3 Male 8/28/2007
Primary
Secondary
Electroencephalogram Abnormal Other Serious 16 Male 9/6/2007 Belgium
Primary
Concomitant
Interacting
Electroencephalogram Abnormal Other Serious 57 Male 9/6/2007 Belgium
Primary
Concomitant
Interacting
Electroencephalogram Abnormal Other Serious 23 Female 9/6/2007 Belgium
Primary
Concomitant
Interacting
Electroencephalogram Abnormal Other Serious 43 Female 9/6/2007 Belgium
Primary
Concomitant
Interacting
Electroencephalogram Abnormal Other Serious 41 Female 9/6/2007 Belgium
Primary
Concomitant
Interacting
Electroencephalogram Abnormal Other Serious 71 Male 9/6/2007 Belgium
Primary
Concomitant
Interacting
Somnolence Hospitalization 22 Female 9/8/2007 Japan
Primary
Concomitant
Somnolence Hospitalization 22 Female 9/20/2007 Japan
Primary
Concomitant
X-ray Abnormal Other Serious 6/3/2007 69 Female 9/24/2007 Pharmacist Japan
Primary
Secondary
Concomitant
X-ray Abnormal Other Serious 6/3/2007 69 Female 10/2/2007 Pharmacist Japan
Primary
Secondary
Concomitant
Drug Ineffective Life Threatening 46 Male 10/2/2007 Physician Czech Republic
Primary
Concomitant
Hypogammaglobulinaemia Required Intervention 3 Male 9/26/2007 Japan
Primary
Secondary
Concomitant
Epilepsy Other Serious 1/4/2005 51 Female 170 lb 10/10/2007 Physician United Kingdom
Primary
Concomitant
Drug Ineffective Other Serious 37 Female 10/15/2007
Primary
Secondary
Drug Ineffective Hospitalization 24 Female 10/15/2007
Primary
Secondary
Sepsis Death 3/30/2006 5 Male 33 lb 10/17/2007 Physician Japan
Primary
Concomitant
Epilepsy Other Serious 1/4/2005 51 Female 170 lb 10/25/2007 Other Health Professional United Kingdom
Primary
Concomitant
Suicide Attempt Other Serious 36 Female 11/13/2007 Japan
Primary
Concomitant
Skull Malformation Hospitalization 31 Female 11/23/2007 Hong Kong
Primary
Secondary
Drug Interaction Other Serious 15 Female 12/18/2007 Other Health Professional Greece
Primary
Concomitant
Interacting
Tachypnoea Hospitalization 1 Female 12/20/2007 Other Health Professional United Kingdom
Primary
Concomitant
Interacting
Muscular Weakness Congenital Anomaly 7/27/2006 Female 6 lb 1/2/2008 Physician United States
Primary
Concomitant
Toxic Epidermal Necrolysis Life Threatening 10/24/2004 Female 1/25/2008 Physician Germany
Primary
Secondary
Concomitant
Toxic Epidermal Necrolysis Life Threatening 10/24/2004 Female 2/14/2008 Physician Germany
Primary
Secondary
Concomitant
Drug Interaction Hospitalization 12/4/1997 57 Female 3/6/2008 Physician Belgium
Primary
Concomitant
Interacting
Epilepsy Other Serious 3/13/2008 Pharmacist Japan
Primary
Concomitant
Toxic Epidermal Necrolysis Life Threatening 10/24/2004 Female 3/6/2008 Physician Germany
Primary
Secondary
Concomitant
Pallor Hospitalization 1/4/2008 Female 189 lb 3/14/2008 Pharmacist United States
Primary
Concomitant
Epilepsy Other Serious 30 Male 3/18/2008 Pharmacist Japan
Primary
Concomitant
Anticonvulsant Drug Level Increased Other Serious 58 Male 3/20/2008 Belgium
Primary
Secondary
Concomitant
Pyrexia Other Serious 11 Male 3/25/2008 Physician Japan
Primary
Secondary
Concomitant
Epilepsy Other Serious 30 Male 4/21/2008 Pharmacist Japan
Primary
Concomitant
No Adverse Event 1 Female 5/20/2008 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
No Adverse Event 1 Female 5/20/2008 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Tachypnoea Hospitalization 1 Female 5/20/2008 United Kingdom
Primary
Concomitant
Interacting
Grand Mal Convulsion Other Serious 3/1/1984 Female 5/30/2008 Physician France
Primary
Secondary
Concomitant
Strabismus Congenital Congenital Anomaly 2/10/2000 Female 6/2/2008 Physician France
Primary
Secondary
Pyrexia Hospitalization 9/13/2007 11 Male 5/16/2008 Physician Japan
Primary
Secondary
Grand Mal Convulsion Other Serious Female 6/2/2008 Physician France
Primary
Secondary
Concomitant
Cytolytic Hepatitis Hospitalization 5/11/2008 88 Female 7/29/2008 Other Health Professional France
Primary
Secondary
Concomitant
Long Qt Syndrome Hospitalization 17 8/4/2008 Other Health Professional Japan
Primary
Concomitant
Nausea Hospitalization 17 8/8/2008 Other Health Professional Japan
Primary
Concomitant
Nausea Hospitalization 17 Male 8/11/2008 Other Health Professional Japan
Primary
Concomitant
Troponin Increased Hospitalization 8/12/2008 Male 210 lb 8/22/2008 Physician United Kingdom
Primary
Secondary
Concomitant
Troponin Increased Hospitalization 8/12/2008 Male 210 lb 8/29/2008 Physician United Kingdom
Primary
Secondary
Concomitant
Troponin Increased Hospitalization 8/12/2008 Male 210 lb 9/4/2008 Physician United Kingdom
Primary
Secondary
Concomitant
Wound Secretion Hospitalization 8/12/2008 Male 210 lb 9/11/2008 Physician United Kingdom
Primary
Secondary
Concomitant
Speech Disorder Developmental Congenital Anomaly Female 7 lb 9/12/2008 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Drug Toxicity Hospitalization 66 Male 9/24/2008 Australia
Primary
Concomitant
False Negative Laboratory Result Other Serious 47 Female 10/23/2008 Physician Belgium
Primary
Secondary
Concomitant
Rash Other Serious 11/4/2008 12/8/2008 Other Health Professional United Kingdom
Primary
Concomitant
Purple Glove Syndrome Life Threatening 11/17/2008 9 1/8/2009
Primary
Concomitant
Pneumonia Hospitalization 1/11/2009 50 Male 1/19/2009 Other Health Professional Japan
Primary
Secondary
Concomitant
Pseudomonas Infection Hospitalization 1/11/2009 50 Male 1/27/2009 Other Health Professional Japan
Primary
Secondary
Concomitant
Muscular Weakness Congenital Anomaly 7/27/2006 Female 6 lb 1/23/2009 Physician United States
Primary
Concomitant
Pseudomonas Infection Hospitalization 1/11/2009 50 Male 2/10/2009 Other Health Professional Japan
Primary
Secondary
Concomitant
Upper Respiratory Tract Infection Other Serious 11/1/2000 59 Male 2/6/2009 Physician New Zealand
Primary
Concomitant
Upper Respiratory Tract Infection Other Serious 11/1/2000 59 Male 2/10/2009 Physician New Zealand
Primary
Concomitant
Toxic Encephalopathy Death Male 2/13/2009 Physician Germany
Primary
Secondary
Infection 3/4/2009 Physician United States
Primary
Concomitant
Hepatic Enzyme Increased 3/4/2009 Other Health Professional United States
Primary
Concomitant
Rash 3/4/2009 Consumer United States
Primary
Interacting
Urine Output Decreased Other Serious 1/14/2009 28 Male 3/6/2009 Consumer Switzerland
Primary
Concomitant
Status Epilepticus Hospitalization 29 Male 3/6/2009 Other Health Professional Japan
Primary
Concomitant
Liver Transplant Required Intervention 33 Female 3/2/2009 United Kingdom
Primary
Concomitant
Pleural Effusion Hospitalization 2/3/2009 25 Male 3/4/2009 Other Health Professional Japan
Primary
Concomitant
Drug Interaction Hospitalization 12/5/2008 60 Female 3/11/2009 Physician United Kingdom
Primary
Concomitant
Interacting
Drug Interaction Other Serious 12/5/2008 60 Female 3/17/2009 Other Health Professional France
Primary
Concomitant
Interacting
Pleural Effusion Other Serious 2/3/2009 25 Male 3/27/2009 Other Health Professional Japan
Primary
Concomitant
Weight Decreased Other Serious Female 4/17/2009 France
Primary
Concomitant
Interacting
Vitamin B6 Deficiency Other Serious 29 Female 4/24/2009 Other Health Professional Spain
Primary
Concomitant
Urine Output Decreased Other Serious 1/14/2009 Male 5/1/2009 Consumer Switzerland
Primary
Concomitant
Leukopenia Other Serious 4/29/2009 Physician Switzerland
Primary
Concomitant
Convulsion 6/1/2006 39 Female 5/4/2009 United Kingdom
Primary
Secondary
Concomitant
Toxic Epidermal Necrolysis Hospitalization 10/1/2008 4 Male 6/2/2009 Japan
Primary
Secondary
Pleural Effusion Other Serious 2/3/2009 25 Male 6/3/2009 Other Health Professional Japan
Primary
Concomitant
Pleural Effusion Other Serious 4 Female 6/18/2009 United Kingdom
Primary
Concomitant
Muscle Rigidity Other Serious 58 Male 6/24/2009 Belgium
Primary
Secondary
Concomitant
Pleural Effusion Other Serious 4 Female 6/26/2009 United Kingdom
Primary
Concomitant
Weight Decreased Hospitalization Female 6/30/2009 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Pleural Effusion Other Serious 4 Female 7/30/2009 United Kingdom
Primary
Concomitant
Sepsis Hospitalization Male 8/7/2009 Other Health Professional Japan
Primary
Concomitant
Malignant Neoplasm Progression Other Serious 6 Female 9/1/2009 Physician Spain
Primary
Secondary
Weight Decreased Other Serious Female 9/14/2009 France
Primary
Concomitant
Interacting
Delirium Other Serious 9/4/2009 45 Male 9/21/2009 Consumer United Kingdom
Primary
Secondary
Concomitant
Pyrexia Other Serious 7/21/2009 45 Male 9/23/2009 Pharmacist United Kingdom
Primary
Secondary
Concomitant
Petechiae Hospitalization 7/21/2009 45 Male 9/29/2009 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Viral Upper Respiratory Tract Infection Required Intervention 21 Female 128 lb 10/6/2009 Switzerland
Primary
Concomitant
Vasoconstriction Death 73 Male 143 lb 10/6/2009 Other Health Professional Switzerland
Primary
Concomitant
Delirium Other Serious 9/4/2009 Male 10/23/2009 Consumer United Kingdom
Primary
Secondary
Concomitant
Muscle Rigidity Hospitalization 58 Male 10/21/2009 Other Health Professional Belgium
Primary
Secondary
Concomitant
Weight Decreased Hospitalization Female 10/21/2009 Physician United Kingdom
Primary
Secondary
Concomitant
Leukopenia Other Serious 3/23/2009 35 Female 10/22/2009 Physician Switzerland
Primary
Concomitant
Petechiae Other Serious 7/1/2009 Male 201 lb 10/28/2009 Pharmacist United Kingdom
Primary
Secondary
Concomitant
Face Oedema Other Serious 9/18/2009 24 Male 10/29/2009 Other Health Professional France
Primary
Secondary
Status Epilepticus Other Serious 45 Male 11/5/2009 Other Health Professional Belgium
Primary
Concomitant

Drug Data