Phenytoin combined with Topiramate

Reports:

Reaction Outcome Event Date Age Sex Weight Reported Reporter Country Treatment
Role Name
Dysphagia Disability 11/1/2005 86 Male 174 lb 1/23/2006 Pharmacist United Kingdom
Primary
Concomitant
Drug Interaction Hospitalization 1/1/2005 2 Female 1/25/2006 Physician United Kingdom
Primary
Secondary
Concomitant
Status Epilepticus Hospitalization 2 Female 1/31/2006 United Kingdom
Primary
Secondary
Concomitant
Tachypnoea Other Serious 2 Female 2/6/2006 Other Health Professional United Kingdom
Primary
Concomitant
Serotonin Syndrome Death 39 Female 2/7/2006 Pharmacist United States
Primary
Secondary
Road Traffic Accident Death 1/25/2006 48 Male 3/6/2006 United States
Primary
Concomitant
Visual Acuity Reduced Hospitalization 1/1/2003 34 Male 270 lb 3/7/2006 Consumer United States
Primary
Concomitant
Visual Field Defect Other Serious 10/19/2004 50 Male 3/16/2006 United Kingdom
Primary
Secondary
Psychotic Disorder Hospitalization 12/2/2004 56 Male 158 lb 1/14/2006 Physician United States
Primary
Concomitant
Road Traffic Accident Death 1/25/2006 48 Male 3/23/2006 United States
Primary
Concomitant
Hypothyroidism Hospitalization 3/27/2006 Male 144 lb 4/25/2006 Physician United States
Primary
Secondary
Concomitant
Tachypnoea Hospitalization 1 Female 4/27/2006 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Transient Ischaemic Attack Other Serious 1/1/2003 Male 209 lb 5/8/2006 Lawyer Canada
Primary
Concomitant
Transient Ischaemic Attack Other Serious 1/1/2002 Male 209 lb 5/10/2006 Lawyer Canada
Primary
Concomitant
Psychotic Disorder Required Intervention 3/31/2006 42 Male 216 lb 6/21/2006 Physician Germany
Primary
Secondary
Concomitant
Coma Required Intervention 40 Female 6/28/2006 Physician United Kingdom
Primary
Concomitant
Treatment Noncompliance Hospitalization 40 Female 7/11/2006 Physician United Kingdom
Primary
Concomitant
Haemodynamic Instability Required Intervention 9 Male 8/31/2006 Physician Belgium
Primary
Concomitant
Treatment Noncompliance Other Serious 37 Female 9/27/2006 Other Health Professional United States
Primary
Concomitant
Toxic Induced Encephalopathy Hospitalization 45 Female 11/3/2006 France
Primary
Concomitant
Psychotic Disorder Disability 3/1/2006 43 220 lb 11/9/2006 Other Health Professional United Kingdom
Primary
Concomitant
Confusional State Hospitalization 9/29/2006 51 Female 3/14/2007 Consumer United States
Primary
Concomitant
Plasmodium Falciparum Infection Hospitalization 2 Female 7/30/2007 Other Health Professional United Kingdom
Primary
Concomitant
Interacting
Somnolence Other Serious 7/29/2004 15 Male 8/3/2007 Physician Thailand
Primary
Concomitant
Tachypnoea Hospitalization 2 Female 8/3/2007 United Kingdom
Primary
Concomitant
Interacting
Tachypnoea Hospitalization 2 Female 8/10/2007 Other Health Professional United Kingdom
Primary
Concomitant
Interacting
Pancytopenia Other Serious 9 Male 8/22/2007 Other Health Professional Korea, Republic Of
Primary
Secondary
Concomitant
Pseudomembranous Colitis Other Serious 4/1/2005 9 Male 8/23/2007 Other Health Professional Korea, Republic Of
Primary
Secondary
Concomitant
Pancytopenia Hospitalization 9 Male 8/25/2007 Korea, Republic Of
Primary
Secondary
Concomitant
Electroencephalogram Abnormal Other Serious 16 Male 9/6/2007 Belgium
Primary
Concomitant
Interacting
Electroencephalogram Abnormal Other Serious 41 Female 9/6/2007 Belgium
Primary
Concomitant
Interacting
Pancytopenia Hospitalization 9 Male 8/30/2007 Korea, Republic Of
Primary
Secondary
Concomitant
Pancytopenia Other Serious 8/1/2005 9 Male 9/14/2007 France
Primary
Secondary
Drug Ineffective Life Threatening 46 Male 10/2/2007 Physician Czech Republic
Primary
Concomitant
Tachypnoea Hospitalization 1 Female 12/20/2007 Other Health Professional United Kingdom
Primary
Concomitant
Interacting
Tachypnoea Hospitalization 2 Female 1/18/2008 Other Health Professional United Kingdom
Primary
Concomitant
Interacting
No Adverse Event 1 Female 5/20/2008 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
No Adverse Event 1 Female 5/20/2008 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
No Adverse Event 2 Female 5/20/2008 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Tachypnoea Hospitalization 1 Female 5/20/2008 United Kingdom
Primary
Concomitant
Interacting
Vision Blurred Other Serious 6/1/2008 Male 230 lb 6/30/2008 Physician United States
Primary
Concomitant
Interacting
Vision Blurred Other Serious 6/1/2008 Male 230 lb 7/2/2008 Physician United States
Primary
Concomitant
Interacting
Pruritus Other Serious 2/10/2008 28 Female 9/3/2008 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Somnolence Required Intervention 6/25/2008 Male 172 lb 9/3/2008 Pharmacist United States
Primary
Concomitant
Pruritus Other Serious 2/10/2008 28 Female 9/12/2008 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Pruritus Other Serious 2/10/2008 28 Female 9/19/2008 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Serotonin Syndrome Other Serious 46 Female 12/4/2008
Primary
Secondary
Concomitant
Wound Infection Staphylococcal Other Serious 10/1/2008 Female 28 lb 1/17/2009 Pharmacist United States
Primary
Secondary
Rectal Haemorrhage Required Intervention 11/24/2008 83 Female 212 lb 12/23/2008 United States
Primary
Concomitant
Renal Failure Hospitalization 4/14/2009 Male 77 lb 6/3/2009 Physician Brazil
Primary
Concomitant
Psychotic Disorder Hospitalization 32 Female 6/22/2009 Other Health Professional Greece
Primary
Secondary
Pneumonia Hospitalization 6/16/2009 50 Male 6/29/2009 Physician United States
Primary
Concomitant
Priapism Other Serious 29 Male 7/13/2009 Other Health Professional United Kingdom
Primary
Concomitant
Death Death 6/10/2009 59 Female 157 lb 6/24/2009 Physician United States
Primary
Concomitant
Foetal Growth Retardation Congenital Anomaly 8/13/2009 Other Health Professional Croatia (Local Name: Hrvatska)
Primary
Secondary
Hepatitis Other Serious 12/1/2008 4 8/26/2009 Consumer Brazil
Primary
Secondary
Concomitant
Hepatitis Other Serious 12/1/2008 4 9/22/2009 Consumer Brazil
Primary
Secondary
Concomitant
Status Asthmaticus Hospitalization 7/13/2009 Male 10/2/2009 Physician United States
Primary
Concomitant
Viral Upper Respiratory Tract Infection Required Intervention 21 Female 128 lb 10/6/2009 Switzerland
Primary
Concomitant
Convulsion Other Serious 36 Female 11/6/2009 Physician Japan
Primary
Secondary
Concomitant
Status Asthmaticus Hospitalization 7/13/2009 Male 10/30/2009 Physician United States
Primary
Concomitant
Maternal Drugs Affecting Foetus Congenital Anomaly Female 12/1/2009 United Kingdom
Primary
Concomitant
Tonic Convulsion Hospitalization Male 154 lb 12/3/2009 Germany
Primary
Concomitant
Memory Impairment Other Serious 32 Male 12/14/2009 Other Health Professional United States
Primary
Concomitant
Therapeutic Agent Toxicity Hospitalization 10/28/2009 33 Female 10/29/2009 United States
Primary
Concomitant
Hyperammonaemic Encephalopathy Other Serious 53 Female 1/1/2010 Other Health Professional United States
Primary
Secondary
Hyperammonaemic Encephalopathy Other Serious 53 Female 1/6/2010 Other Health Professional United States
Primary
Secondary
Status Epilepticus Other Serious 53 Female 1/22/2010
Primary
Secondary
Concomitant
Metabolic Disorder Hospitalization 53 Female 1/23/2010 Other Health Professional United States
Primary
Secondary
Concomitant
Metabolic Encephalopathy Hospitalization 53 Female 2/6/2010 Other Health Professional United States
Primary
Secondary
Concomitant
Vomiting 7/1/2009 39 Female 115 lb 2/26/2010 Consumer United States
Primary
Secondary
Concomitant
Platelet Count Decreased Other Serious 10/13/2009 Female 2/26/2010 Other Health Professional Japan
Primary
Secondary
Concomitant
Metabolic Acidosis Other Serious 9 Female 4/7/2010 Physician United States
Primary
Concomitant
Hepatic Function Abnormal Other Serious 10/23/2009 54 Male 4/12/2010 Other Health Professional Japan
Primary
Concomitant
Metabolic Acidosis Hospitalization 9 Female 4/26/2010
Primary
Secondary
Concomitant
Pneumonia Mycoplasmal Hospitalization 2/18/2010 40 Female 102 lb 5/4/2010 Other Health Professional Japan
Primary
Concomitant
Metabolic Acidosis Hospitalization 9 Female 5/8/2010 Physician United States
Primary
Concomitant
Therapeutic Agent Toxicity Other Serious 29 Male 5/28/2010 Other Health Professional United Kingdom
Primary
Concomitant
Somnolence Hospitalization 46 Female 6/11/2010 Other Health Professional United States
Primary
Concomitant
Ventricular Fibrillation Other Serious 7/14/2010 26 Female 176 lb 7/26/2010 Physician Portugal
Primary
Concomitant
Somnolence Other Serious 46 Female 8/5/2010
Primary
Secondary
Weight Decreased Hospitalization 6/1/2010 46 Female 160 lb 8/13/2010 United States
Primary
Concomitant
Weight Decreased Hospitalization 6/1/2010 46 Female 160 lb 10/13/2010 United States
Primary
Concomitant
Paranoia Other Serious 22 Female 10/21/2010 Other Health Professional Japan
Primary
Concomitant
Renal Disorder Other Serious 2/1/2009 14 Female 10/26/2010 Other Health Professional Japan
Primary
Concomitant
Paranoia Other Serious 30 Female 11/1/2010 Other Health Professional Japan
Primary
Secondary
Concomitant
Renal Disorder Other Serious 2/1/2009 14 Female 11/4/2010 Other Health Professional Japan
Primary
Concomitant
Paranoia Other Serious 22 Female 11/8/2010 Other Health Professional Japan
Primary
Concomitant
Status Epilepticus Other Serious 38 Female 11/4/2010 Italy
Primary
Concomitant
Lennox-gastaut Syndrome Other Serious 38 Female 11/4/2010 Italy
Primary
Concomitant
Foetal Growth Restriction Congenital Anomaly 11/19/2010 Other Health Professional Croatia (Local Name: Hrvatska)
Primary
Secondary
Paranoia Other Serious 1/1/2009 33 Male 150 lb 11/22/2010 Consumer United States
Primary
Secondary
Concomitant
Epilepsy Hospitalization 12/10/2010 12/20/2010 Australia
Primary
Concomitant
Fall Hospitalization 67 Female 1/12/2011 Physician United States
Primary
Concomitant
Interacting
Cardiac Index Decreased Death 10/3/2010 50 Female 1/31/2011 Pharmacist Canada
Primary
Concomitant
Bipolar I Disorder Hospitalization 67 Female 1/24/2011 Physician United States
Primary
Secondary
Concomitant
Speech Disorder Other Serious 21 Female 2/2/2011 Other Health Professional Denmark
Primary
Secondary
Concomitant
Somnolence Other Serious 1/26/2011 Other Health Professional China
Primary
Concomitant
Grand Mal Convulsion Other Serious 21 Female 2/4/2011 United Kingdom
Primary
Secondary
Concomitant
Drug Interaction Hospitalization 11/16/2010 33 Female 80 lb 2/15/2011 Other Health Professional Japan
Primary
Secondary
Concomitant
Convulsion Hospitalization 36 Female 3/3/2011 Other Health Professional United Kingdom
Primary
Secondary
Toxicity To Various Agents Other Serious 74 Female 3/8/2011 Other Health Professional Germany
Primary
Secondary
Concomitant
Diplopia Other Serious 36 Female 3/9/2011 Consumer United Kingdom
Primary
Secondary
Drug Interaction Other Serious 36 Female 3/9/2011 Other Health Professional United Kingdom
Primary
Concomitant
Interacting
Myoclonus Hospitalization Female 3/9/2011 Other Health Professional Germany
Primary
Secondary
Concomitant
Coma Hospitalization Female 3/9/2011 Other Health Professional Germany
Primary
Secondary
Concomitant
Coma Hospitalization Female 3/9/2011 Other Health Professional Germany
Primary
Secondary
Concomitant
Diplopia Hospitalization 36 Female 3/11/2011 Other Health Professional United Kingdom
Primary
Secondary
Inhibitory Drug Interaction Other Serious 36 Female 3/1/2011 Other Health Professional United Kingdom
Primary
Secondary
Quadriparesis Other Serious 74 Female 3/14/2011 Other Health Professional Germany
Primary
Secondary
Concomitant
Paresis Hospitalization 74 Female 3/15/2011 Physician Germany
Primary
Secondary
Psychotic Disorder Other Serious 1/1/2009 39 Male 3/7/2011 Physician Germany
Primary
Secondary
Concomitant
Drug Ineffective Other Serious 36 Female 3/17/2011 Consumer United Kingdom
Primary
Secondary
Balance Disorder Other Serious 36 Female 3/4/2011 Other Health Professional United Kingdom
Primary
Secondary
Diplopia Other Serious 36 Female 3/23/2011 Other Health Professional United Kingdom
Primary
Interacting
Drug Interaction Other Serious 36 Female 3/23/2011 Other Health Professional United Kingdom
Primary
Interacting
Bipolar Disorder Hospitalization 3/28/2011 Other Health Professional Japan
Primary
Concomitant
Anticonvulsant Drug Level Decreased Hospitalization 36 Female 3/21/2011 Other Health Professional United Kingdom
Primary
Secondary
Balance Disorder Other Serious 37 Female 3/21/2011 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Leukoencephalopathy Other Serious 71 Male 3/23/2011 Physician Germany
Primary
Secondary
Concomitant
Drug Interaction Hospitalization 36 Female 4/7/2011 Other Health Professional United Kingdom
Primary
Secondary
Condition Aggravated Other Serious 36 Female 3/25/2011 United Kingdom
Primary
Secondary
Concomitant
Drug Ineffective Death 0 Female 4/8/2011 Other Health Professional France
Primary
Secondary
Grand Mal Convulsion Hospitalization 73 Male 4/13/2011 Consumer Germany
Primary
Secondary
Concomitant
Drug Interaction Hospitalization 36 Female 4/14/2011 Physician United Kingdom
Primary
Interacting
Convulsion Hospitalization 36 Female 4/15/2011 Other Health Professional United Kingdom
Primary
Secondary
Gait Disturbance Other Serious 73 Male 4/8/2011 Other Health Professional Germany
Primary
Secondary
Concomitant
Neurotoxicity Hospitalization 36 Female 4/7/2011 Other Health Professional United Kingdom
Primary
Secondary
Drug Interaction Other Serious 36 Female 4/15/2011 Other Health Professional
Primary
Secondary
Anticonvulsant Drug Level Decreased Hospitalization 36 Female 4/15/2011
Primary
Secondary
Toxicity To Various Agents Hospitalization 67 Female 4/29/2011 Physician United States
Primary
Concomitant
Interacting
Toxicity To Various Agents Other Serious 67 Female 5/2/2011 Other Health Professional United States
Primary
Concomitant
Interacting
Drug Ineffective Other Serious 27 Female 5/4/2011 Other Health Professional United Kingdom
Primary
Secondary
Toxicity To Various Agents Other Serious 67 Female 5/6/2011 Other Health Professional United States
Primary
Secondary
Encephalocele Other Serious 27 Female 4/28/2011 Other Health Professional United Kingdom
Primary
Secondary
Drug Ineffective Other Serious 27 Female 4/27/2011 Other Health Professional United Kingdom
Primary
Secondary
Encephalocele Other Serious 27 Female 5/3/2011 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Amnestic Disorder Other Serious 71 Male 5/3/2011 Physician Germany
Primary
Secondary
Concomitant
Drug Ineffective Other Serious 27 Female 5/11/2011 Other Health Professional United Kingdom
Primary
Concomitant
Drug Ineffective 27 Female 5/3/2011 Other Health Professional United Kingdom
Primary
Secondary
Renal Failure Death Male 5/25/2011 Other Health Professional United Kingdom
Primary
Secondary
Sepsis Death Male 5/27/2011 Other Health Professional United Kingdom
Primary
Secondary
Ileus Other Serious 12/2/2010 3 Male 19 lb 5/27/2011 Physician Japan
Primary
Secondary
Concomitant
Acute Hepatic Failure Death 7/14/2010 7 Female 5/31/2011 Other Health Professional France
Primary
Secondary
Concomitant
Sepsis Death Male 6/6/2011 Physician United Kingdom
Primary
Secondary
Sepsis Death Male 5/31/2011 Other Health Professional United Kingdom
Primary
Secondary
Respiratory Failure Other Serious 4/15/2011 68 Female 6/10/2011 Other Health Professional Japan
Primary
Concomitant
Renal Failure Death Male 6/10/2011 Other Health Professional United Kingdom
Primary
Secondary
Sepsis Death Male 6/10/2011 Other Health Professional United Kingdom
Primary
Concomitant
Hepatic Function Abnormal Hospitalization 4/27/2010 79 Female 6/13/2011 Other Health Professional Japan
Primary
Concomitant

Drug Data