Phenytoin combined with Simvastatin

Reports:

Reaction Outcome Event Date Age Sex Weight Reported Reporter Country Treatment
Role Name
Dysphagia Disability 11/1/2005 86 Male 174 lb 1/23/2006 Pharmacist United Kingdom
Primary
Concomitant
Tremor Hospitalization 10/31/2005 Male 164 lb 12/15/2005 Pharmacist United States
Primary
Concomitant
Pulmonary Embolism Life Threatening 2/21/2006 74 Female 168 lb 4/12/2006 Physician Israel
Primary
Concomitant
Gait Disturbance 1/18/2006 61 Male 4/7/2006 Pharmacist United States
Primary
Concomitant
Thrombocytopenia Other Serious 1/1/2005 60 Male 128 lb 5/2/2006 Pharmacist Singapore
Primary
Concomitant
Therapeutic Response Decreased Other Serious 1/1/2005 Male 5/15/2006 Physician Canada
Primary
Secondary
Concomitant
Treatment Noncompliance Other Serious 6/14/2006 47 Male 297 lb 6/19/2006 Pharmacist United States
Primary
Concomitant
Platelet Disorder Required Intervention 6/23/2006 45 Male 179 lb 7/4/2006 Pharmacist United States
Primary
Concomitant
Blood Potassium Increased Hospitalization 6/19/2006 67 Male 7/7/2006 Pharmacist United States
Primary
Concomitant
Hypotension Other Serious 5/8/2006 80 Male 166 lb 5/8/2006 Pharmacist United States
Primary
Concomitant
Thrombosis In Device Hospitalization 6/2/2006 36 Female 334 lb 8/18/2006 Other Health Professional United States
Primary
Concomitant
Skin Oedema Hospitalization 76 Male 9/21/2006 Physician United Kingdom
Primary
Concomitant
Gastrointestinal Haemorrhage Hospitalization 11/13/2005 62 Female 190 lb 8/11/2006 Pharmacist United States
Primary
Concomitant
Urine Ketone Body Present Other Serious 12/1/2005 Female 12/26/2006 Other Health Professional United Kingdom
Primary
Concomitant
Drug Ineffective Hospitalization 1/3/2007 Female 148 lb 2/6/2007 Consumer United States
Primary
Secondary
Concomitant
Sedation Other Serious 9/1/2006 46 Male 225 lb 2/6/2007 Pharmacist United States
Primary
Concomitant
Sudden Death Hospitalization 12/31/2006 74 Female 2/12/2007 Physician United States
Primary
Concomitant
Sudden Death Hospitalization 12/31/2006 74 Female 4/2/2007 Physician United States
Primary
Concomitant
Asthenia Hospitalization 3/22/2007 Male 153 lb 5/10/2007 Pharmacist United States
Primary
Concomitant
Prostatic Specific Antigen Increased Other Serious 6/1/2007 Male 180 lb 7/23/2007 Physician United States
Primary
Concomitant
Oesophagitis 5/22/2007 73 Male 7/19/2007 Pharmacist United States
Primary
Concomitant
Medication Error Hospitalization 78 Female 7/28/2007 Other Health Professional Ireland
Primary
Secondary
Concomitant
Intestinal Obstruction Other Serious 7/15/2007 65 Female 8/6/2007 Pharmacist United Kingdom
Primary
Concomitant
Middle Insomnia 1/1/2007 81 Female 200 lb 7/10/2007 Consumer United States
Primary
Concomitant
Incorrect Dose Administered Hospitalization 78 Female 8/3/2007 Ireland
Primary
Secondary
Concomitant
Therapeutic Agent Toxicity Hospitalization 78 Female 8/21/2007 Ireland
Primary
Secondary
Interacting
Skin Laceration Hospitalization 8/1/2007 72 Female 132 lb 10/22/2007 Physician United States
Primary
Concomitant
Therapeutic Agent Toxicity Hospitalization 78 Female 12/21/2007 Ireland
Primary
Secondary
Interacting
Incorrect Dose Administered Hospitalization 78 Female 12/27/2007 Ireland
Primary
Concomitant
Skin Laceration Hospitalization 8/8/2007 72 Female 132 lb 1/15/2008 Physician United States
Primary
Concomitant
Sarcoma Other Serious 8/1/2007 Male 270 lb 1/17/2008 Consumer United States
Primary
Secondary
Concomitant
Skin Papilloma Other Serious 1/26/2007 30 Female 4/28/2008 Physician France
Primary
Concomitant
Transaminases Increased Hospitalization 9/3/2007 72 Female 5/16/2008 Other Health Professional Singapore
Primary
Concomitant
Incorrect Dose Administered Other Serious 78 Female 5/30/2008 Ireland
Primary
Secondary
Concomitant
Vision Blurred Other Serious 6/1/2008 Male 230 lb 6/30/2008 Physician United States
Primary
Concomitant
Interacting
Vision Blurred Other Serious 6/1/2008 Male 230 lb 7/2/2008 Physician United States
Primary
Concomitant
Interacting
Musculoskeletal Discomfort Disability 6/2/2008 81 Female 176 lb 7/8/2008 Other Health Professional United Kingdom
Primary
Concomitant
Urine Ketone Body Present Required Intervention 9/30/2006 60 Male 7/3/2008 Physician United States
Primary
Concomitant
Splenic Infarction Other Serious 2/1/2008 52 Male 170 lb 7/21/2008 Physician United States
Primary
Secondary
Concomitant
Vomiting Other Serious 1/1/2008 Male 180 lb 7/25/2008 Consumer United States
Primary
Secondary
Concomitant
Rash Maculo-papular Hospitalization 3/19/2008 85 Female 88 lb 8/6/2008 Other Health Professional Singapore
Primary
Concomitant
Vomiting Life Threatening 5/12/2008 46 Female 8/12/2008 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Vomiting Life Threatening 46 Female 8/18/2008 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Flushing 10/1/2007 Female 182 lb 8/27/2008 Consumer United States
Primary
Concomitant
Splenic Infarction Hospitalization 52 Male 9/17/2008 United States
Primary
Secondary
Drug Toxicity Hospitalization 66 Male 9/24/2008 Australia
Primary
Concomitant
Rash Other Serious 8/13/2008 84 Male 9/22/2008 Physician United Kingdom
Primary
Concomitant
Leukopenia Required Intervention 6/2/2008 65 Female 163 lb 6/26/2008 United States
Primary
Concomitant
Loss Of Consciousness Required Intervention 7/16/2008 55 Male 218 lb 7/31/2008 Pharmacist United States
Primary
Concomitant
Treatment Noncompliance Life Threatening 10/14/2008 43 Female 12/3/2008 Other Health Professional United States
Primary
Concomitant
Deep Vein Thrombosis Other Serious 9/1/2008 Female 1/27/2009 Physician Japan
Primary
Concomitant
Urosepsis Hospitalization 10/14/2008 75 Female 135 lb 2/18/2009 Pharmacist United States
Primary
Concomitant
Angioedema Hospitalization 1/22/2009 2/27/2009 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Deep Vein Thrombosis Other Serious 9/1/2008 Female 3/2/2009 Physician Japan
Primary
Concomitant
Drug Ineffective 4/30/2009 80 Male 5/22/2009 Consumer
Primary
Concomitant
White Blood Cell Disorder Hospitalization 5/12/2009 Female 160 lb 5/28/2009 Other Health Professional United States
Primary
Secondary
Concomitant
Hypomagnesaemia Hospitalization 2/27/2008 83 Male 6/3/2009 Other Health Professional New Zealand
Primary
Concomitant
Sinus Arrhythmia Other Serious 46 Male 176 lb 7/30/2009
Primary
Secondary
Concomitant
Swelling Face Hospitalization 7/17/2008 53 Male 7/24/2009 Pharmacist United States
Primary
Concomitant
Vision Blurred Other Serious 7/9/2009 81 Female 210 lb 7/31/2009 Consumer United States
Primary
Concomitant
White Blood Cell Disorder Hospitalization 5/12/2009 Female 160 lb 8/7/2009 Other Health Professional United States
Primary
Secondary
Concomitant
Tremor Hospitalization 10/24/2008 64 Male 170 lb 10/24/2008 Pharmacist United States
Primary
Secondary
Concomitant
Ventricular Fibrillation Life Threatening 4/28/2009 61 Female 236 lb 10/2/2009 Physician United States
Primary
Concomitant
Toxic Epidermal Necrolysis Other Serious 6/24/2007 Male 209 lb 10/6/2009 Consumer United States
Primary
Concomitant
Rash Pruritic Hospitalization 52 Male 9/18/2009 Other Health Professional United States
Primary
Secondary
Rash Pruritic Hospitalization 52 Male 9/18/2009 United States
Primary
Secondary
Thrombosis Other Serious 9/1/2007 54 Male 132 lb 10/19/2009 Other Health Professional United States
Primary
Concomitant
Haemorrhage Urinary Tract Hospitalization 10/13/2009 Male 209 lb 10/26/2009 United States
Primary
Concomitant
Toxic Epidermal Necrolysis Other Serious 6/24/2007 Male 209 lb 10/27/2009 Consumer United States
Primary
Concomitant
Renal Failure Hospitalization 10/13/2009 Male 209 lb 11/10/2009 United States
Primary
Concomitant
Gastrointestinal Haemorrhage Hospitalization Female 12/8/2009 United States
Primary
Concomitant
Respiratory Distress Life Threatening 9/1/2007 69 Female 12/9/2009 Other Health Professional United States
Primary
Secondary
Concomitant
Transient Ischaemic Attack Other Serious 1/1/2006 66 Female 12/19/2009 Physician United States
Primary
Concomitant
Hypercholesterolaemia Other Serious 10/14/2007 59 Female 12/22/2009 Lawyer United States
Primary
Concomitant
Pruritus Disability 4/17/2008 79 Female 132 lb 12/23/2009 Other Health Professional United Kingdom
Primary
Concomitant
Neutropenia Life Threatening 12/14/2009 Male 184 lb 1/20/2010 United States
Primary
Secondary
Concomitant
Pruritus Disability 5/4/2008 79 Female 132 lb 1/28/2010
Primary
Concomitant
Neutropenia Other Serious 12/14/2009 Male 184 lb 2/9/2010 United States
Primary
Secondary
Concomitant
Thrombosis Other Serious 9/1/2007 54 Male 132 lb 2/24/2010 Other Health Professional United States
Primary
Concomitant
Toxic Epidermal Necrolysis Other Serious 6/24/2007 Male 209 lb 3/1/2010 Consumer United States
Primary
Concomitant
Troponin Increased 4/13/2009 72 Male 160 lb 4/21/2009 Pharmacist United States
Primary
Concomitant
Thrombosis In Device Life Threatening 1/1/2007 69 Female 143 lb 3/12/2010 Other Health Professional United States
Primary
Concomitant
Epilepsy Other Serious 2/23/2010 88 Male 3/25/2010 Other Health Professional United Kingdom
Primary
Concomitant
Suicidal Ideation 1/1/2009 48 Female 183 lb 3/25/2010 Consumer United States
Primary
Concomitant
Epilepsy Other Serious 2/23/2010 88 Male 3/26/2010 Other Health Professional United Kingdom
Primary
Concomitant
Hypotension Hospitalization 2/19/2010 28 Female 119 lb 4/15/2010 Consumer United States
Primary
Concomitant
Vomiting Other Serious 8/1/2009 72 Female 4/15/2010 Netherlands
Primary
Secondary
Concomitant
Diabetic Complication Death 90 Female 5/3/2010 Consumer United States
Primary
Concomitant
Vomiting Other Serious 8/1/2009 72 Female 4/27/2010 Netherlands
Primary
Secondary
Concomitant
Lung Neoplasm Malignant Other Serious 1/1/2008 73 Male 6/10/2010 Lawyer United States
Primary
Concomitant
Hypotension Hospitalization 2/19/2010 28 Female 119 lb 6/14/2010 Consumer United States
Primary
Concomitant
Renal Failure Other Serious 3/1/2008 74 Male 6/15/2010 Lawyer United States
Primary
Concomitant
Weight Decreased Other Serious 8/29/2001 68 Female 180 lb 6/16/2010 United States
Primary
Secondary
Concomitant
Staphylococcal Infection Other Serious 49 Male 290 lb 6/24/2010 Pharmacist United States
Primary
Concomitant
Thrombosis Other Serious 2/19/2010 27 Female 112 lb 7/1/2010 Consumer United States
Primary
Secondary
Concomitant
Weight Decreased Other Serious 8/29/2001 68 Female 180 lb 7/5/2010 United States
Primary
Secondary
Concomitant
Hypotension Other Serious 1/3/2008 76 Male 7/7/2010 Other Health Professional United States
Primary
Concomitant
Weight Decreased Other Serious 8/29/2001 68 Female 180 lb 7/15/2010 United States
Primary
Secondary
Concomitant
Tremor Hospitalization 4/16/2010 73 Female 146 lb 7/13/2010 Pharmacist United States
Primary
Concomitant
Weight Decreased Other Serious 8/29/2001 68 Female 180 lb 7/19/2010 United States
Primary
Secondary
Concomitant
Toxic Epidermal Necrolysis Hospitalization 6/1/2010 63 Male 163 lb 8/5/2010 Physician Spain
Primary
Secondary
Lung Neoplasm Malignant Other Serious 1/1/2008 72 Male 8/5/2010 Other Health Professional United States
Primary
Concomitant
Sarcoma Other Serious 8/1/2007 58 Male 270 lb 8/6/2010 Other Health Professional United States
Primary
Secondary
Concomitant
Surgery Life Threatening 7/27/2010 71 Female 8/9/2010 Pharmacist United Kingdom
Primary
Concomitant
Pneumonia Hospitalization 6/10/2010 71 Female 179 lb 8/7/2010 Pharmacist United States
Primary
Concomitant
Unresponsive To Stimuli Other Serious 1/1/1984 74 Male 8/12/2010 Other Health Professional United States
Primary
Secondary
Concomitant
Strabismus Other Serious Male 8/17/2010 Other Health Professional United Kingdom
Primary
Concomitant
Weight Decreased Hospitalization 6/1/2010 46 Female 160 lb 8/13/2010 United States
Primary
Concomitant
Weight Decreased Other Serious 8/29/2001 68 Female 180 lb 8/20/2010 Other Health Professional United States
Primary
Secondary
Concomitant
Drug Rash With Eosinophilia And Systemic Symptoms Other Serious 9/10/2010 Other Health Professional Singapore
Primary
Secondary
Weight Decreased Hospitalization 6/1/2010 46 Female 160 lb 10/13/2010 United States
Primary
Concomitant
Weight Decreased Other Serious 8/29/2001 68 Female 180 lb 11/3/2010 Other Health Professional United States
Primary
Secondary
Concomitant
Unresponsive To Stimuli Hospitalization 7/29/2010 77 Male 11/8/2010 Pharmacist United States
Primary
Concomitant
Renal Failure Life Threatening 6/1/2010 41 Male 147 lb 11/16/2010 Physician United Kingdom
Primary
Concomitant
Medication Residue Hospitalization 11/4/2010 Female 11/18/2010 Physician United States
Primary
Secondary
Concomitant
Stress Cardiomyopathy Hospitalization Female 200 lb 12/15/2010 Consumer United States
Primary
Concomitant
Ill-defined Disorder Other Serious 1/1/2000 50 Male 215 lb 1/24/2011 Consumer United States
Primary
Secondary
Concomitant
Hypotension Other Serious 1/1/1984 74 Male 2/3/2011 Lawyer United States
Primary
Secondary
Concomitant
Injection Site Haematoma Hospitalization 10/26/2010 67 Female 2/1/2011 Pharmacist United States
Primary
Concomitant
Coronary Artery Disease Other Serious 1/1/2000 Male 215 lb 2/15/2011 Consumer United States
Primary
Secondary
Concomitant
Skin Papilloma Other Serious 2/19/2008 30 Female 3/17/2011 Physician France
Primary
Concomitant
Blood Sodium Decreased Other Serious 2/9/2011 71 Male 3/22/2011 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Blood Sodium Decreased Hospitalization 2/9/2011 71 Male 4/12/2011 Other Health Professional United Kingdom
Primary
Concomitant
Drug Rash With Eosinophilia And Systemic Symptoms Other Serious 44 Female 4/14/2011 Physician United States
Primary
Secondary
Concomitant
Drug Rash With Eosinophilia And Systemic Symptoms Other Serious 44 Female 4/18/2011 Physician United States
Primary
Concomitant
Bile Duct Obstruction Other Serious 2/9/2011 71 Male 4/21/2011 Other Health Professional United Kingdom
Primary
Concomitant
Renal Cancer Hospitalization 11/1/2007 62 Female 145 lb 4/26/2011 Consumer United States
Primary
Concomitant
Drug Hypersensitivity Hospitalization 44 Female 4/20/2011 Physician United States
Primary
Concomitant
Back Pain Hospitalization 3/1/2000 39 Male 5/9/2011 Physician United States
Primary
Concomitant
Speech Disorder Hospitalization 9/5/2001 68 Female 180 lb 5/11/2011 Lawyer United States
Primary
Secondary
Concomitant
Dizziness Hospitalization 11/1/2007 62 Female 145 lb 6/13/2011 Physician United States
Primary
Concomitant
Hypertensive Crisis Other Serious 1/1/2011 64 Female 6/15/2011 Physician United States
Primary
Secondary
Concomitant
Tracheal Stenosis Hospitalization 1/1/2011 64 Female 6/21/2011 Physician United States
Primary
Secondary
Concomitant
Death Death 11/22/2010 52 Male 6/22/2011 Pharmacist United States
Primary
Concomitant
Visual Impairment Hospitalization 7/4/2011 62 Male 7/28/2011 Consumer United States
Primary
Concomitant
Pruritus 10/1/2010 51 Male 145 lb 8/5/2011 Consumer United States
Primary
Concomitant
Anaemia Other Serious 61 Female 130 lb 8/12/2011 Brazil
Primary
Concomitant
Drug Effect Decreased 8/12/2011 61 Male 310 lb 8/18/2011 Consumer United States
Primary
Secondary
Concomitant
Oedema Peripheral Other Serious 7/27/2011 66 Female 215 lb 9/8/2011 Physician United Kingdom
Primary
Concomitant
Mental Status Changes Hospitalization 65 Male 9/8/2011 Other Health Professional United States
Primary
Concomitant
Toxicity To Various Agents Hospitalization 65 Male 9/9/2011 Other Health Professional United States
Primary
Concomitant
Atrioventricular Block Other Serious 60 Female 9/13/2011 Other Health Professional United States
Primary
Concomitant
Blood Pressure Increased Hospitalization 65 Male 9/21/2011 Other Health Professional United States
Primary
Concomitant
Osteonecrosis Of Jaw Other Serious 1/1/2009 81 Female 9/27/2011 Other Health Professional United States
Primary
Concomitant
Speech Disorder Hospitalization 65 Male 9/23/2011 Other Health Professional United States
Primary
Concomitant
Pneumonia Death Male 10/10/2011 Physician United States
Primary
Concomitant
Erythema Other Serious 7/27/2011 66 Female 215 lb 10/24/2011 Physician United Kingdom
Primary
Concomitant
Leukocytosis Life Threatening 44 Female 10/18/2011 Other Health Professional United States
Primary
Secondary
Unresponsive To Stimuli Death 1/1/1984 74 Male 10/26/2011 Lawyer United States
Primary
Secondary
Concomitant
Haemorrhage Female 11/3/2011 Other Health Professional United States
Primary
Concomitant

Drug Data