Paclitaxel combined with Trastuzumab

Reports:

Reaction Outcome Event Date Age Sex Weight Reported Reporter Country Treatment
Role Name
Toothache Other Serious 9/1/2004 69 Female 88 lb 3/11/2006 Physician Japan
Primary
Concomitant
Toothache Other Serious 10/1/2003 64 Female 99 lb 3/11/2006 Physician Japan
Primary
Concomitant
Ventricular Extrasystoles Hospitalization 11/3/2006 85 Female 331 lb 1/12/2007 Other Health Professional France
Primary
Secondary
Scleroderma Other Serious 7/1/2003 37 Female 1/24/2007 Other Health Professional Japan
Primary
Secondary
Scleroderma Other Serious 7/1/2003 37 Female 1/30/2007 Other Health Professional Japan
Primary
Secondary
Concomitant
Paronychia Other Serious 48 Female 2/13/2007 Other Health Professional Italy
Primary
Secondary
Scleroderma Other Serious 7/1/2003 37 Female 2/23/2007 Japan
Primary
Secondary
Dehydration Hospitalization 3/27/2007 55 Female 123 lb 4/4/2007 Physician United States
Primary
Secondary
Concomitant
White Blood Cell Count Increased Death 2/4/2007 Female 99 lb 4/9/2007 Physician United Kingdom
Primary
Secondary
Renal Failure Other Serious 38 Female 4/3/2007 Other Health Professional Austria
Primary
Secondary
Concomitant
Rales Hospitalization 3/20/2007 46 Female 90 lb 4/11/2007 Physician Korea, Republic Of
Primary
Secondary
Concomitant
Rales Hospitalization 3/20/2007 46 Female 90 lb 4/17/2007 Physician Korea, Republic Of
Primary
Secondary
Concomitant
Ventricular Dysfunction Other Serious 2/14/2007 47 Female 186 lb 4/19/2007 Physician United States
Primary
Secondary
Dehydration Hospitalization 3/27/2007 55 Female 123 lb 4/20/2007 Physician United States
Primary
Secondary
Concomitant
Rales Hospitalization 3/20/2007 46 Female 90 lb 4/27/2007 Physician Korea, Republic Of
Primary
Secondary
Concomitant
Optic Nerve Disorder Death Female 5/9/2007 Physician United Kingdom
Primary
Secondary
Concomitant
Rales Hospitalization 3/20/2007 46 Female 90 lb 6/1/2007 Physician Korea, Republic Of
Primary
Secondary
Concomitant
Toothache Other Serious 9/1/2004 69 Female 88 lb 6/2/2007 Japan
Primary
Concomitant
Toothache Other Serious 9/1/2004 69 Female 88 lb 6/12/2007 Japan
Primary
Concomitant
Diarrhoea Other Serious 2/4/2007 Female 99 lb 6/27/2007 Physician United Kingdom
Primary
Secondary
Haemoglobin Decreased Hospitalization 4/29/2007 Female 6/28/2007 Physician United Kingdom
Primary
Secondary
Polyarthritis Other Serious 36 Female 7/6/2007 Other Health Professional Japan
Primary
Secondary
Concomitant
Macular Oedema Other Serious 63 Female 7/10/2007 Other Health Professional United States
Primary
Secondary
Diarrhoea Hospitalization 6/14/2007 Female 7/12/2007 Physician United Kingdom
Primary
Secondary
Febrile Neutropenia Life Threatening 4/7/2007 Female 8/22/2007 Physician United Kingdom
Primary
Secondary
Hypokalaemia Hospitalization 6/6/2006 49 Female 156 lb 8/23/2007 Physician United States
Primary
Secondary
Concomitant
Death Death 8/17/2007 Female 146 lb 9/6/2007 Physician United Kingdom
Primary
Secondary
Stomatitis Life Threatening 3/30/2007 Female 9/21/2007 Physician United Kingdom
Primary
Secondary
Concomitant
General Physical Health Deterioration Hospitalization 6/11/2007 Female 9/24/2007 Physician United Kingdom
Primary
Secondary
Stomatitis Hospitalization 3/30/2007 Female 9/25/2007 Physician United Kingdom
Primary
Secondary
Concomitant
Death Death 8/17/2007 Female 146 lb 10/10/2007 Physician United Kingdom
Primary
Secondary
Concomitant
Intracranial Tumour Haemorrhage Hospitalization 10/21/2007 Female 154 lb 11/13/2007 Physician United Kingdom
Primary
Concomitant
Groin Abscess Hospitalization 10/29/2007 Female 158 lb 11/14/2007 Physician United States
Primary
Secondary
Groin Abscess Hospitalization 10/29/2007 Female 158 lb 11/27/2007 Physician United States
Primary
Secondary
Concomitant
Groin Abscess Hospitalization 10/29/2007 Female 158 lb 11/27/2007 Physician United States
Primary
Secondary
Concomitant
Intracranial Tumour Haemorrhage Hospitalization 10/21/2007 Female 154 lb 12/3/2007 Physician United Kingdom
Primary
Concomitant
Renal Failure Hospitalization 11/23/2007 72 Female 132 lb 12/4/2007 Physician United States
Primary
Secondary
Concomitant
Polyneuropathy Hospitalization 10/21/2007 Female 154 lb 12/11/2007 Physician United Kingdom
Primary
Concomitant
Ulcer Hospitalization 10/29/2007 Female 158 lb 12/11/2007 Physician United States
Primary
Secondary
Concomitant
Sepsis Hospitalization 10/29/2007 Female 158 lb 12/11/2007 Physician United States
Primary
Secondary
Concomitant
Thrombotic Thrombocytopenic Purpura Required Intervention 11/10/2007 62 Female 176 lb 12/11/2007 Physician United States
Primary
Concomitant
Infection Hospitalization 11/25/2007 Female 12/18/2007 Physician United Kingdom
Primary
Secondary
Concomitant
Thrombotic Thrombocytopenic Purpura Required Intervention 11/10/2007 62 Female 176 lb 12/11/2007 Physician United States
Primary
Concomitant
Renal Failure Hospitalization 11/23/2007 72 Female 132 lb 1/7/2008 Physician United States
Primary
Secondary
Concomitant
Neuropathy Peripheral Hospitalization 12/26/2007 53 Female 163 lb 1/10/2008 Physician United States
Primary
Secondary
Concomitant
Drug Exposure During Pregnancy 29 Female 1/10/2008 United States
Primary
Secondary
Haemoglobin Decreased Hospitalization 12/31/2007 61 Female 1/25/2008 Other Health Professional United Kingdom
Primary
Secondary
Infection Hospitalization 11/25/2007 Female 1/26/2008 Physician United Kingdom
Primary
Secondary
Concomitant
Neuropathy Peripheral Hospitalization 12/26/2007 53 Female 163 lb 1/29/2008 Physician United States
Primary
Secondary
Concomitant
Neuropathy Peripheral Hospitalization 12/1/2007 53 Female 1/31/2008 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Lethargy Hospitalization 12/26/2007 Female 2/5/2008 Physician United Kingdom
Primary
Secondary
Concomitant
Osteonecrosis Other Serious 3/1/2005 Female 172 lb 2/14/2008 Physician Germany
Primary
Secondary
Concomitant
Waist Circumference Increased Other Serious 1/1/2004 29 Female 2/15/2008
Primary
Secondary
Concomitant
Cardiac Failure Hospitalization 1/29/2008 69 Male 2/20/2008 Physician Japan
Primary
Secondary
Haemoglobin Decreased Hospitalization 12/31/2007 61 Female 2/25/2008 Other Health Professional United Kingdom
Primary
Secondary
Subcutaneous Emphysema Hospitalization 12/31/2007 61 Female 2/27/2008 Other Health Professional United Kingdom
Primary
Secondary
Aspartate Aminotransferase Increased Other Serious 2/22/2008 22 Female 154 lb 2/28/2008 Physician Ireland
Primary
Secondary
Concomitant
Cardiac Failure Life Threatening 1/29/2008 69 Male 104 lb 3/11/2008 Physician Japan
Primary
Secondary
Concomitant
Cardiac Failure Life Threatening 1/29/2008 Male 104 lb 3/11/2008 Physician United Kingdom
Primary
Secondary
Concomitant
Cardiac Failure Life Threatening 1/29/2008 69 Male 104 lb 3/14/2008 Physician Japan
Primary
Secondary
Concomitant
Hepatic Enzyme Increased Other Serious 2/22/2008 22 Female 154 lb 3/17/2008 Physician Ireland
Primary
Secondary
Concomitant
Haemoglobin Decreased Hospitalization 12/31/2007 61 Female 3/17/2008 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Cardiac Failure Life Threatening 1/29/2008 Male 104 lb 3/18/2008 Physician United Kingdom
Primary
Secondary
Concomitant
Respiratory Failure Hospitalization 12/31/2007 61 Female 3/24/2008 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Cardiac Failure Life Threatening 1/29/2008 Male 104 lb 4/2/2008 Physician United Kingdom
Primary
Secondary
Concomitant
Dermatitis Bullous Other Serious 3/5/2008 Female 174 lb 4/4/2008 Physician Netherlands
Primary
Concomitant
Cardiac Failure Life Threatening 1/29/2008 Male 104 lb 4/4/2008 Physician Japan
Primary
Secondary
Concomitant
Oedema Peripheral Other Serious 1/23/2008 Female 148 lb 4/9/2008 Physician Netherlands
Primary
Concomitant
Hepatic Enzyme Increased Other Serious 2/22/2008 22 Female 154 lb 4/9/2008 Physician Ireland
Primary
Secondary
Concomitant
Rash Other Serious 41 Female 4/15/2008 Other Health Professional Japan
Primary
Secondary
Neuropathy Peripheral Hospitalization 12/26/2007 53 Female 163 lb 4/17/2008 Physician United States
Primary
Secondary
Concomitant
Pain Other Serious 41 Female 4/18/2008 Other Health Professional Japan
Primary
Secondary
Neuropathy Peripheral Hospitalization 12/1/2007 53 Female 4/21/2008 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Pain 41 Female 4/23/2008 Other Health Professional United States
Primary
Secondary
Pain Other Serious 41 Female 4/25/2008 Consumer United States
Primary
Secondary
Pain 41 Female 4/28/2008 Other Health Professional United States
Primary
Secondary
Cardiac Failure Hospitalization 1/29/2008 Male 104 lb 5/1/2008 Physician Japan
Primary
Secondary
Concomitant
Cardiac Failure Life Threatening 2/4/2008 Male 104 lb 5/6/2008 Physician United Kingdom
Primary
Secondary
Concomitant
Blood Triglycerides Increased Female 5/22/2008 Other Health Professional United States
Primary
Secondary
Subcutaneous Emphysema Hospitalization 12/31/2007 61 Female 6/5/2008 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Gastric Haemorrhage Life Threatening 6/3/2008 Female 6/19/2008 Physician United Kingdom
Primary
Secondary
Concomitant
Gastric Haemorrhage Life Threatening 6/3/2008 Female 7/2/2008 Physician United Kingdom
Primary
Secondary
Concomitant
Thrombocytopenia Other Serious Female 7/8/2008 Physician United Kingdom
Primary
Secondary
Concomitant
Neutropenia Other Serious 7/1/2008 56 Female 117 lb 7/22/2008 Physician Greece
Primary
Secondary
Renal Failure Hospitalization 11/23/2007 72 Female 132 lb 7/31/2008 Physician United States
Primary
Secondary
Concomitant
Myocardial Infarction Other Serious 4/21/2008 41 Female 119 lb 8/5/2008 Physician Switzerland
Primary
Secondary
Hepatic Enzyme Increased Other Serious 7/4/2008 59 Female 159 lb 8/6/2008 Physician Ireland
Primary
Secondary
Hypokalaemia Hospitalization 4/30/2008 58 Female 113 lb 8/6/2008 Physician France
Primary
Secondary
Neuropathy Peripheral Hospitalization 12/26/2007 53 Female 163 lb 8/7/2008 Physician United States
Primary
Secondary
Concomitant
Pyrexia Hospitalization 7/30/2008 54 Female 155 lb 8/8/2008 Physician Netherlands
Primary
Secondary
Concomitant
Pulmonary Embolism Hospitalization 7/24/2008 Female 8/11/2008 Consumer United Kingdom
Primary
Secondary
Concomitant
Pyrexia Hospitalization 7/30/2008 Female 8/18/2008 Physician United Kingdom
Primary
Secondary
Concomitant
Liver Function Test Abnormal Other Serious 8/12/2008 56 Female 119 lb 8/21/2008 Physician Greece
Primary
Secondary
Guillain-barre Syndrome Hospitalization 12/26/2007 Female 8/21/2008 Physician United Kingdom
Primary
Secondary
Concomitant
Liver Function Test Abnormal Other Serious 8/12/2008 56 Female 119 lb 8/27/2008 Physician Greece
Primary
Secondary
Myocardial Infarction Other Serious 4/21/2008 41 Female 119 lb 9/4/2008 Physician Switzerland
Primary
Secondary
Perihepatic Discomfort Other Serious 8/25/2008 47 Female 218 lb 9/4/2008 Physician South Africa
Primary
Secondary
Concomitant
Pulmonary Embolism Hospitalization 7/24/2008 Female 9/12/2008 Consumer United Kingdom
Primary
Secondary
Concomitant
Tubulointerstitial Nephritis Hospitalization 5/6/2008 Female 9/12/2008 Physician United Kingdom
Primary
Concomitant
Perihepatic Discomfort Other Serious 8/25/2008 47 Female 218 lb 9/17/2008 Physician South Africa
Primary
Secondary
Concomitant
Pyrexia Hospitalization 9/4/2008 60 Female 121 lb 9/19/2008 Physician New Zealand
Primary
Secondary
Hepatic Enzyme Increased Other Serious 7/4/2008 59 Female 159 lb 9/26/2008 Physician Ireland
Primary
Secondary
Hepatitis Viral Hospitalization 3/31/2008 Female 10/1/2008 Physician United States
Primary
Secondary
Pyrexia Hospitalization 9/9/2008 60 Female 121 lb 10/2/2008 Physician New Zealand
Primary
Secondary
Inflammation Other Serious 2/17/2006 54 Female 10/9/2008 United States
Primary
Concomitant
Perihepatic Discomfort Other Serious 8/25/2008 47 Female 218 lb 10/17/2008 Physician South Africa
Primary
Secondary
Concomitant
Urinary Tract Infection Hospitalization 10/16/2008 45 Female 166 lb 10/27/2008 Physician United States
Primary
Secondary
Neutropenia Other Serious 8/11/2008 72 Female 201 lb 10/31/2008 Physician Spain
Primary
Secondary
Urinary Tract Infection Hospitalization 10/16/2008 45 Female 11/3/2008 Other Health Professional United Kingdom
Primary
Secondary
Decubitus Ulcer Hospitalization 10/21/2008 11/3/2008 Physician United States
Primary
Secondary
Neutropenia Other Serious 8/11/2008 72 Female 201 lb 11/3/2008 Physician Spain
Primary
Secondary
Chills Hospitalization 11/2/2007 44 Female 11/4/2008 United States
Primary
Secondary
Concomitant
Inflammation Other Serious 2/17/2006 54 Female 11/7/2008 United States
Primary
Concomitant
Pyrexia Hospitalization 7/30/2008 54 Female 155 lb 11/10/2008 Physician Netherlands
Primary
Secondary
Concomitant
Palmar-plantar Erythrodysaesthesia Syndrome Life Threatening 10/21/2008 11/11/2008 Physician United States
Primary
Secondary
Concomitant
Hypothyroidism Hospitalization 11/4/2008 57 Female 203 lb 11/14/2008 Physician Israel
Primary
Secondary
Neutropenia Other Serious 10/28/2008 57 Female 203 lb 11/14/2008 Physician Israel
Primary
Secondary
Hypothyroidism Hospitalization 11/4/2008 57 Female 203 lb 11/14/2008 Physician Israel
Primary
Secondary
Palmar-plantar Erythrodysaesthesia Syndrome Life Threatening 10/21/2008 11/17/2008 Physician United States
Primary
Secondary
Concomitant
Chills Hospitalization 7/30/2008 Female 11/18/2008 Physician United Kingdom
Primary
Secondary
Concomitant
Dehydration Hospitalization 9/15/2008 11/18/2008 Physician United Kingdom
Primary
Secondary
Dehydration Hospitalization 9/15/2008 11/18/2008 Physician United Kingdom
Primary
Secondary
Neutropenia Other Serious 8/11/2008 72 Female 201 lb 11/20/2008 Physician Spain
Primary
Secondary
Tachycardia Hospitalization 11/4/2008 57 Female 203 lb 11/21/2008 Physician Israel
Primary
Secondary
Neutropenia Other Serious 10/28/2008 57 Female 203 lb 11/24/2008 Physician Israel
Primary
Secondary
Tachycardia Hospitalization 11/4/2008 57 Female 203 lb 12/2/2008 Physician Israel
Primary
Secondary
Hypokalaemia Hospitalization 10/27/2008 45 Female 163 lb 12/5/2008 Physician Belgium
Primary
Secondary
White Blood Cell Count Decreased Other Serious 11/18/2008 Female 168 lb 12/9/2008 Physician United States
Primary
Secondary
Hypokalaemia Hospitalization 10/22/2008 45 Female 163 lb 12/12/2008 Physician Belgium
Primary
Secondary
Pyrexia Hospitalization 12/12/2008 54 Female 182 lb 12/19/2008 Physician United States
Primary
Secondary
White Blood Cell Count Increased Other Serious 9/25/2007 Female 82 lb 12/29/2008 Other Health Professional Japan
Primary
Secondary
Concomitant
White Blood Cell Count Increased Other Serious 9/25/2007 Female 82 lb 1/5/2009 Other Health Professional Japan
Primary
Secondary
Concomitant
Sciatica Other Serious 65 Female 1/7/2009 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Transfusion Reaction Hospitalization 12/12/2008 54 Female 182 lb 1/12/2009 Physician United States
Primary
Secondary
Vomiting Hospitalization 11/9/2008 67 Female 157 lb 1/15/2009 Physician India
Primary
Secondary
White Blood Cell Count Increased Other Serious 9/25/2007 Female 82 lb 1/16/2009 Other Health Professional Japan
Primary
Secondary
Concomitant
Death Death 12/22/2008 Female 133 lb 1/20/2009 Physician Israel
Primary
Concomitant
Blood Triglycerides Increased Female 1/26/2009 Other Health Professional United States
Primary
Secondary
Pyrexia Hospitalization 12/10/2008 Female 1/26/2009 Consumer United States
Primary
Secondary
Concomitant
Oedema Peripheral Disability 12/25/2008 52 Female 152 lb 1/27/2009 Physician Russian Federation
Primary
Secondary
Oedema Peripheral Disability 12/25/2008 52 Female 152 lb 2/4/2009 Physician Russian Federation
Primary
Secondary
Fatigue Hospitalization 1/27/2009 56 Female 141 lb 2/9/2009 Physician Belgium
Primary
Secondary
Concomitant
Rash Other Serious 2/9/2009 Consumer United States
Primary
Secondary
Concomitant
Oedema Peripheral Disability 12/25/2008 52 Female 152 lb 2/12/2009 Physician Russian Federation
Primary
Secondary
Urinary Tract Infection Hospitalization 12/10/2008 Female 2/13/2009 Consumer United States
Primary
Secondary
Concomitant
Thrombosis Other Serious 45 Female 2/18/2009 Other Health Professional Italy
Primary
Secondary
Thrombosis Other Serious 45 Female 2/23/2009 Other Health Professional Italy
Primary
Secondary
Fatigue Hospitalization 1/27/2009 56 Female 141 lb 3/4/2009 Physician Belgium
Primary
Secondary
Concomitant
Sciatica Other Serious 65 Female 3/9/2009 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Skin Toxicity Required Intervention 66 Female 3/6/2009 Other Health Professional Spain
Primary
Concomitant

Drug Data