Olanzapine combined with Valproic Acid

Reports:

Reaction Outcome Event Date Age Sex Weight Reported Reporter Country Treatment
Role Name
Therapeutic Agent Toxicity Life Threatening 8/15/2005 40 Female 1/31/2006 Physician United Kingdom
Primary
Secondary
Concomitant
Sedation Life Threatening 6/15/2005 40 Female 1/31/2006 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Respiratory Arrest Death 37 Male 2/7/2006 Pharmacist United States
Primary
Secondary
Mania Other Serious 30 Male 2/27/2006 Canada
Primary
Concomitant
Interacting
Completed Suicide Death 30 3/9/2006 United States
Primary
Secondary
Overdose Death 24 3/9/2006 United States
Primary
Secondary
Completed Suicide Death 19 3/9/2006 United States
Primary
Secondary
Vena Cava Thrombosis Hospitalization 1/31/2006 63 Female 3/1/2006 Physician Switzerland
Primary
Concomitant
White Blood Cell Count Increased Hospitalization 61 Male 4/6/2006 Canada
Primary
Secondary
Concomitant
Vena Cava Thrombosis Hospitalization 1/31/2006 63 Female 3/27/2006 Physician Switzerland
Primary
Concomitant
Hyperammonaemia Required Intervention 79 Male 8/29/2005 Other Health Professional United States
Primary
Concomitant
Psychomotor Hyperactivity Other Serious 17 Female 5/26/2006 France
Primary
Interacting
Renal Impairment Other Serious 5/8/2006 15 Unknown 5/23/2006 Chile
Primary
Concomitant
Hypomania Other Serious 5/17/2003 56 Female 5/24/2006 Physician Switzerland
Primary
Secondary
Concomitant
Vomiting Hospitalization 34 Male 7/17/2006 France
Primary
Secondary
Concomitant
Interacting
Rash Macular Other Serious 34 Male 7/21/2006 France
Primary
Concomitant
Treatment Noncompliance Hospitalization 3/12/2006 52 Female 7/26/2006 Pharmacist United States
Primary
Secondary
Concomitant
Suicide Attempt Other Serious Male 8/2/2006 Canada
Primary
Secondary
Concomitant
Neuroleptic Malignant Syndrome Other Serious 66 Female 8/3/2006 Pharmacist United States
Primary
Concomitant
Weight Increased 10/1/2004 48 Male 285 lb 8/8/2006 Consumer United States
Primary
Concomitant
Priapism 6/23/2006 Male 182 lb 9/8/2006 Pharmacist United States
Primary
Concomitant
Polyuria Hospitalization 33 Male 10/20/2006 Consumer Taiwan, Province Of China
Primary
Secondary
Concomitant
Weight Increased 10/1/2004 48 Male 285 lb 10/17/2006 Consumer United States
Primary
Concomitant
Wrong Technique In Drug Usage Process Other Serious 1/1/2000 50 Male 333 lb 11/8/2006 Lawyer United States
Primary
Concomitant
Completed Suicide Death 18 11/9/2006 United States
Primary
Secondary
Wrong Technique In Drug Usage Process Other Serious 1/1/2000 50 Male 333 lb 11/13/2006 Lawyer United States
Primary
Concomitant
Wrong Technique In Drug Usage Process Other Serious 1/1/2000 50 Male 333 lb 11/16/2006 Physician United States
Primary
Concomitant
Therapy Non-responder Other Serious 40 Male 11/9/2006 Physician Brazil
Primary
Secondary
Concomitant
Serotonin Syndrome Required Intervention 10/5/2006 38 Male 11/10/2006 United Kingdom
Primary
Concomitant
Poisoning Death 18 11/16/2006 Physician United States
Primary
Secondary
Serotonin Syndrome Life Threatening 10/5/2006 38 Male 225 lb 12/6/2006 United Kingdom
Primary
Concomitant
Torsade De Pointes Hospitalization 15 Male 180 lb 12/14/2006 United States
Primary
Concomitant
Tricuspid Valve Disease Death 77 Female 166 lb 1/4/2007 Other Health Professional United States
Primary
Concomitant
Mental Status Changes Required Intervention 1/8/2007 57 Male 153 lb 1/8/2007 Pharmacist United States
Primary
Concomitant
White Blood Cell Count Increased Hospitalization 1/4/2005 Female 1/26/2007 Physician Canada
Primary
Concomitant
Cardiac Arrest Life Threatening 1/23/2007 57 Female 2/2/2007 Physician Canada
Primary
Concomitant
Weight Increased Other Serious 33 Female 168 lb 3/14/2007 Other Health Professional Switzerland
Primary
Secondary
Concomitant
Weight Increased Other Serious 33 Female 168 lb 4/6/2007 Other Health Professional Switzerland
Primary
Secondary
Concomitant
Renal Impairment Other Serious 44 Male 4/30/2007 Physician United States
Primary
Concomitant
Urinary Incontinence Other Serious 53 Male 5/10/2007 Physician Canada
Primary
Concomitant
White Blood Cell Count Increased Hospitalization 2/16/2002 40 Female 5/26/2007 Physician Canada
Primary
Secondary
Concomitant
Pleural Effusion Other Serious 19 Female 6/20/2007 United States
Primary
Concomitant
Vomiting Hospitalization 34 Male 6/22/2007 France
Primary
Secondary
Concomitant
Interacting
Toxic Epidermal Necrolysis Hospitalization 74 Male 7/11/2007
Primary
Secondary
Toxic Epidermal Necrolysis Hospitalization 74 Male 7/12/2007 Italy
Primary
Secondary
Suicide Attempt Hospitalization 41 Female 7/13/2007 United Kingdom
Primary
Secondary
Mania Other Serious 27 Male 7/30/2007 Physician United States
Primary
Concomitant
Torticollis Other Serious 60 Female 8/24/2007 France
Primary
Concomitant
Interacting
Overdose Other Serious 1/1/2007 Male 9/21/2007 Pharmacist United States
Primary
Concomitant
Gastroenteritis Other Serious Male 165 lb 11/7/2007 Physician France
Primary
Concomitant
Somnolence Other Serious 10/29/2006 58 Male 11/22/2007 Physician Germany
Primary
Concomitant
Interacting
Drug Toxicity Death 9/11/2004 Female 125 lb 12/17/2007 Lawyer United States
Primary
Concomitant
Overdose Other Serious 1/1/2007 Male 154 lb 12/19/2007 Pharmacist United States
Primary
Concomitant
Pleurothotonus Other Serious 39 Female 1/7/2008 France
Primary
Secondary
Interacting
Pulmonary Embolism Hospitalization 25 Male 3/17/2008 Physician Switzerland
Primary
Secondary
Concomitant
Drug Toxicity Death 9/11/2004 Female 125 lb 4/10/2008 Lawyer United States
Primary
Concomitant
Unevaluable Event Other Serious 49 Female 4/30/2008 Physician Spain
Primary
Secondary
Concomitant
Tremor Hospitalization 76 Female 6/27/2008 Other Health Professional France
Primary
Concomitant
Drug Toxicity Death 9/11/2004 Female 125 lb 7/22/2008 Other Health Professional United States
Primary
Concomitant
White Blood Cell Count Decreased Other Serious 55 Male 8/25/2008 Physician United States
Primary
Secondary
Concomitant
Sedation Death 10/29/2007 58 Female 154 lb 8/26/2008 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Transaminases Increased Other Serious 5/28/2008 Female 8/29/2008 Consumer France
Primary
Secondary
Concomitant
Sedation Death 10/29/2007 9/1/2008 Other Health Professional United Kingdom
Primary
Concomitant
Drug Toxicity Death 9/11/2004 Female 125 lb 10/17/2008 Other Health Professional United States
Primary
Concomitant
Sedation Other Serious 10/29/2007 58 Female 181 lb 10/22/2008 Other Health Professional United Kingdom
Primary
Concomitant
Sedation Death 10/29/2007 58 Female 181 lb 10/23/2008 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Somnolence Other Serious 10/29/2007 58 Female 181 lb 11/6/2008 Other Health Professional United Kingdom
Primary
Concomitant
Psychiatric Symptom Disability 67 Male 11/24/2008 Physician Argentina
Primary
Secondary
Concomitant
Vision Blurred Other Serious 1/1/2008 Female 12/5/2008 Consumer France
Primary
Concomitant
Vision Blurred Other Serious 1/1/2008 Female 12/8/2008 Consumer France
Primary
Concomitant
Postpartum Depression Other Serious 35 Female 1/14/2009
Primary
Secondary
Completed Suicide Death 43 Female 1/16/2009 United States
Primary
Secondary
Pleurothotonus Other Serious 67 Male 1/19/2009 Argentina
Primary
Concomitant
Somnambulism Other Serious 52 Male 1/20/2009
Primary
Secondary
Drug Toxicity Death 9/11/2004 Female 125 lb 1/26/2009 Other Health Professional United States
Primary
Concomitant
Completed Suicide Death 18 1/26/2009 Physician United States
Primary
Concomitant
Poisoning Deliberate Death 43 Female 1/26/2009 Physician United States
Primary
Secondary
Psoriasis Disability 7/15/2008 46 Female 2/4/2009 Consumer Italy
Primary
Concomitant
Pleurothotonus Disability 67 Male 2/5/2009 Physician Argentina
Primary
Secondary
Concomitant
Pleurothotonus Other Serious 67 Male 2/20/2009 Argentina
Primary
Concomitant
Rouleaux Formation Other Serious 34 Male 3/17/2009 Other Health Professional Spain
Primary
Secondary
Concomitant
Reticulocyte Count Decreased Hospitalization 37 Male 3/20/2009 Spain
Primary
Concomitant
Gamma-glutamyltransferase Increased Hospitalization 37 Male 4/6/2009 Spain
Primary
Concomitant
Aplasia Pure Red Cell Hospitalization 37 Male 4/8/2009 Spain
Primary
Concomitant
Posture Abnormal Other Serious 67 Male 4/7/2009 Physician Argentina
Primary
Concomitant
Drug Toxicity Death 9/11/2004 Female 125 lb 4/17/2009 Other Health Professional United States
Primary
Concomitant
Pneumonia Other Serious 26 Female 5/13/2009 Physician United States
Primary
Secondary
Concomitant
Brief Psychotic Disorder, With Postpartum Onset Hospitalization 35 Female 5/15/2009 Physician United States
Primary
Secondary
Suicide Attempt Other Serious 3/1/2009 42 Female 6/18/2009 Physician Mexico
Primary
Concomitant
Trisomy 21 Other Serious 6/30/2009 Other Health Professional Israel
Primary
Secondary
Rhabdomyolysis Hospitalization 17 Female 8/10/2009 Other Health Professional France
Primary
Secondary
Pulmonary Eosinophilia Hospitalization 64 Female 8/6/2009 Physician Spain
Primary
Concomitant
Pleural Effusion Other Serious 64 Female 8/20/2009 Physician Spain
Primary
Concomitant
Psychotic Disorder Other Serious 42 Female 8/28/2009
Primary
Secondary
Concomitant
Psychotic Disorder Other Serious 47 Female 9/16/2009 Other Health Professional Spain
Primary
Concomitant
Urticaria Hospitalization 11/28/2008 Female 9/18/2009 Physician Russian Federation
Primary
Concomitant
Pancreatitis Other Serious 3/30/2001 48 Male 265 lb 9/23/2009 United States
Primary
Concomitant
Schizoaffective Disorder Other Serious 29 Male 10/2/2009
Primary
Secondary
Judgement Impaired Other Serious 26 Male 192 lb 11/8/2009 Other Health Professional United States
Primary
Concomitant
Oedema Peripheral Other Serious 44 Male 11/24/2009
Primary
Secondary
Concomitant
Metabolic Syndrome Hospitalization 28 Female 12/1/2009 Other Health Professional Turkey
Primary
Secondary
Somnolence Other Serious 10/29/2006 58 Male 11/30/2009 Physician Germany
Primary
Concomitant
Interacting
Completed Suicide Death 27 Male 1/20/2010 Physician United States
Primary
Secondary
Poisoning Death 25 Male 1/20/2010 Physician United States
Primary
Secondary
Completed Suicide Death 27 Male 2/22/2010 United States
Primary
Secondary
Death Death 1/1/2008 25 Male 2/24/2010 Physician United States
Primary
Secondary
Concomitant
Completed Suicide Death 27 Male 2/23/2010 Physician United States
Primary
Concomitant
Weight Increased Other Serious 55 Female 2/17/2010 Physician Switzerland
Primary
Secondary
Concomitant
Myoclonus Hospitalization 38 Male 3/22/2010 Other Health Professional United States
Primary
Secondary
Concomitant
Myoclonus Hospitalization 38 Male 3/22/2010 Other Health Professional United States
Primary
Secondary
Concomitant
Trisomy 21 Congenital Anomaly 3/31/2010 Other Health Professional United Kingdom
Primary
Secondary
Tubulointerstitial Nephritis Other Serious 57 Female 4/12/2010 Other Health Professional United Kingdom
Primary
Concomitant
Vomiting Other Serious 8/1/2009 72 Female 4/15/2010 Netherlands
Primary
Secondary
Concomitant
Restlessness Other Serious 12 Female 77 lb 4/16/2010 Other Health Professional India
Primary
Concomitant
Vomiting Other Serious 8/1/2009 72 Female 4/27/2010 Netherlands
Primary
Secondary
Concomitant
Brief Psychotic Disorder, With Postpartum Onset Hospitalization 35 Female 5/13/2010 Physician United States
Primary
Secondary
Therapeutic Agent Toxicity Hospitalization 62 Female 6/10/2010 Physician United States
Primary
Secondary
Concomitant
Somnolence 2/1/2008 22 Male 180 lb 6/23/2010 Other Health Professional United States
Primary
Concomitant
Drug Ineffective Other Serious Female 6/24/2010 Physician United States
Primary
Secondary
Psychotic Disorder Other Serious 3/1/2009 24 Female 126 lb 6/18/2010 Physician Germany
Primary
Concomitant
Weight Increased Other Serious 39 Female 123 lb 7/2/2010
Primary
Secondary
Speech Disorder Other Serious 1/1/2005 21 Male 7/6/2010 Physician Korea, Republic Of
Primary
Concomitant
Pulmonary Embolism Death 47 Male 7/12/2010 Other Health Professional United States
Primary
Secondary
Syncope Other Serious 77 Female 8/2/2010 Consumer Germany
Primary
Secondary
Concomitant
Syncope Hospitalization 77 Female 8/18/2010 Consumer Germany
Primary
Secondary
Concomitant
Syncope Hospitalization 77 Female 8/18/2010 Consumer Germany
Primary
Secondary
Concomitant
Weight Increased Other Serious 38 Female 8/26/2010 Physician Turkey
Primary
Secondary
Weight Increased Other Serious 38 Female 9/1/2010 Other Health Professional Turkey
Primary
Secondary
Weight Increased Other Serious 38 Female 9/3/2010 Other Health Professional Turkey
Primary
Secondary
Weight Increased Other Serious 38 Female 9/3/2010 Other Health Professional Turkey
Primary
Secondary
Platelet Count Decreased Other Serious 9/1/2010 85 Female 9/15/2010 Physician Japan
Primary
Concomitant
Osteoporosis Other Serious 29 Male 9/27/2010 Other Health Professional United Kingdom
Primary
Secondary
Non-dipping Hospitalization 77 Female 9/30/2010 Germany
Primary
Secondary
Concomitant
Weight Increased Other Serious 38 Female 10/14/2010 Consumer Turkey
Primary
Secondary
Sepsis Other Serious 36 Male 10/25/2010 Consumer Croatia (Local Name: Hrvatska)
Primary
Secondary
Concomitant
Somnolence Other Serious 36 Male 10/29/2010 Consumer Croatia (Local Name: Hrvatska)
Primary
Secondary
Concomitant
Salivary Hypersecretion Other Serious 10/1/2010 9 Male 11/1/2010 Consumer Canada
Primary
Secondary
Concomitant
Sedation Other Serious 46 Male 10/25/2010 Pharmacist Canada
Primary
Secondary
Concomitant
Sepsis Hospitalization 36 Male 11/15/2010 Other Health Professional Croatia (Local Name: Hrvatska)
Primary
Concomitant
Syncope Other Serious 10/1/2010 9 Male 11/22/2010 Consumer Canada
Primary
Secondary
Concomitant
Psychotic Disorder Other Serious Female 126 lb 12/3/2010 Physician Germany
Primary
Concomitant
Dysarthria Other Serious 10/1/2010 9 Male 1/5/2011 Consumer Argentina
Primary
Secondary
Concomitant
Blood Creatine Phosphokinase Increased Hospitalization 26 Male 2/21/2011 Other Health Professional Turkey
Primary
Secondary
Concomitant
Antipsychotic Drug Level Increased Other Serious Male 4/15/2011 Consumer Poland
Primary
Secondary
Prothrombin Time Prolonged Hospitalization 42 Female 4/14/2011 Physician Korea, Republic Of
Primary
Concomitant
Bipolar Disorder Hospitalization 57 Female 4/14/2011 Other Health Professional Japan
Primary
Concomitant
Drug Interaction Other Serious 36 Female 4/21/2011 Physician France
Primary
Interacting
Antipsychotic Drug Level Increased Other Serious Male 5/2/2011 Consumer Poland
Primary
Secondary
Mental Disorder Other Serious 4/1/2011 39 5/2/2011 Other Health Professional United Kingdom
Primary
Concomitant
Grandiosity Hospitalization 75 Female 5/3/2011 Other Health Professional Brazil
Primary
Concomitant
Interacting

Drug Data