Naproxen combined with Simvastatin

Reports:

Reaction Outcome Event Date Age Sex Weight Reported Reporter Country Treatment
Role Name
Renal Failure Life Threatening 9/2/2003 Male 1/4/2006 Finland
Primary
Concomitant
Cardiac Failure Congestive Required Intervention 1/25/2006 60 Male 281 lb 1/25/2006 Pharmacist United States
Primary
Concomitant
Pneumonitis Death 6/1/2005 69 Male 1/30/2006 United Kingdom
Primary
Concomitant
Gastrointestinal Haemorrhage Hospitalization 11/1/2005 82 Male 172 lb 11/1/2005 Pharmacist United States
Primary
Concomitant
Pneumonitis Death 6/1/2005 69 Male 2/6/2006 United Kingdom
Primary
Concomitant
Weight Decreased Hospitalization 10/24/2005 58 Male 203 lb 12/1/2005 Pharmacist United States
Primary
Concomitant
Nausea Hospitalization 11/20/2005 57 Male 144 lb 12/14/2005 Pharmacist United States
Primary
Secondary
Concomitant
Subcutaneous Emphysema Other Serious 10/1/2003 Male 203 lb 2/9/2006 United Kingdom
Primary
Secondary
Concomitant
Nosocomial Infection Other Serious 10/6/2003 Male 240 lb 2/20/2006 Physician United States
Primary
Secondary
Concomitant
Syncope Hospitalization 4/13/2004 70 Female 125 lb 12/21/2005 United States
Primary
Secondary
Concomitant
Vomiting Other Serious 9/26/2005 71 Female 182 lb 4/13/2006 Pharmacist United States
Primary
Concomitant
Acute Coronary Syndrome Hospitalization 3/24/2006 79 Female 4/17/2006 United Kingdom
Primary
Concomitant
Surgery Hospitalization 1/1/2002 67 Male 176 lb 4/25/2006 Lawyer United States
Primary
Concomitant
Vestibular Neuronitis Other Serious 8/7/2001 74 Female 5/1/2006 Norway
Primary
Concomitant
Surgery Hospitalization 1/1/2002 65 Male 176 lb 5/1/2006 Physician United States
Primary
Concomitant
Soft Tissue Necrosis Hospitalization 1/1/2005 Male 132 lb 6/9/2006 Physician United States
Primary
Concomitant
Oral Intake Reduced Hospitalization 5/23/2006 60 Male 148 lb 5/25/2006 Pharmacist United States
Primary
Secondary
Concomitant
International Normalised Ratio Increased Hospitalization 4/24/2006 67 Male 7/5/2006 Pharmacist United States
Primary
Secondary
Concomitant
Convulsion Hospitalization 6/14/2006 Male 150 lb 7/19/2006 Physician United States
Primary
Concomitant
Insomnia 4/1/2006 67 Female 230 lb 7/12/2006 Consumer United States
Primary
Concomitant
Rhabdomyolysis Death 5/1/2006 81 Male 159 lb 8/7/2006 United Kingdom
Primary
Concomitant
Rectal Haemorrhage Hospitalization 5/13/2006 49 Male 250 lb 6/15/2006 Other Health Professional United States
Primary
Secondary
Concomitant
Rash Other Serious 6/30/2006 66 Male 208 lb 6/30/2006 Pharmacist United States
Primary
Concomitant
Respiratory Failure Death 6/27/2005 Male 176 lb 9/1/2006 United Kingdom
Primary
Secondary
Concomitant
Pyelonephritis Acute Other Serious 10/23/2006 46 Female 11/1/2006 Other Health Professional Thailand
Primary
Concomitant
Respiratory Rate Increased Other Serious 10/23/2006 46 Female 11/13/2006 Other Health Professional Thailand
Primary
Concomitant
Cerebral Infarction Hospitalization 5/15/2006 55 Male 216 lb 11/20/2006 Other Health Professional United Kingdom
Primary
Concomitant
Lip Swelling Life Threatening 6/8/2006 65 Female 12/15/2006 Pharmacist United States
Primary
Concomitant
Visual Disturbance Other Serious 12/19/2006 Male 245 lb 12/28/2006 Consumer United States
Primary
Concomitant
Visual Disturbance Disability 8/4/2006 Female 207 lb 1/19/2007 Consumer France
Primary
Concomitant
Renal Impairment Hospitalization 12/15/2006 1/26/2007 Consumer United Kingdom
Primary
Concomitant
Subcutaneous Emphysema Hospitalization 10/1/2003 66 Male 1/27/2007 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Ulcer Other Serious 7/5/2006 Female 119 lb 1/27/2007 Consumer Brazil
Primary
Concomitant
Occult Blood Positive Hospitalization 11/22/2006 Male 180 lb 12/22/2006 Pharmacist United States
Primary
Concomitant
Subcutaneous Emphysema Other Serious 10/1/2003 66 Male 2/1/2007 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Vision Blurred Hospitalization 5/20/2005 61 Male 194 lb 2/6/2007 Pharmacist United States
Primary
Concomitant
Presyncope Hospitalization 10/16/2006 67 Male 236 lb 1/5/2007 Pharmacist United States
Primary
Secondary
Concomitant
Gynaecomastia Other Serious 1/29/2007 Male 212 lb 2/22/2007 Other Health Professional United Kingdom
Primary
Concomitant
Muscle Spasms Other Serious 9/1/2006 Male 211 lb 12/15/2006 Pharmacist United States
Primary
Concomitant
Urine Output Decreased Hospitalization 3/9/2007 89 Male 156 lb 3/29/2007 Pharmacist United States
Primary
Secondary
Concomitant
Weight Decreased Other Serious 1/1/2005 85 Male 185 lb 3/29/2007 Physician United States
Primary
Concomitant
Ventricular Hypertrophy Hospitalization 2/20/2007 63 Male 150 lb 4/9/2007 United States
Primary
Concomitant
Oral Pain Required Intervention 1/22/2007 76 Male 190 lb 2/7/2007 Physician United States
Primary
Concomitant
Swollen Tongue Hospitalization 4/15/2007 59 Male 245 lb 4/30/2007 Pharmacist United States
Primary
Secondary
Concomitant
Unresponsive To Stimuli Other Serious 9/15/2006 67 Female 5/17/2007 Other Health Professional United States
Primary
Secondary
Concomitant
Syncope Hospitalization 6/16/2004 82 Male 3/7/2007 Other Health Professional United States
Primary
Secondary
Concomitant
Pseudoporphyria Other Serious 65 Male 6/7/2007 Physician United States
Primary
Concomitant
Nausea 3/1/2007 55 Male 4/10/2007 Consumer United States
Primary
Concomitant
Deep Vein Thrombosis Hospitalization 5/21/2007 Female 7/9/2007 United Kingdom
Primary
Concomitant
Haemoglobin Decreased Hospitalization 5/21/2007 79 Female 7/12/2007 Other Health Professional United Kingdom
Primary
Concomitant
Drug Dose Omission Hospitalization 5/21/2007 79 Female 7/24/2007 Other Health Professional United Kingdom
Primary
Concomitant
Type 2 Diabetes Mellitus 1/1/2006 33 Female 230 lb 9/18/2007 Physician United States
Primary
Concomitant
Vomiting Other Serious 7/3/2007 67 Female 377 lb 10/1/2007 Other Health Professional United Kingdom
Primary
Concomitant
Pain In Extremity Other Serious 5/1/2007 68 Male 198 lb 10/5/2007 Physician United Kingdom
Primary
Secondary
Concomitant
Pain In Extremity Other Serious 5/1/2007 68 Male 198 lb 10/22/2007 Physician United Kingdom
Primary
Secondary
Concomitant
Headache 3/8/2007 80 Female 10/24/2007 Consumer United States
Primary
Concomitant
Withdrawal Syndrome Other Serious 11/29/2001 46 Male 262 lb 11/8/2007 Consumer United States
Primary
Concomitant
Skin Discolouration 1/16/2007 70 Female 11/14/2007 Consumer United States
Primary
Concomitant
Surgery Other Serious Female 11/16/2007 Other Health Professional United Kingdom
Primary
Concomitant
Angioedema 10/15/2007 54 Male 228 lb 11/16/2007 Consumer United States
Primary
Secondary
Concomitant
Necrotising Retinitis Other Serious 9/1/2007 54 Female 11/26/2007
Primary
Secondary
Concomitant
Retinal Infarction Other Serious 9/1/2007 54 Female 12/2/2007 United Kingdom
Primary
Secondary
Concomitant
Necrotising Retinitis Hospitalization 9/1/2007 54 Female 11/30/2007 United Kingdom
Primary
Secondary
Concomitant
Laceration 10/1/2007 Female 130 lb 12/14/2007 Consumer United States
Primary
Concomitant
Withdrawal Syndrome Other Serious 11/29/2001 46 Male 262 lb 1/10/2008 Consumer United States
Primary
Concomitant
Pulmonary Mass Other Serious 11/15/2007 Male 168 lb 1/18/2008 United Kingdom
Primary
Concomitant
Renal Failure Chronic Other Serious 10/1/2007 Male 244 lb 2/22/2008 Consumer United States
Primary
Secondary
Concomitant
Renal Impairment Other Serious 2/1/2008 81 Male 2/26/2008 Other Health Professional United Kingdom
Primary
Concomitant
Myocardial Infarction Other Serious 2/3/2008 Female 150 lb 3/15/2008 Consumer United States
Primary
Concomitant
Renal Impairment Other Serious 2/1/2008 81 Male 3/26/2008 Other Health Professional United Kingdom
Primary
Concomitant
Carotid Artery Occlusion Hospitalization 3/27/2008 60 4/9/2008 Other Health Professional
Primary
Secondary
Concomitant
Carotid Artery Occlusion Hospitalization 3/27/2008 60 Male 4/17/2008 Other Health Professional United States
Primary
Secondary
Concomitant
Vitamin B12 Deficiency Hospitalization 3/27/2008 60 Male 4/28/2008 Other Health Professional United States
Primary
Secondary
Concomitant
Atrial Fibrillation Hospitalization 2/28/2008 Female 5/8/2008 Consumer United Kingdom
Primary
Concomitant
Unresponsive To Stimuli Hospitalization 1/12/2008 63 Female 170 lb 4/21/2008 United States
Primary
Secondary
Concomitant
Renal Impairment Other Serious 2/1/2008 81 Male 154 lb 5/5/2008 Other Health Professional United Kingdom
Primary
Concomitant
Nasal Ulcer 73 Male 5/9/2008 Consumer United States
Primary
Concomitant
Renal Failure Acute Hospitalization 5/9/2008 Female 161 lb 5/27/2008
Primary
Secondary
Concomitant
Renal Failure Acute Hospitalization 5/9/2008 62 Female 161 lb 6/5/2008 Consumer United States
Primary
Secondary
Concomitant
Pharmaceutical Product Complaint 1/1/2007 73 Male 225 lb 5/7/2008 United States
Primary
Concomitant
Renal Failure Acute Hospitalization 5/9/2008 Female 172 lb 6/10/2008
Primary
Secondary
Concomitant
Renal Failure Acute Hospitalization 5/9/2008 62 Female 172 lb 6/26/2008 Consumer United States
Primary
Secondary
Concomitant
Weight Decreased Other Serious 5/1/2008 Male 7/7/2008 Consumer United States
Primary
Concomitant
Pathological Gambling 1/1/2000 Male 190 lb 8/1/2008 Consumer United States
Primary
Concomitant
Sexual Dysfunction 1/23/2008 55 Male 8/5/2008 Consumer United States
Primary
Concomitant
Rheumatoid Arthritis Death 1/9/2008 Male 223 lb 8/28/2008 United Kingdom
Primary
Concomitant
Urticaria Female 8/29/2008 United States
Primary
Concomitant
Pain In Extremity Hospitalization 68 Male 8/27/2008 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Vitamin B12 Deficiency Hospitalization 5/19/2008 Male 209 lb 9/12/2008 Physician United States
Primary
Concomitant
Stevens-johnson Syndrome Hospitalization 8/30/2007 Male 218 lb 9/19/2008 Physician United Kingdom
Primary
Concomitant
Erectile Dysfunction 5/22/2008 72 Male 9/22/2008 Pharmacist United States
Primary
Concomitant
Surgery Other Serious Female 9/23/2008 Other Health Professional United Kingdom
Primary
Concomitant
Myocardial Infarction Death Male 9/29/2008 Pharmacist United States
Primary
Concomitant
Palpitations Disability 9/2/2008 63 Male 10/6/2008 Other Health Professional United Kingdom
Primary
Concomitant
Wrist Fracture Hospitalization 4/24/2008 52 Female 9/29/2008 United States
Primary
Concomitant
Pneumonitis Hospitalization 10/9/2008 66 Female 190 lb 10/15/2008 Pharmacist United States
Primary
Concomitant
Palpitations Disability 9/2/2008 63 Male 10/14/2008 Other Health Professional United Kingdom
Primary
Concomitant
Palpitations Disability 9/2/2008 63 Male 10/14/2008 Other Health Professional United Kingdom
Primary
Concomitant
Swelling Face Hospitalization 8/2/2008 56 Female 10/10/2008 Other Health Professional United Kingdom
Primary
Concomitant
Palpitations Disability 9/2/2008 63 Male 10/10/2008 Other Health Professional United Kingdom
Primary
Concomitant
Dysgeusia Other Serious 1/1/2007 54 Female 106 lb 10/17/2008 United States
Primary
Concomitant
Palpitations Disability 9/2/2008 63 Male 11/7/2008 Other Health Professional United Kingdom
Primary
Concomitant
Interacting
Vomiting Other Serious 9/1/2008 47 Female 180 lb 9/30/2008 Pharmacist United States
Primary
Concomitant
Drug Ineffective 7/26/2008 Male 210 lb 12/12/2008 United States
Primary
Concomitant
Pain Female 12/12/2008 United States
Primary
Concomitant
Encephalopathy Hospitalization 7/7/2008 Female 286 lb 12/22/2008 Physician United States
Primary
Secondary
Concomitant
Death Death 11/28/2008 Male 12/30/2008 Physician Switzerland
Primary
Concomitant
Encephalopathy Hospitalization 7/7/2008 Female 286 lb 1/5/2009 Physician United States
Primary
Secondary
Concomitant
Follicle Centre Lymphoma, Follicular Grade I, Ii, Iii Other Serious 6/2/2008 Female 150 lb 1/13/2009 Other Health Professional United States
Primary
Secondary
Concomitant
Vitamin B12 Deficiency Hospitalization 5/19/2008 Male 209 lb 1/28/2009 Physician United States
Primary
Concomitant
Vomiting 1/29/2009 Female 2/3/2009 Consumer
Primary
Secondary
Concomitant
Myocardial Ischaemia Hospitalization 5/29/2007 59 Female 190 lb 2/4/2009 Lawyer United States
Primary
Secondary
Concomitant
Rheumatoid Arthritis Death Male 203 lb 2/5/2009 United Kingdom
Primary
Concomitant
Rheumatoid Arthritis Death 1/9/2008 Male 223 lb 2/18/2009 United Kingdom
Primary
Concomitant
Vomiting Death 1/1/2006 Female 2/19/2009 Physician Netherlands
Primary
Concomitant
Chest Discomfort Hospitalization 4/27/2007 60 Male 183 lb 1/16/2009 Physician United States
Primary
Secondary
Concomitant
Knee Arthroplasty Hospitalization 7/16/2008 Male 262 lb 2/23/2009 Other Health Professional United States
Primary
Secondary
Concomitant
Weight Increased Other Serious 1/1/2006 Male 2/20/2009 Physician Canada
Primary
Concomitant
Myocardial Infarction Hospitalization 1/1/2006 68 Male 165 lb 3/16/2009 Consumer United States
Primary
Concomitant
Renal Failure Acute Hospitalization 2/11/2009 Female 173 lb 3/23/2009 Other Health Professional United States
Primary
Secondary
Concomitant
Road Traffic Accident Hospitalization 5/10/2008 Female 176 lb 3/25/2009 Other Health Professional United States
Primary
Secondary
Concomitant
Pulmonary Mass Other Serious 11/15/2007 Male 168 lb 3/31/2009 United Kingdom
Primary
Concomitant
Arteriosclerosis Death 11/28/2008 Male 3/31/2009 Physician Switzerland
Primary
Concomitant
Pulmonary Oedema Other Serious 1/1/2009 4/2/2009 Other Health Professional Canada
Primary
Secondary
Concomitant
Upper Respiratory Tract Infection Other Serious 5/30/2005 49 Female 268 lb 4/10/2009 United States
Primary
Concomitant
Wheezing Other Serious 7/23/2007 52 Male 253 lb 4/13/2009 Other Health Professional United States
Primary
Concomitant
Interacting
Aortic Aneurysm Repair Hospitalization 1/1/2005 Male 220 lb 4/20/2009 Physician United States
Primary
Secondary
Concomitant
Gastrointestinal Pain 2/7/2008 54 Female 218 lb 12/19/2008 Pharmacist United States
Primary
Concomitant
Knee Arthroplasty Hospitalization 7/16/2008 Male 262 lb 4/24/2009 Other Health Professional United States
Primary
Secondary
Concomitant
Transient Ischaemic Attack Hospitalization 7/1/2008 Female 4/29/2009 Physician Sweden
Primary
Concomitant
Suicide Attempt Hospitalization 1/19/2006 34 Female 222 lb 3/30/2009 Consumer United States
Primary
Concomitant
Wheezing Other Serious 7/23/2007 52 Male 253 lb 5/7/2009 Other Health Professional United States
Primary
Concomitant
Interacting
Osteoporosis Other Serious 11/1/2008 Male 159 lb 5/13/2009 Brazil
Primary
Concomitant
Wheezing Other Serious 7/23/2007 52 Male 253 lb 5/18/2009 Other Health Professional United States
Primary
Concomitant
Interacting
Urinary Incontinence Other Serious 1/1/1998 51 Male 214 lb 5/20/2009 United States
Primary
Concomitant
Visual Impairment Hospitalization 1/1/2008 Female 5/14/2009 Consumer United States
Primary
Concomitant
Osteoporosis Other Serious 11/1/2008 Male 159 lb 5/26/2009 Brazil
Primary
Concomitant
Obesity Hospitalization 3/10/2009 Female 229 lb 5/27/2009 United States
Primary
Secondary
Concomitant
Gastrooesophageal Reflux Disease Hospitalization 5/9/2009 Female 162 lb 5/28/2009 United States
Primary
Concomitant
Rheumatoid Vasculitis Hospitalization 9/15/2008 Male 181 lb 5/29/2009 Other Health Professional United Kingdom
Primary
Concomitant
Palpitations Hospitalization 73 Female 5/28/2009 United States
Primary
Concomitant
Atrial Fibrillation Hospitalization 4/9/2009 Male 319 lb 6/7/2009 Other Health Professional United States
Primary
Secondary
Concomitant
Oesophageal Spasm Hospitalization 2/27/2009 Female 245 lb 6/5/2009 Other Health Professional United States
Primary
Secondary
Concomitant
Vision Blurred Other Serious 1/1/2007 54 Female 106 lb 6/9/2009 Physician United States
Primary
Concomitant
Pleural Effusion Other Serious 1/1/2009 Male 6/19/2009 Physician United States
Primary
Concomitant
Gastrooesophageal Reflux Disease Hospitalization 5/9/2009 Female 162 lb 6/19/2009 United States
Primary
Concomitant
Type 2 Diabetes Mellitus Other Serious 1/1/2000 52 Female 298 lb 6/24/2009 United States
Primary
Concomitant
Weight Increased Other Serious 1/1/2004 50 Female 194 lb 6/29/2009 United States
Primary
Concomitant
Urinary Tract Infection Hospitalization 4/1/2009 Female 7/1/2009 Physician United Kingdom
Primary
Concomitant
Vomiting Hospitalization 73 Female 6/30/2009 United States
Primary
Concomitant

Drug Data