Morphine combined with Voriconazole

Reports:

Reaction Outcome Event Date Age Sex Weight Reported Reporter Country Treatment
Role Name
International Normalised Ratio Increased 11/23/2004 9/12/2005 Physician United States
Primary
Concomitant
International Normalised Ratio Increased 11/23/2004 1/6/2006 Physician United States
Primary
Concomitant
Thrombotic Stroke Death 10/27/2005 45 Female 1/25/2006 Physician United States
Primary
Secondary
Concomitant
Thrombocytopenia Death 3/26/2006 73 Male 4/24/2006 Physician United States
Primary
Secondary
Concomitant
Stem Cell Transplant Hospitalization 9/10/2006 47 Female 266 lb 9/12/2006 Other Health Professional United States
Primary
Secondary
Concomitant
Rhabdomyolysis Required Intervention 8/31/2006 65 Male 189 lb 9/27/2006 Pharmacist United States
Primary
Concomitant
Vomiting 2/8/2006 36 Male Physician United States
Primary
Concomitant
Pleural Effusion Hospitalization 1/22/2007 5 Female 27 lb 2/7/2007 United States
Primary
Secondary
Concomitant
Ventricular Hypertrophy Life Threatening 8/6/2005 48 Male 216 lb 3/14/2007 Physician Switzerland
Primary
Secondary
Concomitant
Splenomegaly Life Threatening 8/6/2005 48 Male 216 lb 3/26/2007 Physician Switzerland
Primary
Secondary
Concomitant
Sepsis Life Threatening 5/8/2007 57 Male 5/17/2007 Physician United States
Primary
Secondary
Concomitant
Weight Decreased Hospitalization 5/11/2007 9 Female 56 lb 6/25/2007 Other Health Professional United States
Primary
Secondary
Concomitant
Ventricular Fibrillation Hospitalization 4/22/2007 Female 158 lb 7/11/2007 Physician United States
Primary
Secondary
Concomitant
Weight Decreased Hospitalization 5/11/2007 9 Female 56 lb 7/16/2007 Physician United States
Primary
Secondary
Concomitant
Weight Decreased Hospitalization 5/11/2007 9 Female 56 lb 7/27/2007 United States
Primary
Secondary
Concomitant
Thrombosis Required Intervention 6/17/2007 35 Male 88 lb 6/20/2007 Pharmacist United States
Primary
Secondary
Concomitant
Vision Blurred Hospitalization 6/8/2007 Male 107 lb 6/11/2007 Pharmacist United States
Primary
Concomitant
Vision Blurred Hospitalization 6/8/2007 Male 98 lb 6/20/2007 United States
Primary
Concomitant
Venoocclusive Disease Other Serious 9/19/2007 Female 137 lb 11/2/2007 Pharmacist United Kingdom
Primary
Secondary
Concomitant
White Blood Cell Count Decreased Hospitalization 5/11/2007 9 Female 56 lb 11/2/2007 United States
Primary
Secondary
Concomitant
Staphylococcal Bacteraemia Life Threatening 10/7/2007 14 Male 203 lb 11/8/2007 Physician United States
Primary
Secondary
Concomitant
Venoocclusive Disease Life Threatening 9/19/2007 19 Female 11/19/2007 Consumer United Kingdom
Primary
Secondary
Dilatation Intrahepatic Duct Acquired Life Threatening 9/19/2007 19 Female 11/21/2007 United Kingdom
Primary
Secondary
Venoocclusive Disease Other Serious 9/19/2007 19 Female 11/21/2007 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Venoocclusive Disease Other Serious 9/19/2007 19 Female 11/26/2007 Other Health Professional United Kingdom
Primary
Secondary
Venoocclusive Disease Other Serious 9/19/2007 19 Female 11/27/2007 Other Health Professional United Kingdom
Primary
Secondary
Dilatation Intrahepatic Duct Acquired Life Threatening 9/19/2007 19 Female 11/26/2007 United Kingdom
Primary
Secondary
Venoocclusive Disease Other Serious 19 Female 11/27/2007 Other Health Professional United Kingdom
Primary
Secondary
White Blood Cell Count Decreased Life Threatening 11/2/2007 15 Female 208 lb 11/19/2007 Other Health Professional United States
Primary
Secondary
Concomitant
Venoocclusive Disease Other Serious 9/19/2007 12/1/2007 Other Health Professional United Kingdom
Primary
Secondary
Venoocclusive Disease Other Serious 19 Female 11/30/2007 Pharmacist United Kingdom
Primary
Concomitant
Venoocclusive Disease Life Threatening 11/5/2007 15 Female 208 lb 12/3/2007 Other Health Professional United States
Primary
Secondary
Concomitant
White Blood Cell Count Decreased Hospitalization 5/11/2007 9 Female 56 lb 12/13/2007 United States
Primary
Secondary
Concomitant
Venoocclusive Disease Other Serious 9/19/2007 Female 137 lb 12/26/2007 Pharmacist United Kingdom
Primary
Secondary
Concomitant
Weight Decreased Hospitalization 5/11/2007 9 Female 56 lb 12/13/2007 United States
Primary
Secondary
Concomitant
Tricuspid Valve Incompetence Hospitalization 1/13/2008 11 Female 44 lb 2/26/2008 Physician Ireland
Primary
Concomitant
Vomiting Hospitalization 1/13/2008 11 Female 44 lb 3/13/2008 Ireland
Primary
Concomitant
Cardiac Failure Death 3/8/2008 14 Female 4/25/2008 Physician Italy
Primary
Secondary
Concomitant
Cardiac Failure Death 3/8/2008 14 Female 5/6/2008 Physician Italy
Primary
Secondary
Concomitant
Electrocardiogram Qt Prolonged Life Threatening 3/12/2008 Male 195 lb 3/13/2008 Pharmacist United States
Primary
Concomitant
Respiratory Failure Death Male 193 lb 7/1/2008 Physician United States
Primary
Secondary
Concomitant
Respiratory Failure Hospitalization 3/25/2007 Male 193 lb 7/14/2008 Physician United States
Primary
Secondary
Concomitant
Staphylococcal Infection Death 3/1/2007 59 Male 193 lb 7/10/2008 Other Health Professional United States
Primary
Secondary
Concomitant
Withdrawal Syndrome Hospitalization 16 Female 106 lb 7/28/2008 Poland
Primary
Concomitant
Withdrawal Syndrome Hospitalization 16 Female 106 lb 7/30/2008 Poland
Primary
Concomitant
Withdrawal Syndrome Hospitalization 16 Female 106 lb 8/1/2008 Poland
Primary
Concomitant
Electrocardiogram Qt Interval Abnormal Life Threatening 3/12/2008 65 Male 195 lb 8/4/2008 Pharmacist United States
Primary
Concomitant
Vomiting Other Serious 5/19/2008 Male 52 lb 8/15/2008 Other Health Professional Brazil
Primary
Secondary
Concomitant
Withdrawal Syndrome Hospitalization 16 Female 106 lb 8/22/2008 Poland
Primary
Concomitant
Rash Life Threatening 3/12/2008 Male 195 lb 8/27/2008 United States
Primary
Concomitant
Vomiting Other Serious 5/19/2008 Male 52 lb 10/16/2008 Other Health Professional Brazil
Primary
Secondary
Concomitant
Pneumonia Hospitalization 8/21/2008 15 Female 86 lb 10/30/2008 Other Health Professional United States
Primary
Concomitant
Ileus Hospitalization 8/21/2008 15 Female 86 lb 11/6/2008 Consumer United States
Primary
Concomitant
Vomiting Other Serious 5/19/2008 Male 52 lb 11/5/2008 Other Health Professional Brazil
Primary
Concomitant
Rash Erythematous Life Threatening 3/12/2008 Male 195 lb 11/21/2008 Pharmacist United States
Primary
Concomitant
Interacting
Venoocclusive Disease Other Serious 9/19/2007 19 Female 2/23/2009 Other Health Professional United Kingdom
Primary
Secondary
Respiratory Failure Other Serious 11/1/2007 3/11/2009 Other Health Professional Canada
Primary
Concomitant
Rash Required Intervention 12/19/2008 69 Male 190 lb 1/6/2009 Pharmacist United States
Primary
Concomitant
Leukaemia Recurrent Hospitalization 12/26/2006 20 5/12/2009 Physician France
Primary
Concomitant
Respiratory Distress Death 1/18/2009 48 5/21/2009 Physician Korea, Republic Of
Primary
Secondary
Concomitant
Respiratory Failure Other Serious 11/1/2007 43 5/25/2009 Other Health Professional Canada
Primary
Concomitant
Respiratory Distress Other Serious 1/29/2009 Male 186 lb 6/26/2009 Other Health Professional United States
Primary
Secondary
Concomitant
Hallucination Life Threatening 3/7/2009 30 Male 174 lb 4/3/2009 Pharmacist United States
Primary
Secondary
Concomitant
Somnolence Hospitalization 8/11/2009 Male 39 lb 8/18/2009 United States
Primary
Secondary
Concomitant
Respiratory Failure Hospitalization 6/30/2009 Female 8/24/2009 Physician United States
Primary
Concomitant
Pulmonary Embolism Hospitalization 7/5/2009 Male 8/31/2009 Netherlands
Primary
Concomitant
Somnolence Hospitalization 8/11/2009 Male 39 lb 8/24/2009 United States
Primary
Secondary
Concomitant
Respiratory Failure Hospitalization 6/30/2009 Female 9/21/2009 Physician United States
Primary
Concomitant
Small Intestinal Obstruction Hospitalization 7/24/2009 60 Male 9/24/2009 Physician United States
Primary
Secondary
Concomitant
Urinary Hesitation Hospitalization 7/28/2008 65 Male 207 lb 10/6/2009 United States
Primary
Secondary
Concomitant
Unresponsive To Stimuli Hospitalization 7/24/2009 60 Male 223 lb 10/21/2009 Physician United States
Primary
Secondary
Concomitant
Unresponsive To Stimuli Other Serious 7/24/2009 60 Male 223 lb 11/5/2009 Physician United States
Primary
Secondary
Concomitant
Visual Impairment Hospitalization 3/20/2009 57 Female 11/20/2009 Consumer France
Primary
Secondary
Concomitant
Respiratory Failure Other Serious 11/14/2009 56 Female 136 lb 1/21/2010 United States
Primary
Secondary
Concomitant
Treatment Failure Life Threatening 3/6/2008 61 Male 2/19/2010 Other Health Professional United States
Primary
Secondary
Concomitant
Wound Infection Staphylococcal Life Threatening 11/8/2007 20 Male 118 lb 3/12/2010 Physician United States
Primary
Secondary
Concomitant
Tumour Lysis Syndrome Life Threatening 9/19/2009 17 Male 198 lb 4/6/2010 Other Health Professional United States
Primary
Secondary
Concomitant
Interacting
Stevens-johnson Syndrome Hospitalization 1/19/2010 18 Male 4/22/2010 Other Health Professional France
Primary
Secondary
Concomitant
No Therapeutic Response Death 8/17/2007 60 Female 154 lb 6/10/2010 Physician Korea, Republic Of
Primary
Concomitant
Leukaemia Death 8/17/2007 60 Female 154 lb 6/22/2010 Physician Korea, Republic Of
Primary
Concomitant
Prothrombin Time Prolonged 1/26/2007 76 Female 204 lb 6/24/2010 Other Health Professional United States
Primary
Concomitant
Wound Infection Staphylococcal Life Threatening 11/8/2007 20 Male 118 lb 6/30/2010 Physician United States
Primary
Secondary
Concomitant
Renal Failure Other Serious 1/23/2010 48 Male 7/9/2010 Physician Germany
Primary
Secondary
Concomitant
Renal Failure Other Serious 1/23/2010 48 Male 7/13/2010 Physician Germany
Primary
Secondary
Concomitant
Tumour Lysis Syndrome Life Threatening 9/19/2009 17 Male 198 lb 7/21/2010 Other Health Professional United States
Primary
Secondary
Concomitant
Interacting
Tumour Lysis Syndrome Life Threatening 9/19/2009 17 Male 198 lb 8/9/2010 Other Health Professional United States
Primary
Secondary
Concomitant
Interacting
Weight Decreased Hospitalization 4/26/2007 9 Female 56 lb 8/4/2010 Physician United States
Primary
Secondary
Concomitant
White Blood Cell Count Decreased Hospitalization 4/26/2007 9 Female 56 lb 8/11/2010 Physician United States
Primary
Secondary
Concomitant
Wound Infection Staphylococcal Life Threatening 11/8/2007 20 Male 118 lb 8/18/2010 Physician United States
Primary
Secondary
Concomitant
Venoocclusive Liver Disease Life Threatening Female 8/30/2010 Pharmacist United Kingdom
Primary
Secondary
Venoocclusive Disease Other Serious 9/19/2007 19 Female 9/7/2010 Other Health Professional United Kingdom
Primary
Secondary
Venoocclusive Liver Disease Other Serious 19 Female 9/7/2010 Pharmacist United Kingdom
Primary
Secondary
Venoocclusive Liver Disease Life Threatening 9/19/2007 19 Female 9/9/2010 Consumer United Kingdom
Primary
Secondary
Venoocclusive Liver Disease Life Threatening Female 9/9/2010 Pharmacist United Kingdom
Primary
Secondary
Venoocclusive Liver Disease Other Serious 9/19/2007 19 Female 9/10/2010 Other Health Professional United Kingdom
Primary
Secondary
Venoocclusive Liver Disease Other Serious 19 Female 9/10/2010 Pharmacist United Kingdom
Primary
Secondary
Venoocclusive Liver Disease Life Threatening 19 Female 9/10/2010 Consumer United Kingdom
Primary
Secondary
Venoocclusive Disease Other Serious 9/19/2007 19 Female 9/10/2010 Other Health Professional United Kingdom
Primary
Secondary
Dilatation Intrahepatic Duct Acquired Other Serious 1/1/2007 19 Female 9/10/2010 Other Health Professional United Kingdom
Primary
Secondary
Venoocclusive Liver Disease Life Threatening 9/19/2007 19 Female 9/10/2010 Other Health Professional United Kingdom
Primary
Secondary
Dilatation Intrahepatic Duct Acquired Other Serious 1/1/2007 19 Female 9/10/2010 Other Health Professional United Kingdom
Primary
Secondary
Venoocclusive Liver Disease Life Threatening 9/19/2007 19 Female 9/10/2010 Other Health Professional United Kingdom
Primary
Secondary
Venoocclusive Disease Other Serious 9/19/2007 19 Female 9/14/2010 Other Health Professional United Kingdom
Primary
Secondary
Venoocclusive Liver Disease Life Threatening 22 Female 9/9/2010 Other Health Professional United Kingdom
Primary
Secondary
Venoocclusive Liver Disease Life Threatening 19 Female 9/15/2010 Other Health Professional United Kingdom
Primary
Secondary
Venoocclusive Liver Disease Life Threatening 22 Female 9/16/2010 Other Health Professional United Kingdom
Primary
Secondary
Venoocclusive Liver Disease Other Serious 19 Female 9/10/2010 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Venoocclusive Liver Disease Other Serious 19 Female 9/9/2010 Consumer United Kingdom
Primary
Secondary
Venoocclusive Disease Other Serious 9/19/2007 19 Female 137 lb 9/17/2010 Pharmacist United Kingdom
Primary
Secondary
Venoocclusive Liver Disease Other Serious 9/20/2010 Other Health Professional United Kingdom
Primary
Secondary
Venoocclusive Liver Disease Life Threatening 19 Female 9/7/2010 United Kingdom
Primary
Secondary
Venoocclusive Disease Other Serious 9/19/2007 19 Female 9/21/2010 Other Health Professional United Kingdom
Primary
Secondary
Dilatation Intrahepatic Duct Acquired Other Serious 1/1/2007 19 Female 9/21/2010 Other Health Professional United Kingdom
Primary
Secondary
Venoocclusive Liver Disease Other Serious 9/19/2007 9/22/2010 Other Health Professional United Kingdom
Primary
Secondary
Venoocclusive Liver Disease Other Serious 19 Female 9/17/2010 Other Health Professional
Primary
Secondary
Venoocclusive Liver Disease Life Threatening 19 Female 9/23/2010 Pharmacist United Kingdom
Primary
Secondary
Venoocclusive Liver Disease Other Serious 19 Female 9/22/2010 Other Health Professional
Primary
Secondary
Dermatitis Exfoliative Other Serious 5/21/2010 59 Male 163 lb 9/28/2010 Physician Netherlands
Primary
Secondary
Concomitant
Venoocclusive Liver Disease Other Serious 19 Female 9/28/2010 Pharmacist United Kingdom
Primary
Secondary
Venoocclusive Liver Disease Life Threatening 19 Female 9/28/2010 Other Health Professional United Kingdom
Primary
Secondary
Tumour Lysis Syndrome Other Serious 8/17/2010 77 Male 9/29/2010 Other Health Professional United Kingdom
Primary
Concomitant
Venoocclusive Liver Disease Other Serious 19 Female 9/27/2010 Other Health Professional United Kingdom
Primary
Secondary
Venoocclusive Liver Disease Other Serious 9/19/2007 10/1/2010 Other Health Professional United Kingdom
Primary
Secondary
Venoocclusive Liver Disease Other Serious 19 Female 10/1/2010 Other Health Professional
Primary
Secondary
Pulmonary Haemorrhage Life Threatening 2/8/2010 15 Female 110 lb 10/15/2010 Other Health Professional Germany
Primary
Secondary
Concomitant
Dermatitis Exfoliative Other Serious 5/21/2010 59 Male 163 lb 10/20/2010 Physician Netherlands
Primary
Secondary
Concomitant
Pneumonia Life Threatening 10/16/2010 50 Male 141 lb 10/25/2010 Pharmacist United States
Primary
Concomitant
Nausea Other Serious 8/26/2010 26 Female 87 lb 10/27/2010 Other Health Professional United States
Primary
Concomitant
Tumour Lysis Syndrome Hospitalization 8/19/2010 77 Male 11/2/2010 Other Health Professional United Kingdom
Primary
Concomitant
Respiratory Arrest Death 11/8/2010 2 Male 22 lb 11/8/2010 Other Health Professional United States
Primary
Concomitant
Alanine Aminotransferase Increased Life Threatening 9/19/2007 19 Female 1/25/2011 United Kingdom
Primary
Secondary
Abdominal Distension Hospitalization 2/1/2011 28 Female 2/15/2011 Physician United Kingdom
Primary
Secondary
Concomitant
Venoocclusive Liver Disease Life Threatening 9/19/2007 19 Female 137 lb 2/18/2011 Pharmacist United Kingdom
Primary
Secondary
Alanine Aminotransferase Increased Other Serious 1/1/2007 19 Female 137 lb 2/21/2011 Other Health Professional United Kingdom
Primary
Secondary
Venoocclusive Liver Disease Life Threatening 9/19/2007 19 Female 137 lb 2/24/2011 Other Health Professional United Kingdom
Primary
Secondary
Blood Bilirubin Increased Life Threatening 22 Female 2/23/2011 Other Health Professional United Kingdom
Primary
Secondary
Chills Death 1/21/2011 62 Female 110 lb 3/4/2011 Other Health Professional United States
Primary
Secondary
Concomitant
Cystitis Haemorrhagic Death 10/14/2010 49 Male 2/23/2011 Physician United States
Primary
Concomitant
Blood Alkaline Phosphatase Increased Other Serious 19 Female 3/2/2011 Other Health Professional
Primary
Secondary
Abdominal Distension Other Serious 10/7/2010 49 Male 3/10/2011 Other Health Professional United States
Primary
Concomitant
Circulatory Collapse Hospitalization 1/21/2011 62 Female 110 lb 3/27/2011 Other Health Professional United States
Primary
Secondary
Concomitant
Bronchopulmonary Aspergillosis Death 81 Male 3/22/2011 Physician United Kingdom
Primary
Concomitant
Haemoglobin Decreased Hospitalization 1/4/2011 81 Male 3/31/2011 Physician United Kingdom
Primary
Concomitant
Condition Aggravated Hospitalization 12/1/2010 33 Male 4/22/2011 Other Health Professional France
Primary
Secondary
Concomitant
Atrial Fibrillation Other Serious 12/1/2010 71 Female 127 lb 4/27/2011 Other Health Professional Canada
Primary
Secondary
Concomitant
Acute Graft Versus Host Disease In Intestine Hospitalization 4/9/2011 42 Female 197 lb 4/28/2011 Consumer United States
Primary
Secondary
Concomitant
Acute Graft Versus Host Disease In Intestine Hospitalization 4/9/2011 42 Female 197 lb 5/15/2011 Physician United States
Primary
Secondary
Concomitant
Liver Function Test Abnormal Hospitalization 5/22/2011 53 Female 6/22/2011 Other Health Professional United Kingdom
Primary
Concomitant
White Blood Cell Count Decreased Other Serious 10/7/2010 49 Male 6/29/2011 Other Health Professional United States
Primary
Concomitant
Hepatotoxicity Life Threatening 9/19/2007 19 Female 7/21/2011 Consumer United Kingdom
Primary
Secondary
Concomitant

Drug Data