Metoprolol combined with Sodium Bicarbonate

Reports:

Reaction Outcome Event Date Age Sex Weight Reported Reporter Country Treatment
Role Name
International Normalised Ratio Increased 6/30/2004 53 9/12/2005 Pharmacist United States
Primary
Concomitant
Liver Function Test Abnormal 12/18/2004 38 9/12/2005 Pharmacist United States
Primary
Concomitant
International Normalised Ratio Increased 4/30/2004 60 9/12/2005 Physician United States
Primary
Concomitant
International Normalised Ratio Increased 8/24/2004 65 9/12/2005 Physician United States
Primary
Concomitant
Reticulocyte Count Decreased Hospitalization 2/1/2006 Male 2/24/2006 Physician United States
Primary
Concomitant
White Blood Cell Count Decreased Hospitalization 2/10/2006 Male 154 lb 3/6/2006 Physician United States
Primary
Concomitant
Therapeutic Response Decreased Hospitalization 2/10/2006 Male 154 lb 3/21/2006 Physician United States
Primary
Concomitant
Staphylococcal Infection Other Serious 1/1/2006 63 Male 121 lb 5/18/2006 Physician United States
Primary
Secondary
Concomitant
Urinary Tract Infection Hospitalization 7/2/2006 66 198 lb 7/11/2006 Pharmacist United States
Primary
Concomitant
Visual Disturbance 5/1/2005 Female 7/21/2006 Consumer United States
Primary
Concomitant
Pulmonary Oedema Other Serious 1/1/2006 Male 7/19/2006 Pharmacist United States
Primary
Concomitant
Infusion Related Reaction Other Serious 7/1/2006 Male 9/20/2006 Pharmacist United States
Primary
Concomitant
Clostridial Infection Hospitalization 10/11/2006 83 Male 158 lb 10/13/2006 Pharmacist United States
Primary
Concomitant
Altered State Of Consciousness Hospitalization 1/11/2007 48 Male 9/24/2007 Physician United States
Primary
Secondary
Concomitant
Dyspnoea Life Threatening 6/8/2007 53 Female 169 lb 10/4/2007 Physician United States
Primary
Secondary
Concomitant
Tachycardia Life Threatening 9/28/2007 21 Female 150 lb 11/21/2007 Consumer United States
Primary
Secondary
Concomitant
Urinary Tract Infection Hospitalization 8/1/2007 Female 11/27/2007 Physician United States
Primary
Concomitant
Unresponsive To Stimuli Life Threatening 9/28/2007 21 Female 150 lb 12/3/2007 Physician United States
Primary
Secondary
Concomitant
Sepsis Death 3/26/2007 66 Male 176 lb 6/27/2008 Other Health Professional Germany
Primary
Secondary
Concomitant
Urinary Tract Infection Other Serious 1/1/2007 66 Male 176 lb 7/3/2008 Other Health Professional Germany
Primary
Secondary
Concomitant
Rhabdomyolysis Hospitalization 7/9/2008 41 8/11/2008 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Anaemia Other Serious Male 12/31/2008 Physician United States
Primary
Concomitant
Thrombocytopenia Other Serious 11/4/2007 Male 181 lb 1/23/2009 United States
Primary
Secondary
Concomitant
Drug Ineffective Other Serious Male 1/26/2009 Physician United States
Primary
Concomitant
Vitamin B12 Deficiency Other Serious 6/1/2007 Male 219 lb 2/11/2009 Physician United States
Primary
Secondary
Concomitant
Atrial Fibrillation Hospitalization 1/30/2008 Female 213 lb 3/9/2009 Physician United States
Primary
Concomitant
Transaminases Increased Other Serious 4/1/2008 Female 3/27/2009 Physician United States
Primary
Concomitant
Pericardial Effusion Death 11/11/2008 4/1/2009 Other Health Professional India
Primary
Concomitant
Parathyroid Tumour Benign Other Serious 12/16/2008 53 Male 4/2/2009 Physician Germany
Primary
Secondary
Concomitant
Parathyroid Tumour Benign Other Serious 12/16/2008 53 Male 4/28/2009 Physician Germany
Primary
Secondary
Concomitant
Yellow Skin Other Serious 5/1/2007 67 Male 165 lb 5/11/2009 Physician United States
Primary
Secondary
Concomitant
Off Label Use Other Serious 2/5/2004 7/7/2009 Physician United States
Primary
Secondary
Concomitant
Tumour Lysis Syndrome Other Serious 5/19/2009 Male 7/9/2009 United States
Primary
Secondary
Concomitant
Urinary Tract Infection Other Serious 1/1/2007 66 Male 176 lb 7/15/2009 Other Health Professional Germany
Primary
Secondary
Concomitant
Flushing Male 8/22/2009 United States
Primary
Concomitant
Diarrhoea Male 196 lb 8/22/2009 Consumer United States
Primary
Concomitant
Renal Failure Other Serious 2/6/2008 51 Male 163 lb 1/25/2010 Consumer United States
Primary
Concomitant
Tinnitus Disability 9/1/2000 1/27/2010 Other Health Professional Australia
Primary
Secondary
Concomitant
Hypotension Death 10/1/2009 66 Male 152 lb 2/24/2010 Pharmacist United States
Primary
Concomitant
Wound Drainage Other Serious 2/1/2002 3/31/2010 Physician United States
Primary
Secondary
Concomitant
Renal Failure Acute Other Serious 12/1/2007 79 Male 205 lb 4/29/2010 Other Health Professional United States
Primary
Secondary
Concomitant
Sepsis Hospitalization 1/31/2010 55 Male 5/5/2010 Pharmacist Canada
Primary
Concomitant
Vomiting Other Serious 2/1/2008 81 Female 5/7/2010 Other Health Professional United States
Primary
Concomitant
Therapeutic Agent Toxicity Hospitalization 78 Female 117 lb 4/26/2010 United States
Primary
Concomitant
White Blood Cell Count Increased Other Serious 8/23/2006 56 Female 5/12/2010 Physician United States
Primary
Concomitant
Respiratory Failure Other Serious 12/1/2007 79 Male 205 lb 5/24/2010 Other Health Professional United States
Primary
Secondary
Concomitant
Coagulation Time Prolonged 78 Male 130 lb 6/24/2010 Other Health Professional United States
Primary
Concomitant
Respiratory Tract Inflammation Other Serious 4/1/2010 64 Male 6/28/2010 Physician United States
Primary
Concomitant
Somnolence Other Serious 6/1/2010 69 Female 100 lb 6/30/2010 Physician United States
Primary
Secondary
Concomitant
Respiratory Tract Inflammation Other Serious 4/1/2010 64 Male 7/7/2010 Physician United States
Primary
Concomitant
Hypotension Other Serious 1/3/2008 76 Male 7/7/2010 Other Health Professional United States
Primary
Concomitant
Somnolence Other Serious 6/1/2010 69 Female 100 lb 7/12/2010 Physician United States
Primary
Secondary
Concomitant
Respiratory Tract Inflammation Other Serious 4/1/2010 64 Male 7/13/2010 Physician United States
Primary
Concomitant
Vomiting 8/16/2007 62 Male 198 lb 7/15/2010 Consumer United States
Primary
Concomitant
Hypotension Other Serious 10/1/2007 56 Male 7/20/2010 Lawyer United States
Primary
Concomitant
Therapeutic Response Decreased Other Serious 7/1/2009 81 Male 7/20/2010 Other Health Professional Australia
Primary
Concomitant
White Blood Cell Count Increased Other Serious 74 Female 7/16/2010 United States
Primary
Concomitant
Ventricular Fibrillation Life Threatening 12/4/2007 69 Female 326 lb 7/19/2010 Lawyer United States
Primary
Secondary
Concomitant
Skin Induration Other Serious 4/1/2007 64 Female 174 lb 8/4/2010 Other Health Professional United States
Primary
Secondary
Concomitant
Lung Neoplasm Malignant Other Serious 1/1/2008 72 Male 8/5/2010 Other Health Professional United States
Primary
Concomitant
Urinary Retention Other Serious 7/6/2007 81 Male 250 lb 8/6/2010 Other Health Professional United States
Primary
Concomitant
Wound Drainage Other Serious 2/1/2002 63 Male 140 lb 8/26/2010 Physician United States
Primary
Secondary
Concomitant
Ventricular Fibrillation Other Serious 5/17/2010 55 Male 147 lb 9/2/2010 Other Health Professional United States
Primary
Secondary
Concomitant
Vomiting Other Serious 2/6/2008 51 Male 163 lb 9/21/2010 Other Health Professional United States
Primary
Concomitant
Subdural Haematoma Hospitalization 8/18/2010 67 Male 9/22/2010 Physician Germany
Primary
Secondary
Concomitant
Transplant Failure Hospitalization Female 273 lb 10/14/2010 Physician United States
Primary
Secondary
Concomitant
Renal Impairment Hospitalization 2/15/2009 63 Female 148 lb 10/18/2010 Physician Sweden
Primary
Secondary
Concomitant
Multi-organ Failure Death 10/9/2010 Male 194 lb 10/25/2010 Other Health Professional United States
Primary
Secondary
Concomitant
White Blood Cell Count Decreased Death 10/9/2010 66 Male 194 lb 11/2/2010 Other Health Professional United States
Primary
Secondary
Concomitant
Throat Tightness Other Serious 5/1/2010 75 Female 9/14/2010 United States
Primary
Concomitant
Weight Decreased Other Serious 1/1/2004 69 Male 142 lb 11/11/2010 United States
Primary
Secondary
Concomitant
Renal Failure Hospitalization 10/29/2010 81 Male 11/12/2010 Other Health Professional United States
Primary
Concomitant
Death Death 10/6/2010 77 Male 11/17/2010 Other Health Professional Germany
Primary
Secondary
Concomitant
Weight Decreased Other Serious 1/1/2008 19 Female 99 lb 11/17/2010 Other Health Professional United States
Primary
Concomitant
Aplasia Pure Red Cell Other Serious 10/1/2009 70 Female 11/18/2010 Physician United States
Primary
Secondary
Concomitant
Rash Other Serious 11/1/2007 40 Male 245 lb 11/23/2010 Other Health Professional United States
Primary
Concomitant
Road Traffic Accident Hospitalization 9/1/2005 67 Female 238 lb 11/18/2010 Consumer United States
Primary
Concomitant
Renal Failure Female 194 lb 11/22/2010 United States
Primary
Concomitant
Treatment Noncompliance Other Serious 9/1/2005 67 Female 238 lb 11/29/2010 Physician United States
Primary
Concomitant
Arrhythmia Hospitalization 10/29/2010 81 Male 1/18/2011 Other Health Professional United States
Primary
Concomitant
Stress Urinary Incontinence Hospitalization 4/26/2008 85 Female 100 lb 1/13/2011 Lawyer United States
Primary
Concomitant
Skin Discolouration Other Serious 5/15/2003 55 Female 198 lb 1/28/2011 Other Health Professional United States
Primary
Secondary
Concomitant
Acute Myeloid Leukaemia Other Serious 6/1/2010 45 Female 185 lb 2/16/2011 Physician United States
Primary
Concomitant
Drug Level Increased Hospitalization 1/4/2011 72 Male 2/22/2011 Other Health Professional Sweden
Primary
Concomitant
Interacting
Drug Therapeutic Incompatibility Hospitalization 1/4/2011 72 Male 2/24/2011 Other Health Professional Sweden
Primary
Concomitant
Interacting
Haemoglobin Decreased Hospitalization 10/1/2010 83 Male 175 lb 11/4/2010 Pharmacist United States
Primary
Secondary
Concomitant
Renal Impairment Hospitalization 2/24/2004 68 Male 3/3/2011 Other Health Professional United States
Primary
Concomitant
Stevens-johnson Syndrome Hospitalization 8/2/2004 65 Female 3/4/2011 Lawyer United States
Primary
Secondary
Concomitant
Aortic Aneurysm Other Serious 1/1/2004 69 Male 142 lb 3/7/2011 Physician United States
Primary
Secondary
Concomitant
Injury Other Serious 9/5/2005 51 Male 295 lb 3/9/2011 Lawyer United States
Primary
Concomitant
Arrhythmia Other Serious 9/5/2005 51 Male 295 lb 3/9/2011 Consumer United States
Primary
Concomitant
Transplant Failure Other Serious 11/12/2009 67 Female 273 lb 3/15/2011 Consumer United States
Primary
Secondary
Concomitant
Multiple Myeloma Death 1/11/2011 70 Male 3/22/2011 Physician United States
Primary
Concomitant
Pain Hospitalization 2/1/2000 52 Male 235 lb 3/22/2011 Lawyer United States
Primary
Concomitant
Renal Failure Hospitalization 2/1/2000 52 Male 235 lb 3/22/2011 Other Health Professional United States
Primary
Concomitant
Anxiety Hospitalization 12/7/1999 61 Male 212 lb 3/23/2011 Lawyer United States
Primary
Secondary
Concomitant
Renal Failure Acute Hospitalization 2/24/2004 68 Male 3/23/2011 Lawyer United States
Primary
Concomitant
Renal Failure Other Serious 6/1/2006 68 Male 248 lb 3/31/2011 Consumer United States
Primary
Concomitant
Cervical Spinal Stenosis Hospitalization 2/1/2002 63 Male 140 lb 4/1/2011 Physician United States
Primary
Secondary
Concomitant
Fear Other Serious 12/7/1999 61 Male 212 lb 4/4/2011 Consumer United States
Primary
Concomitant
Blood Pressure Inadequately Controlled Hospitalization Female 3/24/2011 United States
Primary
Concomitant
Renal Impairment Other Serious 2/6/2004 62 Female 126 lb 4/8/2011 Lawyer United States
Primary
Concomitant
Anxiety Other Serious 2/6/2004 62 Female 126 lb 4/8/2011 Lawyer United States
Primary
Concomitant
Renal Failure Chronic Death 45 Male 4/20/2011 Consumer Philippines
Primary
Concomitant
Sepsis Hospitalization 11/12/2009 67 Female 273 lb 4/25/2011 Physician United States
Primary
Secondary
Concomitant
Oliguria Hospitalization 11/12/2009 67 Female 273 lb 4/25/2011 Physician United States
Primary
Secondary
Concomitant
Oedema Peripheral Other Serious 1/1/2007 65 Female 174 lb 4/27/2011 Other Health Professional United States
Primary
Secondary
Concomitant
Leukocytosis Life Threatening 12/22/2007 20 Female 4/28/2011 Pharmacist China
Primary
Concomitant
Urinary Tract Infection Other Serious 1/1/2004 69 Male 142 lb 4/28/2011 Physician United States
Primary
Secondary
Concomitant
Pain Death 9/3/2003 80 Male 175 lb 5/7/2011 Lawyer United States
Primary
Concomitant
Medication Residue 3/1/2011 46 Male 185 lb 5/16/2011 Consumer United States
Primary
Concomitant
Anxiety Death 3/27/2001 76 Male 203 lb 5/25/2011 Other Health Professional United States
Primary
Concomitant
Anhedonia Hospitalization 12/18/2006 64 Male 130 lb 6/8/2011 Lawyer United States
Primary
Concomitant
Fear Other Serious 12/20/2005 80 Female 177 lb 6/14/2011 Other Health Professional United States
Primary
Concomitant
Skin Hypertrophy Other Serious 5/1/2008 68 Female 190 lb 6/16/2011 Other Health Professional Canada
Primary
Secondary
Concomitant
Blood Pressure Diastolic Decreased Other Serious 12/19/2007 45 Female 149 lb 8/26/2011 Physician United States
Primary
Concomitant
Dyspnoea Other Serious 7/25/2011 67 Male 182 lb 8/28/2011 Physician United States
Primary
Concomitant
Failure To Thrive Other Serious 7/25/2011 67 Male 182 lb 9/2/2011 Physician United States
Primary
Concomitant
Nephrogenic Systemic Fibrosis Other Serious 2/1/2004 43 Female 128 lb 9/30/2011 Other Health Professional United States
Primary
Secondary
Concomitant
Hypercholesterolaemia Hospitalization 5/1/2008 41 Female 225 lb 11/9/2011 Physician United States
Primary
Concomitant
Back Pain Other Serious 2/1/2002 63 Male 140 lb 1/25/2012 Physician United States
Primary
Secondary
Concomitant
Activated Partial Thromboplastin Time Prolonged Hospitalization 1/1/2011 67 Male 2/3/2012 Other Health Professional Sweden
Primary
Concomitant
Loss Of Consciousness Other Serious 2/3/2012 1 Male 2/23/2012 Physician Germany
Primary
Concomitant
Nephrogenic Anaemia Hospitalization 4/8/2010 Female 2/27/2012 Consumer China
Primary
Concomitant
Renal Impairment Hospitalization 1/16/2012 60 Male 3/14/2012 Other Health Professional United States
Primary
Concomitant
Renal Injury Other Serious 53 Male 291 lb 5/21/2012 Lawyer United States
Primary
Concomitant
Renal Failure Hospitalization 1/20/2012 76 Male 5/23/2012 Other Health Professional United States
Primary
Concomitant
Drug Resistance Other Serious 6/1/2011 64 Male 150 lb 6/7/2012 Physician United States
Primary
Secondary
Concomitant
Bone Marrow Failure Hospitalization 1/19/2011 67 Male 207 lb 6/1/2012 Physician United States
Primary
Concomitant
Myoclonus Hospitalization 6/20/2012 61 Male 107 lb 7/9/2012 Other Health Professional United States
Primary
Secondary
Concomitant
Weight Decreased Death 2004 Male 142 lb 11/6/2012 Consumer Us
Primary
Secondary
Concomitant
Ventricular Tachycardia Death 3/17/2009 67 Female 273 lb 9/5/2012 Consumer Us
Primary
Secondary
Concomitant
Renal Injury Other Serious 68 Female 123 lb 11/21/2012 Other Health Professional Us
Primary
Concomitant
Sepsis Death 11/12/2009 67 Female 273 lb 9/12/2012 Physician Us
Primary
Secondary
Concomitant
Urinary Tract Infection Staphylococcal Hospitalization 1/19/2011 67 Male 207 lb 10/25/2012 Physician Us
Primary
Concomitant
Renal Failure Acute Hospitalization 7/9/2011 62 Female 102 lb 10/22/2012 Other Health Professional Us
Primary
Concomitant
Macrocytosis Other Serious 11/20/2012 Other Health Professional Au
Primary
Secondary
Concomitant
Bk Virus Infection Other Serious 6/17/2009 47 Male 10/24/2012 Physician Us
Primary
Secondary
Concomitant
Uterine Leiomyoma Hospitalization 2003 41 Female 9/4/2012 Physician Ca
Primary
Secondary
Concomitant
Interacting
Neuropathy Peripheral Other Serious 8/2012 Female 9/6/2012 Other Health Professional Us
Primary
Concomitant
Sepsis Other Serious 9/24/2012 Physician Us
Primary
Secondary
Concomitant
Acute Myocardial Infarction Death 72 Female 11/11/2012 Physician Us
Primary
Concomitant
Respiratory Failure Hospitalization 7/19/2012 41 Male 218 lb 11/21/2012 Physician Us
Primary
Secondary
Concomitant
Transplant Rejection Other Serious 8/24/2012 49 Male 181 lb 12/6/2012 Other Health Professional Us
Primary
Concomitant
Respiratory Failure Other Serious 34 Male 240 lb 10/19/2012 Consumer Us
Primary
Concomitant
Vomiting Hospitalization 9/4/2012 44 Female 10/23/2012 Consumer Us
Primary
Concomitant
Pelvic Venous Thrombosis Hospitalization 5/4/2011 60 Male 170 lb 10/30/2012 Physician Us
Primary
Secondary
Concomitant
Urinary Retention Other Serious 8/13/2012 49 Female 172 lb 11/19/2012 Physician Nl
Primary
Secondary
Concomitant
Urinary Tract Infection Bacterial Hospitalization 2012 49 Female 12/21/2012 Physician Ca
Primary
Secondary
Concomitant
Interacting
Death Death Female 1/4/2013 Consumer Ca
Primary
Secondary
Concomitant

Drug Data