Metolazone combined with Warfarin Sodium

Reports:

Reaction Outcome Event Date Age Sex Weight Reported Reporter Country Treatment
Role Name
Renal Failure Acute Hospitalization 11/16/2005 Male 2/15/2006 Pharmacist United States
Primary
Concomitant
Pulmonary Oedema Required Intervention 57 Female 3/30/2006 Other Health Professional United States
Primary
Secondary
Concomitant
Staring Hospitalization 83 Female 4/11/2006 Other Health Professional United States
Primary
Secondary
Concomitant
Staring Hospitalization 83 Female 4/5/2006
Primary
Secondary
Concomitant
Rectal Haemorrhage Hospitalization 2/26/2006 57 Male 223 lb 4/18/2006 Consumer United States
Primary
Concomitant
Hallucination, Visual Other Serious 5/6/2005 Female 12/30/2005 Pharmacist United States
Primary
Concomitant
Staring Hospitalization 83 Female 4/21/2006 Other Health Professional United States
Primary
Secondary
Concomitant
Vomiting Other Serious 4/1/2002 70 Male 4/27/2006 Canada
Primary
Secondary
Concomitant
Pain In Extremity Other Serious 89 Male 142 lb 5/10/2006 United States
Primary
Concomitant
Vomiting Hospitalization 5/1/2006 57 Male 226 lb 5/31/2006 Physician United States
Primary
Concomitant
Fatigue 1/1/2005 58 Female 152 lb 4/25/2006 Other Health Professional United States
Primary
Concomitant
Urinary Tract Infection Hospitalization 5/1/2006 76 Female 180 lb 6/14/2006 Pharmacist United States
Primary
Concomitant
Pulmonary Oedema Hospitalization 2/22/2006 74 Male 225 lb 6/23/2006 Physician United States
Primary
Concomitant
Pulmonary Oedema Hospitalization 2/22/2006 74 Male 225 lb 6/23/2006 Physician United States
Primary
Concomitant
Tearfulness Required Intervention 77 Female 7/26/2006 Physician United States
Primary
Concomitant
Oedema Peripheral Hospitalization 7/7/2006 59 Female 118 lb 7/21/2006 Physician Canada
Primary
Concomitant
Syncope 4/19/2006 87 Male 155 lb 7/19/2006 Pharmacist United States
Primary
Concomitant
Subdural Haematoma 4/19/2006 87 Male 155 lb 7/19/2006 Pharmacist United States
Primary
Concomitant
Therapy Non-responder Other Serious 1/1/2006 77 Female 8/14/2006 Physician United States
Primary
Concomitant
Weight Increased Hospitalization 6/9/2006 64 Male 199 lb 6/9/2006 United States
Primary
Concomitant
Respiratory Failure Death 9/5/2006 45 Male 200 lb 9/19/2006 Pharmacist United States
Primary
Concomitant
Rectal Haemorrhage Hospitalization 4/19/2005 81 Male 247 lb 9/28/2006 Pharmacist United States
Primary
Secondary
Concomitant
Therapeutic Agent Toxicity Other Serious 6/13/2006 89 Male 183 lb 11/8/2006 Other Health Professional France
Primary
Secondary
Concomitant
Death Death 10/17/2006 71 Male 11/17/2006 Other Health Professional United States
Primary
Concomitant
Therapeutic Agent Toxicity Other Serious 6/13/2006 89 Male 183 lb 12/18/2006 Other Health Professional France
Primary
Secondary
Concomitant
Upper Gastrointestinal Haemorrhage Hospitalization 12/6/2006 58 Male 182 lb 12/18/2006 Pharmacist United States
Primary
Secondary
Concomitant
Urine Output Increased Other Serious 6/13/2006 89 Male 183 lb 12/27/2006 Other Health Professional France
Primary
Secondary
Concomitant
Rectal Haemorrhage Required Intervention 7/11/2006 74 Female 177 lb 7/15/2006 Pharmacist United States
Primary
Concomitant
Delusion Of Replacement Hospitalization 1/1/2006 77 Female 10/8/2006 Physician United States
Primary
Concomitant
Dry Throat 59 Female 205 lb 10/24/2006 Qatar
Primary
Concomitant
Fatigue 1/1/2005 58 Female 152 lb 10/24/2006 Other Health Professional United States
Primary
Concomitant
Drug Toxicity Hospitalization 2/3/2007 53 Male 173 lb 2/12/2007 Pharmacist United States
Primary
Concomitant
White Blood Cell Count Decreased Other Serious 4/9/2006 66 Male 3/10/2007 Physician Canada
Primary
Secondary
Concomitant
Wound Secretion Hospitalization 10/26/2004 75 Male 180 lb 3/14/2007 Other Health Professional United States
Primary
Secondary
Concomitant
Delusion Of Replacement Death 77 Female 3/23/2007
Primary
Secondary
Concomitant
Cerebrovascular Accident Hospitalization 3/12/2007 Female 3/27/2007 Other Health Professional United States
Primary
Concomitant
Throat Irritation 11/12/2006 45 Female 281 lb 1/23/2007 Consumer United States
Primary
Concomitant
Palpitations 37 Female 224 lb 1/23/2007 Consumer United States
Primary
Concomitant
Gait Disturbance 8/1/2005 52 Female 369 lb 1/23/2007 Pharmacist United States
Primary
Concomitant
Shock Life Threatening 12/8/2006 Male 317 lb 4/20/2007 Pharmacist United States
Primary
Concomitant
Rash Other Serious Female 200 lb 4/27/2007 Physician United States
Primary
Concomitant
Interacting
Therapeutic Agent Toxicity Other Serious 6/13/2006 89 Male 183 lb 4/30/2007 Other Health Professional France
Primary
Secondary
Concomitant
Cardiac Arrest Life Threatening 1/27/2007 51 Female 463 lb 5/10/2007 Consumer United States
Primary
Concomitant
Therapeutic Agent Toxicity Other Serious 6/13/2006 89 Male 183 lb 5/11/2007 Other Health Professional France
Primary
Secondary
Concomitant
Pain In Jaw Other Serious 5/18/2007 72 Female 201 lb 5/23/2007 Consumer United States
Primary
Concomitant
Vomiting Hospitalization 7/13/2006 72 Female 6/15/2007 Physician United Kingdom
Primary
Secondary
Vomiting Hospitalization 72 Female 6/20/2007 Consumer United Kingdom
Primary
Secondary
Renal Impairment Hospitalization 1/1/2000 75 Female 6/21/2007 Consumer United States
Primary
Concomitant
Tendon Injury Hospitalization 3/12/2007 60 Male 6/19/2007 Consumer United States
Primary
Concomitant
Vomiting Death 72 Female 6/20/2007 United Kingdom
Primary
Concomitant
Vomiting Hospitalization 72 Female 6/19/2007 United Kingdom
Primary
Secondary
Vomiting Hospitalization 72 Female 6/19/2007 United Kingdom
Primary
Secondary
Concomitant
Vomiting Hospitalization 72 Female 6/22/2007 Other Health Professional United Kingdom
Primary
Secondary
Renal Impairment Hospitalization 1/1/2000 75 Female 7/9/2007 Consumer United States
Primary
Concomitant
Haemoglobin Decreased Hospitalization 6/18/2007 46 Male 7/26/2007 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Vomiting Hospitalization 7/13/2006 72 Female 7/9/2007 United Kingdom
Primary
Secondary
Fall Hospitalization 68 Male 8/6/2007 Consumer United States
Primary
Concomitant
Fatigue Other Serious 7/8/2007 Male 8/24/2007 Pharmacist United States
Primary
Concomitant
Weight Increased Hospitalization 11/1/2006 67 Male 230 lb 8/24/2007 Consumer United States
Primary
Concomitant
Oedema Peripheral Hospitalization 7/12/2007 Female 273 lb 9/5/2007 Pharmacist United States
Primary
Concomitant
Thrombosis Hospitalization 2/18/2007 Male 240 lb 4/11/2007 Pharmacist United States
Primary
Concomitant
Dyspnoea 81 Male 11/13/2007 Consumer United States
Primary
Concomitant
Right Ventricular Failure Hospitalization 8/1/2007 75 Female 11/20/2007 Physician United States
Primary
Concomitant
Weight Increased Hospitalization 11/23/2006 66 Male 230 lb 11/30/2007 Other Health Professional United States
Primary
Concomitant
Pleural Effusion Hospitalization 2/4/2008 Male 2/18/2008 United States
Primary
Concomitant
Rhabdomyolysis Hospitalization 1/1/2001 73 Male 3/5/2008 Physician United Kingdom
Primary
Concomitant
Ventricular Tachycardia Other Serious 4/16/2004 57 Female 194 lb 5/2/2007 United States
Primary
Concomitant
Pleural Effusion Hospitalization 2/4/2008 Male 4/4/2008 United States
Primary
Concomitant
Peritonitis Hospitalization 3/15/2008 71 Male 201 lb 4/10/2008 Physician United States
Primary
Concomitant
Tachycardia Other Serious 68 Male 5/13/2008 Physician United States
Primary
Concomitant
Respiratory Distress Hospitalization 4/29/2008 Male 260 lb 5/27/2008 Physician United States
Primary
Concomitant
Vomiting Death 3/17/2008 70 Male 5/28/2008 United States
Primary
Concomitant
Cardiac Failure Hospitalization 10/10/2007 Male 175 lb 6/4/2008 United States
Primary
Concomitant
Removal Of Transplanted Organ Other Serious 4/19/2008 45 Female 180 lb 6/9/2008 Physician United States
Primary
Concomitant
Blood Glucose Increased Hospitalization 3/17/2008 77 Male 175 lb 4/30/2008 United States
Primary
Concomitant
Removal Of Transplanted Organ Other Serious 4/11/2008 Female 180 lb 7/2/2008 Pharmacist United States
Primary
Concomitant
Vomiting Hospitalization 12/1/2007 84 Male 150 lb 6/28/2008 United States
Primary
Concomitant
Respiratory Depression Death 4/1/2005 57 Female 7/7/2008 Pharmacist Canada
Primary
Concomitant
Haemoglobin Decreased Hospitalization 6/18/2007 46 Male 7/11/2008 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Medication Error Hospitalization 1/1/2006 68 Male 7/16/2008 Consumer United States
Primary
Concomitant
Swelling Hospitalization 1/1/2007 Female 315 lb 7/24/2008 Consumer United States
Primary
Concomitant
Swelling Hospitalization 1/1/2007 Female 315 lb 8/7/2008 Physician United States
Primary
Concomitant
Rash Macular 7/11/2008 Female 8/29/2008 United States
Primary
Concomitant
Swelling Hospitalization 1/1/2007 Female 315 lb 9/4/2008 Physician United States
Primary
Concomitant
Staring Other Serious 83 Female 10/3/2008 Physician United States
Primary
Secondary
Concomitant
Withdrawal Syndrome Other Serious 10/19/2007 65 Female 240 lb 10/7/2008 Pharmacist United States
Primary
Secondary
Concomitant
Pulmonary Embolism Other Serious 1/1/2007 57 Male 8/24/2007 Pharmacist United States
Primary
Secondary
Concomitant
Syncope Hospitalization 66 Male 218 lb 10/28/2008 Physician United States
Primary
Secondary
Concomitant
Vomiting Life Threatening 12/1/2007 84 Male 150 lb 11/9/2008 United States
Primary
Concomitant
International Normalised Ratio Increased Required Intervention 6/4/2008 82 Male 207 lb 6/25/2008 Pharmacist United States
Primary
Concomitant
International Normalised Ratio Increased Required Intervention 7/30/2008 66 Female 287 lb 8/4/2008 Pharmacist United States
Primary
Concomitant
Syncope Hospitalization 66 Male 218 lb 11/21/2008 Physician United States
Primary
Secondary
Concomitant
Death Death Female 133 lb 11/21/2008 United States
Primary
Concomitant
Syncope Hospitalization 4/3/2008 Male 218 lb 11/26/2008 Physician United States
Primary
Secondary
Concomitant
Pruritus 7/31/2008 Male 11/26/2008 United States
Primary
Concomitant
Influenza Like Illness 10/6/2008 Female 12/12/2008 Physician United States
Primary
Concomitant
Product Quality Issue Other Serious 8/1/2008 83 Female 2/13/2009 Consumer United States
Primary
Secondary
Concomitant
Chest Pain Hospitalization Female 195 lb 3/3/2009 Other Health Professional United States
Primary
Concomitant
Pleural Effusion Hospitalization Female 195 lb 3/5/2009 Physician United States
Primary
Concomitant
Sudden Death Death 1/6/2009 Male 220 lb 3/6/2009 United States
Primary
Concomitant
Multiple Injuries Death 67 Male 3/12/2009 United States
Primary
Concomitant
Infection Other Serious 11/2/2008 Female 123 lb 3/24/2009 United States
Primary
Secondary
Concomitant
Weight Decreased Other Serious Male 326 lb 3/24/2009 Other Health Professional United States
Primary
Concomitant
Pulmonary Embolism Other Serious 11/1/1995 Female 134 lb 4/27/2009 Lawyer United States
Primary
Secondary
Concomitant
Rectal Haemorrhage Hospitalization 4/19/2006 67 Male 180 lb 5/1/2009 United States
Primary
Concomitant
Vomiting Required Intervention 5/9/2009 82 Male 227 lb 6/9/2009 Pharmacist United States
Primary
Concomitant
Renal Function Test Abnormal Disability 1/1/2006 Male 7/6/2009 Consumer United States
Primary
Concomitant
Cardiac Failure Congestive Life Threatening 5/11/2009 Male 203 lb 7/15/2009 Canada
Primary
Secondary
Concomitant
Fluid Retention Hospitalization 7/11/2009 Female 7/22/2009 Consumer United States
Primary
Concomitant
Unevaluable Event Hospitalization 7/1/2007 48 Male 7/28/2009 Consumer United States
Primary
Concomitant
Pain In Extremity 6/1/2009 89 Male 174 lb 8/7/2009 Consumer United States
Primary
Concomitant
Wheezing Death 52 Female 8/4/2009 Lawyer United States
Primary
Concomitant
Wound Secretion Other Serious 10/26/2004 75 Male 180 lb 8/14/2009 Other Health Professional United States
Primary
Secondary
Concomitant
Unevaluable Event Death Female 8/20/2009 United States
Primary
Concomitant
Death Death Female 279 lb 9/2/2009 Consumer United States
Primary
Concomitant
Vomiting Hospitalization 7/1/2007 48 Male 456 lb 9/1/2009 United States
Primary
Concomitant
Unevaluable Event Hospitalization 47 Male 9/2/2009 United States
Primary
Concomitant
Weight Increased Hospitalization 46 Male 9/2/2009 United States
Primary
Concomitant
Renal Failure Hospitalization Female 241 lb 9/23/2009 Physician United States
Primary
Concomitant
Rectal Haemorrhage Required Intervention 4/24/2009 53 Female 226 lb 6/1/2009 United States
Primary
Concomitant
Retroperitoneal Haematoma Required Intervention 11/8/2008 72 Female 234 lb 11/21/2008 Pharmacist United States
Primary
Secondary
Concomitant
Rash Generalised Other Serious 7/29/2009 58 Male 254 lb 8/4/2009 Physician United States
Primary
Concomitant
Weight Increased Hospitalization 7/1/2007 48 Male 456 lb 9/23/2009 United States
Primary
Concomitant
Urinary Tract Infection Other Serious 4/23/2007 54 Female 258 lb 9/24/2009 United States
Primary
Concomitant
Weight Increased Hospitalization 46 Male 9/22/2009 United States
Primary
Concomitant
Wheezing Hospitalization 61 Female 9/25/2009 United States
Primary
Concomitant
Renal Failure Acute Hospitalization 88 Male 179 lb Pharmacist United States
Primary
Concomitant
Weight Increased Hospitalization 7/1/2007 48 Male 456 lb 10/10/2009 United States
Primary
Concomitant
Weight Decreased Hospitalization 46 Male 10/10/2009 United States
Primary
Concomitant
Ventricular Tachycardia Other Serious Male 10/19/2009 United States
Primary
Concomitant
Weight Increased Hospitalization 7/1/2007 48 Male 456 lb 10/16/2009 Lawyer United States
Primary
Concomitant
Pneumonia Hospitalization Female 10/18/2009 United States
Primary
Concomitant
Ventricular Tachycardia Hospitalization 7/1/2009 Male 214 lb 10/28/2009 Physician United States
Primary
Concomitant
Weight Fluctuation Hospitalization 46 Male 10/22/2009 Lawyer United States
Primary
Concomitant
Ventricular Tachycardia Other Serious 37 Male 10/26/2009 Lawyer United States
Primary
Concomitant
Pain In Extremity Hospitalization 47 Male 10/27/2009 United States
Primary
Concomitant
Ventricular Tachycardia Other Serious 37 Male 11/4/2009 Consumer United States
Primary
Concomitant
Weight Decreased Hospitalization 46 Male 11/3/2009 United States
Primary
Concomitant
Social Problem Hospitalization Female 11/3/2009 Lawyer United States
Primary
Concomitant
Feeling Hot 9/1/2009 345 lb 11/25/2009 United States
Primary
Concomitant
Waist Circumference Increased Hospitalization 72 Male 256 lb 11/16/2009 United States
Primary
Concomitant
Weight Decreased Hospitalization 46 Male 326 lb 11/16/2009 United States
Primary
Concomitant
Ventricular Tachycardia Other Serious 37 Male 11/16/2009 Lawyer United States
Primary
Concomitant
Weight Increased Hospitalization 4/23/2007 54 Female 258 lb 11/18/2009 United States
Primary
Concomitant
Vomiting Other Serious 82 Female 11/16/2009 United States
Primary
Concomitant
Ventricular Tachycardia Other Serious 37 Male 11/24/2009 Lawyer United States
Primary
Concomitant
Swelling Hospitalization 1/1/2007 Female 315 lb 12/1/2009 Physician United States
Primary
Concomitant
Social Avoidant Behaviour Death 6/1/2007 74 Male 12/1/2009 United States
Primary
Concomitant
Thrombocytopenia Hospitalization 72 Female 12/2/2009 United States
Primary
Concomitant
Therapeutic Agent Toxicity Other Serious 6/13/2006 89 Male 183 lb 12/17/2009 Other Health Professional France
Primary
Secondary
Concomitant

Drug Data