Metolazone combined with Spironolactone

Reports:


Reaction Outcome Event Date Age Sex Weight Reported Reporter Country Treatment
Role Name
Hypokalaemia Hospitalization 6/17/2005 Female 160 lb 10/14/2005 Pharmacist United States
Primary
Secondary
Concomitant
Pulmonary Oedema Other Serious 57 Female 3/1/2006 Other Health Professional United States
Primary
Secondary
Concomitant
Syncope Hospitalization 12/8/2004 48 Male 269 lb 11/21/2005 Physician United States
Primary
Secondary
Concomitant
Pneumonia Hospitalization 1/1/2005 Female 3/27/2006 Physician United States
Primary
Concomitant
Pulmonary Toxicity Required Intervention 4/26/2005 72 Male 175 lb 4/20/2006 Pharmacist United States
Primary
Concomitant
Vomiting Other Serious 4/1/2002 70 Male 4/27/2006 Canada
Primary
Secondary
Concomitant
Tearfulness Required Intervention 77 Female 7/26/2006 Physician United States
Primary
Concomitant
Oedema Peripheral Hospitalization 7/7/2006 59 Female 118 lb 7/21/2006 Physician Canada
Primary
Concomitant
Therapy Non-responder Other Serious 1/1/2006 77 Female 8/14/2006 Physician United States
Primary
Concomitant
Somnolence 47 Male 253 lb 7/24/2006 Other Health Professional United States
Primary
Concomitant
Oesophagitis Life Threatening 11/16/2005 88 Female 165 lb 9/14/2006 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Oesophagitis Life Threatening 11/16/2005 88 Female 165 lb 9/13/2006 United Kingdom
Primary
Secondary
Concomitant
Pharmaceutical Product Complaint Other Serious 9/30/2006 60 Female 10/9/2006 Consumer United States
Primary
Concomitant
Serotonin Syndrome Hospitalization 9/30/2005 66 Female 10/23/2006 Switzerland
Primary
Concomitant
Serotonin Syndrome Hospitalization 9/30/2005 66 Female 10/23/2006 Switzerland
Primary
Concomitant
Weight Decreased Hospitalization 10/1/2005 52 Male 11/13/2006 Consumer United States
Primary
Concomitant
Paraesthesia Other Serious Male 345 lb 11/27/2006 United States
Primary
Secondary
Concomitant
Weight Increased Other Serious Male 345 lb 12/22/2006 Physician United States
Primary
Secondary
Concomitant
Pharmaceutical Product Complaint Other Serious 9/30/2006 60 Female 1/8/2007 Consumer United States
Primary
Concomitant
Rectal Haemorrhage Required Intervention 7/11/2006 74 Female 177 lb 7/15/2006 Pharmacist United States
Primary
Concomitant
Delusion Of Replacement Hospitalization 1/1/2006 77 Female 10/8/2006 Physician United States
Primary
Concomitant
Dry Throat 59 Female 205 lb 10/24/2006 Qatar
Primary
Concomitant
Delusion Of Replacement Hospitalization 1/1/2006 77 Female 10/8/2006 Physician United States
Primary
Concomitant
Blood Glucose Increased Other Serious 1/19/2007 Female 138 lb 1/31/2007 Consumer United States
Primary
Concomitant
Frequent Bowel Movements Other Serious 73 Female 137 lb 8/19/2005 Physician United States
Primary
Concomitant
Hypotension Hospitalization 10/27/2006 64 Male 2/16/2007 Pharmacist United States
Primary
Secondary
Concomitant
Pharmaceutical Product Complaint 2/1/2007 45 Female 134 lb 2/23/2007 Other Health Professional United States
Primary
Concomitant
Hypomagnesaemia Hospitalization 1/3/2007 48 Female 2/28/2007 Physician United States
Primary
Concomitant
Pharmaceutical Product Complaint Other Serious 2/3/2007 45 Female 134 lb 3/2/2007 Consumer United States
Primary
Concomitant
White Blood Cell Count Decreased Other Serious 4/9/2006 66 Male 3/10/2007 Physician Canada
Primary
Secondary
Concomitant
Pharmaceutical Product Complaint Other Serious 2/3/2007 45 Female 134 lb 3/12/2007 Consumer United States
Primary
Concomitant
Delusion Of Replacement Death 77 Female 3/23/2007
Primary
Secondary
Concomitant
Pharmaceutical Product Complaint Other Serious 2/6/2007 45 Female 134 lb 3/28/2007 Consumer United States
Primary
Concomitant
Palpitations 37 Female 224 lb 1/23/2007 Consumer United States
Primary
Concomitant
Rash Other Serious Female 200 lb 4/27/2007 Physician United States
Primary
Concomitant
Interacting
Myocardial Infarction Other Serious 3/1/2007 56 Female 207 lb 5/7/2007 United States
Primary
Concomitant
Loss Of Consciousness Disability 4/14/2007 59 Male 243 lb 7/30/2007 Pharmacist United States
Primary
Concomitant
Fatigue Other Serious 7/8/2007 Male 8/24/2007 Pharmacist United States
Primary
Concomitant
Weight Increased 9/1/2006 39 Male 11/14/2007 Consumer United States
Primary
Secondary
Concomitant
Sneezing Hospitalization 7/12/2007 Female 208 lb 11/5/2007 Physician United States
Primary
Secondary
Concomitant
Sneezing Hospitalization 7/12/2007 Female 208 lb 11/5/2007 Physician United States
Primary
Secondary
Concomitant
Fall Other Serious 5/1/2007 Female 219 lb 12/11/2007 United States
Primary
Secondary
Concomitant
Nausea Other Serious 10/1/2007 90 Female 134 lb 1/15/2008 Physician United States
Primary
Concomitant
Death Death 12/16/2007 Male 1/29/2008 Physician United States
Primary
Concomitant
Epistaxis Other Serious 8/1/2005 80 Female 180 lb 11/29/2007 Consumer United States
Primary
Concomitant
Vomiting Hospitalization 10/4/2007 44 Female 2/15/2008 Physician United States
Primary
Concomitant
Vomiting Hospitalization 10/4/2007 44 Female 3/5/2008 Physician United States
Primary
Concomitant
Ventricular Tachycardia Other Serious 4/16/2004 57 Female 194 lb 5/2/2007 United States
Primary
Concomitant
Vomiting Hospitalization 10/4/2007 44 Female 3/28/2008 Physician United States
Primary
Concomitant
Orthostatic Hypotension Hospitalization 1/17/2007 Female 182 lb 4/10/2008 United States
Primary
Concomitant
Peritonitis Hospitalization 3/15/2008 71 Male 201 lb 4/10/2008 Physician United States
Primary
Concomitant
Renal Failure Hospitalization 10/10/2007 Female 250 lb 4/30/2008 Physician United States
Primary
Concomitant
Loss Of Consciousness Hospitalization 4/10/2008 Female 5/12/2008 Pharmacist United States
Primary
Secondary
Concomitant
Renal Failure Acute Hospitalization 9/1/2007 84 Male 5/10/2008 Pharmacist United States
Primary
Secondary
Visual Disturbance Hospitalization 5/27/2008 Consumer United States
Primary
Concomitant
Swelling Hospitalization 3/1/2008 74 Female 180 lb 5/27/2008 United States
Primary
Concomitant
Vomiting Death 3/17/2008 70 Male 5/28/2008 United States
Primary
Concomitant
Myocardial Infarction Hospitalization 12/17/2005 66 Male 227 lb 6/20/2008 Consumer United States
Primary
Concomitant
Visual Brightness Hospitalization 42 Male 275 lb 6/19/2008 United States
Primary
Concomitant
Sepsis Hospitalization 1/29/2008 74 Male 6/13/2008 Physician Canada
Primary
Concomitant
Wheezing Other Serious 1/1/2005 Male 7/1/2008 Physician United States
Primary
Concomitant
Visual Impairment Hospitalization 3/18/2008 7/8/2008 Consumer United States
Primary
Concomitant
Sleep Apnoea Syndrome Other Serious 5/16/2008 7/23/2008 Consumer United States
Primary
Secondary
Concomitant
Clostridium Difficile Colitis Other Serious 6/27/2008 Female 175 lb 8/4/2008 Physician United States
Primary
Concomitant
Dry Mouth Disability 8/5/2008 Female 8/21/2008 Consumer United States
Primary
Concomitant
Myocardial Infarction Hospitalization 12/17/2005 66 Male 227 lb 8/27/2008 Consumer United States
Primary
Concomitant
Muscle Disorder Other Serious 1/1/2004 60 Female 8/27/2008 Physician United States
Primary
Secondary
Concomitant
Renal Failure Acute Required Intervention 6/17/2008 59 Male 8/27/2008 Physician United States
Primary
Concomitant
Tremor Hospitalization 7/11/2008 Female 170 lb 9/12/2008 Consumer United States
Primary
Concomitant
Renal Failure Acute Hospitalization 6/21/2008 58 Male 7/21/2008 Pharmacist United States
Primary
Secondary
Withdrawal Syndrome Other Serious 10/19/2007 65 Female 240 lb 10/7/2008 Pharmacist United States
Primary
Secondary
Concomitant
Therapeutic Response Decreased Other Serious 9/8/2008 Male 10/9/2008 Other Health Professional United States
Primary
Secondary
Concomitant
Right Ventricular Failure Other Serious Female 150 lb 10/14/2008 Physician United States
Primary
Concomitant
Pulmonary Embolism Other Serious 1/1/2007 57 Male 8/24/2007 Pharmacist United States
Primary
Secondary
Concomitant
Tremor Hospitalization 7/11/2008 Female 170 lb 11/10/2008 Consumer United States
Primary
Concomitant
Weight Decreased Other Serious 7/17/2008 58 Male 210 lb 11/7/2008 Physician United States
Primary
Concomitant
Swelling 78 Female 11/13/2008 Consumer United States
Primary
Concomitant
Anaphylactic Reaction Life Threatening 2/14/2008 Female 326 lb 10/27/2008 Physician United States
Primary
Concomitant
Sleep Apnoea Syndrome Other Serious 5/16/2008 11/21/2008 Consumer United States
Primary
Secondary
Concomitant
Renal Failure Acute Hospitalization 59 Female 11/26/2008 Pharmacist United States
Primary
Concomitant
Death Death Male 225 lb 12/23/2008 Consumer United States
Primary
Concomitant
Cardio-respiratory Arrest Death Male 225 lb 1/6/2009 Physician United States
Primary
Concomitant
Renal Failure Acute Hospitalization 59 Female 216 lb 1/12/2009
Primary
Secondary
Concomitant
Flushing Hospitalization 1/1/2006 Female 123 lb 1/28/2009 Physician United States
Primary
Concomitant
Weight Increased Other Serious 1/1/2008 Female 329 lb 2/2/2009 Consumer United States
Primary
Concomitant
Renal Failure Acute Required Intervention 6/17/2008 59 Male 2/4/2009 Physician United States
Primary
Concomitant
Liver Function Test Abnormal 12/5/2008 Male 2/24/2009 United States
Primary
Concomitant
Chest Pain Hospitalization Female 195 lb 3/3/2009 Other Health Professional United States
Primary
Concomitant
Death Death 1/8/2009 Male 162 lb 3/4/2009 Consumer United States
Primary
Concomitant
Drug Ineffective 1/1/2008 74 Female 3/4/2009 Consumer United States
Primary
Concomitant
Pleural Effusion Hospitalization Female 195 lb 3/5/2009 Physician United States
Primary
Concomitant
Scab Hospitalization 66 Male 2/28/2009 United States
Primary
Concomitant
Death Death 2/22/2009 Female 162 lb 3/5/2009 Consumer United States
Primary
Concomitant
Sudden Death Death 1/6/2009 Male 220 lb 3/6/2009 United States
Primary
Concomitant
Blood Glucose Increased 10/14/2008 75 Male 234 lb 2/3/2009 Physician United States
Primary
Concomitant
Pulmonary Hypertension Death Female 195 lb 4/8/2009 Physician United States
Primary
Concomitant
Xanthopsia Hospitalization 73 Female 166 lb 4/7/2009 United States
Primary
Concomitant
Renal Failure Hospitalization 66 Male 4/7/2009 United States
Primary
Concomitant
Pulmonary Embolism Other Serious 11/1/1995 Female 134 lb 4/27/2009 Lawyer United States
Primary
Secondary
Concomitant
Weight Increased Hospitalization 4/28/2008 66 Male 5/1/2009 United States
Primary
Concomitant
Azotaemia Hospitalization 66 Male 5/11/2009 Other Health Professional Denmark
Primary
Secondary
Renal Disorder Hospitalization 3/1/2007 66 Male 5/15/2009 Consumer Denmark
Primary
Secondary
Hypotension Hospitalization 66 Male 5/18/2009 Physician Denmark
Primary
Secondary
Laboratory Test Abnormal Other Serious 9/1/2006 66 Male 5/29/2009
Primary
Secondary
Weight Decreased Hospitalization 4/28/2008 65 Male 5/24/2009 United States
Primary
Concomitant
Unevaluable Event Death 71 Male 5/28/2009 United States
Primary
Concomitant
Weight Increased Hospitalization 4/28/2008 65 Male 6/5/2009 United States
Primary
Concomitant
Muscle Spasms 85 Female 6/19/2009 Consumer United States
Primary
Concomitant
Vomiting Hospitalization 10/4/2007 44 Female 6/26/2009 Pharmacist United States
Primary
Concomitant
Vertigo Hospitalization 4/28/2008 65 Male 7/1/2009 Lawyer United States
Primary
Concomitant
Renal Function Test Abnormal Disability 1/1/2006 Male 7/6/2009 Consumer United States
Primary
Concomitant
Cardiac Failure Congestive Life Threatening 6/24/2009 58 Female 7/10/2009 Consumer United States
Primary
Secondary
Concomitant
Therapeutic Agent Toxicity Hospitalization 5/11/2009 74 Male 7/7/2009 Pharmacist United States
Primary
Concomitant
Renal Disorder Hospitalization 4/28/2008 65 Male 7/7/2009 United States
Primary
Concomitant
Surgery Death 73 Female 7/13/2009 United States
Primary
Concomitant
Urticaria 1/29/2009 61 Male 320 lb 7/24/2009 Other Health Professional United States
Primary
Concomitant
Weight Decreased Other Serious 76 Male 7/22/2009 Lawyer United States
Primary
Concomitant
Unevaluable Event Hospitalization 71 Female 7/22/2009 United States
Primary
Concomitant
Death Death 7/16/2009 Male 312 lb 8/6/2009 Consumer United States
Primary
Concomitant
Type 2 Diabetes Mellitus Death 60 Male 8/3/2009 United States
Primary
Concomitant
Weight Increased Hospitalization 9/28/2005 71 Female 8/5/2009 United States
Primary
Concomitant
Weight Decreased Hospitalization 10/25/2007 73 Male 229 lb 8/4/2009 United States
Primary
Concomitant
Unevaluable Event Hospitalization 47 Male 8/11/2009 United States
Primary
Concomitant
Wheezing Hospitalization 9/28/2005 71 Female 8/11/2009 United States
Primary
Concomitant
Vomiting Hospitalization 7/1/2007 48 Male 8/12/2009 United States
Primary
Concomitant
Weight Increased Other Serious 7/22/2008 69 Male 8/27/2009 Physician United States
Primary
Secondary
Concomitant
Renal Failure Death Male 312 lb 8/31/2009 Physician United States
Primary
Concomitant
Weight Decreased Death 73 Female 8/28/2009 United States
Primary
Concomitant
Unevaluable Event Death 71 Male 8/23/2009 United States
Primary
Concomitant
Vomiting Hospitalization 7/1/2007 48 Male 456 lb 9/1/2009 United States
Primary
Concomitant
Weight Decreased Other Serious 76 Male 9/1/2009 Lawyer United States
Primary
Concomitant
Unevaluable Event Hospitalization 47 Male 9/2/2009 United States
Primary
Concomitant
Weight Increased Hospitalization 46 Male 9/2/2009 United States
Primary
Concomitant
Vomiting Hospitalization 7/1/2007 48 Male 456 lb 9/4/2009 United States
Primary
Concomitant
Wheezing Death 60 Male 9/4/2009 United States
Primary
Concomitant
Surgery Hospitalization 47 Male 9/3/2009 United States
Primary
Concomitant
Multiple Injuries Hospitalization 46 Male 9/3/2009 Lawyer United States
Primary
Concomitant
Wheezing Hospitalization 9/28/2005 71 Female 9/8/2009 United States
Primary
Concomitant
Weight Decreased Hospitalization 64 Male 9/15/2009 United States
Primary
Concomitant
Renal Failure Hospitalization Female 9/16/2009 United States
Primary
Concomitant
Oesophagitis Life Threatening 11/16/2005 88 Female 9/16/2009 United Kingdom
Primary
Concomitant
Weight Increased Hospitalization 46 Male 9/18/2009 Consumer United States
Primary
Concomitant
Weight Increased Hospitalization 7/1/2007 48 Male 456 lb 9/17/2009 Consumer United States
Primary
Concomitant
Treatment Noncompliance Hospitalization 54 Male 281 lb 9/22/2009 United States
Primary
Concomitant
Weight Increased Hospitalization 7/1/2007 48 Male 456 lb 9/23/2009 United States
Primary
Concomitant
Wound Infection Death 56 Male 325 lb 9/22/2009 United States
Primary
Concomitant
Weight Decreased Hospitalization 10/25/2007 68 Male 229 lb 9/24/2009 United States
Primary
Concomitant
Weight Increased Hospitalization 46 Male 9/22/2009 United States
Primary
Concomitant
Weight Increased Hospitalization 50 Male 354 lb 9/22/2009 United States
Primary
Concomitant
Wound Infection Hospitalization 29 Female 276 lb 9/29/2009 United States
Primary
Concomitant