Metolazone combined with Simvastatin

Reports:

Reaction Outcome Event Date Age Sex Weight Reported Reporter Country Treatment
Role Name
Pulmonary Toxicity Required Intervention 4/26/2005 72 Male 175 lb 4/20/2006 Pharmacist United States
Primary
Concomitant
Fall Hospitalization 2/21/2006 74 Male 5/8/2006 United States
Primary
Secondary
Concomitant
Blood Potassium Increased Hospitalization 6/19/2006 67 Male 7/7/2006 Pharmacist United States
Primary
Concomitant
Therapeutic Agent Toxicity Other Serious 6/13/2006 89 Male 183 lb 11/8/2006 Other Health Professional France
Primary
Secondary
Concomitant
Milk-alkali Syndrome Hospitalization 37 Female 11/29/2006
Primary
Secondary
Concomitant
Therapeutic Agent Toxicity Other Serious 6/13/2006 89 Male 183 lb 12/18/2006 Other Health Professional France
Primary
Secondary
Concomitant
Upper Gastrointestinal Haemorrhage Hospitalization 12/6/2006 58 Male 182 lb 12/18/2006 Pharmacist United States
Primary
Secondary
Concomitant
Urine Output Increased Other Serious 6/13/2006 89 Male 183 lb 12/27/2006 Other Health Professional France
Primary
Secondary
Concomitant
Milk-alkali Syndrome Hospitalization 37 Female 12/28/2006
Primary
Secondary
Concomitant
Rectal Haemorrhage Required Intervention 7/11/2006 74 Female 177 lb 7/15/2006 Pharmacist United States
Primary
Concomitant
Drug Toxicity Hospitalization 2/3/2007 53 Male 173 lb 2/12/2007 Pharmacist United States
Primary
Concomitant
Waist Circumference Increased Other Serious 47 Female 162 lb 2/22/2007 Pharmacist United States
Primary
Concomitant
Incorrect Dose Administered Hospitalization 9/28/2006 40 Female 3/30/2007 Other Health Professional Switzerland
Primary
Secondary
Concomitant
Incorrect Dose Administered Hospitalization 9/28/2006 40 Female 4/2/2007 Other Health Professional Switzerland
Primary
Secondary
Concomitant
Middle Insomnia 1/1/2006 82 Female 126 lb 1/12/2007 Consumer United States
Primary
Concomitant
Shock Life Threatening 12/8/2006 Male 317 lb 4/20/2007 Pharmacist United States
Primary
Concomitant
Tetany Other Serious 37 Female 4/26/2007 Other Health Professional United States
Primary
Concomitant
Tetany Other Serious 37 Female 4/26/2007 Other Health Professional United States
Primary
Concomitant
Therapeutic Agent Toxicity Other Serious 6/13/2006 89 Male 183 lb 4/30/2007 Other Health Professional France
Primary
Secondary
Concomitant
Therapeutic Agent Toxicity Other Serious 6/13/2006 89 Male 183 lb 5/11/2007 Other Health Professional France
Primary
Secondary
Concomitant
Rhabdomyolysis Other Serious 12/26/2006 76 Male 218 lb 7/12/2007 Physician United States
Primary
Concomitant
Thrombocytopenia Hospitalization 7/3/2007 Male 7/16/2007 Pharmacist United States
Primary
Concomitant
Rash 81 Male 249 lb 9/20/2007 Consumer United States
Primary
Concomitant
Weight Increased Hospitalization 1/1/2007 77 Male 10/25/2007 United States
Primary
Secondary
Concomitant
Myoclonus Required Intervention 1/29/2006 65 Male 12/11/2007 Pharmacist United States
Primary
Secondary
Concomitant
Myoclonus Hospitalization 1/29/2006 65 Male 12/18/2007 Other Health Professional France
Primary
Concomitant
Interacting
Pharmaceutical Product Complaint Other Serious 12/27/2007 81 Female 1/28/2008 Portugal
Primary
Concomitant
Medication Error Other Serious 12/27/2007 81 Female 3/5/2008 Portugal
Primary
Concomitant
Ventricular Tachycardia Other Serious 4/16/2004 57 Female 194 lb 5/2/2007 United States
Primary
Concomitant
Orthostatic Hypotension Hospitalization 1/17/2007 Female 182 lb 4/10/2008 United States
Primary
Concomitant
Visual Brightness Hospitalization 42 Male 275 lb 6/19/2008 United States
Primary
Concomitant
Rhabdomyolysis Hospitalization 76 Male 7/3/2008 Physician United States
Primary
Secondary
Concomitant
Weight Decreased Required Intervention 10/15/2007 60 Male 153 lb 7/24/2008 United States
Primary
Concomitant
Cardiac Failure Congestive Hospitalization 56 Male 250 lb 9/19/2008 Lawyer United States
Primary
Concomitant
Therapeutic Response Decreased Other Serious 9/8/2008 Male 10/9/2008 Other Health Professional United States
Primary
Secondary
Concomitant
Thrombocytopenia Other Serious 53 Female 10/10/2008 United States
Primary
Concomitant
Rhabdomyolysis Hospitalization 76 Male 10/16/2008 Physician United States
Primary
Secondary
Concomitant
Thrombocytopenia Other Serious 53 Female 10/22/2008 Germany
Primary
Concomitant
Rhabdomyolysis Hospitalization 76 Male 11/18/2008 Physician United States
Primary
Secondary
Concomitant
Rhabdomyolysis Life Threatening 76 Male 11/13/2008 Physician United States
Primary
Secondary
Concomitant
International Normalised Ratio Increased Required Intervention 7/30/2008 66 Female 287 lb 8/4/2008 Pharmacist United States
Primary
Concomitant
Pruritus 7/31/2008 Male 11/26/2008 United States
Primary
Concomitant
Vomiting Other Serious 12/6/2008 54 Female 12/11/2008 Consumer United States
Primary
Concomitant
Neck Pain Other Serious 12/6/2008 54 Female 12/23/2008 Consumer United States
Primary
Concomitant
Ventricular Tachycardia Hospitalization 10/3/2008 72 Male 1/13/2009 Physician Switzerland
Primary
Secondary
Concomitant
Ventricular Tachycardia Hospitalization 10/3/2008 72 Male 1/13/2009 Physician Switzerland
Primary
Secondary
Concomitant
Liver Function Test Abnormal 12/5/2008 Male 2/24/2009 United States
Primary
Concomitant
Transient Ischaemic Attack Hospitalization 3/1/2009 78 Male 5/4/2009 Other Health Professional United States
Primary
Concomitant
Rhabdomyolysis Hospitalization 4/1/2009 81 Male 5/12/2009 Physician United States
Primary
Concomitant
Unevaluable Event Death 71 Male 5/28/2009 United States
Primary
Concomitant
Vomiting Required Intervention 5/9/2009 82 Male 227 lb 6/9/2009 Pharmacist United States
Primary
Concomitant
Renal Failure Chronic Hospitalization Male 217 lb 6/30/2009 Physician United States
Primary
Concomitant
Renal Failure Acute Life Threatening 4/6/2009 85 Male 326 lb 7/1/2009 Other Health Professional United States
Primary
Concomitant
Unevaluable Event Hospitalization 71 Female 7/22/2009 United States
Primary
Concomitant
Type 2 Diabetes Mellitus Death 60 Male 8/3/2009 United States
Primary
Concomitant
Weight Increased Hospitalization 9/28/2005 71 Female 8/5/2009 United States
Primary
Concomitant
Wheezing Hospitalization 9/28/2005 71 Female 8/11/2009 United States
Primary
Concomitant
Nausea Male 175 lb 8/23/2009 United States
Primary
Concomitant
Unevaluable Event Death Female 8/20/2009 United States
Primary
Concomitant
Vomiting Hospitalization 62 Female 8/25/2009 Lawyer United States
Primary
Concomitant
Weight Decreased Death 73 Female 8/28/2009 United States
Primary
Concomitant
Unevaluable Event Death 71 Male 8/23/2009 United States
Primary
Concomitant
Wheezing Death 60 Male 9/4/2009 United States
Primary
Concomitant
Upper Gastrointestinal Haemorrhage Hospitalization 50 Male 9/4/2009 United States
Primary
Concomitant
Wheezing Hospitalization 9/28/2005 71 Female 9/8/2009 United States
Primary
Concomitant
Injury Death 64 Female 9/10/2009 Lawyer United States
Primary
Concomitant
Upper Gastrointestinal Haemorrhage Hospitalization 50 Male 9/10/2009 United States
Primary
Concomitant
Weight Decreased Hospitalization 64 Male 9/15/2009 United States
Primary
Concomitant
Vomiting Hospitalization 56 Female 9/17/2009 United States
Primary
Concomitant
Shock Other Serious 12/1/2007 71 Male 9/30/2009 Other Health Professional United States
Primary
Concomitant
Treatment Noncompliance Hospitalization 54 Male 281 lb 9/22/2009 United States
Primary
Concomitant
Vomiting Hospitalization 53 Female 9/24/2009 United States
Primary
Concomitant
Wound Infection Death 56 Male 325 lb 9/22/2009 United States
Primary
Concomitant
Urinary Tract Infection Other Serious 4/23/2007 54 Female 258 lb 9/24/2009 United States
Primary
Concomitant
Sudden Cardiac Death Death 9/4/2009 42 Male 9/29/2009 Other Health Professional United States
Primary
Concomitant
Weight Increased Hospitalization 50 Male 354 lb 9/22/2009 United States
Primary
Concomitant
Wound Infection Hospitalization 56 Male 325 lb 10/9/2009 United States
Primary
Concomitant
Sudden Death Death 9/4/2009 42 Male 10/14/2009 Other Health Professional United States
Primary
Concomitant
Vomiting Other Serious 1/1/1999 Male 10/15/2009 Consumer United States
Primary
Concomitant
Pneumonia Hospitalization Female 10/18/2009 United States
Primary
Concomitant
Weight Decreased Hospitalization 8/17/2009 Male 130 lb 8/27/2009 Pharmacist United States
Primary
Secondary
Concomitant
Wound Infection Hospitalization 56 Male 325 lb 10/27/2009 United States
Primary
Concomitant
Therapeutic Agent Toxicity Hospitalization 84 Female 10/26/2009 Lawyer United States
Primary
Concomitant
Renal Failure Chronic Hospitalization 64 Male 11/9/2009 United States
Primary
Concomitant
Vomiting Hospitalization 53 Female 11/4/2009 United States
Primary
Concomitant
Therapeutic Agent Toxicity Hospitalization 84 Female 11/9/2009 Lawyer United States
Primary
Concomitant
Weight Decreased Death 73 Female 11/5/2009 United States
Primary
Concomitant
Wound Infection Hospitalization 56 Male 325 lb 11/4/2009 United States
Primary
Concomitant
Social Problem Hospitalization Female 11/3/2009 Lawyer United States
Primary
Concomitant
Wound Infection Hospitalization 56 Male 325 lb 11/17/2009 United States
Primary
Concomitant
X-ray Limb Abnormal Other Serious 72 Male 11/16/2009 United States
Primary
Concomitant
Weight Decreased Hospitalization 64 Male 11/18/2009 United States
Primary
Concomitant
Upper Gastrointestinal Haemorrhage Hospitalization 50 Male 11/18/2009 United States
Primary
Concomitant
Weight Increased Hospitalization 4/23/2007 54 Female 258 lb 11/18/2009 United States
Primary
Concomitant
Weight Increased Hospitalization 9/28/2005 70 Female 11/18/2009 United States
Primary
Concomitant
Thrombocytopenia Hospitalization 72 Female 12/2/2009 United States
Primary
Concomitant
Peritonitis Bacterial Other Serious 11/1/2008 70 Male 11/3/2009 Other Health Professional United States
Primary
Secondary
Concomitant
Peritonitis Bacterial Hospitalization 3/1/2008 69 Male 11/3/2009 Other Health Professional United States
Primary
Secondary
Concomitant
Death Death 12/10/2009 Female 139 lb 12/15/2009 Other Health Professional United States
Primary
Concomitant
Therapeutic Agent Toxicity Other Serious 6/13/2006 89 Male 183 lb 12/17/2009 Other Health Professional France
Primary
Secondary
Concomitant
Unevaluable Event Hospitalization 72 Female 12/10/2009 United States
Primary
Concomitant
Weight Increased Hospitalization 53 Female 12/10/2009 United States
Primary
Concomitant
Pulmonary Hypertension Death Female 139 lb 12/18/2009 Physician United States
Primary
Concomitant
Shock Other Serious 12/1/2007 71 Male 322 lb 12/31/2009 Other Health Professional United States
Primary
Secondary
Concomitant
Dizziness 8/29/2009 46 Female 1/8/2010 Consumer United States
Primary
Secondary
Concomitant
Weight Decreased Hospitalization 64 Male 12/28/2009 United States
Primary
Concomitant
Weight Increased Hospitalization 2/27/2003 78 Male 183 lb 1/20/2010 Other Health Professional United States
Primary
Concomitant
Ventricular Tachycardia Death 60 Male 200 lb 1/11/2010 United States
Primary
Concomitant
Weight Decreased Other Serious 72 Male 201 lb 1/11/2010 United States
Primary
Concomitant
Weight Decreased 64 Female 1/7/2010 United States
Primary
Concomitant
Weight Decreased Other Serious 72 Male 201 lb 1/20/2010 United States
Primary
Concomitant
Weight Decreased 64 Female 1/21/2010 United States
Primary
Concomitant
Ventricular Tachycardia Death 60 Male 200 lb 1/22/2010 United States
Primary
Concomitant
Syncope Hospitalization Female 220 lb 2/19/2010 Consumer United States
Primary
Concomitant
Syncope Hospitalization Female 220 lb 3/4/2010 Physician United States
Primary
Concomitant
Tongue Neoplasm Malignant Stage Unspecified Other Serious 2/1/2010 74 Female 3/8/2010 Pharmacist United States
Primary
Concomitant
Weight Decreased Hospitalization 64 Male 3/31/2010 Lawyer United States
Primary
Concomitant
Weight Increased Hospitalization 53 Female 4/15/2010 United States
Primary
Concomitant
Tongue Neoplasm Malignant Stage Unspecified Other Serious 2/1/2010 74 Female 4/29/2010 Pharmacist United States
Primary
Concomitant
Dyspnoea 1/1/2010 66 Male 4/29/2010 Consumer
Primary
Concomitant
Ventricular Tachycardia Other Serious 9/1/2007 77 Male 183 lb 5/3/2010 Other Health Professional United States
Primary
Secondary
Concomitant
Skin Cancer Other Serious 4/18/2010 87 Female 170 lb 5/6/2010 United States
Primary
Concomitant
Pain Hospitalization Female 5/10/2010 Consumer United States
Primary
Concomitant
Vomiting Other Serious 4/8/2008 68 Male 5/14/2010 Lawyer United States
Primary
Concomitant
Prostate Cancer Other Serious 1/12/2010 71 Male 5/20/2010 Other Health Professional United States
Primary
Secondary
Concomitant
Urinary Tract Infection Hospitalization 71 Female 5/18/2010 Lawyer United States
Primary
Concomitant
Neuroendocrine Carcinoma Of The Skin Other Serious 4/18/2010 87 Female 170 lb 5/24/2010 United States
Primary
Concomitant
Death Death 4/29/2010 79 Male 6/9/2010 Consumer United States
Primary
Concomitant
Skin Ulcer Hospitalization 6/7/2010 70 Male 250 lb 6/14/2010 Pharmacist United States
Primary
Secondary
Concomitant
Overdose Hospitalization 6/11/2010 Male 6/23/2010 Consumer United States
Primary
Concomitant
Urinary Tract Infection Other Serious 80 Female 6/30/2010 United States
Primary
Concomitant
Splenomegaly Hospitalization 1/1/2010 67 Female 294 lb 7/13/2010 Physician United States
Primary
Concomitant
Respiratory Failure Death 4/29/2010 79 Male 7/20/2010 Other Health Professional United States
Primary
Concomitant
Viith Nerve Paralysis Other Serious 9/1/2007 77 Male 183 lb 7/21/2010 Other Health Professional United States
Primary
Secondary
Concomitant
Skin Burning Sensation Other Serious 4/1/2010 87 Female 170 lb 8/4/2010 Consumer United States
Primary
Concomitant
Rhabdomyolysis Life Threatening 6/29/2010 67 Male 8/13/2010 Physician Switzerland
Primary
Concomitant
Interacting
Sudden Death Death 9/4/2009 42 Male 8/13/2010 Other Health Professional United States
Primary
Concomitant
Weight Decreased Other Serious 49 Male 8/10/2010 United States
Primary
Concomitant
Pruritus 6/1/2009 63 Male 360 lb 8/28/2010 Consumer United States
Primary
Concomitant
Blood Glucose Increased Male 250 lb 8/29/2010 Consumer United States
Primary
Concomitant
Skin Warm 6/1/2010 60 Female 175 lb 8/29/2010 Consumer United States
Primary
Concomitant
Ischaemic Cardiomyopathy Death 7/28/2010 64 Male 205 lb 8/30/2010 Physician United States
Primary
Concomitant
Weight Decreased Other Serious 77 Male 201 lb 8/27/2010 United States
Primary
Concomitant
Type 2 Diabetes Mellitus Death 7/15/2010 59 Male 202 lb 8/30/2010 Physician United States
Primary
Concomitant
Vision Blurred 11/1/2009 87 Male 125 lb 9/14/2010 Consumer United States
Primary
Concomitant
Urinary Tract Infection Hospitalization 71 Female 9/10/2010 United States
Primary
Secondary
Concomitant
Urinary Bladder Polyp Other Serious 1/12/2010 71 Male 9/15/2010 United States
Primary
Secondary
Concomitant
Unresponsive To Stimuli Other Serious 3/1/2008 78 Female 9/22/2010 Other Health Professional United States
Primary
Secondary
Concomitant
Weight Increased Other Serious 34 Female 9/16/2010 United States
Primary
Concomitant
Upper Limb Fracture Hospitalization 65 Female 9/17/2010 Other Health Professional United States
Primary
Concomitant

Drug Data