Methylprednisolone combined with Voriconazole

Reports:

Reaction Outcome Event Date Age Sex Weight Reported Reporter Country Treatment
Role Name
International Normalised Ratio Increased 6/30/2004 53 9/12/2005 Pharmacist United States
Primary
Concomitant
Thrombocytopenia Required Intervention 1/6/2006 41 Female 152 lb 1/20/2006 Other Health Professional United States
Primary
Concomitant
Sepsis Syndrome Required Intervention 11/1/2005 23 Female 139 lb 12/5/2005 United States
Primary
Concomitant
Platelet Count Decreased Hospitalization 10/30/2004 29 Female 121 lb 2/18/2006 Other Health Professional United States
Primary
Concomitant
Lymphocyte Count Decreased Hospitalization 10/30/2004 29 Female 121 lb 4/1/2006 United States
Primary
Concomitant
White Blood Cell Count Decreased Other Serious 4/3/2006 37 Male 4/22/2006 United States
Primary
Secondary
Concomitant
Vomiting Hospitalization 4/8/2006 12 Female 62 lb 6/13/2006 Consumer United States
Primary
Concomitant
Vomiting Death 6/20/2006 Male 125 lb 6/20/2006 Other Health Professional United States
Primary
Secondary
Concomitant
Renal Failure Acute Other Serious 9/11/2007 58 Male 176 lb 9/20/2007 Pharmacist United States
Primary
Concomitant
Renal Failure Acute Other Serious 28 Male 10/17/2007
Primary
Secondary
Concomitant
Pleural Effusion Required Intervention 6/25/2007 44 Female 86 lb 7/30/2007 United States
Primary
Concomitant
Neuropathy Other Serious 52 Male 11/12/2007 Physician Belgium
Primary
Concomitant
Ureaplasma Infection Other Serious 28 Male 11/5/2007 Switzerland
Primary
Secondary
Concomitant
Staphylococcal Bacteraemia Life Threatening 10/7/2007 14 Male 203 lb 11/8/2007 Physician United States
Primary
Secondary
Concomitant
Neuropathy Other Serious 52 Male 11/19/2007 Physician Belgium
Primary
Concomitant
Tachycardia Life Threatening 9/28/2007 21 Female 150 lb 11/21/2007 Consumer United States
Primary
Secondary
Concomitant
Pseudomonas Infection Required Intervention 9/27/2007 39 Male 154 lb 11/1/2007 Pharmacist United States
Primary
Concomitant
Unresponsive To Stimuli Life Threatening 9/28/2007 21 Female 150 lb 12/3/2007 Physician United States
Primary
Secondary
Concomitant
Respiratory Failure Other Serious 15 Male 3/12/2008 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Respiratory Failure Other Serious 15 Male 3/28/2008 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Venoocclusive Liver Disease Other Serious 36 Female 3/28/2008 Other Health Professional United States
Primary
Secondary
Concomitant
Respiratory Distress Hospitalization 17 Male 3/28/2008 Consumer United States
Primary
Secondary
Concomitant
Pneumonia Other Serious 4/5/2008 53 Female 157 lb 6/12/2008 Other Health Professional United States
Primary
Secondary
Concomitant
Respiratory Failure Hospitalization 3/25/2007 Male 193 lb 7/14/2008 Physician United States
Primary
Secondary
Concomitant
Staphylococcal Infection Death 3/1/2007 59 Male 193 lb 7/10/2008 Other Health Professional United States
Primary
Secondary
Concomitant
Septic Shock Hospitalization 49 Male 203 lb 7/18/2008 Other Health Professional Switzerland
Primary
Secondary
Concomitant
Respiratory Failure Other Serious 15 Male 7/18/2008 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Respiratory Failure Other Serious 15 Male 7/21/2008 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Hepatic Function Abnormal Other Serious 3/22/2006 56 Male 128 lb 7/22/2008 Japan
Primary
Secondary
Concomitant
Hepatic Function Abnormal Other Serious 11/29/2005 56 Male 128 lb 7/28/2008 Japan
Primary
Secondary
Concomitant
Hepatic Function Abnormal Other Serious 12/1/2005 56 Male 128 lb 8/4/2008 Japan
Primary
Secondary
Concomitant
Acanthamoeba Infection Other Serious 53 Male 9/25/2008 United States
Primary
Concomitant
Mucosal Inflammation Hospitalization 12/9/2008 Male 96 lb 1/15/2009 Other Health Professional United States
Primary
Secondary
Concomitant
Leukoencephalopathy Other Serious 2/13/2007 45 5/26/2009 Physician France
Primary
Concomitant
Transplant Rejection Other Serious 2/13/2007 45 5/26/2009 Physician France
Primary
Concomitant
Visual Impairment Hospitalization 38 Female 5/21/2009 Physician United States
Primary
Secondary
Concomitant
Transplant Rejection Hospitalization 4/9/2009 Male 56 lb 5/27/2009 United States
Primary
Concomitant
Thrombotic Thrombocytopenic Purpura Other Serious 54 7/21/2009 Physician Korea, Republic Of
Primary
Concomitant
Sepsis Other Serious 3/6/2009 60 Male 128 lb 8/7/2009 Physician Japan
Primary
Secondary
Concomitant
Visual Impairment Other Serious 6/1/2006 38 Female 8/13/2009 Physician United States
Primary
Secondary
Concomitant
Thoracic Cavity Drainage Other Serious 8/1/2006 31 Male 8/21/2009 Physician China
Primary
Secondary
Concomitant
Thrombotic Thrombocytopenic Purpura Other Serious 9/1/2008 54 8/21/2009 Physician Korea, Republic Of
Primary
Concomitant
Small Intestine Ulcer Other Serious 5/1/2009 61 Male 8/19/2009 Physician United States
Primary
Concomitant
Tumour Lysis Syndrome Death 11/23/2007 62 Male 9/12/2009 Physician Japan
Primary
Concomitant
Thrombotic Thrombocytopenic Purpura Other Serious 9/1/2008 54 9/21/2009 Physician Korea, Republic Of
Primary
Concomitant
Venoocclusive Disease Death 9 Male 10/9/2009 Other Health Professional United Kingdom
Primary
Concomitant
Death Death 1/5/2009 41 10/28/2009 Physician Korea, Republic Of
Primary
Concomitant
Death Death 16 10/28/2009 Physician Korea, Republic Of
Primary
Concomitant
Death Death 3/2/2006 27 10/28/2009 Physician Korea, Republic Of
Primary
Concomitant
Death Death 10/18/2008 12 10/28/2009 Physician Korea, Republic Of
Primary
Concomitant
Graft Versus Host Disease Death 2/28/2006 27 Male 121 lb 11/9/2009 Physician Korea, Republic Of
Primary
Concomitant
Diffuse Large B-cell Lymphoma Death 11/10/2008 41 Female 99 lb 11/9/2009 Physician Korea, Republic Of
Primary
Concomitant
Disseminated Intravascular Coagulation Death 12 Male 11/9/2009 Physician Korea, Republic Of
Primary
Concomitant
Acute Myeloid Leukaemia Death 16 Female 82 lb 11/9/2009 Physician Korea, Republic Of
Primary
Concomitant
Multi-organ Failure Hospitalization 14 Male 11/20/2009 Physician United Kingdom
Primary
Concomitant
White Blood Cell Count Decreased Other Serious 9/23/2009 Male 255 lb 12/2/2009 United States
Primary
Secondary
Concomitant
White Blood Cell Count Decreased Other Serious 9/23/2009 Male 255 lb 12/2/2009 United States
Primary
Secondary
Concomitant
White Blood Cell Count Decreased Hospitalization 57 Male 12/22/2009 United States
Primary
Secondary
Concomitant
Visual Acuity Reduced Death 2/28/2006 27 Male 121 lb 1/25/2010 Physician Korea, Republic Of
Primary
Concomitant
Acute Myeloid Leukaemia Death 7/11/2007 16 Female 82 lb 1/25/2010 Physician Korea, Republic Of
Primary
Concomitant
Septic Embolus Other Serious 24 Female 1/27/2010 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Multi-organ Failure Hospitalization 14 Male 2/25/2010 Physician United Kingdom
Primary
Concomitant
Squamous Cell Carcinoma Other Serious 9 Male 3/1/2010 Other Health Professional United States
Primary
Secondary
Concomitant
Squamous Cell Carcinoma Other Serious 41 Male 3/1/2010 Other Health Professional United States
Primary
Secondary
Thrombosis In Device Other Serious 1 Female 5/27/2010
Primary
Secondary
Duodenal Ulcer Haemorrhage Other Serious 5/17/2010 24 Male 141 lb 5/31/2010 Physician Russian Federation
Primary
Secondary
White Blood Cell Count Decreased Death 7/1/2009 78 Female 88 lb 6/22/2010 Physician Japan
Primary
Concomitant
Thrombotic Thrombocytopenic Purpura Other Serious 9/1/2008 54 Female 115 lb 6/25/2010 Physician Korea, Republic Of
Primary
Concomitant
Zygomycosis Other Serious 23 Female 7/21/2010 Physician Germany
Primary
Secondary
Concomitant
Vomiting Other Serious 43 Male 104 lb 7/20/2010 Taiwan, Province Of China
Primary
Secondary
Concomitant
Bradycardia Death 7/22/2010 68 Female 143 lb 7/29/2010 Physician France
Primary
Secondary
Concomitant
Bradycardia Death 7/22/2010 68 Female 143 lb 8/3/2010 Physician France
Primary
Secondary
Concomitant
Thrombotic Thrombocytopenic Purpura Other Serious 9/1/2008 54 Female 115 lb 8/9/2010 Physician Korea, Republic Of
Primary
Concomitant
Hypotension Death 7/22/2010 68 Female 143 lb 8/13/2010 Consumer United States
Primary
Secondary
Concomitant
Hypotension Death 7/22/2010 68 Female 143 lb 8/16/2010 Other Health Professional United States
Primary
Concomitant
Pyrexia Death 9/6/2010 16 Male 84 lb 9/14/2010 Pharmacist United States
Primary
Concomitant
Staphylococcal Sepsis Hospitalization 3/15/2009 38 Male 128 lb 9/30/2010 Physician Japan
Primary
Concomitant
Pneumonia Life Threatening 10/16/2010 50 Male 141 lb 10/25/2010 Pharmacist United States
Primary
Concomitant
Duodenal Ulcer Haemorrhage Other Serious 5/17/2010 24 Male 141 lb 11/4/2010 Physician Russian Federation
Primary
Secondary
Concomitant
Tachycardia Hospitalization 4/28/2010 19 Female 115 lb 11/8/2010 Physician Japan
Primary
Concomitant
Stenotrophomonas Sepsis Hospitalization 8/11/2009 57 Male 146 lb 11/4/2010 Physician Japan
Primary
Concomitant
Pathogen Resistance Death 52 Male 12/8/2010 Other Health Professional United States
Primary
Concomitant
Vision Blurred Other Serious 1/1/2010 18 Female 12/10/2010 Pharmacist China
Primary
Secondary
Concomitant
Zygomycosis Death 75 Male 112 lb 12/10/2010 Physician Japan
Primary
Concomitant
Enterococcal Sepsis Death 11 Female 12/17/2010 Physician Italy
Primary
Secondary
Concomitant
Pancytopenia Death 11 Female 12/21/2010 United States
Primary
Secondary
Concomitant
Eschar Death 63 Male 1/20/2011 Physician United States
Primary
Secondary
Concomitant
Respiratory Arrest Death 12/30/2009 27 Female 220 lb 1/13/2011 Physician Japan
Primary
Concomitant
Cardiac Failure Life Threatening 6/23/2010 43 Female 119 lb 2/14/2011 Physician Japan
Primary
Secondary
Concomitant
Systemic Mycosis Death 41 Female 2/28/2011 Physician Switzerland
Primary
Secondary
Concomitant
Systemic Mycosis Death 41 Female 2/28/2011 Physician Switzerland
Primary
Secondary
Concomitant
Fungal Infection Other Serious 18 Female 3/10/2011 Other Health Professional China
Primary
Concomitant
Interacting
Productive Cough Other Serious 18 Female 3/11/2011 Other Health Professional China
Primary
Concomitant
Interacting
Respiratory Arrest Death 11/30/2009 27 Female 220 lb 3/22/2011 Physician Japan
Primary
Concomitant
Jaundice Life Threatening 6/23/2010 43 Female 119 lb 4/20/2011 Physician Japan
Primary
Secondary
Concomitant
Skin Exfoliation Other Serious 9/18/2010 49 Male 176 lb 5/5/2011 Physician Thailand
Primary
Concomitant
Cerebral Haemorrhage Death 8/11/2009 57 Male 146 lb 4/15/2011 Physician Japan
Primary
Concomitant
Off Label Use Other Serious 67 Male 6/6/2011 Physician Greece
Primary
Secondary
Subcutaneous Nodule Other Serious 63 Male 6/15/2011 Other Health Professional United States
Primary
Secondary
Bradycardia Death 7/22/2010 68 Female 143 lb 6/15/2011 Physician France
Primary
Secondary
Concomitant
Hyperkalaemia Death 7/22/2010 68 Female 143 lb 6/23/2011 Consumer United States
Primary
Secondary
Concomitant
Blood Creatinine Increased Other Serious 66 Male 6/28/2011 Other Health Professional Korea, Republic Of
Primary
Secondary
Concomitant
Renal Haemorrhage Other Serious 1/1/2007 63 Female 6/30/2011 Other Health Professional Japan
Primary
Concomitant
Blood Potassium Increased Death 7/22/2010 68 Female 143 lb 6/30/2011 Consumer United States
Primary
Secondary
Concomitant
Bronchopulmonary Aspergillosis Other Serious 67 Male 6/30/2011 Physician Greece
Primary
Secondary
Acute Graft Versus Host Disease In Intestine Death 4/7/2010 54 Male 110 lb 7/15/2011 Physician Japan
Primary
Secondary
Concomitant
Respiratory Failure Hospitalization 60 Male 7/19/2011 Other Health Professional Japan
Primary
Secondary
Multi-organ Failure Other Serious 4/26/2010 59 Female 115 lb 7/20/2011 Physician Japan
Primary
Secondary
Concomitant
Acute Respiratory Failure Death 58 Male 7/18/2011 Other Health Professional Japan
Primary
Secondary
Concomitant
Thrombotic Thrombocytopenic Purpura Death 11/20/2009 34 Male 130 lb 7/22/2011 Physician Japan
Primary
Secondary
Concomitant
Bradycardia Death 7/22/2010 68 Female 143 lb 7/29/2011 Physician France
Primary
Secondary
Concomitant
Drug Ineffective Death 58 Male 8/2/2011 Physician Japan
Primary
Secondary
Hyperkalaemia Death 7/22/2010 68 Female 143 lb 8/4/2011 Consumer France
Primary
Secondary
Concomitant
Bradycardia Death 7/22/2010 68 Female 143 lb 8/8/2011 Consumer United States
Primary
Concomitant
Surgical Procedure Repeated Hospitalization 6/1/2011 2 Male 31 lb 8/4/2011 Other Health Professional United States
Primary
Concomitant
Mycotic Aneurysm Death 55 Male 8/15/2011 Physician Australia
Primary
Secondary
Concomitant
Duodenal Ulcer Haemorrhage Other Serious 5/17/2010 24 Male 141 lb 9/2/2011 Physician Russian Federation
Primary
Secondary
Concomitant
Duodenal Ulcer Haemorrhage Life Threatening 5/17/2010 24 Male 141 lb 9/8/2011 Physician Russian Federation
Primary
Secondary
Concomitant
Rash Erythematous Other Serious Female 132 lb 9/15/2011 Pharmacist Brazil
Primary
Concomitant
Haematuria Other Serious 1/1/2011 21 Female 119 lb 9/23/2011 Pharmacist Brazil
Primary
Concomitant
Acute Graft Versus Host Disease In Skin Life Threatening 10/21/2009 22 Female 104 lb 9/26/2011 Physician Japan
Primary
Secondary
Concomitant
Acute Graft Versus Host Disease In Skin Other Serious 10/21/2009 22 Female 104 lb 9/26/2011 Physician Japan
Primary
Secondary
Concomitant
Skin Reaction Other Serious Female 132 lb 9/27/2011 Pharmacist Brazil
Primary
Concomitant
Multi-organ Failure Life Threatening 5/7/2009 50 Female 90 lb 10/6/2011 Physician Japan
Primary
Concomitant
Pseudomonal Sepsis Other Serious 10/21/2009 22 Female 104 lb 10/11/2011 Physician Japan
Primary
Secondary
Concomitant
Muscle Rigidity Life Threatening 8/26/2011 10 Male 66 lb 10/27/2011 Physician China
Primary
Concomitant
Nephropathy Toxic Life Threatening 34 Male 10/31/2011 Other Health Professional Korea, Republic Of
Primary
Secondary
Central Nervous System Lesion Other Serious 8/26/2011 10 Male 66 lb 11/1/2011 Physician China
Primary
Concomitant
Hypertension Life Threatening 8/26/2011 10 Male 66 lb 11/9/2011 Physician China
Primary
Concomitant
Diarrhoea Other Serious 29 Male 11/11/2011 Physician Australia
Primary
Secondary
Concomitant
Graft Versus Host Disease In Skin Other Serious 4/7/2010 54 Male 110 lb 11/18/2011 Physician Japan
Primary
Secondary
Concomitant
Bradycardia Death 7/22/2010 68 Female 143 lb 11/21/2011 Physician France
Primary
Secondary
Concomitant
Bradycardia Death 7/22/2010 68 Female 143 lb 11/21/2011 Physician United States
Primary
Secondary
Concomitant
Hyperkalaemia Other Serious 7/22/2010 68 Female 143 lb 11/21/2011 Physician United States
Primary
Secondary
Concomitant
Hypotension Death 7/22/2010 68 Female 143 lb 11/23/2011 Consumer United States
Primary
Concomitant
Infection Disability 4/28/2010 19 Female 115 lb 11/29/2011 Physician Japan
Primary
Concomitant
Viral Haemorrhagic Cystitis Death 6/24/2010 29 Female 99 lb 12/8/2011 Other Health Professional Japan
Primary
Concomitant
Zygomycosis Hospitalization 18 Male 12/9/2011 Other Health Professional Romania
Primary
Secondary
Hydrocephalus Death 5/7/2010 39 Female 115 lb 12/19/2011 Physician Japan
Primary
Concomitant
Cytomegalovirus Chorioretinitis Hospitalization 8/24/2009 21 Male 104 lb 12/20/2011 Physician Japan
Primary
Concomitant
Dialysis Other Serious 2/21/2011 43 Male 157 lb 12/23/2011 Physician Japan
Primary
Concomitant
Pseudomonal Sepsis Death 10/21/2009 22 Female 104 lb 2/21/2012 Physician Japan
Primary
Secondary
Concomitant
Acute Graft Versus Host Disease In Skin Other Serious 8/24/2009 21 Male 104 lb 2/22/2012 Physician Japan
Primary
Concomitant
Acute Graft Versus Host Disease Death 10/12/2011 35 Male 121 lb 2/23/2012 Physician Japan
Primary
Secondary
Concomitant
Interstitial Lung Disease Death 6/24/2010 29 Female 99 lb 3/2/2012 Other Health Professional Japan
Primary
Concomitant
Zygomycosis Death 62 Female 3/6/2012 Physician Japan
Primary
Concomitant
Bronchopulmonary Aspergillosis Hospitalization 5/13/2010 Male 20 lb 3/13/2012 Physician Japan
Primary
Secondary
Concomitant
Acute Graft Versus Host Disease Hospitalization 51 Male 3/19/2012 Physician Japan
Primary
Secondary
Concomitant
Cystitis Haemorrhagic Disability 4/28/2010 19 Female 115 lb 3/21/2012 Physician Japan
Primary
Concomitant
Renal Tubular Disorder Other Serious 29 Male 4/24/2012 Physician Australia
Primary
Secondary
Concomitant

Drug Data