Methotrexate combined with Zopiclone

Reports:

Reaction Outcome Event Date Age Sex Weight Reported Reporter Country Treatment
Role Name
Wheezing Other Serious 1/19/2001 69 Female 115 lb 2/24/2006 Physician United Kingdom
Primary
Concomitant
Streptococcal Bacteraemia Hospitalization 9/12/2003 Female 3/1/2006 Physician Norway
Primary
Concomitant
Urinary Tract Infection Other Serious 1/11/2001 69 Female 115 lb 3/2/2006 Physician United Kingdom
Primary
Concomitant
Disseminated Tuberculosis Other Serious 5/15/2003 78 Female 3/28/2006 Physician Sweden
Primary
Concomitant
Urinary Tract Infection Other Serious 10/25/2005 Female 119 lb 4/7/2006 Other Health Professional United Kingdom
Primary
Concomitant
Metastases To Lung Hospitalization 2/28/2004 Female 4/7/2006 Physician United Kingdom
Primary
Concomitant
Haemoptysis Hospitalization 3/27/2006 Male 148 lb 4/14/2006 Norway
Primary
Concomitant
Haemoptysis Hospitalization 3/27/2006 Male 148 lb 4/28/2006 Norway
Primary
Concomitant
Urinary Tract Infection Hospitalization 1/11/2001 69 Female 115 lb 5/18/2006 Physician United Kingdom
Primary
Concomitant
Therapy Non-responder Hospitalization 3/27/2006 Male 148 lb 7/7/2006 Norway
Primary
Concomitant
Haemoptysis Hospitalization 3/27/2006 Male 148 lb 7/7/2006 Norway
Primary
Concomitant
Swelling Face Other Serious 6/3/2006 69 Female 172 lb 7/14/2006 Other Health Professional United Kingdom
Primary
Concomitant
Large Intestinal Haemorrhage Other Serious 6/28/2006 Female 8/4/2006 Consumer Canada
Primary
Concomitant
Transient Ischaemic Attack Other Serious 7/30/2004 Female 8/25/2006 Other Health Professional Sweden
Primary
Concomitant
Transient Ischaemic Attack Other Serious 7/30/2004 Female 9/8/2006 Other Health Professional Sweden
Primary
Concomitant
Transient Ischaemic Attack Other Serious 7/30/2004 Female 9/8/2006 Other Health Professional Sweden
Primary
Concomitant
Large Intestinal Haemorrhage Other Serious 7/12/2006 Female 9/22/2006 Physician Canada
Primary
Concomitant
Skin Graft Life Threatening 3/1/2005 57 Female 10/16/2006 Netherlands
Primary
Concomitant
Subcorneal Pustular Dermatosis Hospitalization 6/1/2006 Female 11/6/2006 Other Health Professional Norway
Primary
Concomitant
Throat Cancer Other Serious 8/3/2006 Male 187 lb 11/15/2006 Other Health Professional United Kingdom
Primary
Concomitant
Myocardial Infarction Death 9/21/2006 Female 130 lb 11/20/2006 Physician Canada
Primary
Concomitant
Death Other Serious Male 139 lb 1/11/2007 Consumer United Kingdom
Primary
Concomitant
Spinal Fracture Life Threatening 3/1/2005 Female 154 lb 1/25/2007 Belgium
Primary
Concomitant
Aortic Valve Stenosis Other Serious Male 139 lb 2/13/2007 Consumer United Kingdom
Primary
Concomitant
Pneumonia Legionella Hospitalization 2/16/2007 Male 139 lb 3/7/2007 Pharmacist France
Primary
Concomitant
Transient Ischaemic Attack Other Serious 7/30/2004 Female 3/8/2007 Other Health Professional Sweden
Primary
Concomitant
Breast Cancer Other Serious 7/1/2006 64 Female 121 lb 3/20/2007 Other Health Professional Canada
Primary
Concomitant
Pneumonia Legionella Hospitalization 2/16/2007 Male 139 lb 3/28/2007 Pharmacist France
Primary
Secondary
Concomitant
Suicidal Ideation Hospitalization 7/28/2004 Male 4/12/2007 Physician Belgium
Primary
Concomitant
Sepsis Death 3/7/2007 78 Male 163 lb 4/19/2007 Other Health Professional United Kingdom
Primary
Concomitant
Toe Operation Other Serious 9/1/2006 Male 163 lb 5/3/2007 Other Health Professional United Kingdom
Primary
Concomitant
Transient Ischaemic Attack Other Serious 7/30/2004 Female 5/4/2007 Other Health Professional Sweden
Primary
Concomitant
Death Death 4/1/2007 Male 187 lb 5/24/2007 Other Health Professional United Kingdom
Primary
Concomitant
White Blood Cell Count Decreased Other Serious 9 Male 7/10/2007 Other Health Professional Sweden
Primary
Concomitant
Spinal Fracture Life Threatening 3/1/2005 Female 154 lb 7/13/2007 Belgium
Primary
Concomitant
Skin Lesion Other Serious 10/24/2006 Female 157 lb 7/19/2007 Other Health Professional United Kingdom
Primary
Concomitant
White Blood Cell Count Decreased Other Serious 9 Male 8/3/2007 Other Health Professional Sweden
Primary
Concomitant
Temperature Intolerance Other Serious 10/1/2006 Female 159 lb 8/20/2007 Other Health Professional Canada
Primary
Concomitant
Transient Ischaemic Attack Other Serious 7/30/2004 Female 8/27/2007 Other Health Professional Sweden
Primary
Concomitant
Toxic Epidermal Necrolysis Required Intervention 10 Male 9/17/2007 Other Health Professional Sweden
Primary
Secondary
Concomitant
Transient Ischaemic Attack Other Serious 1/1/2007 79 Female 121 lb 9/25/2007 Physician
Primary
Concomitant
White Blood Cell Count Decreased Hospitalization 10 Male 11/8/2007 Sweden
Primary
Secondary
Concomitant
Death Death Male 187 lb 12/3/2007 Other Health Professional United Kingdom
Primary
Concomitant
Basal Cell Carcinoma Other Serious Female 176 lb 12/4/2007 Physician United Kingdom
Primary
Secondary
Concomitant
Basal Cell Carcinoma Other Serious 6/21/2007 Female 176 lb 12/14/2007 Physician United Kingdom
Primary
Secondary
Concomitant
Toxic Epidermal Necrolysis Other Serious 10 Male 12/14/2007 Sweden
Primary
Secondary
Concomitant
Syncope Vasovagal Hospitalization 12/16/2007 Female 1/11/2008 United Kingdom
Primary
Concomitant
Renal Failure Acute Other Serious 4/4/2003 Female 1/21/2008 Ireland
Primary
Concomitant
Musculoskeletal Pain Other Serious Female 154 lb 1/29/2008 Canada
Primary
Concomitant
Skin Ulcer Life Threatening 3/8/2007 Male 163 lb 2/13/2008 Pharmacist United Kingdom
Primary
Concomitant
Listeria Sepsis Hospitalization 3/21/2007 Female 132 lb 2/15/2008 Other Health Professional United Kingdom
Primary
Concomitant
Cardiomegaly Death 8/13/2007 Male 183 lb 2/21/2008 United Kingdom
Primary
Concomitant
Subdural Haemorrhage Death Male 187 lb 2/25/2008 Other Health Professional United Kingdom
Primary
Concomitant
Musculoskeletal Pain Other Serious Female 154 lb 2/25/2008 Canada
Primary
Concomitant
Tooth Abscess Other Serious 8/24/2007 56 Female 3/17/2008 Physician Canada
Primary
Concomitant
Gastrointestinal Disorder Other Serious 8/29/2007 Female 119 lb 3/28/2008 Consumer United Kingdom
Primary
Concomitant
Tremor Other Serious Male 250 lb 4/15/2008 Canada
Primary
Concomitant
Listeria Sepsis Hospitalization 3/21/2007 Female 132 lb 6/10/2008 Other Health Professional United Kingdom
Primary
Concomitant
Toe Operation Other Serious 9/1/2006 Male 163 lb 7/29/2008 Other Health Professional United Kingdom
Primary
Concomitant
Toe Operation Other Serious 9/1/2006 Male 163 lb 7/29/2008 Other Health Professional United Kingdom
Primary
Concomitant
Dyspnoea Hospitalization 8/30/2008 Male 183 lb 9/19/2008 Canada
Primary
Secondary
Concomitant
Interstitial Lung Disease Hospitalization 8/30/2008 Male 183 lb 10/10/2008 Canada
Primary
Secondary
Concomitant
Interstitial Lung Disease Hospitalization 8/30/2008 Male 183 lb 10/24/2008 Canada
Primary
Secondary
Concomitant
Coronary Artery Disease Hospitalization 9/26/2008 Female 11/5/2008 Belgium
Primary
Concomitant
Metastases To Bone Hospitalization 1/7/2008 Female 148 lb 11/5/2008 United Kingdom
Primary
Concomitant
Coronary Artery Disease Hospitalization 9/26/2008 Female 11/12/2008 Belgium
Primary
Concomitant
Pleural Effusion Hospitalization 8/30/2008 Male 183 lb 11/14/2008 Canada
Primary
Secondary
Concomitant
Renal Colic Hospitalization 12/3/2008 63 Female 134 lb 12/19/2008 Germany
Primary
Secondary
Concomitant
Ear Operation Other Serious 12/1/2008 Female 238 lb 12/23/2008 Other Health Professional Canada
Primary
Concomitant
Unevaluable Event Other Serious 2/1/2009 Male 181 lb 3/9/2009 Canada
Primary
Concomitant
Tinnitus Other Serious 2/1/2009 Male 181 lb 3/11/2009 Canada
Primary
Concomitant
Progressive Multifocal Leukoencephalopathy Hospitalization 1/6/2009 84 Female 3/31/2009 Other Health Professional United Kingdom
Primary
Concomitant
Tinnitus Other Serious 2/1/2009 Male 181 lb 4/22/2009 Canada
Primary
Concomitant
Osteonecrosis Hospitalization 12/1/2008 79 Female 6/30/2009 Other Health Professional Norway
Primary
Secondary
Concomitant
Pneumonia Hospitalization 5/1/2009 Female 139 lb 7/9/2009 Japan
Primary
Secondary
Concomitant
Pneumonia Hospitalization 5/1/2009 Female 139 lb 7/15/2009 Japan
Primary
Secondary
Concomitant
Basal Cell Carcinoma Other Serious 6/21/2007 Female 176 lb 7/17/2009 Physician United Kingdom
Primary
Secondary
Concomitant
Pneumonia Hospitalization 5/1/2009 Female 139 lb 7/20/2009 Japan
Primary
Secondary
Concomitant
Ear Operation Other Serious 12/1/2008 Female 238 lb 7/23/2009 Other Health Professional Canada
Primary
Concomitant
Rheumatoid Arthritis Disability 6/14/2009 60 7/24/2009 Pharmacist Canada
Primary
Concomitant
Pyelonephritis Hospitalization 2/25/2009 Female 81 lb 8/21/2009 Japan
Primary
Concomitant
Haemoptysis Hospitalization 3/27/2006 Male 148 lb 8/28/2009 Norway
Primary
Concomitant
Basal Cell Carcinoma Other Serious 6/21/2007 Female 176 lb 9/9/2009 Physician United Kingdom
Primary
Secondary
Concomitant
Osteonecrosis Hospitalization 12/1/2008 79 Female 9/15/2009 Other Health Professional Norway
Primary
Secondary
Concomitant
Pneumonia Hospitalization 5/1/2009 Female 139 lb 9/18/2009 Japan
Primary
Secondary
Concomitant
Interstitial Lung Disease Hospitalization 8/30/2008 Male 183 lb 9/21/2009 Canada
Primary
Secondary
Concomitant
Pyelonephritis Hospitalization 2/25/2009 Female 81 lb 9/24/2009 Japan
Primary
Concomitant
Cardiac Failure Death 6/6/2009 Male 10/6/2009 Physician United Kingdom
Primary
Concomitant
Cardiac Failure Congestive Death 6/6/2009 Male 10/29/2009 Physician United Kingdom
Primary
Concomitant
Type 2 Diabetes Mellitus Hospitalization 5/1/2009 49 Female 216 lb 11/3/2009 Other Health Professional Canada
Primary
Concomitant
Pulmonary Fibrosis Other Serious 10/21/2008 Female 196 lb 11/16/2009 Other Health Professional United Kingdom
Primary
Concomitant
Respiratory Failure Death 6/6/2009 Male 11/20/2009 Physician United Kingdom
Primary
Concomitant
Tendon Rupture Hospitalization 11/5/2008 Female 103 lb 12/29/2009 Physician Japan
Primary
Secondary
Concomitant
Pyrexia Hospitalization 1/22/2009 69 Female 12/18/2009 United Kingdom
Primary
Concomitant
Listeria Sepsis Hospitalization 9/3/2007 58 Female 132 lb 1/15/2010 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Vomiting Hospitalization 1/17/2010 65 Female 200 lb 2/12/2010 Pharmacist Canada
Primary
Concomitant
Tendon Rupture Hospitalization 11/5/2008 Female 103 lb 2/22/2010 Physician Japan
Primary
Secondary
Concomitant
Pancytopenia Hospitalization 7/28/2009 Female 99 lb 3/11/2010 Japan
Primary
Secondary
Concomitant
Vomiting Hospitalization 1/17/2010 65 Female 200 lb 4/14/2010 Pharmacist Canada
Primary
Concomitant
Pancytopenia Hospitalization 7/24/2009 69 Female 99 lb 5/19/2010 Japan
Primary
Secondary
Concomitant
Intervertebral Disc Protrusion Other Serious 1/1/2010 65 Male 167 lb 6/10/2010 Other Health Professional Canada
Primary
Concomitant
Respiratory Failure Death 6/6/2009 69 Male 7/9/2010 Physician United Kingdom
Primary
Concomitant
Basal Cell Carcinoma Other Serious 6/18/2010 65 Male 172 lb 7/19/2010 Other Health Professional Canada
Primary
Concomitant
Pancytopenia Hospitalization 7/24/2009 69 Female 99 lb 7/28/2010 Physician Japan
Primary
Secondary
Concomitant
Hydrocele Hospitalization 7/20/2010 71 Male 116 lb 8/2/2010 Physician Japan
Primary
Secondary
Concomitant
Uveitis Other Serious 7/15/2010 42 Female 131 lb 8/27/2010 Other Health Professional Canada
Primary
Concomitant
General Physical Health Deterioration Hospitalization 8/10/2010 Female 8/27/2010 Physician Belgium
Primary
Secondary
Concomitant
Hydrocele Hospitalization 7/20/2010 71 Male 116 lb 9/7/2010 Physician Japan
Primary
Secondary
Concomitant
Vertigo Hospitalization 1/1/2000 Female 9/10/2010 Physician Sweden
Primary
Concomitant
Interacting
Vertigo Other Serious 1/1/2000 59 Female 110 lb 9/15/2010 Other Health Professional Sweden
Primary
Concomitant
Interacting
Lung Infiltration Other Serious 1/1/2000 59 Female 110 lb 9/23/2010
Primary
Secondary
Fall Other Serious 8/8/2010 67 Female 105 lb 10/4/2010 Other Health Professional Canada
Primary
Concomitant
Psychotic Disorder Hospitalization 58 Female 10/5/2010 Consumer United Kingdom
Primary
Concomitant
Vertigo Hospitalization 1/1/2000 Female 10/13/2010 Physician Sweden
Primary
Concomitant
Interacting
Pneumonia Legionella Other Serious 9/18/2010 57 Male 314 lb 10/26/2010 Physician Canada
Primary
Secondary
Concomitant
Haemoglobin Decreased Other Serious 9/6/2010 58 Female 10/26/2010 Consumer Canada
Primary
Concomitant
Psychotic Disorder Hospitalization 9/18/2010 58 Female 11/3/2010 Consumer United Kingdom
Primary
Concomitant
Hydrocele Hospitalization 1/1/2010 70 Male 116 lb 11/11/2010 Physician Japan
Primary
Secondary
Concomitant
Pulmonary Hypertension Other Serious 3/1/2010 11/12/2010 Other Health Professional Canada
Primary
Secondary
Concomitant
Neurotoxicity Hospitalization 7/1/2007 70 Female 150 lb 11/9/2010 Physician Germany
Primary
Concomitant
Pulmonary Hypertension Other Serious 3/1/2010 11/23/2010 Other Health Professional Canada
Primary
Secondary
Concomitant
Parathyroid Disorder Other Serious 7/1/2010 79 Female 96 lb 11/24/2010 Other Health Professional United Kingdom
Primary
Concomitant
Vomiting Hospitalization 7/1/2010 73 Female 11/22/2010 Other Health Professional Sweden
Primary
Secondary
Concomitant
White Blood Cell Count Decreased Other Serious 1/29/2010 49 Male 110 lb 12/13/2010 Physician Japan
Primary
Concomitant
White Blood Cell Count Decreased Other Serious 1/29/2010 49 Male 110 lb 12/13/2010 Physician Japan
Primary
Concomitant
Hydrocele Hospitalization 1/1/2010 70 Male 116 lb 12/16/2010 Physician Japan
Primary
Secondary
Concomitant
Renal Failure Other Serious 9/1/2010 57 Male 314 lb 1/3/2011 Physician Canada
Primary
Secondary
Concomitant
Abdominal Abscess Hospitalization 9/6/2010 58 Female 1/31/2011 Physician Canada
Primary
Concomitant
Hip Arthroplasty Hospitalization 1/21/2011 66 Female 2/9/2011 Consumer Canada
Primary
Concomitant
Pneumonia Legionella Life Threatening 9/1/2010 57 Male 314 lb 2/15/2011 Physician Canada
Primary
Secondary
Concomitant
Incorrect Storage Of Drug Other Serious 11/10/2010 35 Female 2/23/2011 Other Health Professional United Kingdom
Primary
Concomitant
Atrial Fibrillation Other Serious 2/16/2010 70 Male 2/11/2011 United Kingdom
Primary
Concomitant
Sepsis Hospitalization 9/1/2010 57 Male 314 lb 3/2/2011 Physician Canada
Primary
Secondary
Concomitant
Basal Cell Carcinoma Other Serious 6/18/2010 65 Male 172 lb 3/4/2011 Other Health Professional Canada
Primary
Concomitant
Systemic Lupus Erythematosus Other Serious 3/1/2011 53 Female 168 lb 3/11/2011 Other Health Professional Canada
Primary
Concomitant
Pneumonia Death 11/19/2009 69 Male 179 lb 3/16/2011 Consumer United Kingdom
Primary
Concomitant
Hepatic Function Abnormal Hospitalization 7/24/2009 69 Female 99 lb 3/22/2011 Physician Japan
Primary
Secondary
Concomitant
Weight Increased Other Serious 1/1/2010 61 Female 258 lb 5/6/2011 Physician Canada
Primary
Concomitant
Petechiae Other Serious 1/29/2010 49 Male 110 lb 5/20/2011 Physician Japan
Primary
Concomitant
Atrial Fibrillation Other Serious 2/16/2010 70 Male 6/6/2011 Physician United Kingdom
Primary
Concomitant
Atrial Fibrillation Other Serious 2/16/2010 70 Male 6/16/2011 Consumer United Kingdom
Primary
Concomitant
Graft Versus Host Disease Hospitalization 5/25/2010 23 Female 73 lb 6/23/2011 Physician Japan
Primary
Secondary
Concomitant
Lung Cancer Metastatic Death 2/24/2011 70 Female 209 lb 6/29/2011 Physician Canada
Primary
Secondary
Concomitant
Gastric Cancer Other Serious 6/24/2011 72 Male 116 lb 7/27/2011 Physician Japan
Primary
Secondary
Concomitant
Alcohol Poisoning Hospitalization 8/1/2010 Female 8/30/2011 Physician Belgium
Primary
Secondary
Concomitant
Adverse Event Other Serious 74 Female 9/6/2011 Consumer Canada
Primary
Concomitant
Back Pain Other Serious 8/4/2011 74 Female 9/7/2011 Consumer Canada
Primary
Concomitant
Alcohol Poisoning Hospitalization 8/1/2010 Female 9/16/2011 Physician Belgium
Primary
Secondary
Concomitant
Death Death 7/1/2011 46 Female 9/23/2011 Other Health Professional Canada
Primary
Concomitant
Joint Swelling Other Serious 7/29/2011 67 Male 182 lb 9/29/2011 Other Health Professional Canada
Primary
Concomitant

Drug Data