Methotrexate combined with Zofran

Reports:

Reaction Outcome Event Date Age Sex Weight Reported Reporter Country Treatment
Role Name
Transient Ischaemic Attack Hospitalization 1/5/2006 Female 110 lb 1/13/2006 Physician United States
Primary
Secondary
Concomitant
Peripheral Motor Neuropathy Other Serious 1/4/2006 5 Female 35 lb 2/3/2006 Physician United States
Primary
Secondary
Concomitant
Coronary Artery Stenosis Hospitalization 1/31/2006 Male 194 lb 2/8/2006 Other Health Professional United States
Primary
Concomitant
Acute Myocardial Infarction Life Threatening 1/31/2006 Male 194 lb 2/17/2006 Physician United States
Primary
Secondary
Concomitant
Acute Myocardial Infarction Life Threatening 1/31/2006 Male 194 lb 2/23/2006 Physician United States
Primary
Secondary
Concomitant
Acute Myocardial Infarction Life Threatening 1/31/2006 Male 194 lb 2/28/2006 Physician United States
Primary
Secondary
Concomitant
Toe Deformity Other Serious 12/1/2001 Female 286 lb 3/7/2006 Other Health Professional United States
Primary
Concomitant
Disseminated Intravascular Coagulation Hospitalization 2/3/2006 56 Female 3/11/2006 Japan
Primary
Concomitant
Visual Disturbance Other Serious 2/20/2006 Male 134 lb 4/7/2006 Physician United States
Primary
Secondary
Concomitant
Pulmonary Oedema Life Threatening 3/27/2006 Female 116 lb 4/18/2006 Physician United States
Primary
Secondary
Concomitant
White Blood Cell Count Decreased Other Serious 2/24/2006 65 Male 134 lb 4/11/2006 Physician Japan
Primary
Concomitant
Eye Movement Disorder 1/1/2006 47 Female 4/28/2006 Consumer United States
Primary
Concomitant
Pyrexia Other Serious 2/2/2006 56 Female 110 lb 4/20/2006 Physician Japan
Primary
Concomitant
Ventricular Hypertrophy Life Threatening 3/27/2006 Female 116 lb 5/3/2006 Physician United States
Primary
Secondary
Concomitant
Ventricular Arrhythmia Hospitalization 4/17/2006 5 Female 38 lb 5/18/2006 Physician United States
Primary
Secondary
Concomitant
White Blood Cell Count Decreased Life Threatening 3/20/2006 70 Female 117 lb 5/11/2006 Physician United States
Primary
Secondary
Concomitant
White Blood Cell Count Decreased Life Threatening 4/7/2006 70 Female 5/12/2006 United States
Primary
Secondary
Concomitant
Vomiting Hospitalization 3/15/2006 Female 5/19/2006 Physician United States
Primary
Concomitant
Venoocclusive Liver Disease Disability 1/1/2004 61 Female 98 lb 5/15/2006 Physician Japan
Primary
Secondary
Concomitant
Pulmonary Oedema Life Threatening 3/27/2006 Female 116 lb 5/26/2006 Physician United States
Primary
Secondary
Concomitant
Pulmonary Oedema Life Threatening 3/27/2006 Female 116 lb 6/9/2006 Physician United States
Primary
Secondary
Concomitant
Venoocclusive Liver Disease Disability 1/1/2004 61 Female 98 lb 6/7/2006 Physician Japan
Primary
Secondary
Concomitant
Pain In Jaw Other Serious 2/21/2006 78 Female 6/26/2006 Physician United States
Primary
Concomitant
Vomiting Hospitalization 3/15/2006 Female 6/28/2006 Physician United States
Primary
Concomitant
Exposure To Toxic Agent Hospitalization 6/22/2006 Male 143 lb 8/3/2006 Physician United States
Primary
Concomitant
Abdominal Pain Hospitalization 5/4/2006 Male 143 lb 8/3/2006 Physician United States
Primary
Concomitant
Pain In Jaw Other Serious 2/21/2006 78 Female 8/4/2006 Physician United States
Primary
Concomitant
Pulmonary Oedema Life Threatening 4/7/2006 Female 116 lb 8/10/2006 Physician United States
Primary
Secondary
Concomitant
Toxic Induced Encephalopathy Hospitalization 6/30/2006 59 Male 8/8/2006 Physician United States
Primary
Secondary
Concomitant
Aggression Other Serious 6/11/2006 7 Female 44 lb 8/16/2006 Consumer United Kingdom
Primary
Secondary
Weight Decreased Other Serious 4/1/2006 73 Male 201 lb 8/18/2006 United States
Primary
Concomitant
Aggression Other Serious 6/11/2006 7 Female 44 lb 8/18/2006 Consumer United Kingdom
Primary
Concomitant
Toxic Induced Encephalopathy Other Serious 6/1/2006 59 Male 8/8/2006 Other Health Professional United States
Primary
Concomitant
Aggression Other Serious 6/11/2006 7 Female 44 lb 8/25/2006 Consumer United Kingdom
Primary
Secondary
Aggression Other Serious 6/11/2006 7 Female 44 lb 8/25/2006 Consumer United Kingdom
Primary
Concomitant
Aggression Other Serious 6/11/2006 7 Female 44 lb 8/25/2006 Consumer United Kingdom
Primary
Secondary
Aggression Other Serious 6/11/2006 7 Female 44 lb 8/25/2006 Consumer United Kingdom
Primary
Concomitant
Toxic Induced Encephalopathy Other Serious 6/1/2006 59 Male 8/14/2006 Other Health Professional United States
Primary
Concomitant
Chest Discomfort Disability 2/16/2006 43 Female 8/30/2006 Australia
Primary
Secondary
Concomitant
Vomiting Hospitalization 9/15/2006 Male 29 lb 9/15/2006 United States
Primary
Secondary
Concomitant
Vomiting Hospitalization 8/4/2005 Female 170 lb 10/24/2006 United States
Primary
Secondary
Concomitant
Vomiting Hospitalization 9/15/2006 Male 29 lb 11/6/2006 United States
Primary
Secondary
Concomitant
Thrombocytopenia Other Serious Female 11/29/2006 Consumer France
Primary
Secondary
Concomitant
Thrombocytopenia Hospitalization 8/1/2006 60 Female 121 lb 12/22/2006 Consumer France
Primary
Secondary
Concomitant
Tremor Hospitalization 8/19/2006 30 Female 276 lb 11/6/2006 Pharmacist United States
Primary
Concomitant
Thrombocytopenia Hospitalization 5/1/2006 60 Female 121 lb 1/2/2007 Consumer France
Primary
Secondary
Concomitant
Rash Other Serious 39 Female 1/9/2007 Pharmacist Canada
Primary
Concomitant
Heart Rate Abnormal Disability 2/16/2006 43 Female 2/17/2007 Australia
Primary
Secondary
Concomitant
Aspartate Aminotransferase Increased Hospitalization 8/31/2006 Female 105 lb 2/16/2007 United States
Primary
Secondary
Concomitant
Musculoskeletal Chest Pain 2/2/2006 Female 3/28/2007 Consumer United States
Primary
Concomitant
Ventricular Dysfunction Other Serious 2/26/2007 Male 173 lb 4/11/2007 Physician United States
Primary
Concomitant
Drug Interaction Other Serious 2/22/2007 14 Male 62 lb 4/12/2007 Other Health Professional Germany
Primary
Secondary
Concomitant
Drug Interaction Other Serious 2/22/2007 14 Male 62 lb 5/2/2007 Other Health Professional Germany
Primary
Secondary
Concomitant
Hyperglycaemia Other Serious 5/3/2007 46 Female 5/18/2007 Consumer United States
Primary
Secondary
Concomitant
Drug Ineffective Hospitalization 1/1/2000 21 Female 5/24/2007 Consumer United States
Primary
Secondary
Concomitant
Hyperglycaemia Other Serious 5/3/2007 46 Female 6/13/2007 Consumer United States
Primary
Secondary
Concomitant
Methaemoglobinaemia Life Threatening 4/26/2007 Female 141 lb 6/13/2007 Other Health Professional France
Primary
Concomitant
Mydriasis 5/1/2007 47 Female 101 lb 6/25/2007 Other Health Professional United States
Primary
Concomitant
White Blood Cell Count Decreased Other Serious 6/27/2006 30 Female 90 lb 7/3/2007 Japan
Primary
Secondary
Concomitant
White Blood Cell Count Decreased Other Serious 6/27/2006 30 Female 90 lb 7/3/2007 Japan
Primary
Secondary
Concomitant
Hyperglycaemia Other Serious 5/3/2007 46 Female 7/11/2007 Consumer United States
Primary
Secondary
Concomitant
White Blood Cell Count Decreased Other Serious 6/27/2006 30 Female 90 lb 7/12/2007 Japan
Primary
Secondary
Concomitant
Hyperglycaemia Other Serious 5/3/2007 Female 331 lb 7/23/2007 Consumer United States
Primary
Secondary
Concomitant
Vomiting Hospitalization 5/14/2007 59 Female 146 lb 7/24/2007 Physician France
Primary
Secondary
Wrong Technique In Drug Usage Process Hospitalization 6/1/2007 Female 168 lb 8/29/2007 Consumer United States
Primary
Secondary
Concomitant
Diarrhoea Other Serious 2/1/2007 Male 9/11/2007 Physician Switzerland
Primary
Concomitant
Hyperglycaemia Other Serious 5/3/2007 Female 331 lb 9/11/2007 Consumer United States
Primary
Secondary
Concomitant
Transaminases Increased Hospitalization 8/29/2007 12 10/17/2007 Other Health Professional France
Primary
Secondary
Concomitant
Staring Hospitalization 11/13/2007 Female 104 lb 11/28/2007 United States
Primary
Secondary
Concomitant
Drug Toxicity Other Serious 2/22/2007 14 Male 62 lb 11/29/2007 Physician Germany
Primary
Secondary
Concomitant
Pulmonary Toxicity Hospitalization 7/15/2007 58 Female 143 lb 11/5/2007 Pharmacist United States
Primary
Concomitant
Pancreatitis Acute Hospitalization 21 Male 2/21/2008 France
Primary
Secondary
Concomitant
Petechiae Other Serious 7/23/2007 Female 179 lb 3/10/2008 Physician Germany
Primary
Concomitant
Vomiting Hospitalization 3/15/2008 43 Female 128 lb 3/26/2008 Pharmacist United States
Primary
Concomitant
Skin Injury Hospitalization 3/6/2008 49 Male 277 lb 3/24/2008 Physician United States
Primary
Secondary
Concomitant
Alanine Aminotransferase Increased Other Serious 11/22/2007 46 Female 4/16/2008 Consumer United States
Primary
Secondary
Concomitant
Hypokalaemia Other Serious 3/29/2007 69 Female 4/16/2008 Consumer United States
Primary
Secondary
Concomitant
Alanine Aminotransferase Increased Other Serious 12/6/2007 32 Female 4/17/2008 Consumer United States
Primary
Secondary
Concomitant
Alanine Aminotransferase Abnormal Other Serious 6/5/2006 40 Female 4/17/2008 Consumer United States
Primary
Secondary
Concomitant
Gamma-glutamyltransferase Abnormal Other Serious 2/14/2007 42 Female 4/17/2008 Consumer United States
Primary
Secondary
Concomitant
Rash Other Serious 1/17/2008 51 Female 4/21/2008 Consumer United States
Primary
Secondary
Concomitant
Insomnia Disability 4/20/2007 61 Male 5/23/2008 Physician United States
Primary
Concomitant
Stomatitis Hospitalization 6/3/2008 27 Male 88 lb 6/30/2008 Physician United States
Primary
Secondary
Concomitant
Vomiting Hospitalization 7/22/2007 Male 97 lb 8/13/2008 Other Health Professional Brazil
Primary
Concomitant
Vomiting Other Serious 5/19/2008 Male 52 lb 8/15/2008 Other Health Professional Brazil
Primary
Secondary
Concomitant
Vomiting Hospitalization 7/22/2007 Male 97 lb 10/10/2008 Other Health Professional Brazil
Primary
Concomitant
Vomiting Other Serious 5/19/2008 Male 52 lb 10/16/2008 Other Health Professional Brazil
Primary
Secondary
Concomitant
Shock Other Serious 11/30/2007 Male 35 lb 11/3/2008 Other Health Professional Brazil
Primary
Concomitant
Visual Acuity Reduced Other Serious 4/18/2008 Male 57 lb 11/4/2008 Other Health Professional Brazil
Primary
Concomitant
Vision Blurred Hospitalization 12/14/2007 Male 52 lb 11/4/2008 Other Health Professional Brazil
Primary
Concomitant
Visual Impairment Other Serious 4/21/2008 Male 36 lb 11/4/2008 Pharmacist Brazil
Primary
Concomitant
Vomiting Hospitalization 7/22/2007 Male 97 lb 11/4/2008 Other Health Professional Brazil
Primary
Concomitant
Vomiting Other Serious 5/19/2008 Male 52 lb 11/5/2008 Other Health Professional Brazil
Primary
Concomitant
Withdrawal Syndrome Hospitalization 6/25/2008 27 Male 162 lb 12/1/2008 Physician United States
Primary
Secondary
Concomitant
Rhabdomyolysis Other Serious 10/24/2008 2 Male 27 lb 1/20/2009 Physician Japan
Primary
Concomitant
Toxic Epidermal Necrolysis Hospitalization 11/25/2008 62 Female 163 lb 1/28/2009 Other Health Professional France
Primary
Concomitant
Vomiting Other Serious 51 Female 198 lb 2/11/2009 Consumer United States
Primary
Secondary
Concomitant
Rhabdomyolysis Other Serious 10/24/2008 2 Male 27 lb 2/20/2009 Physician Japan
Primary
Concomitant
Vomiting Hospitalization 2/27/2009 Female 63 lb 3/4/2009 United States
Primary
Secondary
Concomitant
Rhabdomyolysis Other Serious 10/24/2008 2 Male 27 lb 3/18/2009 Physician Japan
Primary
Concomitant
Respiratory Failure Other Serious 10/1/2007 Female 3/24/2009 Physician United States
Primary
Secondary
Concomitant
White Blood Cell Count Increased Hospitalization 3/24/2008 5 Male 47 lb 3/25/2009 Physician Japan
Primary
Secondary
Concomitant
Peripheral Sensory Neuropathy Other Serious 3/4/2009 23 Male 116 lb 3/24/2009 Physician United States
Primary
Secondary
Concomitant
Unresponsive To Stimuli Other Serious 11/27/2008 55 Male 2/23/2009 Physician United States
Primary
Secondary
Concomitant
Systemic Candida Other Serious 11/27/2008 55 Male 2/23/2009 Physician United States
Primary
Secondary
Concomitant
Weight Decreased Other Serious 2/2/2007 Female 5/18/2009 Physician United States
Primary
Secondary
Concomitant
Malaise Hospitalization 4/26/2007 Male 112 lb 6/10/2009 Other Health Professional Japan
Primary
Concomitant
Vomiting Hospitalization 9/1/2008 Female 293 lb 6/11/2009 United States
Primary
Concomitant
Malaise Life Threatening 3/1/2007 Male 134 lb 6/18/2009 Physician Japan
Primary
Concomitant
Respiratory Failure Other Serious 10/1/2007 Female 6/19/2009 Physician United States
Primary
Secondary
Concomitant
Salivary Gland Mass Other Serious 1/1/2008 38 Female 6/17/2009 Other Health Professional United States
Primary
Secondary
Concomitant
Hallucination Life Threatening 3/7/2009 30 Male 174 lb 4/3/2009 Pharmacist United States
Primary
Secondary
Concomitant
Vanillyl Mandelic Acid Urine Increased Death 6/12/2009 4 Male 40 lb 6/15/2009 Physician United States
Primary
Concomitant
Leukaemia Death Female 7/9/2009 United States
Primary
Concomitant
Weight Decreased Death Female 8/3/2009 United States
Primary
Concomitant
Weight Decreased Death Female 8/4/2009 United States
Primary
Concomitant
Hepatotoxicity Other Serious 5/1/2009 24 Female 203 lb 8/6/2009 Pharmacist United States
Primary
Concomitant
Vomiting Hospitalization 7/24/2009 18 Male 220 lb 8/11/2009 Pharmacist United States
Primary
Concomitant
Vomiting Hospitalization 8/10/2009 Male 79 lb 8/26/2009 United States
Primary
Secondary
Concomitant
Ventricular Tachycardia Hospitalization 7/24/2009 18 Male 220 lb 9/15/2009 Pharmacist United States
Primary
Concomitant
Vomiting Hospitalization 53 Female 9/24/2009 United States
Primary
Concomitant
Loss Of Consciousness Other Serious 9/1/2009 Male 10/2/2009 Consumer United States
Primary
Secondary
White Blood Cell Count Increased Hospitalization 1/21/2008 Male 47 lb 10/9/2009 Physician Japan
Primary
Secondary
Concomitant
Vomiting Life Threatening 9/26/2009 Female 116 lb 10/8/2009 Physician United States
Primary
Concomitant
Upper Respiratory Tract Infection Hospitalization 8/10/2009 Male 79 lb 10/22/2009 United States
Primary
Secondary
Concomitant
Vomiting Hospitalization 53 Female 11/4/2009 United States
Primary
Concomitant
Throat Irritation Other Serious 1/1/2005 Female 153 lb 11/16/2009 Pharmacist United States
Primary
Concomitant
Weight Increased Other Serious 3/27/2006 Female 170 lb 11/19/2009 Physician United States
Primary
Concomitant
Diverticulitis Other Serious 5/1/2009 Female 141 lb 11/19/2009 Physician United States
Primary
Secondary
Concomitant
Nausea Other Serious 1/1/2007 Female 75 lb 11/20/2009 Consumer United States
Primary
Secondary
Concomitant
Nausea 7/1/2009 Male 159 lb 11/27/2009 Physician United States
Primary
Concomitant
Syncope Other Serious 9/1/2009 56 Male 243 lb 12/1/2009 Consumer United States
Primary
Secondary
Concomitant
Injection Site Urticaria 4/3/2008 Female 116 lb 12/1/2009 Physician United States
Primary
Concomitant
Vomiting Hospitalization 4/23/2009 12 Female 75 lb 12/4/2009 Physician Austria
Primary
Concomitant
Weight Increased Hospitalization 53 Female 12/10/2009 United States
Primary
Concomitant
Stress Cardiomyopathy Hospitalization 10/1/2009 Female 116 lb 1/8/2010 Physician United States
Primary
Concomitant
Tachycardia Foetal Other Serious 11/11/2009 Male 3 lb 1/11/2010 Physician United States
Primary
Concomitant
Premature Labour Other Serious 1/1/2009 Female 215 lb 1/11/2010 Physician United States
Primary
Concomitant
Throat Irritation Other Serious 1/1/2005 Female 153 lb 1/11/2010 Pharmacist United States
Primary
Concomitant
Tachycardia Foetal Other Serious 11/19/2009 Male 3 lb 1/14/2010 Physician United States
Primary
Secondary
Concomitant
Premature Labour Other Serious 1/1/2009 Female 215 lb 1/14/2010 Physician United States
Primary
Secondary
Concomitant
Throat Irritation Other Serious 1/1/2005 Female 153 lb 1/21/2010 Pharmacist United States
Primary
Concomitant
Rash Pruritic 9/17/2009 Female 103 lb 1/30/2010 United States
Primary
Concomitant
Myositis 1/1/2009 Male 145 lb 1/30/2010 Physician United States
Primary
Concomitant
Sinusitis 8/1/2009 Male 155 lb 1/30/2010 Other Health Professional United States
Primary
Concomitant
Vision Blurred Other Serious 1/1/2005 Female 153 lb 1/30/2010 Pharmacist United States
Primary
Concomitant
Vision Blurred Other Serious 1/1/2005 Female 153 lb 2/8/2010 Pharmacist United States
Primary
Concomitant
Wound Infection Staphylococcal Other Serious 4/1/1997 Female 2/8/2010 Physician United States
Primary
Secondary
Concomitant
Wound Infection Staphylococcal Other Serious 4/1/1997 Female 138 lb 2/16/2010 Physician United States
Primary
Secondary
Concomitant
Oesophageal Obstruction Other Serious 7/16/2009 Female 186 lb 2/22/2010 Consumer United States
Primary
Concomitant

Drug Data