Methotrexate combined with Warfarin

Reports:

Reaction Outcome Event Date Age Sex Weight Reported Reporter Country Treatment
Role Name
Breast Cancer Stage Iii Hospitalization 9/19/2005 Female 1/5/2006 Other Health Professional United Kingdom
Primary
Concomitant
Urticaria Hospitalization 8/23/2005 49 Female 120 lb 1/10/2006 Physician Japan
Primary
Concomitant
Peripheral Artery Aneurysm Death 10/22/2005 Male 1/18/2006 United Kingdom
Primary
Concomitant
Breast Cancer Life Threatening Female 122 lb 1/17/2006 Pharmacist United States
Primary
Concomitant
Transient Ischaemic Attack Hospitalization 1/1/2000 69 Male 295 lb 2/3/2006 Physician United States
Primary
Concomitant
Atrial Fibrillation Other Serious 7/15/2005 Female 216 lb 2/16/2006 Other Health Professional United Kingdom
Primary
Concomitant
Transient Ischaemic Attack Hospitalization 1/1/2000 69 Male 295 lb 2/21/2006 Physician United States
Primary
Concomitant
Rheumatoid Arthritis Disability 11/1/2005 Female 156 lb 2/21/2006 Other Health Professional United Kingdom
Primary
Concomitant
Initial Insomnia 10/28/2005 62 Female 1/5/2006 Consumer United States
Primary
Concomitant
Thrombocytopenia Hospitalization 1/1/2000 53 Female 198 lb 2/23/2006 Physician United States
Primary
Concomitant
Sepsis Hospitalization 9/25/2005 Female 108 lb 3/3/2006 Other Health Professional United Kingdom
Primary
Concomitant
Breast Cancer Other Serious 12/16/2005 Female 135 lb 3/28/2006 Physician United States
Primary
Concomitant
Renal Failure Chronic Hospitalization 1/1/2000 78 Female 150 lb 4/7/2006 Physician United States
Primary
Concomitant
Muscle Spasms Hospitalization 11/17/1999 41 Female 154 lb 4/10/2006 Lawyer United States
Primary
Concomitant
Sepsis Hospitalization 9/25/2005 Female 108 lb 4/13/2006 Other Health Professional United Kingdom
Primary
Concomitant
Respiratory Distress Hospitalization 1/1/2000 78 Female 150 lb 5/3/2006 Physician United States
Primary
Concomitant
Thrombosis Hospitalization 1/1/2003 62 Female 7/13/2006 Consumer Australia
Primary
Concomitant
Ventricular Tachycardia Other Serious 1/18/2006 Female 138 lb 9/21/2006 Other Health Professional United Kingdom
Primary
Concomitant
Hypergammaglobulinaemia Benign Monoclonal Other Serious 4/10/2007 Female 110 lb 4/24/2007 Other Health Professional United Kingdom
Primary
Concomitant
Tuberculosis Hospitalization 77 Female 5/3/2007 Other Health Professional United States
Primary
Concomitant
Sepsis Hospitalization 71 Female 5/11/2007 Other Health Professional United Kingdom
Primary
Concomitant
Rash Other Serious 3/1/2006 Female 175 lb 5/14/2007 Physician
Primary
Concomitant
Muscular Weakness Hospitalization 42 Female 5/21/2007 Other Health Professional Australia
Primary
Concomitant
Breast Cancer Stage Iii Hospitalization 9/19/2005 Female 212 lb 6/22/2007 Physician United Kingdom
Primary
Concomitant
Hip Fracture Other Serious 8/1/2007 67 Female 1/23/2008 Consumer Australia
Primary
Secondary
Concomitant
Weight Decreased Other Serious 1/1/1999 60 Female 1/25/2008 Other Health Professional United States
Primary
Concomitant
Renal Failure Acute Hospitalization 2/22/2006 79 Female 5/19/2008 Physician United States
Primary
Secondary
Concomitant
Femur Fracture Other Serious 10/1/2004 63 Female 6/25/2008 Physician Australia
Primary
Concomitant
Impaired Healing Other Serious 6/13/2008 80 Female 10/1/2008 Other Health Professional United Kingdom
Primary
Concomitant
Systemic Lupus Erythematosus Other Serious 59 Female 1/26/2009
Primary
Secondary
Tooth Infection Other Serious 12/1/2008 Male 153 lb 2/25/2009 United States
Primary
Concomitant
Pyrexia Other Serious 8/1/2007 Female 4/10/2009 Brazil
Primary
Concomitant
Non-hodgkin's Lymphoma Other Serious 7/11/2008 67 Female 4/29/2009 Consumer United Kingdom
Primary
Concomitant
Weight Increased Hospitalization Female 165 lb 5/5/2009 Canada
Primary
Concomitant
Multi-organ Failure Hospitalization 12/15/2008 Female 196 lb 6/8/2009 Physician United Kingdom
Primary
Concomitant
Vocal Cord Paralysis Hospitalization 7/25/2008 Female 108 lb 7/6/2009 Other Health Professional United Kingdom
Primary
Concomitant
Urinary Tract Infection Hospitalization 4/11/2008 Female 8/21/2009 Consumer United Kingdom
Primary
Concomitant
Death Hospitalization 43 Female 152 lb 9/28/2009 Physician United States
Primary
Concomitant
Skin Ulcer Hospitalization 5/24/2007 68 Female 9/18/2009 Physician United Kingdom
Primary
Concomitant
Weight Decreased Hospitalization 2/8/2006 64 Female 12/10/2009 Consumer United States
Primary
Concomitant
Staphylococcal Infection Other Serious 1/1/2009 72 Female 128 lb 12/8/2009 Physician United States
Primary
Secondary
Concomitant
Transient Ischaemic Attack Other Serious 2/24/2009 Female 1/21/2010 Other Health Professional United Kingdom
Primary
Concomitant
Transient Ischaemic Attack Other Serious 2/24/2009 Female 1/22/2010 Other Health Professional United Kingdom
Primary
Concomitant
Vomiting Other Serious 1/1/2007 63 Male 1/25/2010 Lawyer United States
Primary
Secondary
Concomitant
Thrombosis Other Serious 1/1/2010 Male 2/16/2010 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Total Cholesterol/hdl Ratio Increased Other Serious 1/1/2007 44 Female 205 lb 5/14/2010 Consumer United States
Primary
Secondary
Concomitant
Weight Decreased Other Serious 6/15/2009 50 Female 165 lb 6/2/2010 Consumer Brazil
Primary
Concomitant
Weight Decreased Other Serious 6/15/2009 50 Female 165 lb 6/3/2010 Consumer Brazil
Primary
Concomitant
Injection Site Haematoma 1/25/2010 60 Male 298 lb 5/11/2010 Consumer United States
Primary
Concomitant
Subdural Haematoma Other Serious 12/1/2009 82 Male 190 lb 6/16/2010 Other Health Professional Australia
Primary
Secondary
Concomitant
Dyspnoea Other Serious 1/1/2010 88 Male 6/16/2010 Consumer United States
Primary
Concomitant
Renal Failure Hospitalization 62 Male 6/17/2010 Physician United Kingdom
Primary
Concomitant
Spinal Osteoarthritis Hospitalization 3/26/2007 72 Female 110 lb 6/25/2010 Other Health Professional United Kingdom
Primary
Concomitant
Rheumatoid Arthritis 8/11/2009 71 Female 184 lb 6/29/2010 Consumer United States
Primary
Concomitant
No Adverse Event 1/21/2007 54 Female 137 lb 7/9/2010 Consumer United States
Primary
Concomitant
Sleep Apnoea Syndrome Hospitalization 7/5/2010 52 Female 203 lb 7/22/2010 Other Health Professional Australia
Primary
Concomitant
Dyspnoea Other Serious 1/1/2010 88 Male 8/4/2010 Consumer United States
Primary
Concomitant
Post Procedural Infection Other Serious 6/1/2010 Female 8/5/2010 Consumer United Kingdom
Primary
Concomitant
Interacting
Haematology Test Abnormal 6/23/2009 77 Male 224 lb 8/6/2010 Consumer United States
Primary
Concomitant
Venous Occlusion Other Serious 1/1/2010 59 Male 185 lb 8/12/2010 Consumer Brazil
Primary
Concomitant
Tinea Versicolour Hospitalization 3/28/2010 82 Male 8/13/2010 Physician United States
Primary
Secondary
Concomitant
Pneumonia Hospitalization 8/7/2010 54 Female 86 lb 8/20/2010 Physician Japan
Primary
Concomitant
Wrong Technique In Drug Usage Process 1/1/2010 64 Female 135 lb 8/24/2010 Consumer United States
Primary
Concomitant
Urinary Retention Hospitalization 1/15/2010 74 Male 225 lb 9/10/2010 Other Health Professional United Kingdom
Primary
Concomitant
B-cell Lymphoma Other Serious 2/13/2007 66 Male 181 lb 9/27/2010 Physician United Kingdom
Primary
Concomitant
Syncope Hospitalization 7/2/2010 62 Male 9/8/2010 Consumer United States
Primary
Concomitant
Pulmonary Fibrosis Other Serious 5/11/2010 72 Female 196 lb 10/20/2010 Physician United Kingdom
Primary
Concomitant
Fungal Infection 1/1/2010 61 Female 250 lb 10/22/2010 Consumer United States
Primary
Concomitant
Thrombosis Other Serious 1/1/2010 11/8/2010 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Tremor Hospitalization 8/1/2010 41 Female 220 lb 11/9/2010 Other Health Professional United States
Primary
Concomitant
Vertebral Wedging Other Serious 1/1/2000 61 Female 11/16/2010 Other Health Professional United States
Primary
Secondary
Concomitant
Injection Site Warmth 6/6/2010 12/22/2010 Consumer United States
Primary
Concomitant
Abdominal Pain 6/14/2010 12/22/2010 Consumer United States
Primary
Concomitant
Oedema Peripheral Other Serious 6/1/2009 50 Female 12/29/2010 Physician Israel
Primary
Concomitant
Vertebral Wedging Other Serious 1/1/2001 62 Female 12/30/2010 Other Health Professional United States
Primary
Secondary
Concomitant
Limb Asymmetry Hospitalization 1/1/2010 74 Female 158 lb 1/5/2011 Consumer United States
Primary
Concomitant
Rib Fracture Other Serious 1/1/2001 62 Female 1/6/2011 Other Health Professional United States
Primary
Secondary
Concomitant
Vomiting Other Serious 5/24/2007 68 Female 12/28/2010 Other Health Professional United Kingdom
Primary
Concomitant
Renal Failure Hospitalization 1/1/2007 63 Male 192 lb 1/6/2011 Other Health Professional United States
Primary
Secondary
Concomitant
Dyspnoea Hospitalization 8/1/2010 52 Female 1/10/2011 Other Health Professional Canada
Primary
Concomitant
Pain In Jaw 7/1/2010 72 Male 1/30/2011 Consumer United States
Primary
Concomitant
Injection Site Haemorrhage 9/25/2010 74 Male 1/30/2011 Consumer United States
Primary
Concomitant
Diffuse Large B-cell Lymphoma Hospitalization 1/1/2010 72 Female 231 lb 1/30/2011 Physician United States
Primary
Concomitant
Fungal Infection Female 1/30/2011 Consumer United States
Primary
Concomitant
Drug Ineffective 10/1/2010 76 Female 1/30/2011 Consumer United States
Primary
Concomitant
Fall Hospitalization 72 Female 2/3/2011 Pharmacist Ireland
Primary
Concomitant
Blood Cholesterol Increased Hospitalization 8/1/2010 52 Female 2/11/2011 Other Health Professional Canada
Primary
Concomitant
Product Taste Abnormal 2/16/2011 83 Female 2/21/2011 Pharmacist United States
Primary
Concomitant
Ligament Rupture Disability 1/9/2011 45 Female 2/23/2011 Other Health Professional United Kingdom
Primary
Concomitant
Dental Caries Other Serious 1/1/2008 65 Female 134 lb 2/24/2011 Physician United States
Primary
Concomitant
Pleural Effusion Death 5/7/2010 70 Male 190 lb 3/1/2011 Consumer Japan
Primary
Concomitant
Atrial Fibrillation Other Serious 2/16/2010 70 Male 2/11/2011 United Kingdom
Primary
Concomitant
Constipation Hospitalization 8/1/2009 71 Female 3/1/2011 Consumer United States
Primary
Concomitant
Interacting
Hip Arthroplasty Hospitalization 1/25/2011 72 Female 3/4/2011 Pharmacist Ireland
Primary
Concomitant
Organising Pneumonia Other Serious 9/1/2010 63 Female 165 lb 3/4/2011 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Blood Cholesterol Increased Hospitalization 8/1/2010 52 Female 244 lb 3/7/2011 Consumer Canada
Primary
Concomitant
Off Label Use Other Serious 2/11/2011 76 Male 3/15/2011 Other Health Professional United Kingdom
Primary
Concomitant
Bronchial Carcinoma Other Serious 2/6/2009 74 Female 3/15/2011 Other Health Professional United Kingdom
Primary
Concomitant
Acidosis Death 9/1/2010 63 Female 165 lb 3/16/2011 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Pneumonia Other Serious 7/1/2010 63 Female 165 lb 3/17/2011 Physician United Kingdom
Primary
Secondary
Concomitant
Pneumonia Hospitalization Male 161 lb 3/4/2011 Consumer Canada
Primary
Concomitant
Pneumonitis Death 4/1/2010 63 Female 154 lb 3/23/2011 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Ejection Fraction Decreased Hospitalization 8/1/2009 65 Female 242 lb 3/25/2011 Physician United States
Primary
Secondary
Concomitant
Thrombosis Hospitalization 1/1/2010 43 Male 258 lb 3/28/2011 Physician United Kingdom
Primary
Secondary
Concomitant
Rheumatoid Arthritis Hospitalization 8/1/2010 52 Female 244 lb 4/5/2011 Consumer Canada
Primary
Concomitant
Pleural Effusion Other Serious 1/1/2001 62 Female 4/5/2011 Other Health Professional United States
Primary
Secondary
Concomitant
Throat Irritation 2/16/2011 83 Female 4/7/2011 Physician United States
Primary
Concomitant
Rheumatoid Arthritis Hospitalization 8/1/2010 52 Female 244 lb 4/11/2011 Consumer Canada
Primary
Concomitant
Sepsis Hospitalization 6/28/2010 75 Female 90 lb 4/12/2011 Other Health Professional United Kingdom
Primary
Concomitant
Faeces Discoloured Other Serious 1/1/2011 49 Male 4/15/2011 Consumer United States
Primary
Concomitant
Panic Disorder 11/11/2010 72 Female 166 lb 2/7/2011 Consumer United States
Primary
Concomitant
Pain In Extremity Hospitalization 1/1/2010 68 Female 185 lb 4/27/2011 Physician United States
Primary
Secondary
Concomitant
Hypotension Hospitalization 12/27/2010 49 Female 4/28/2011 Physician United States
Primary
Concomitant
Pain Hospitalization 1/1/2010 68 Female 185 lb 5/2/2011 Physician United States
Primary
Secondary
Concomitant
Abdominal Pain Hospitalization 12/1/2009 77 Female 144 lb 5/3/2011 Physician Canada
Primary
Concomitant
Systemic Lupus Erythematosus Hospitalization 67 Female 7/26/2011 Consumer United States
Primary
Secondary
Concomitant
Myocardial Infarction Death 4/29/2011 74 Female 8/9/2011 Physician United Kingdom
Primary
Concomitant
Paranoia Other Serious 1/1/2011 64 Female 187 lb 8/26/2011 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Pulmonary Granuloma Hospitalization 6/1/2009 Female 209 lb 9/7/2011 Other Health Professional United Kingdom
Primary
Concomitant
Throat Irritation 1/1/2011 82 Female 125 lb 12/1/2011 Consumer United States
Primary
Concomitant
Cardiac Failure Other Serious 1/1/2011 74 Female 12/21/2011 Physician Canada
Primary
Concomitant
Thrombosis Other Serious 1/1/2011 60 Male 245 lb 2/17/2012 Consumer United States
Primary
Concomitant
Mental Status Changes Hospitalization 6/1/2009 56 Female 6/22/2012 Lawyer United States
Primary
Concomitant
Urinary Tract Infection Other Serious 12/1/2003 65 Female 142 lb 8/2/2012 Lawyer United States
Primary
Secondary
Concomitant
Sepsis Hospitalization 5/1/2012 79 Female 88 lb 8/27/2012 Physician Japan
Primary
Concomitant
Upper Respiratory Tract Infection Other Serious 2008 Female 134 lb 11/15/2012 Physician Country Not Specified
Primary
Concomitant
Thoracic Vertebral Fracture Other Serious 2010 Female 192 lb 9/18/2012 Physician Au
Primary
Secondary
Concomitant
Urinary Bladder Haemorrhage Hospitalization 8/2011 Female 140 lb 12/13/2012 Physician Ca
Primary
Concomitant
Pneumonia Death 1/12/2012 60 Female 11/7/2012 Physician Gb
Primary
Concomitant
N-terminal Prohormone Brain Natriuretic Peptide Increased Other Serious 1/28/2012 57 Female 143 lb 11/1/2012 Physician Jp
Primary
Secondary
Concomitant
Toxic Epidermal Necrolysis Death 6/2/2012 79 Female 122 lb 11/14/2012 Pharmacist Gb
Primary
Secondary
Concomitant
Toxic Epidermal Necrolysis Death 6/2/2012 79 Female 122 lb 8/30/2012 Other Health Professional Gb
Primary
Secondary
Concomitant
Toxic Epidermal Necrolysis Death 6/2/2012 79 Female 122 lb 10/24/2012 Other Health Professional Gb
Primary
Secondary
Concomitant
Toxic Epidermal Necrolysis Death 6/2/2012 79 Female 122 lb 10/2/2012 Other Health Professional Gb
Primary
Secondary
Concomitant
Sepsis Hospitalization 5/1/2012 79 Female 88 lb 9/18/2012 Physician Jp
Primary
Concomitant
Tachycardia Death Female 110 lb 8/31/2012 Other Health Professional Country Not Specified
Primary
Secondary
Concomitant
Musculoskeletal Pain 75 Female 9/14/2012 Physician Ca
Primary
Concomitant
Septic Shock Hospitalization 7/15/2012 50 Female 105 lb 9/4/2012 Physician Jp
Primary
Secondary
Concomitant
Weight Decreased Hospitalization Male 11/12/2012 Physician Ca
Primary
Concomitant
Thrombocytopenia Other Serious 1/2012 Male 148 lb 9/19/2012 Physician Uy
Primary
Secondary
Concomitant
Vomiting Other Serious 2009 Female 112 lb 9/8/2012 Consumer Us
Primary
Secondary
Concomitant
Herpes Zoster 2012 Male 9/13/2012 Consumer Us
Primary
Concomitant
Atrial Fibrillation Hospitalization Female 287 lb 11/6/2012 Physician Gb
Primary
Concomitant
Atrial Fibrillation Other Serious 1/24/2012 78 Male 156 lb 10/2/2012 Consumer Ca
Primary
Concomitant
Sepsis Hospitalization 12/4/2011 76 Female 126 lb 11/27/2012 Physician Gb
Primary
Concomitant
International Normalised Ratio Increased Other Serious 10/2012 Male 270 lb 10/25/2012 Consumer Us
Primary
Concomitant
Injection Site Swelling 70 Female 124 lb 10/25/2012 Physician Us
Primary
Concomitant
Nasopharyngitis 3/5/2012 84 Female 130 lb 10/25/2012 Physician Us
Primary
Concomitant
Cystitis 3/2012 71 Male 10/25/2012 Physician Us
Primary
Concomitant
Oropharyngeal Pain 10/11/2011 44 Female 220 lb 11/7/2012 Physician Us
Primary
Concomitant

Drug Data