Methotrexate combined with Voriconazole

Reports:

Reaction Outcome Event Date Age Sex Weight Reported Reporter Country Treatment
Role Name
Tracheostomy Hospitalization 40 Male 2/15/2006 Other Health Professional Germany
Primary
Secondary
Concomitant
White Blood Cell Count Decreased Other Serious 11/29/2006 17 Female 1/10/2007 Consumer
Primary
Concomitant
Polyserositis Other Serious 10/15/2006 15 Female 104 lb 2/22/2007 Other Health Professional Switzerland
Primary
Secondary
Concomitant
Polyserositis Other Serious 10/15/2006 15 Female 104 lb 2/27/2007 Other Health Professional Switzerland
Primary
Secondary
Concomitant
Pseudoporphyria Other Serious 4/1/2005 55 Female 2/27/2007 United Kingdom
Primary
Concomitant
Septic Shock Other Serious 10/15/2006 15 Female 104 lb 4/16/2007 Other Health Professional Switzerland
Primary
Secondary
Concomitant
Renal Tubular Disorder Death 7 Female 5/24/2007 Physician Italy
Primary
Secondary
Concomitant
Renal Tubular Disorder Other Serious 7 Female 5/30/2007 Physician Italy
Primary
Secondary
Concomitant
Cerebellar Syndrome Death 5/21/2007 17 Male 7/24/2007 Other Health Professional France
Primary
Secondary
Concomitant
Renal Tubular Disorder Other Serious 7 Female 8/14/2007 Physician Italy
Primary
Secondary
Concomitant
Cerebellar Syndrome Death 5/21/2007 16 Male 8/21/2007 Other Health Professional France
Primary
Secondary
Concomitant
Leukoencephalopathy Hospitalization 12/5/2006 70 Female 9/6/2007 Physician Japan
Primary
Secondary
Concomitant
Oesophageal Stenosis Other Serious 3 Female 9/7/2007 Other Health Professional Denmark
Primary
Secondary
Concomitant
Squamous Cell Carcinoma Other Serious 44 Female 10/12/2007 Physician France
Primary
Secondary
Renal Failure Acute Other Serious 28 Male 10/17/2007
Primary
Secondary
Concomitant
Pericarditis Fungal Other Serious 11/11/2005 3 Female 10/23/2007
Primary
Secondary
Concomitant
Ureaplasma Infection Other Serious 28 Male 11/5/2007 Switzerland
Primary
Secondary
Concomitant
Stomatitis Other Serious 6 Male 12/23/2007 Japan
Primary
Concomitant
Stomatitis Other Serious 5/1/2007 6 Male 1/3/2008 Japan
Primary
Concomitant
Wolff-parkinson-white Syndrome Hospitalization 8/6/2007 80 Male 3/6/2008 Japan
Primary
Secondary
Concomitant
Nocardiosis Other Serious Female 3/13/2008 Physician United States
Primary
Concomitant
Pyrexia Other Serious 10 Male 3/24/2008 Other Health Professional Pakistan
Primary
Secondary
Concomitant
Venoocclusive Liver Disease Other Serious 36 Female 3/28/2008 Other Health Professional United States
Primary
Secondary
Concomitant
Respiratory Distress Hospitalization 17 Male 3/28/2008 Consumer United States
Primary
Secondary
Concomitant
Splenic Granuloma Hospitalization 76 Female 4/9/2008 Physician United States
Primary
Secondary
Concomitant
Sinus Congestion Hospitalization 5/17/2008 Male 185 lb 5/30/2008 United States
Primary
Secondary
Concomitant
Virus Urine Test Positive Hospitalization 17 Male 6/5/2008
Primary
Secondary
Concomitant
Malaise Hospitalization 5/17/2008 Male 185 lb 6/11/2008 United States
Primary
Secondary
Concomitant
Tuberculosis Other Serious 63 Female 7/31/2008
Primary
Secondary
Concomitant
Vomiting Other Serious 5/19/2008 Male 52 lb 8/15/2008 Other Health Professional Brazil
Primary
Secondary
Concomitant
Ventricular Fibrillation Other Serious 8/1/2000 54 Female 170 lb 9/5/2008 Physician Germany
Primary
Secondary
Concomitant
Vomiting Other Serious 5/19/2008 Male 52 lb 10/16/2008 Other Health Professional Brazil
Primary
Secondary
Concomitant
Vomiting Other Serious 5/19/2008 Male 52 lb 11/5/2008 Other Health Professional Brazil
Primary
Concomitant
Pneumocystis Jiroveci Pneumonia Other Serious 53 Male 11/21/2008
Primary
Secondary
Concomitant
Gingival Hyperplasia 7/20/2008 Male 11/24/2008 Physician United States
Primary
Secondary
Concomitant
Rhabdomyolysis Other Serious 1/1/2007 54 Male 11/24/2008 Physician Spain
Primary
Secondary
Concomitant
Rhabdomyolysis Other Serious 1/1/2007 54 Male 12/2/2008 Physician Spain
Primary
Secondary
Concomitant
Sinusitis Hospitalization 1/1/2007 60 Male 143 lb 12/16/2008 Physician Spain
Primary
Secondary
Concomitant
Sinusitis Hospitalization 1/1/2007 60 Male 143 lb 12/19/2008 Physician Spain
Primary
Secondary
Concomitant
Tachyarrhythmia Other Serious 57 Female 2/12/2009 Other Health Professional Germany
Primary
Concomitant
Respiratory Failure Other Serious 11/1/2007 3/11/2009 Other Health Professional Canada
Primary
Concomitant
Stomatitis Other Serious 54 Male 4/30/2009 Other Health Professional Spain
Primary
Concomitant
Interacting
Blood Bilirubin Increased Required Intervention 2/22/2009 30 Female 235 lb 2/24/2009 Pharmacist United States
Primary
Concomitant
Influenza Like Illness Required Intervention 2/16/2009 58 Male 192 lb 3/5/2009 Pharmacist United States
Primary
Concomitant
Rhabdomyolysis Other Serious 54 Male 5/4/2009 Spain
Primary
Concomitant
Interacting
Renal Failure Acute Other Serious 54 Male 5/8/2009 Other Health Professional Spain
Primary
Secondary
Concomitant
Renal Failure Acute Other Serious 54 Male 5/11/2009 Other Health Professional Spain
Primary
Secondary
Concomitant
Rhabdomyolysis Other Serious 57 Male 5/8/2009 Physician Spain
Primary
Secondary
Concomitant
Respiratory Failure Other Serious 11/1/2007 43 5/25/2009 Other Health Professional Canada
Primary
Concomitant
Systemic Mycosis Hospitalization 7/1/2006 50 Female 5/29/2009 Other Health Professional Italy
Primary
Secondary
Concomitant
Hallucination Life Threatening 3/7/2009 30 Male 174 lb 4/3/2009 Pharmacist United States
Primary
Secondary
Concomitant
Hepatic Cirrhosis Other Serious 7/29/2009 Physician Denmark
Primary
Secondary
Systemic Mycosis Hospitalization 7/1/2006 50 Female 11/24/2009 Other Health Professional Italy
Primary
Secondary
Concomitant
Multi-organ Failure Death 10/1/2009 52 Male 12/22/2009 Physician Japan
Primary
Concomitant
Stem Cell Transplant Death 9/16/2009 24 Female 126 lb 12/31/2009 Physician Japan
Primary
Concomitant
Stenotrophomonas Infection Other Serious 10/5/2006 35 Female 1/25/2010
Primary
Secondary
Concomitant
Hypersensitivity Hospitalization 1/24/2010 Male 200 lb 2/12/2010 Other Health Professional United States
Primary
Concomitant
Pseudoporphyria Other Serious 4/1/2005 55 Female 143 lb 2/19/2010 Other Health Professional United Kingdom
Primary
Concomitant
Telangiectasia Other Serious 46 Male 3/1/2010 Other Health Professional United States
Primary
Secondary
Thrombotic Microangiopathy Death 12/10/2008 51 Female 3/3/2010 Japan
Primary
Secondary
Concomitant
Tachypnoea Hospitalization 2 Male 3/9/2010 Australia
Primary
Secondary
Concomitant
Squamous Cell Carcinoma Death 46 Male 3/17/2010 Physician United States
Primary
Secondary
Squamous Cell Carcinoma Other Serious 1/1/2010 46 Male 3/18/2010 Physician United States
Primary
Secondary
Dyspnoea At Rest Hospitalization 10/15/2009 68 Female 3/16/2010 Other Health Professional Spain
Primary
Concomitant
Vocal Cord Paralysis Hospitalization 2 Male 3/24/2010 Physician Australia
Primary
Secondary
Concomitant
Meningitis Cryptococcal Hospitalization 2/15/2010 69 Male 192 lb 6/18/2010 Physician United Kingdom
Primary
Concomitant
Pleural Effusion Disability 2/18/2009 10 Female 44 lb 6/28/2010 Physician Japan
Primary
Secondary
Concomitant
Syncope Other Serious 10/6/2007 50 Male 194 lb 6/30/2010 Lawyer United States
Primary
Concomitant
Pyrexia Other Serious 2/16/2009 23 Male 161 lb 7/20/2010 Other Health Professional Japan
Primary
Concomitant
Graft Versus Host Disease Other Serious 7/23/2010 Other Health Professional United States
Primary
Concomitant
Graft Versus Host Disease Death 7/23/2010 Other Health Professional United States
Primary
Concomitant
Neurotoxicity Death 7/23/2010 Other Health Professional United States
Primary
Concomitant
Neurotoxicity Death 7/23/2010 Other Health Professional United States
Primary
Concomitant
Pyrexia Other Serious 9/21/2009 37 Female 93 lb 8/9/2010 Physician Japan
Primary
Concomitant
Lipase Increased Other Serious 8/3/2010 13 Female 99 lb 8/20/2010 Physician United States
Primary
Secondary
Concomitant
Tachycardia Other Serious 9/20/2007 50 Male 194 lb 8/27/2010 Other Health Professional United States
Primary
Secondary
Concomitant
Pyrexia Other Serious 2/16/2009 23 Male 161 lb 9/1/2010 Other Health Professional Japan
Primary
Concomitant
Acute Myeloid Leukaemia Recurrent Other Serious 12/10/2009 5 Male 53 lb 9/1/2010 Physician Japan
Primary
Concomitant
Lipase Increased Other Serious 8/3/2010 13 Female 99 lb 9/8/2010 Physician United States
Primary
Secondary
Concomitant
Lipase Increased Other Serious 8/3/2010 13 Female 99 lb 9/24/2010 Physician United States
Primary
Secondary
Concomitant
Pneumonia Life Threatening 9/20/2010 32 Female 188 lb 10/12/2010 Other Health Professional United States
Primary
Secondary
Concomitant
Lipase Increased Other Serious 8/3/2010 13 Female 99 lb 10/14/2010 Physician United States
Primary
Secondary
Concomitant
Pneumonia Life Threatening 9/20/2010 32 Female 188 lb 11/2/2010 Other Health Professional United States
Primary
Secondary
Concomitant
Aspartate Aminotransferase Increased Other Serious 9/7/2009 5 Male 38 lb Other Health Professional United States
Primary
Secondary
Concomitant
White Blood Cell Count Abnormal Other Serious 9/20/2010 32 Female 188 lb 11/9/2010 Other Health Professional United States
Primary
Secondary
Concomitant
Pseudomonal Sepsis Other Serious 5/21/2010 Male 154 lb 12/3/2010 Physician Japan
Primary
Concomitant
White Blood Cell Count Decreased Other Serious 1/29/2010 49 Male 110 lb 12/13/2010 Physician Japan
Primary
Concomitant
White Blood Cell Count Decreased Other Serious 1/29/2010 49 Male 110 lb 12/13/2010 Physician Japan
Primary
Concomitant
Enterococcal Sepsis Death 11 Female 12/17/2010 Physician Italy
Primary
Secondary
Concomitant
Pancytopenia Death 11 Female 12/21/2010 United States
Primary
Secondary
Concomitant
Subclavian Vein Thrombosis Life Threatening 7 Female 12/22/2010 Other Health Professional Germany
Primary
Secondary
Concomitant
Subclavian Vein Thrombosis Life Threatening 7 Female 12/22/2010 Other Health Professional Germany
Primary
Secondary
Concomitant
Headache Other Serious 9/1/2007 50 Male 194 lb 1/12/2011 Other Health Professional United States
Primary
Secondary
Concomitant
Adult T-cell Lymphoma/leukaemia Death Female 126 lb 1/13/2011 Physician Japan
Primary
Secondary
Concomitant
Fungal Sepsis Death 1/1/2007 63 Female 1/18/2011 Other Health Professional Japan
Primary
Concomitant
Staphylococcal Infection Hospitalization 9/10/2009 18 Male 137 lb 1/24/2011 Physician Japan
Primary
Concomitant
Respiratory Arrest Death 12/30/2009 27 Female 220 lb 1/13/2011 Physician Japan
Primary
Concomitant
Hy's Law Case Hospitalization 1/25/2011 15 Male 115 lb 2/9/2011 Physician Thailand
Primary
Concomitant
Sepsis Other Serious 9/10/2009 18 Male 137 lb 2/15/2011 Physician Japan
Primary
Concomitant
Hy's Law Case Other Serious 1/25/2011 15 Male 115 lb 2/18/2011 Physician Thailand
Primary
Concomitant
Hy's Law Case Hospitalization 1/25/2011 15 Male 115 lb 2/25/2011 Physician Thailand
Primary
Concomitant
Deep Vein Thrombosis Death 1/1/2010 61 Female 3/11/2011 Physician Netherlands
Primary
Secondary
Concomitant
Muscular Weakness Hospitalization 1/25/2011 15 Male 115 lb 3/18/2011 Physician Thailand
Primary
Secondary
Concomitant
Hypophosphataemia Other Serious 9 Female 3/7/2011 Other Health Professional France
Primary
Secondary
Concomitant
Hy's Law Case Other Serious 1/25/2011 15 Male 115 lb 3/23/2011 Physician Thailand
Primary
Secondary
Concomitant
Hy's Law Case Other Serious 1/25/2011 15 Male 115 lb 3/23/2011 Physician Thailand
Primary
Secondary
Concomitant
Diffuse Large B-cell Lymphoma Other Serious 55 Male 3/18/2011 Physician Japan
Primary
Concomitant
Abdominal Pain Other Serious 6/25/2007 9 Female 3/15/2011 Other Health Professional France
Primary
Secondary
Concomitant
Respiratory Arrest Death 11/30/2009 27 Female 220 lb 3/22/2011 Physician Japan
Primary
Concomitant
Hy's Law Case Hospitalization 1/25/2011 15 Male 115 lb 4/7/2011 Physician Thailand
Primary
Secondary
Concomitant
Leukoencephalopathy Other Serious 8/4/2010 13 Female 99 lb 4/12/2011 Physician United States
Primary
Secondary
Concomitant
Toothache Hospitalization 9/21/2009 37 Female 93 lb 4/14/2011 Physician Japan
Primary
Concomitant
Febrile Neutropenia Hospitalization 10/15/2009 57 Female 106 lb 4/19/2011 Physician Japan
Primary
Concomitant
Cytomegalovirus Gastroenteritis Death 55 Male 4/20/2011 Physician Japan
Primary
Concomitant
Pancytopenia Hospitalization 2/21/2011 16 Female 4/11/2011 Physician Spain
Primary
Secondary
Concomitant
Abscess Bacterial Death 11/25/2009 61 Male 141 lb 4/25/2011 Physician Japan
Primary
Secondary
Concomitant
Pancytopenia Hospitalization 2/21/2011 16 Female 4/18/2011 Physician Spain
Primary
Secondary
Concomitant
Petechiae Other Serious 1/29/2010 49 Male 110 lb 5/20/2011 Physician Japan
Primary
Concomitant
Nocardiosis Other Serious 50 Female 4/1/2011 Physician United States
Primary
Concomitant
Diarrhoea Other Serious 11/29/2010 21 Female 185 lb 6/7/2011 Physician Germany
Primary
Secondary
Concomitant
Drug Ineffective Death 17 Male 6/7/2011 Other Health Professional Portugal
Primary
Secondary
Dehydration Hospitalization 4/7/2010 61 Female 6/10/2011 Physician Netherlands
Primary
Secondary
Concomitant
Bronchopulmonary Aspergillosis Death 9/2/2010 2 Female 18 lb 6/21/2011 Physician Japan
Primary
Secondary
Concomitant
Acute Graft Versus Host Disease Other Serious 34 Female 6/29/2011 Physician Japan
Primary
Concomitant
Interacting
Renal Haemorrhage Other Serious 1/1/2007 63 Female 6/30/2011 Other Health Professional Japan
Primary
Concomitant
Hypertension Life Threatening 4/22/2010 13 Male 90 lb 7/5/2011 Physician Japan
Primary
Concomitant
Abdominal Pain Other Serious 6/14/2010 7 Female 31 lb 7/8/2011 Physician Japan
Primary
Concomitant
Cytomegalovirus Gastritis Other Serious 5/21/2010 Male 154 lb 7/18/2011 Physician Japan
Primary
Concomitant
Abscess Bacterial Hospitalization 11/25/2009 61 Male 141 lb 7/18/2011 Physician Japan
Primary
Secondary
Concomitant
Acute Graft Versus Host Disease In Skin Death 12/10/2009 7 Male 53 lb 7/19/2011 Physician Japan
Primary
Concomitant
Pneumonia Hospitalization 5/17/2010 57 Female 134 lb 8/22/2011 Physician Japan
Primary
Secondary
Concomitant
Off Label Use Other Serious 53 Female 8/24/2011 Other Health Professional United States
Primary
Concomitant
Hy's Law Case Other Serious 1/25/2011 15 Male 115 lb 8/29/2011 Physician Thailand
Primary
Secondary
Concomitant
Meningitis Cryptococcal Hospitalization 2/15/2010 69 Male 192 lb 9/15/2011 Consumer United Kingdom
Primary
Concomitant
Neuropathy Peripheral Other Serious 9/15/2011 Other Health Professional Netherlands
Primary
Concomitant
Interacting
Epstein-barr Virus Associated Lymphoproliferative Disorder Death 5/19/2009 10 Male 49 lb 9/19/2011 Physician Japan
Primary
Concomitant
Hy's Law Case Hospitalization 1/25/2011 15 Male 115 lb 9/21/2011 Physician Thailand
Primary
Secondary
Concomitant
Bronchopulmonary Aspergillosis Death 66 Female 10/3/2011 Other Health Professional Korea, Republic Of
Primary
Secondary
Concomitant
Periorbital Oedema Life Threatening 1/27/2011 6 Female 40 lb 10/3/2011 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Deep Vein Thrombosis Death 12/7/2010 6 Female 40 lb 10/4/2011 Pharmacist United Kingdom
Primary
Secondary
Concomitant
Acute Myeloid Leukaemia Recurrent Other Serious 10/10/2011 Other Health Professional Japan
Primary
Concomitant
Febrile Neutropenia Life Threatening 6 Female 40 lb 10/6/2011 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Pneumonia Cryptococcal Hospitalization Male 10/12/2011 Physician United States
Primary
Concomitant
Haematemesis Other Serious 4 Male 38 lb 10/14/2011 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Herpes Zoster Hospitalization 10/24/2010 19 Male 97 lb 10/21/2011 Physician Japan
Primary
Concomitant
Venoocclusive Liver Disease Death 1/24/2011 3 Male 35 lb 10/18/2011 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Posterior Reversible Encephalopathy Syndrome Hospitalization 10/8/2011 9 Male 57 lb 11/3/2011 Physician Czech Republic
Primary
Secondary
Concomitant
Posterior Reversible Encephalopathy Syndrome Hospitalization 10/8/2011 9 Male 55 lb 11/8/2011 Physician United States
Primary
Secondary
Concomitant
Abscess Bacterial Hospitalization 11/25/2009 61 Male 141 lb 11/17/2011 Physician Japan
Primary
Secondary
Concomitant
Acute Graft Versus Host Disease In Skin Other Serious 3/29/2011 36 Male 148 lb 11/21/2011 Physician Japan
Primary
Concomitant

Drug Data