Methotrexate combined with Vitamin B6

Reports:

Reaction Outcome Event Date Age Sex Weight Reported Reporter Country Treatment
Role Name
Cutaneous Lupus Erythematosus Other Serious 7/1/2004 Female 2/24/2006 Physician United States
Primary
Concomitant
Weight Decreased Hospitalization 3/29/2006 Male 119 lb 4/18/2006 Other Health Professional Canada
Primary
Concomitant
Pyrexia Hospitalization 4/10/2006 62 Female 4/24/2006 Other Health Professional United States
Primary
Concomitant
Weight Decreased Hospitalization 3/29/2006 Male 119 lb 4/28/2006 Other Health Professional Canada
Primary
Secondary
Concomitant
Weight Decreased Hospitalization 3/29/2006 Male 119 lb 4/28/2006 Other Health Professional Canada
Primary
Secondary
Concomitant
Squamous Cell Carcinoma Other Serious 9/1/2005 Female 125 lb 5/11/2006 Physician United States
Primary
Concomitant
Gastroenteritis Hospitalization 4/10/2006 62 Female 5/16/2006 Other Health Professional United States
Primary
Concomitant
Weight Decreased Hospitalization 3/29/2006 Male 115 lb 6/2/2006 Other Health Professional Canada
Primary
Secondary
Concomitant
Weight Decreased Hospitalization 3/29/2006 Male 115 lb 6/2/2006 Other Health Professional Canada
Primary
Secondary
Concomitant
Respiratory Failure Hospitalization 3/21/2006 Female 6/26/2006 Physician Canada
Primary
Secondary
Concomitant
Weight Decreased Hospitalization 1/1/2006 Male 119 lb 6/28/2006 Other Health Professional Canada
Primary
Secondary
Concomitant
Weight Decreased Hospitalization 1/1/2006 Male 119 lb 6/28/2006 Other Health Professional Canada
Primary
Secondary
Concomitant
Ureteral Stent Insertion Hospitalization 7/1/2005 Female 156 lb 9/11/2006 Physician United States
Primary
Concomitant
Gastrointestinal Haemorrhage Hospitalization 6/11/2006 70 Male 12/6/2006 Consumer United States
Primary
Secondary
Concomitant
Gastrointestinal Haemorrhage Hospitalization 6/11/2006 70 Male 3/13/2007 Consumer United States
Primary
Secondary
Concomitant
Weight Decreased Hospitalization 1/1/2006 Male 119 lb 3/20/2007 Other Health Professional Canada
Primary
Secondary
Concomitant
Dyspnoea Hospitalization 12/5/2006 Female 4/5/2007 Physician United States
Primary
Concomitant
Rheumatoid Arthritis Hospitalization 3/14/2007 Female 150 lb 4/25/2007 Physician United States
Primary
Concomitant
Gastrointestinal Haemorrhage Hospitalization 6/11/2006 70 Male 5/10/2007 Consumer United States
Primary
Secondary
Concomitant
Genital Herpes 3/1/2007 64 Female 9/26/2007 Consumer United States
Primary
Concomitant
Influenza Hospitalization 2/18/2008 Female 194 lb 2/28/2008 Consumer United States
Primary
Concomitant
Myocardial Infarction Other Serious 5/8/2007 Female 185 lb 4/14/2008 Consumer Canada
Primary
Secondary
Concomitant
Coronary Artery Disease Hospitalization 8/9/2008 Female 203 lb 9/26/2008 Physician Ukraine
Primary
Secondary
Concomitant
Arrhythmia Death 8/7/2007 10/24/2008 Consumer Argentina
Primary
Secondary
Concomitant
Latent Tuberculosis Death Female 11/17/2008 Other Health Professional United States
Primary
Concomitant
Pneumonia 12/1/2007 Female 12/11/2008 Consumer United States
Primary
Concomitant
Osteolysis Hospitalization 2/9/2007 Male 160 lb 12/26/2008 United States
Primary
Concomitant
Puncture Site Infection Hospitalization 12/21/2008 4 Male 44 lb 1/22/2009 Physician Germany
Primary
Secondary
Concomitant
Systemic Candida Hospitalization 11/10/2008 Female 115 lb 1/30/2009 Belgium
Primary
Secondary
Concomitant
Staphylococcal Infection Other Serious Female 135 lb 2/3/2009 Canada
Primary
Concomitant
Transaminases Increased Hospitalization 12/21/2008 4 Male 44 lb 2/2/2009 Physician Germany
Primary
Secondary
Concomitant
Migraine With Aura Other Serious 1/1/2004 Female 250 lb 3/6/2009 Physician United States
Primary
Concomitant
Systemic Candida Hospitalization 11/10/2008 Female 115 lb 3/9/2009 Belgium
Primary
Secondary
Concomitant
Weight Control Hospitalization 9/1/2008 Female 4/29/2009 Puerto Rico
Primary
Secondary
Concomitant
Systemic Candida Hospitalization 11/10/2008 Female 115 lb 6/1/2009 Belgium
Primary
Secondary
Concomitant
Ear Infection Hospitalization 4/12/2008 65 Female 134 lb 6/22/2009 Russian Federation
Primary
Concomitant
Transaminases Increased Hospitalization 12/21/2008 4 Male 44 lb 6/26/2009 Physician Germany
Primary
Secondary
Concomitant
Coronary Artery Occlusion Other Serious 6/9/2009 Male 191 lb 7/23/2009 Canada
Primary
Concomitant
Systemic Candida Hospitalization 11/10/2008 Female 115 lb 7/24/2009 Belgium
Primary
Secondary
Concomitant
Coronary Artery Occlusion Other Serious 6/9/2009 Male 191 lb 8/11/2009 Canada
Primary
Concomitant
Respiratory Failure Hospitalization 11/10/2008 Female 115 lb 8/13/2009 Belgium
Primary
Secondary
Concomitant
Vision Blurred Other Serious 2/9/2004 Female 8/14/2009 Other Health Professional United States
Primary
Concomitant
Pancreatitis Acute Hospitalization 8/12/2009 Female 118 lb 8/25/2009 Physician United States
Primary
Secondary
Concomitant
Pancreatitis Acute Hospitalization 8/12/2009 Female 118 lb 9/2/2009 Physician United States
Primary
Secondary
Concomitant
Overdose Life Threatening 7/5/2008 14 Male 101 lb 9/1/2009 Poland
Primary
Secondary
Concomitant
Drug Dose Omission 6/16/2009 Male 237 lb 9/19/2009 United States
Primary
Concomitant
Injection Site Irritation 2/1/2009 Female 142 lb 9/19/2009 Consumer United States
Primary
Concomitant
Pain 4/1/2009 Female 219 lb 9/19/2009 United States
Primary
Concomitant
Grand Mal Convulsion Life Threatening 7/5/2008 14 Male 101 lb 9/14/2009 Physician Poland
Primary
Secondary
Concomitant
Overdose Life Threatening 7/5/2008 14 Male 101 lb 9/21/2009 Physician Poland
Primary
Secondary
Concomitant
Tuberculin Test Positive Hospitalization 4/12/2008 65 Female 134 lb 9/29/2009 Other Health Professional Russian Federation
Primary
Concomitant
Surgery Other Serious 1/1/2008 Female 226 lb 10/14/2009 Canada
Primary
Concomitant
Vision Blurred Other Serious 2/9/2004 Female 11/2/2009 Other Health Professional United States
Primary
Concomitant
Stress Cardiomyopathy Hospitalization 11/10/2008 Female 115 lb 11/6/2009 Belgium
Primary
Secondary
Concomitant
Respiratory Failure Hospitalization 11/10/2008 Female 115 lb 11/9/2009 Belgium
Primary
Secondary
Concomitant
Throat Irritation Other Serious 1/1/2005 Female 153 lb 11/16/2009 Pharmacist United States
Primary
Concomitant
Respiratory Failure Hospitalization 11/10/2008 Female 115 lb 11/16/2009 Belgium
Primary
Secondary
Concomitant
Respiratory Failure Hospitalization 11/10/2008 Female 115 lb 11/25/2009 Belgium
Primary
Secondary
Concomitant
Volvulus Other Serious 11/17/2009 Male 225 lb 12/1/2009 Canada
Primary
Concomitant
Thrombocytopenia Other Serious 1/1/2009 72 Female 142 lb 12/4/2009 Other Health Professional Finland
Primary
Secondary
Concomitant
Vision Blurred Other Serious 2/9/2004 Female 12/4/2009 Other Health Professional United States
Primary
Concomitant
Thrombocytopenia Other Serious 1/1/2009 72 Female 142 lb 12/28/2009 Other Health Professional Finland
Primary
Secondary
Concomitant
Vision Blurred Other Serious 2/9/2004 Female 12/29/2009 Other Health Professional United States
Primary
Concomitant
Thalamus Haemorrhage Hospitalization 12/12/2009 57 Male 176 lb 12/31/2009 Other Health Professional Canada
Primary
Concomitant
Thalamus Haemorrhage Hospitalization 12/12/2009 57 Male 176 lb 1/8/2010 Other Health Professional Canada
Primary
Concomitant
Throat Irritation Other Serious 1/1/2005 Female 153 lb 1/11/2010 Pharmacist United States
Primary
Concomitant
Throat Irritation Other Serious 1/1/2005 Female 153 lb 1/21/2010 Pharmacist United States
Primary
Concomitant
Diarrhoea Hospitalization 1/18/2010 Female 232 lb 1/26/2010 Other Health Professional United States
Primary
Concomitant
Vision Blurred Other Serious 1/1/2005 Female 153 lb 1/30/2010 Pharmacist United States
Primary
Concomitant
Diarrhoea Hospitalization 1/18/2010 Female 232 lb 2/3/2010 Other Health Professional United States
Primary
Secondary
Concomitant
Vision Blurred Other Serious 1/1/2005 Female 153 lb 2/8/2010 Pharmacist United States
Primary
Concomitant
Spinal Column Stenosis Other Serious Female 2/19/2010 Physician United States
Primary
Secondary
Concomitant
Weight Decreased 75 Female 139 lb 2/22/2010 Consumer United States
Primary
Concomitant
Cardiac Failure Congestive Other Serious 1/28/2010 Female 2/24/2010 Consumer United States
Primary
Concomitant
Respiratory Failure Hospitalization 11/10/2008 Female 115 lb 3/5/2010 Belgium
Primary
Secondary
Concomitant
Myelodysplastic Syndrome Other Serious 1/1/2008 Male 211 lb 3/5/2010 Consumer United States
Primary
Concomitant
Walking Aid User Other Serious 7/1/2005 Female 3/8/2010 Physician United States
Primary
Secondary
Concomitant
Walking Aid User Other Serious 1/9/2004 Female 3/22/2010 Physician United States
Primary
Secondary
Concomitant
Squamous Cell Carcinoma Other Serious 2/25/2010 Female 161 lb 3/16/2010 United States
Primary
Concomitant
Walking Aid User Other Serious 1/9/2004 69 Female 4/9/2010 Physician United States
Primary
Concomitant
Walking Aid User Other Serious 1/9/2004 69 Female 4/19/2010 Physician United States
Primary
Concomitant
Unresponsive To Stimuli Other Serious 1/1/2007 82 Female 121 lb 4/20/2010 Other Health Professional United States
Primary
Secondary
Concomitant
Vision Blurred Other Serious Male 144 lb 4/23/2010 Other Health Professional Canada
Primary
Concomitant
Pleurisy Hospitalization 11/9/2009 55 Female 203 lb 4/27/2010 Physician Ukraine
Primary
Concomitant
Wound Infection Staphylococcal Other Serious 1/1/2008 Female 5/13/2010 Consumer United States
Primary
Concomitant
Vision Blurred Other Serious 1/1/2005 64 Female 153 lb 6/11/2010 United States
Primary
Concomitant
Visual Acuity Reduced Female 130 lb 6/28/2010 Consumer United States
Primary
Concomitant
Pelvic Abscess Life Threatening 5/11/2010 76 Female 137 lb 7/7/2010 Physician United States
Primary
Concomitant
Weight Decreased Male 135 lb 7/7/2010 Consumer United States
Primary
Secondary
Concomitant
Rheumatoid Arthritis Other Serious 2/1/2009 59 Female 7/8/2010 Physician United States
Primary
Concomitant
Pelvic Abscess Life Threatening 5/11/2010 76 Female 137 lb 7/16/2010 Physician United States
Primary
Concomitant
Synovitis Hospitalization 6/2/2010 56 Female 199 lb 7/14/2010 Other Health Professional Ukraine
Primary
Concomitant
Walking Aid User Other Serious 1/9/2004 69 Female 7/22/2010 United States
Primary
Concomitant
Vision Blurred Other Serious 1/1/2005 64 Female 153 lb 7/27/2010 United States
Primary
Concomitant
Walking Aid User Other Serious 1/9/2004 69 Female 8/6/2010 Other Health Professional United States
Primary
Concomitant
Walking Aid User Other Serious 1/9/2004 69 Female 8/16/2010 Other Health Professional United States
Primary
Concomitant
Vision Blurred Other Serious 1/1/2005 64 Female 153 lb 8/20/2010 United States
Primary
Concomitant
Abdominal Pain Hospitalization 2/16/2010 13 Female 122 lb 8/25/2010 Physician United States
Primary
Concomitant
Walking Aid User Other Serious 1/9/2004 69 Female 9/22/2010 Other Health Professional United States
Primary
Concomitant
Vision Blurred Other Serious 1/1/2005 64 Female 153 lb 10/1/2010 United States
Primary
Concomitant
Weight Decreased Other Serious 6/25/2005 55 Female 10/15/2010 United States
Primary
Secondary
Concomitant
Weight Decreased Life Threatening 5/11/2010 76 Female 137 lb 11/10/2010 Physician United States
Primary
Concomitant
Wound Secretion Other Serious 10/1/2010 66 Female 11/11/2010 Consumer Canada
Primary
Concomitant
Vision Blurred Other Serious Male 144 lb 11/19/2010 Physician United States
Primary
Concomitant
White Blood Cell Count Decreased Life Threatening 5/11/2010 76 Female 137 lb 11/19/2010 Physician United States
Primary
Concomitant
Vision Blurred Other Serious 1/1/2005 64 Female 153 lb 12/2/2010 United States
Primary
Concomitant
Medication Error Other Serious 1/1/2010 63 Male 186 lb 11/17/2010 Canada
Primary
Concomitant
Supraventricular Tachycardia Life Threatening 5/11/2010 76 Female 137 lb 12/8/2010 Physician United States
Primary
Concomitant
Pyrexia Hospitalization 1/9/2004 69 Female 1/13/2011 Other Health Professional United States
Primary
Concomitant
Hepatitis Toxic Hospitalization 10/15/2010 51 Male 172 lb 1/26/2011 Physician Poland
Primary
Secondary
Concomitant
Osteoarthritis Other Serious 1/1/2008 63 Male 175 lb 1/28/2011 Physician United States
Primary
Concomitant
Dyspepsia 1/1/2009 58 Female 245 lb 1/30/2011 Physician United States
Primary
Concomitant
Mobility Decreased 10/1/2010 61 Female 179 lb 1/30/2011 Consumer United States
Primary
Secondary
Concomitant
Injection Site Pain 10/1/2010 28 Male 190 lb 1/30/2011 Consumer United States
Primary
Concomitant
Hepatitis Toxic Hospitalization 10/13/2010 51 Male 172 lb 2/11/2011 Physician Poland
Primary
Secondary
Concomitant
Squamous Cell Carcinoma Of Skin Other Serious 2/25/2010 48 Female 161 lb 2/3/2011 United States
Primary
Concomitant
Lung Neoplasm Malignant Other Serious 11/29/2010 60 Female 2/28/2011 Physician United States
Primary
Concomitant
Squamous Cell Carcinoma Of Skin Other Serious 2/25/2010 48 Female 161 lb 2/15/2011 Other Health Professional United States
Primary
Concomitant
Thrombocytopenia Other Serious 1/9/2004 69 Female 3/23/2011 Other Health Professional United States
Primary
Concomitant
Hepatitis Toxic Hospitalization 10/15/2010 51 Male 172 lb 3/25/2011 Physician Poland
Primary
Secondary
Concomitant
Intestinal Resection Other Serious Male 145 lb 4/26/2011 Other Health Professional Canada
Primary
Concomitant
Failure To Thrive Other Serious 1/9/2004 69 Female 5/13/2011 Physician United States
Primary
Concomitant
Urosepsis Hospitalization 1/9/2004 69 Female 5/17/2011 Lawyer United States
Primary
Concomitant
Cardiac Failure Death 12/14/2009 51 Male 6/13/2011 Consumer Poland
Primary
Secondary
Concomitant
Hereditary Sideroblastic Anaemia Other Serious 31 Female 7/26/2011 Physician Japan
Primary
Concomitant
Vomiting Hospitalization 55 Female 8/2/2011 Physician United States
Primary
Concomitant
Pleurisy Hospitalization 10/30/2009 55 Female 203 lb 8/11/2011 Physician Ukraine
Primary
Concomitant
Pain In Extremity Other Serious 6/1/2011 47 Female 239 lb 8/16/2011 Other Health Professional United States
Primary
Concomitant
Pain In Extremity 6/1/2011 47 Female 239 lb 9/16/2011 Physician United States
Primary
Concomitant
Diabetic Enteropathy Hospitalization 1/9/2004 62 Female 10/3/2011 Other Health Professional United States
Primary
Concomitant
Splenomegaly Hospitalization 6/25/2005 55 Female 10/13/2011 United States
Primary
Secondary
Concomitant
Dizziness 4/1/2011 68 Female 10/24/2011 Consumer United States
Primary
Secondary
Concomitant
Fatigue 5/5/2011 57 Male 170 lb 11/2/2011 Consumer United States
Primary
Concomitant
White Blood Cell Count Decreased 3/8/2011 38 Female 188 lb 11/17/2011 Other Health Professional United States
Primary
Concomitant
Arterial Occlusive Disease Other Serious 1/1/2005 71 Male 12/7/2011 Consumer United States
Primary
Concomitant
Arthralgia 1/1/2011 62 Female 170 lb 1/28/2012 Consumer United States
Primary
Concomitant
Injection Site Pain 3/21/2011 55 Female 205 lb 1/28/2012 Consumer United States
Primary
Concomitant
Tinea Pedis Male 220 lb 1/28/2012 Consumer United States
Primary
Concomitant
Injection Site Pain 10/1/2011 52 Female 125 lb 1/29/2012 Consumer United States
Primary
Concomitant
Musculoskeletal Stiffness Male 1/28/2012 Consumer United States
Primary
Concomitant
Injection Site Swelling 9/27/2011 69 Female 1/29/2012 Consumer United States
Primary
Concomitant
Drug Interaction 8/3/2011 70 Female 2/3/2012 Consumer United States
Primary
Concomitant
Clostridium Difficile Colitis Other Serious 1/9/2004 62 Female 2/6/2012 Other Health Professional United States
Primary
Concomitant
Eye Swelling Other Serious 1/4/2012 65 Female 150 lb 2/9/2012 Other Health Professional Canada
Primary
Concomitant
Oedema Peripheral Other Serious 11/1/2011 82 Female 2/17/2012 Physician Canada
Primary
Concomitant
Visual Impairment Other Serious Male 131 lb 3/25/2012 Consumer United States
Primary
Concomitant
Nail Disorder Other Serious 11/1/2011 82 Female 110 lb 4/6/2012 Consumer Canada
Primary
Concomitant
Lymphoma Other Serious 2/1/2012 68 Female 126 lb 4/27/2012 Other Health Professional Canada
Primary
Concomitant
Gastrointestinal Tract Irritation Hospitalization Female 2/7/2012 Consumer United States
Primary
Concomitant
Pancytopenia Death 1/9/2004 62 Female 6/7/2012 Consumer United States
Primary
Concomitant

Drug Data