Methotrexate combined with Vitamin B12

Reports:

Reaction Outcome Event Date Age Sex Weight Reported Reporter Country Treatment
Role Name
Vision Blurred Other Serious 1/1/2006 Female 154 lb 6/16/2006 Physician United States
Primary
Concomitant
Haemorrhage Hospitalization 5/30/2006 55 Female 116 lb 12/4/2006 United States
Primary
Concomitant
Wound Drainage Other Serious 1/1/2004 75 Female 4/24/2008 Physician United States
Primary
Secondary
Concomitant
Wrist Fracture Other Serious 1/17/2006 72 Female 147 lb 9/10/2008 Consumer United States
Primary
Concomitant
Injection Site Mass Other Serious 10/1/2010 67 Female 1700 lb 2/7/2011 Consumer United States
Primary
Concomitant
Sleep Disorder Other Serious Female 170 lb 5/12/2011 Consumer United States
Primary
Concomitant
Insomnia 1/30/2011 58 Female 157 lb 5/11/2011 Consumer United States
Primary
Concomitant
Osteoporosis Hospitalization 64 Male 3/26/2012 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Haemorrhage Subcutaneous Hospitalization 4/28/2009 75 Female 4/27/2012 Japan
Primary
Secondary
Concomitant
Haemorrhage Subcutaneous Hospitalization 4/28/2009 75 Female 6/6/2012 Japan
Primary
Secondary
Concomitant
Hepatic Function Abnormal Other Serious 5/17/2012 44 Male 181 lb 7/2/2012 Physician Japan
Primary
Secondary
Concomitant
Hepatic Function Abnormal Other Serious 5/17/2012 44 Male 181 lb 7/2/2012 Physician Japan
Primary
Secondary
Concomitant
Lung Neoplasm Malignant Other Serious 2/14/2012 75 Male 148 lb 7/6/2012 Physician Japan
Primary
Concomitant
Platelet Count Decreased Other Serious 3/5/2009 64 Male 121 lb 8/1/2012 Physician Japan
Primary
Secondary
Concomitant
Respiratory Failure Hospitalization 9/26/2011 83 Female 8/2/2012 Consumer Japan
Primary
Secondary
Concomitant
Interstitial Lung Disease Death 9/26/2011 83 Female 8/7/2012 Consumer Japan
Primary
Secondary
Concomitant
Bronchopneumonia Hospitalization 12/5/2011 71 Female 123 lb 8/9/2012 Physician Japan
Primary
Secondary
Concomitant
Vomiting Other Serious 2009 Male 230 lb 1/8/2013 Physician Country Not Specified
Primary
Concomitant
Pyrexia Other Serious 12/2011 33 Female 5/1/2013 Consumer Ca
Primary
Concomitant
Thyroid Neoplasm Other Serious Female 3/12/2013 Consumer Country Not Specified
Primary
Concomitant
Therapeutic Response Decreased Hospitalization 8/30/2010 69 Female 128 lb 12/11/2012 Physician Br
Primary
Concomitant
Raynaud's Phenomenon Hospitalization 11/2005 Female 135 lb 9/19/2012 Physician Country Not Specified
Primary
Secondary
Concomitant
Toxicity To Various Agents Hospitalization 4/2012 37 Female 1/28/2013 Physician Ca
Primary
Secondary
Concomitant
Ophthalmoplegia Other Serious Female 12/12/2012 Consumer Ca
Primary
Concomitant
Renal Disorder Hospitalization 2006 62 Female 186 lb 6/19/2013 Consumer Us
Primary
Concomitant
Tachycardia Death Female 110 lb 8/31/2012 Other Health Professional Country Not Specified
Primary
Secondary
Concomitant
Musculoskeletal Pain 75 Female 9/14/2012 Physician Ca
Primary
Concomitant
Weight Decreased Other Serious 1/2012 Female 119 lb 8/29/2012 Physician Country Not Specified
Primary
Secondary
Concomitant
Gastroenteritis Viral Hospitalization 8/13/2012 23 Male 133 lb 8/29/2012 Physician Us
Primary
Concomitant
Wound Hospitalization 10/23/2011 60 Female 198 lb 10/19/2012 Physician Ca
Primary
Concomitant
Procedural Haemorrhage Other Serious 8/11/2012 62 Female 9/6/2012 Other Health Professional Au
Primary
Secondary
Concomitant
Pain 2010 51 Female 145 lb 9/3/2012 Consumer Us
Primary
Concomitant
Post Procedural Swelling Other Serious 2012 52 Female 145 lb 9/4/2012 Consumer Us
Primary
Concomitant
Injection Site Pain Other Serious 9/2009 49 Female 9/21/2012 Consumer Country Not Specified
Primary
Concomitant
Septic Shock Other Serious 69 Female 8/30/2012 Physician Ca
Primary
Concomitant
Swelling Other Serious 2/2009 Male 184 lb 10/10/2012 Physician Country Not Specified
Primary
Concomitant
Carpal Tunnel Syndrome Other Serious Female 185 lb 9/10/2012 Other Health Professional Ca
Primary
Concomitant
Precancerous Cells Present Other Serious 2007 56 Female 9/24/2012 Physician Country Not Specified
Primary
Concomitant
Rhinorrhoea Other Serious 2012 82 Male 180 lb 11/20/2012 Consumer Us
Primary
Concomitant
Infusion Related Reaction Life Threatening 9/18/2012 12 Male 61 lb 11/5/2012 Physician De
Primary
Concomitant
Gallbladder Disorder Hospitalization Female 218 lb 1/18/2013 Physician Ca
Primary
Concomitant
Sneezing Other Serious 10/4/2012 43 Female 165 lb 10/31/2012 Other Health Professional Us
Primary
Concomitant
Weight Increased Other Serious 4/2012 59 Female 162 lb 5/13/2013 Physician Ca
Primary
Concomitant
Rash Other Serious 9/5/2012 39 Male 129 lb 10/17/2012 Other Health Professional Ca
Primary
Concomitant
Trismus Other Serious Female 10/17/2012 Physician Us
Primary
Concomitant
Pilonidal Cyst Other Serious 4/2009 Female 138 lb 10/22/2012 Consumer Country Not Specified
Primary
Concomitant
Systemic Mycosis Other Serious Female 10/24/2012 Physician Us
Primary
Concomitant
Rectal Polyp Hospitalization 8/2012 Female 10/25/2012 Consumer Country Not Specified
Primary
Secondary
Concomitant
Pneumonia Bacterial Hospitalization 7/10/2012 72 Female 12/31/2012 Consumer Us
Primary
Concomitant
Rheumatoid Arthritis Other Serious 2011 Female 127 lb 12/17/2012 Consumer Us
Primary
Secondary
Concomitant
Thrombosis In Device Hospitalization 2012 Male 116 lb 11/1/2012 Physician Ca
Primary
Concomitant
Diarrhoea Hospitalization 10/15/2012 80 Female 10/31/2012 Physician Ca
Primary
Concomitant
Pneumonia Hospitalization 8/2012 Female 275 lb 11/19/2012 Consumer Ca
Primary
Concomitant
Musculoskeletal Stiffness 10/26/2011 57 Male 11/7/2012 Other Health Professional Us
Primary
Concomitant
Post Procedural Complication Other Serious 9/24/2012 48 Female 192 lb 11/23/2012 Other Health Professional Ca
Primary
Concomitant
Nephrolithiasis Other Serious 2007 Male 207 lb 1/15/2013 Physician Country Not Specified
Primary
Concomitant
Flatulence Hospitalization 11/19/2012 66 Male 176 lb 12/3/2012 Other Health Professional Ca
Primary
Concomitant
Rheumatoid Arthritis Other Serious 2012 71 Female 2/1/2013 Physician Ca
Primary
Concomitant
Syncope Other Serious 11/26/2012 65 Female 65 lb 12/7/2012 Other Health Professional Ca
Primary
Concomitant
Rectal Haemorrhage Other Serious Female 113 lb 3/20/2013 Physician Country Not Specified
Primary
Concomitant
Vision Blurred Other Serious 12/17/2012 61 Female 1/24/2013 Other Health Professional Au
Primary
Concomitant
Procedural Pain Hospitalization 5/2012 Female 2/11/2013 Physician Country Not Specified
Primary
Concomitant
Intestinal Resection Hospitalization 11/10/2011 53 Male 146 lb 1/2/2013 Other Health Professional Ca
Primary
Concomitant
Urticaria Other Serious 8/2011 47 Female 1/7/2013 Other Health Professional Us
Primary
Concomitant
Pyrexia Hospitalization 10/2012 Male 215 lb 1/31/2013 Physician Country Not Specified
Primary
Secondary
Concomitant
Local Swelling 1/13/2013 69 Male 1/21/2013 Consumer Us
Primary
Concomitant
Fatigue 12/2011 Female 155 lb 1/28/2013 Consumer Country Not Specified
Primary
Concomitant
Productive Cough 1/13/2012 54 Male 1/28/2013 Consumer Country Not Specified
Primary
Concomitant
Headache 2/18/2012 51 Male 1/28/2013 Consumer Country Not Specified
Primary
Concomitant
Sputum Discoloured Other Serious 12/21/2011 45 Female 1/28/2013 Physician Country Not Specified
Primary
Concomitant
Wrong Technique In Drug Usage Process 10/2011 NotSpecified 134 lb 1/28/2013 Consumer Country Not Specified
Primary
Concomitant
Rash 12/2011 NotSpecified 1/28/2013 Physician Us
Primary
Concomitant
Injection Site Pain 3/5/2012 69 Female 1/29/2013 Consumer Country Not Specified
Primary
Concomitant
Respiratory Tract Infection 1/2012 Female 195 lb 1/29/2013 Consumer Country Not Specified
Primary
Concomitant
Weight Bearing Difficulty Other Serious 1/5/2012 Female 1/28/2013 Consumer Country Not Specified
Primary
Concomitant
Injection Site Pain Female 1/28/2013 Consumer Country Not Specified
Primary
Concomitant
Nephrolithiasis Female 140 lb 1/28/2013 Physician Country Not Specified
Primary
Concomitant
Hypersomnia 1/2011 63 Female 1/28/2013 Consumer Country Not Specified
Primary
Concomitant
Injection Site Bruising 2/15/2012 63 Female 1/28/2013 Consumer Country Not Specified
Primary
Concomitant
Joint Swelling 2010 Female 1/28/2013 Consumer Country Not Specified
Primary
Concomitant
Sleep Apnoea Syndrome Hospitalization Male 1/28/2013 Consumer Country Not Specified
Primary
Concomitant
Multiple Sclerosis Other Serious Female 162 lb 1/28/2013 Physician Country Not Specified
Primary
Concomitant
Drug Ineffective 2/27/2012 63 Female 1/28/2013 Consumer Country Not Specified
Primary
Concomitant
Unevaluable Event Hospitalization 10/26/2011 71 Female 1/28/2013 Consumer Country Not Specified
Primary
Concomitant
Limb Operation 2/16/2012 65 Female 1/28/2013 Consumer Country Not Specified
Primary
Concomitant
Pruritus 2012 Female 1/30/2013 Consumer Country Not Specified
Primary
Concomitant
Vomiting 5/11/2012 Male 127 lb 1/30/2013 Physician Country Not Specified
Primary
Concomitant
Herpes Zoster Male 194 lb 1/31/2013 Physician Country Not Specified
Primary
Concomitant
Kidney Infection 8/2012 Female 1/31/2013 Consumer Country Not Specified
Primary
Concomitant
Chills 8/23/2012 53 Female 1/30/2013 Consumer Country Not Specified
Primary
Concomitant
White Blood Cell Count Decreased Hospitalization 1/9/2013 Male 153 lb 2/4/2013 Other Health Professional Ca
Primary
Secondary
Concomitant
Injection Site Pruritus Female 1/31/2013 Consumer Country Not Specified
Primary
Concomitant
Subdural Haematoma Hospitalization 10/15/2012 75 Female 136 lb 10/26/2012 Pharmacist Us
Primary
Concomitant
Injection Site Pain 7/8/2012 47 Female 1/30/2013 Consumer Country Not Specified
Primary
Concomitant
Injection Site Urticaria 2012 Female 1/30/2013 Consumer Country Not Specified
Primary
Concomitant
Rash 10/2012 59 Female 1/31/2013 Consumer Country Not Specified
Primary
Concomitant
Psoriasis 5/2012 69 Female 1/30/2013 Consumer Country Not Specified
Primary
Concomitant
Injection Site Rash 5/2012 Female 1/30/2013 Consumer Country Not Specified
Primary
Concomitant
Tooth Extraction 9/25/2012 68 Female 1/31/2013 Consumer Country Not Specified
Primary
Concomitant
Sneezing Other Serious 10/2012 Female 169 lb 1/31/2013 Consumer Country Not Specified
Primary
Concomitant
Injection Site Pain 11/28/2012 51 Female 1/31/2013 Consumer Country Not Specified
Primary
Concomitant
Sinus Congestion 11/22/2012 70 Female 1/31/2013 Consumer Country Not Specified
Primary
Concomitant
Weight Increased 9/2012 Female 1/31/2013 Consumer Country Not Specified
Primary
Secondary
Concomitant
Postoperative Wound Infection Other Serious 42 Male 1/29/2013 Physician Country Not Specified
Primary
Concomitant
Injection Site Reaction 2/23/2012 65 Female 139 lb 1/28/2013 Consumer Country Not Specified
Primary
Concomitant
Thirst 2/23/2012 65 Female 138 lb 1/28/2013 Consumer Country Not Specified
Primary
Concomitant
Nasopharyngitis Other Serious 3/5/2012 59 Female 192 lb 1/29/2013 Physician Country Not Specified
Primary
Concomitant
Skin Discolouration 3/9/2012 54 Female 1/29/2013 Consumer Country Not Specified
Primary
Concomitant
Psoriasis Female 140 lb 1/28/2013 Consumer Country Not Specified
Primary
Concomitant
Pain In Extremity 2012 Female 135 lb 1/31/2013 Consumer Country Not Specified
Primary
Concomitant
Drug Dose Omission 4/20/2012 53 Female 1/29/2013 Consumer Country Not Specified
Primary
Concomitant
Rheumatoid Arthritis 6/2012 Female 1/29/2013 Consumer Country Not Specified
Primary
Concomitant
Sinusitis 5/2012 Female 171 lb 1/30/2013 Consumer Country Not Specified
Primary
Concomitant
Stress Other Serious Female 205 lb 3/1/2013 Physician Country Not Specified
Primary
Concomitant
Rubber Sensitivity 7/11/2012 22 Female 1/30/2013 Consumer Country Not Specified
Primary
Concomitant
Injection Site Pain 6/20/2012 53 NotSpecified 158 lb 1/30/2013 Consumer Country Not Specified
Primary
Concomitant
Injection Site Reaction 8/2012 Female 1/30/2013 Consumer Country Not Specified
Primary
Concomitant
Injection Site Induration 12/2010 29 Female 1/30/2013 Consumer Country Not Specified
Primary
Concomitant
Injection Site Pain 7/26/2012 55 Female 1/30/2013 Consumer Country Not Specified
Primary
Concomitant
Psoriasis 8/16/2012 54 Female 1/30/2013 Consumer Country Not Specified
Primary
Concomitant
Sinusitis 8/28/2012 36 Female 190 lb 1/31/2013 Consumer Country Not Specified
Primary
Concomitant
Herpes Virus Infection 9/2012 Female 1/31/2013 Consumer Country Not Specified
Primary
Concomitant
Hot Flush 2/2012 63 Female 1/30/2013 Consumer Country Not Specified
Primary
Concomitant
Injection Site Erythema 9/8/2012 70 Female 1/30/2013 Consumer Country Not Specified
Primary
Concomitant
Pain 2011 Male 184 lb 1/30/2013 Consumer Country Not Specified
Primary
Concomitant
Sinusitis 8/29/2012 34 Female 1/31/2013 Consumer Country Not Specified
Primary
Concomitant
Rheumatoid Arthritis 12/2011 70 Female 1/31/2013 Consumer Country Not Specified
Primary
Concomitant
Injection Site Rash 12/3/2012 50 Female 2/1/2013 Consumer Country Not Specified
Primary
Concomitant
Upper Respiratory Tract Infection 11/28/2012 57 Female 180 lb 2/1/2013 Consumer Country Not Specified
Primary
Concomitant
Rash Papular 12/15/2012 67 Female 2/1/2013 Consumer Country Not Specified
Primary
Concomitant
Injection Site Pain 2012 Female 2/1/2013 Consumer Country Not Specified
Primary
Concomitant
Laceration 11/2012 53 Female 1/31/2013 Consumer Country Not Specified
Primary
Concomitant
Weight Increased Other Serious 11/24/2012 66 Male 191 lb 3/6/2013 Consumer Ca
Primary
Concomitant
Headache 53 Female 170 lb 2/19/2013 Consumer Us
Primary
Concomitant
Drug Ineffective 70 Male 248 lb 2/19/2013 Consumer Us
Primary
Concomitant
Pain In Extremity 69 Male 182 lb 2/19/2013 Consumer Us
Primary
Concomitant
Meniscus Injury Other Serious 1/16/2013 47 Female 251 lb 2/8/2013 Other Health Professional Ca
Primary
Concomitant
Somnolence 4/12/2012 64 Female 1/29/2013 Consumer Country Not Specified
Primary
Secondary
Concomitant
Somnolence 4/12/2012 64 Female 1/29/2013 Consumer Country Not Specified
Primary
Secondary
Concomitant
Skeletal Injury 1/2012 Female 126 lb 1/29/2013 Consumer Country Not Specified
Primary
Concomitant
Skeletal Injury 1/2012 Female 126 lb 1/29/2013 Consumer Country Not Specified
Primary
Concomitant
Pruritus Other Serious Female 219 lb 2/27/2013 Other Health Professional Ca
Primary
Concomitant
Throat Tightness Other Serious 8/21/2012 61 Female 170 lb 2/28/2013 Physician Us
Primary
Concomitant
Rash Maculo-papular Hospitalization 1/2013 31 Female 2/28/2013 Other Health Professional Us
Primary
Secondary
Concomitant
Weight Increased 4/2012 Female 150 lb 1/29/2013 Consumer Country Not Specified
Primary
Concomitant
Poor Quality Drug Administered Female 100 lb 1/29/2013 Consumer Country Not Specified
Primary
Concomitant
Pruritus 4/2012 63 Female 2/19/2013 Consumer Us
Primary
Concomitant
Wound Other Serious 58 Female 3/4/2013 Consumer Country Not Specified
Primary
Concomitant
Sinusitis Other Serious 6/2010 Female 141 lb 3/15/2013 Other Health Professional Ca
Primary
Concomitant
Gastrointestinal Disorder Hospitalization Female 220 lb 3/27/2013 Other Health Professional Ca
Primary
Concomitant

Drug Data