Methotrexate combined with Vitamin B-12

Reports:

Reaction Outcome Event Date Age Sex Weight Reported Reporter Country Treatment
Role Name
Recurrent Cancer Hospitalization 8/22/2005 Male 1/18/2006 Other Health Professional United Kingdom
Primary
Concomitant
Cutaneous Lupus Erythematosus Other Serious 7/1/2004 Female 2/24/2006 Physician United States
Primary
Concomitant
Gastroenteritis Hospitalization 8/24/2005 Female 3/1/2006 Physician United States
Primary
Concomitant
Nausea 9/1/2005 47 Female 203 lb 1/20/2006 Consumer United States
Primary
Concomitant
Peritonitis Other Serious 12/1/1998 Female 113 lb 5/19/2006 Physician United States
Primary
Concomitant
Pneumonitis Death 10/1/2002 59 Female 6/29/2006 Other Health Professional United Kingdom
Primary
Concomitant
Myalgia 5/1/2006 56 Male 209 lb 6/30/2006 Consumer United States
Primary
Concomitant
Vitamin B12 Decreased Hospitalization 4/1/2006 56 Female 193 lb 8/8/2006 Physician United States
Primary
Concomitant
Ureteral Stent Insertion Hospitalization 7/1/2005 Female 156 lb 9/11/2006 Physician United States
Primary
Concomitant
Gastrointestinal Haemorrhage Hospitalization 6/11/2006 70 Male 12/6/2006 Consumer United States
Primary
Secondary
Concomitant
Malignant Melanoma Other Serious 11/10/2006 Male 168 lb 12/7/2006 Physician Canada
Primary
Concomitant
Injection Site Reaction Other Serious 5/3/2006 59 Female 130 lb 6/30/2006 Consumer United States
Primary
Concomitant
Pneumothorax Other Serious 6/30/2006 Female 133 lb 1/24/2007 Physician Canada
Primary
Secondary
Concomitant
Gastrointestinal Haemorrhage Hospitalization 6/11/2006 70 Male 3/13/2007 Consumer United States
Primary
Secondary
Concomitant
Mobility Decreased Other Serious 12/22/2006 Female 134 lb 3/20/2007 Other Health Professional United Kingdom
Primary
Concomitant
Myocardial Infarction Other Serious 1/18/2007 Female 181 lb 5/3/2007 Other Health Professional United Kingdom
Primary
Concomitant
Gastrointestinal Haemorrhage Hospitalization 6/11/2006 70 Male 5/10/2007 Consumer United States
Primary
Secondary
Concomitant
Myocardial Infarction Other Serious 1/18/2007 Female 181 lb 6/27/2007 Other Health Professional United Kingdom
Primary
Concomitant
Type 2 Diabetes Mellitus Other Serious 1/18/2007 Female 181 lb 9/7/2007 Other Health Professional United Kingdom
Primary
Concomitant
Mycobacterium Abscessus Infection Other Serious Female 172 lb 10/11/2007 Other Health Professional United States
Primary
Concomitant
Skin Disorder Other Serious Female 12/3/2007 Other Health Professional Canada
Primary
Concomitant
Rash Other Serious 9/18/2007 31 Female 12/7/2007 Physician Canada
Primary
Concomitant
Sciatica Hospitalization 8/1/2007 56 Female 227 lb 12/7/2007 Other Health Professional France
Primary
Concomitant
Synovitis 8/4/2006 Female 124 lb 12/10/2007 Physician United States
Primary
Concomitant
Vitamin D Decreased Disability 2/20/2007 Female 12/20/2007 Physician Canada
Primary
Concomitant
Vomiting Other Serious 6/21/2007 Female 132 lb 12/28/2007 Other Health Professional United Kingdom
Primary
Concomitant
Skin Disorder Other Serious Female 1/23/2008 Other Health Professional Canada
Primary
Concomitant
Intestinal Obstruction Hospitalization 6/8/2006 Female 152 lb 1/29/2008 Other Health Professional Canada
Primary
Concomitant
Skin Disorder Other Serious 8/1/2007 Female 2/7/2008 Other Health Professional Canada
Primary
Concomitant
Listeria Sepsis Hospitalization 3/21/2007 Female 132 lb 2/15/2008 Other Health Professional United Kingdom
Primary
Concomitant
Breast Cancer Other Serious 6/4/2007 Female 137 lb 3/4/2008 Other Health Professional United Kingdom
Primary
Concomitant
Transient Ischaemic Attack Life Threatening 1/1/2008 86 Female 3/5/2008 Physician United States
Primary
Concomitant
Transient Ischaemic Attack Life Threatening 1/1/2008 86 Female 3/11/2008 Physician United States
Primary
Concomitant
White Blood Cell Count Decreased Other Serious 6/1/2005 Female 143 lb 3/25/2008 Physician United States
Primary
Concomitant
White Blood Cell Count Decreased Other Serious 2/7/2008 60 Female 3/27/2008 Physician Canada
Primary
Secondary
Concomitant
Urticaria Other Serious 12/21/2006 Female 179 lb 3/28/2008 Physician United States
Primary
Concomitant
Haematochezia Other Serious 1/1/2008 70 Female 141 lb 3/28/2008 Other Health Professional Canada
Primary
Concomitant
White Blood Cell Count Decreased Other Serious 6/1/2005 Female 143 lb 4/8/2008 Physician United States
Primary
Concomitant
Emotional Distress Other Serious 3/1/2008 Female 170 lb 4/10/2008 United States
Primary
Concomitant
Myocardial Infarction Other Serious 5/8/2007 Female 185 lb 4/14/2008 Consumer Canada
Primary
Secondary
Concomitant
Lung Neoplasm Malignant Other Serious 9/15/2007 Male 143 lb 4/17/2008 Other Health Professional United Kingdom
Primary
Concomitant
Transient Ischaemic Attack Life Threatening 1/1/2008 86 Female 5/9/2008 Physician United States
Primary
Concomitant
White Blood Cell Count Decreased Other Serious 2/7/2008 60 Female 5/12/2008 Physician Canada
Primary
Secondary
Concomitant
Listeria Sepsis Hospitalization 3/21/2007 Female 132 lb 6/10/2008 Other Health Professional United Kingdom
Primary
Concomitant
Migraine Other Serious 11/1/2007 60 Female 132 lb 6/10/2008 Other Health Professional United Kingdom
Primary
Concomitant
Weight Increased Female 5/14/2008 Consumer United States
Primary
Concomitant
Blood Pressure Decreased Other Serious 82 Female 236 lb 6/25/2008 Consumer United States
Primary
Concomitant
Thrombocytopenia Death 6/9/2008 Male 120 lb 6/24/2008 Physician Korea, Republic Of
Primary
Concomitant
Pneumonia Hospitalization 6/9/2008 Male 120 lb 7/16/2008 Physician Korea, Republic Of
Primary
Concomitant
Post Herpetic Neuralgia Hospitalization 8/2/2008 57 Female 137 lb 8/4/2008 Other Health Professional United States
Primary
Concomitant
White Blood Cell Count Decreased Other Serious 2/7/2008 60 Female 8/13/2008 Other Health Professional Canada
Primary
Secondary
Concomitant
White Blood Cell Count Decreased Other Serious 2/7/2008 60 Female 8/14/2008 Other Health Professional Canada
Primary
Secondary
Concomitant
Oesophageal Candidiasis Hospitalization 7/17/2008 Female 121 lb 9/3/2008 Physician United States
Primary
Concomitant
Pneumonia Other Serious 7/1/2008 Female 170 lb 9/12/2008 Consumer United States
Primary
Concomitant
Urinary Incontinence Other Serious 1/1/2006 Female 160 lb 9/18/2008 Physician United States
Primary
Concomitant
Arrhythmia Death 8/7/2007 10/24/2008 Consumer Argentina
Primary
Secondary
Concomitant
Infectious Mononucleosis Other Serious 11/1/2006 Female 147 lb 12/1/2008 Physician United States
Primary
Concomitant
Pneumonia 12/1/2007 Female 12/11/2008 Consumer United States
Primary
Concomitant
Pain 4/14/2008 Female 12/11/2008 Physician United States
Primary
Concomitant
Sneezing 11/28/2007 Female 163 lb 12/15/2008 Physician United States
Primary
Concomitant
Osteolysis Hospitalization 2/9/2007 Male 160 lb 12/26/2008 United States
Primary
Concomitant
Systemic Lupus Erythematosus Hospitalization 1/1/2007 Female 1/5/2009 Consumer United States
Primary
Concomitant
Staphylococcal Infection Other Serious Female 135 lb 2/3/2009 Canada
Primary
Concomitant
Fall Other Serious 9/7/2008 Female 2/6/2009 Other Health Professional United Kingdom
Primary
Concomitant
Systemic Lupus Erythematosus Hospitalization 1/1/2007 Female 2/13/2009 Consumer United States
Primary
Concomitant
Wrong Technique In Drug Usage Process Other Serious 12/31/2008 Female 218 lb 3/13/2009 Consumer United States
Primary
Concomitant
Uterine Enlargement 6/1/2008 Female 180 lb 3/13/2009 Puerto Rico
Primary
Concomitant
Crohn's Disease Hospitalization 1/13/2009 Male 155 lb 3/19/2009 Canada
Primary
Concomitant
Surgery Other Serious 1/1/2007 Female 180 lb 3/23/2009 Consumer United States
Primary
Concomitant
Secretion Discharge Other Serious 3/25/2009 Male 310 lb 4/16/2009 Canada
Primary
Concomitant
Road Traffic Accident Death 4/11/2009 Male 195 lb 4/24/2009 Canada
Primary
Concomitant
Wrist Fracture Other Serious 1/1/2006 Female 147 lb 4/28/2009 Physician United States
Primary
Concomitant
Weight Control Hospitalization 9/1/2008 Female 4/29/2009 Puerto Rico
Primary
Secondary
Concomitant
Tongue Paralysis Other Serious 12/1/2007 Female 176 lb 4/30/2009 United Kingdom
Primary
Concomitant
Pneumonitis Hospitalization 4/18/2009 Female 183 lb 5/4/2009 New Zealand
Primary
Secondary
Concomitant
Weight Increased Hospitalization Female 165 lb 5/5/2009 Canada
Primary
Concomitant
Secretion Discharge Other Serious 3/25/2009 Male 310 lb 5/5/2009 Canada
Primary
Concomitant
Inflammatory Bowel Disease Other Serious 6/30/2008 Female 5/7/2009 Other Health Professional United Kingdom
Primary
Concomitant
Tremor Hospitalization 1/1/2004 66 Female 165 lb 5/8/2009 Consumer United States
Primary
Secondary
Concomitant
Application Site Burn Other Serious 5/3/2009 59 Female 197 lb 5/13/2009 Consumer United States
Primary
Concomitant
Pneumonitis Hospitalization 4/18/2009 Female 183 lb 5/21/2009 New Zealand
Primary
Secondary
Concomitant
Accidental Exposure 8/23/2008 Female 130 lb 6/11/2009 Consumer United States
Primary
Concomitant
Nasopharyngitis 10/2/2008 Female 128 lb 6/11/2009 United States
Primary
Concomitant
Paraesthesia 9/1/2008 Female 175 lb 6/11/2009 United States
Primary
Concomitant
Injection Site Pain 4/25/2009 Female 6/12/2009 Consumer United States
Primary
Concomitant
Ill-defined Disorder 5/1/2009 Female 170 lb 6/12/2009 Consumer United States
Primary
Concomitant
White Blood Cell Count Increased Other Serious 3/1/2009 Female 145 lb 6/12/2009 Canada
Primary
Concomitant
Acute Respiratory Distress Syndrome Life Threatening 4/23/2008 Female 115 lb 6/19/2009 Canada
Primary
Secondary
Concomitant
Death Death Female 7/7/2009 Consumer United States
Primary
Concomitant
Pyelonephritis Hospitalization 6/17/2009 51 Female 122 lb 7/2/2009 Other Health Professional United States
Primary
Concomitant
Dry Mouth Other Serious 6/7/2009 Male 115 lb 7/10/2009 Other Health Professional Canada
Primary
Concomitant
Lung Disorder Hospitalization Female 219 lb 7/13/2009 Physician United States
Primary
Concomitant
Rash Hospitalization 1/11/2009 Male 128 lb 7/20/2009 Canada
Primary
Concomitant
Generalised Oedema Hospitalization 6/23/2009 Female 316 lb 7/21/2009 Physician United States
Primary
Secondary
Concomitant
Generalised Oedema Life Threatening 6/23/2009 Female 316 lb 7/24/2009 Physician United States
Primary
Secondary
Concomitant
Alveolitis Allergic Hospitalization 4/18/2009 Female 183 lb 7/29/2009 New Zealand
Primary
Secondary
Concomitant
Generalised Oedema Life Threatening 6/23/2009 Female 316 lb 7/31/2009 Physician United States
Primary
Secondary
Concomitant
Lymphoma Hospitalization 7/12/2009 Female 128 lb 8/10/2009 Physician Canada
Primary
Secondary
Concomitant
Lymphoma Hospitalization 7/12/2009 Female 128 lb 8/14/2009 Physician Canada
Primary
Secondary
Concomitant
Alveolitis Allergic Hospitalization 4/18/2009 Female 183 lb 8/20/2009 New Zealand
Primary
Secondary
Concomitant
Ulcer Haemorrhage Hospitalization 2/1/2009 Female 170 lb 8/21/2009 Consumer Argentina
Primary
Concomitant
Flushing 12/1/2008 Male 8/22/2009 United States
Primary
Concomitant
Vertigo Hospitalization 11/16/1999 Male 231 lb 8/28/2009 United States
Primary
Secondary
Concomitant
Rotator Cuff Syndrome Other Serious 9/1/2007 Female 165 lb 8/28/2009 Physician United States
Primary
Concomitant
Streptococcal Infection Other Serious Female 276 lb 8/31/2009 Other Health Professional Canada
Primary
Concomitant
Road Traffic Accident Death 4/11/2009 Male 195 lb 8/31/2009 Canada
Primary
Concomitant
Road Traffic Accident Death 4/11/2009 Male 195 lb 8/31/2009 Canada
Primary
Concomitant
Ulcer Haemorrhage Hospitalization 2/1/2009 Female 170 lb 9/4/2009 Consumer Argentina
Primary
Concomitant
Lymphoma Hospitalization 7/12/2009 Female 128 lb 9/11/2009 Physician Canada
Primary
Secondary
Concomitant
Injection Site Extravasation 7/13/2007 Female 137 lb 9/12/2009 Consumer United States
Primary
Concomitant
Injection Site Extravasation 8/23/2008 Female 130 lb 9/12/2009 Consumer United States
Primary
Concomitant
Lymphoma Hospitalization 7/12/2009 Female 128 lb 9/18/2009 Physician Canada
Primary
Secondary
Concomitant
Injection Site Rash Hospitalization Female 9/19/2009 Physician United States
Primary
Concomitant
Weight Decreased 8/18/2009 Female 120 lb 9/19/2009 Consumer United States
Primary
Concomitant
Generalised Oedema Life Threatening 6/23/2009 Female 316 lb 9/25/2009 Physician United States
Primary
Secondary
Concomitant
Upper Respiratory Tract Infection Hospitalization 11/16/1999 Male 231 lb 9/25/2009 United States
Primary
Secondary
Concomitant
Wound Dehiscence Life Threatening 10/17/2005 67 Male 9/28/2009 Other Health Professional Germany
Primary
Secondary
Concomitant
Presyncope Hospitalization 8/21/2009 35 Female 94 lb 9/25/2009 Consumer United States
Primary
Concomitant
B-cell Lymphoma Stage Iii Life Threatening 76 Female 10/13/2009 Physician United Kingdom
Primary
Concomitant
Lung Neoplasm Malignant Other Serious Male 161 lb 10/14/2009 Canada
Primary
Secondary
Concomitant
Vaginal Discharge Disability 7/1/2009 71 Female 139 lb 10/16/2009 Physician United Kingdom
Primary
Concomitant
Oesophageal Perforation Other Serious 4/1/2009 Female 185 lb 10/16/2009 United States
Primary
Concomitant
Dyspnoea 9/9/2009 Female 10/19/2009 Consumer
Primary
Concomitant
Lung Neoplasm Malignant Other Serious 9/15/2009 Male 161 lb 10/28/2009 Canada
Primary
Secondary
Concomitant
Collapse Of Lung Other Serious 10/7/2009 Male 110 lb 10/29/2009 Other Health Professional Canada
Primary
Concomitant
Diffuse Large B-cell Lymphoma Hospitalization 7/12/2009 Female 128 lb 10/30/2009 Physician Canada
Primary
Secondary
Concomitant
Wheezing Other Serious 1/1/2006 Female 129 lb 11/5/2009 Physician United States
Primary
Concomitant
Generalised Oedema Life Threatening 6/23/2009 Female 316 lb 11/6/2009 Physician United States
Primary
Secondary
Concomitant
Lung Infection Hospitalization 8/1/2009 Female 150 lb 11/10/2009 Consumer United States
Primary
Secondary
Concomitant
Meningioma Benign Other Serious 6/16/2008 Female 126 lb 11/17/2009 United Kingdom
Primary
Concomitant
Uterine Leiomyoma Hospitalization 7/12/2009 Female 128 lb 11/20/2009 Physician Canada
Primary
Secondary
Concomitant
Rheumatoid Arthritis Other Serious 1/1/2006 Female 129 lb 11/23/2009 Physician United States
Primary
Concomitant
Lung Neoplasm Malignant Other Serious 9/15/2009 Male 161 lb 12/2/2009 Canada
Primary
Secondary
Concomitant
Vitamin D Decreased Disability 2/20/2007 Female 11/30/2009 Physician Canada
Primary
Concomitant
Wrist Fracture Other Serious 1/1/2006 Female 147 lb 11/30/2009 Physician United States
Primary
Concomitant
Oesophageal Candidiasis Hospitalization 7/17/2008 Female 121 lb 12/1/2009 Physician United States
Primary
Concomitant
Eczema Other Serious 11/19/2009 Female 138 lb 12/4/2009 Pharmacist United States
Primary
Concomitant
Glaucoma 7/1/2008 Female 160 lb 12/9/2009 Other Health Professional United States
Primary
Concomitant
Swelling 9/16/2009 77 Female 146 lb 10/30/2009 Consumer United States
Primary
Concomitant
Pruritus 10/10/2009 55 Female 134 lb 10/29/2009 Consumer United States
Primary
Concomitant
Urinary Tract Infection Other Serious 3/26/2008 Female 121 lb 12/15/2009 Physician United States
Primary
Concomitant
Metastatic Neoplasm Death 8/6/2009 Male 377 lb 12/16/2009 Physician United Kingdom
Primary
Concomitant
Thermal Burn Other Serious 6/1/2009 Male 110 lb 12/21/2009 Other Health Professional United Kingdom
Primary
Concomitant
Generalised Oedema Life Threatening 6/23/2009 Female 316 lb 12/23/2009 Physician United States
Primary
Secondary
Concomitant
Throat Tightness Other Serious 8/9/2004 Female 180 lb 12/29/2009 Consumer United States
Primary
Concomitant
Swelling Face Other Serious 1/1/2009 Female 110 lb 12/29/2009 Other Health Professional Canada
Primary
Concomitant
Weight Decreased Other Serious 1/1/2009 Male 135 lb 1/14/2010 United States
Primary
Concomitant
Subcutaneous Abscess Hospitalization Female 1/14/2010 United Kingdom
Primary
Concomitant
Listeria Sepsis Hospitalization 9/3/2007 58 Female 132 lb 1/15/2010 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Intervertebral Disc Degeneration Hospitalization 11/2/2009 69 Female 158 lb 1/19/2010 Physician United States
Primary
Secondary
Concomitant

Drug Data