Methotrexate combined with Vincristine

Reports:

Reaction Outcome Event Date Age Sex Weight Reported Reporter Country Treatment
Role Name
Tongue Disorder Other Serious 12/5/2005 Male 216 lb 12/27/2005 United States
Primary
Secondary
Malaise Hospitalization 10/15/2005 4 Female 1/5/2006 Other Health Professional France
Primary
Secondary
Concomitant
Respiratory Distress Hospitalization 12/9/2005 72 Male 163 lb 1/13/2006 Consumer United States
Primary
Secondary
Concomitant
Visual Acuity Reduced Hospitalization 10/10/2005 4 Female 35 lb 1/16/2006 Consumer France
Primary
Secondary
Concomitant
Respiratory Distress Hospitalization 12/12/2005 72 Male 1/12/2006 France
Primary
Secondary
Concomitant
Prothrombin Level Decreased Hospitalization 2/24/2005 8 Male 42 lb 1/24/2006 Consumer France
Primary
Concomitant
Respiratory Distress Hospitalization 12/9/2005 72 Male 163 lb 1/20/2006 Physician France
Primary
Secondary
Concomitant
Pancreatitis Necrotising Hospitalization 9/30/2005 7 Female 53 lb 1/23/2006 United States
Primary
Concomitant
Respiratory Disorder Other Serious 17 Male 2/2/2006 Other Health Professional Ireland
Primary
Secondary
Vomiting Death Female 1/31/2006 Other Health Professional United Kingdom
Primary
Secondary
Pseudobulbar Palsy Other Serious 17 Male 2/3/2006 Other Health Professional Ireland
Primary
Secondary
Concomitant
Peripheral Motor Neuropathy Other Serious 1/4/2006 5 Female 35 lb 2/3/2006 Physician United States
Primary
Secondary
Concomitant
Steroid Withdrawal Syndrome Hospitalization 13 Male 1/27/2006 Physician United States
Primary
Concomitant
Visual Acuity Reduced Hospitalization 10/10/2005 4 Female 35 lb 2/20/2006 Consumer France
Primary
Secondary
Concomitant
Urinary Incontinence Hospitalization 4/1/1998 16 Male 2/15/2006 Physician Spain
Primary
Secondary
Concomitant
Visual Disturbance Hospitalization 10/15/2005 4 Female 2/14/2006 France
Primary
Secondary
Concomitant
Tongue Paralysis Life Threatening 17 Male 2/15/2006
Primary
Secondary
Pseudobulbar Palsy Other Serious 17 Male 3/1/2006 Physician Ireland
Primary
Concomitant
Staphylococcal Infection Hospitalization 11/23/2005 Male 3/1/2006 Other Health Professional United States
Primary
Secondary
Concomitant
Urinary Incontinence Hospitalization 4/1/1998 16 Male 3/1/2006 Physician Spain
Primary
Secondary
Concomitant
Visual Disturbance Other Serious 2/20/2006 Male 134 lb 3/8/2006 Consumer United States
Primary
Secondary
Concomitant
White Blood Cell Count Decreased Other Serious 11/10/2004 68 Male 152 lb 3/7/2006 Physician Japan
Primary
Secondary
Concomitant
Urinary Incontinence Disability 18 Male 3/15/2006
Primary
Secondary
Concomitant
Urinary Incontinence Hospitalization 48 Female 3/15/2006
Primary
Concomitant
Sepsis Other Serious 15 Male 3/17/2006 United States
Primary
Secondary
Concomitant
Polyuria Other Serious 13 Female 3/17/2006 United States
Primary
Concomitant
Rash Generalised Hospitalization 1/13/2006 59 Female 3/28/2006 Other Health Professional France
Primary
Secondary
Concomitant
Respiratory Arrest Death 32 Male 3/29/2006 Other Health Professional United States
Primary
Concomitant
Transverse Sinus Thrombosis Hospitalization 12/9/2005 Female 43 lb 4/4/2006 Physician United States
Primary
Concomitant
Visual Disturbance Other Serious 2/20/2006 Male 134 lb 4/7/2006 Physician United States
Primary
Secondary
Concomitant
Visual Acuity Reduced Required Intervention 6/20/2005 18 Female 4/5/2006 Physician United States
Primary
Concomitant
Stem Cell Transplant Hospitalization 1/13/2006 59 Female 4/18/2006 Other Health Professional France
Primary
Secondary
Concomitant
Pulmonary Oedema Life Threatening 3/27/2006 Female 116 lb 4/18/2006 Physician United States
Primary
Secondary
Concomitant
Pneumonia Death 2/13/2004 63 Male 4/14/2006 Physician Japan
Primary
Secondary
Concomitant
Pyrexia Hospitalization 2/17/2006 5 Female 39 lb 4/10/2006 Other Health Professional Canada
Primary
Concomitant
Visual Acuity Reduced Required Intervention 6/20/2005 18 Female 4/17/2006 Physician United States
Primary
Concomitant
Therapy Non-responder Other Serious 66 Male 4/18/2006 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Therapy Non-responder Other Serious 66 Male 4/21/2006 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Ventricular Hypertrophy Life Threatening 3/27/2006 Female 116 lb 5/3/2006 Physician United States
Primary
Secondary
Concomitant
Venoocclusive Liver Disease Hospitalization 12/1/2005 3 Male 5/5/2006 Physician France
Primary
Secondary
Concomitant
Therapy Non-responder Hospitalization 66 Male 5/5/2006 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Thrombocytopenia Hospitalization 6/1/2003 43 Male 5/5/2006 Other Health Professional Japan
Primary
Secondary
Concomitant
Vith Nerve Paralysis Hospitalization 69 Female 5/5/2006 Physician United States
Primary
Concomitant
T-cell Lymphoma Death 66 Male 5/12/2006 Consumer United States
Primary
Secondary
Concomitant
Urinary Incontinence Hospitalization 3/1/1997 16 Male 5/1/2006 Physician Spain
Primary
Secondary
Anaphylactic Reaction Other Serious 8/26/2005 7 Female 53 lb 3/30/2006 Other Health Professional United States
Primary
Concomitant
Swelling Other Serious 12/1/2004 64 Female 143 lb 5/23/2006 Physician Hungary
Primary
Secondary
Concomitant
Vitamin B12 Increased Hospitalization 1/1/2001 43 Male 5/16/2006
Primary
Secondary
White Blood Cell Count Decreased Life Threatening 4/7/2006 70 Female 5/12/2006 United States
Primary
Secondary
Concomitant
Therapeutic Response Decreased Other Serious 17 Male 5/18/2006
Primary
Secondary
Pulmonary Oedema Life Threatening 3/27/2006 Female 116 lb 5/26/2006 Physician United States
Primary
Secondary
Concomitant
Death Death 50 Male 5/23/2006 United States
Primary
Secondary
Pulmonary Oedema Life Threatening 3/27/2006 Female 116 lb 6/9/2006 Physician United States
Primary
Secondary
Concomitant
Idiopathic Thrombocytopenic Purpura Other Serious 10 Female 6/3/2006 Physician Canada
Primary
Secondary
Plasmacytoma Other Serious 3/1/2002 Female 5/30/2006 Physician Japan
Primary
Secondary
Thrombocytopenia Other Serious 16 Male 6/6/2006 Physician United States
Primary
Concomitant
Tachypnoea Death 4/4/2006 43 Male 163 lb 6/20/2006 Physician Spain
Primary
Secondary
Septic Shock Life Threatening 8/12/2005 65 Male 6/20/2006 Other Health Professional France
Primary
Secondary
Concomitant
Cerebral Haemorrhage Hospitalization 5/10/2006 49 Female 212 lb 6/29/2006 Other Health Professional France
Primary
Secondary
Thrombocytopenia Hospitalization 5/19/2006 59 Male 143 lb 6/26/2006 Physician France
Primary
Secondary
Sepsis Hospitalization 5/10/2006 49 Female 6/29/2006 France
Primary
Secondary
Thrombocytopenia Hospitalization 7/2/2006 Male 9 lb 7/5/2006 United States
Primary
Secondary
Concomitant
Tongue Disorder Hospitalization 6/1/2006 Male 212 lb 7/18/2006 Physician Germany
Primary
Secondary
Concomitant
Cerebral Haemorrhage Hospitalization 5/10/2006 49 Female 212 lb 7/19/2006 Other Health Professional France
Primary
Secondary
Visual Field Defect Other Serious Female 7/13/2006
Primary
Secondary
Concomitant
Pancytopenia Other Serious 5/18/2006 49 Male 146 lb 7/28/2006 Physician France
Primary
Secondary
Concomitant
Metastasis Other Serious 3 Male 7/25/2006 Physician Turkey
Primary
Secondary
Mucoepidermoid Carcinoma Other Serious 13 Female 7/25/2006 Physician Turkey
Primary
Secondary
Primitive Neuroectodermal Tumour Death 10 Male 7/25/2006 Physician Turkey
Primary
Secondary
Insulin-like Growth Factor Decreased Other Serious 15 Male 122 lb 7/28/2006 Physician United States
Primary
Secondary
Concomitant
Convulsion Other Serious 7/26/2006 Physician United States
Primary
Concomitant
Soft Tissue Disorder Other Serious 7/26/2006 Physician United States
Primary
Concomitant
Soft Tissue Disorder Other Serious 7/26/2006 Physician United States
Primary
Concomitant
Sepsis Death 7/26/2006 Physician United States
Primary
Secondary
Staphylococcal Sepsis Death 7/26/2006 Physician United States
Primary
Secondary
Enterobacter Sepsis Death 7/26/2006 Physician United States
Primary
Secondary
Bacterial Sepsis Death 7/26/2006 Physician United States
Primary
Secondary
Soft Tissue Disorder Required Intervention Unknown 7/26/2006 Physician United States
Primary
Concomitant
Soft Tissue Disorder Required Intervention Unknown 7/26/2006 Physician United States
Primary
Concomitant
Convulsion Other Serious Unknown 7/26/2006 Physician United States
Primary
Concomitant
Convulsion Other Serious Unknown 7/26/2006 Physician United States
Primary
Concomitant
Convulsion Other Serious Unknown 7/26/2006 Physician United States
Primary
Concomitant
Respiratory Failure Required Intervention 20 Female 7/24/2006 Other Health Professional Japan
Primary
Secondary
Pulmonary Mycosis Required Intervention 8 Female 7/25/2006 Consumer Israel
Primary
Secondary
Concomitant
Blood Growth Hormone Decreased Other Serious 12 Female 8/4/2006 Other Health Professional United States
Primary
Secondary
Epiphyseal Disorder Other Serious 15 Male 8/4/2006 Other Health Professional United States
Primary
Secondary
Sinus Disorder Required Intervention 8 Female 7/25/2006 Israel
Primary
Secondary
Concomitant
Tumour Perforation Required Intervention 20 Female 8/1/2006 Other Health Professional Japan
Primary
Secondary
Pulmonary Oedema Life Threatening 4/7/2006 Female 116 lb 8/10/2006 Physician United States
Primary
Secondary
Concomitant
Strabismus Other Serious 7/1/2006 30 Male 8/4/2006 Physician Austria
Primary
Secondary
Concomitant
Cerebral Atrophy Hospitalization 11/9/2004 68 Female 106 lb 8/7/2006 Physician France
Primary
Secondary
Urticaria Required Intervention 7/20/2006 19 Male 146 lb 8/8/2006 Physician United States
Primary
Concomitant
Myelodysplastic Syndrome Other Serious 26 Female 8/16/2006 Physician United States
Primary
Secondary
Growth Hormone Deficiency Other Serious 12 Female 8/7/2006 United States
Primary
Secondary
Growth Hormone Deficiency Other Serious 15 Male 8/7/2006 United States
Primary
Secondary
Vomiting Life Threatening 8/15/2006 18 Female 124 lb 8/16/2006 Other Health Professional United States
Primary
Concomitant
Type Iv Hypersensitivity Reaction Required Intervention 7/20/2006 19 Male 146 lb 8/8/2006 Physician United States
Primary
Concomitant
Urticaria Required Intervention 7/20/2006 19 Male 146 lb 8/16/2006 Physician United States
Primary
Concomitant
Vith Nerve Paralysis Hospitalization 69 Female 8/23/2006 Physician United States
Primary
Concomitant
Refusal Of Treatment By Patient Hospitalization 58 Female 9/1/2006 United States
Primary
Secondary
Urinary Incontinence Required Intervention 16 Male 9/1/2006 Other Health Professional Spain
Primary
Concomitant
Pyrexia Hospitalization 9/4/2006 24 Male 176 lb 9/5/2006 Other Health Professional United States
Primary
Secondary
Urticaria Generalised Hospitalization 8/25/2006 Female 33 lb 9/1/2006 United States
Primary
Secondary
Vertigo Hospitalization 7/16/2006 57 Male 198 lb 9/5/2006 United Kingdom
Primary
Concomitant
Septic Shock Life Threatening 8/29/2006 50 Male 9/18/2006 Physician Israel
Primary
Concomitant
Pyrexia Other Serious 9/11/2006 35 Male 154 lb 9/19/2006 Physician France
Primary
Secondary
Pyrexia Other Serious 9/11/2006 35 Male 154 lb 9/19/2006 Physician France
Primary
Secondary
Nausea Hospitalization 2/17/2006 5 Female 39 lb 9/13/2006 Canada
Primary
Concomitant
Vomiting Life Threatening 8 Male 9/19/2006 Physician Kenya
Primary
Secondary
Urticaria Generalised Life Threatening 7/24/2006 3 Female 33 lb 9/20/2006 Pharmacist United States
Primary
Concomitant
Vomiting Life Threatening 9/6/2006 3 Male 33 lb 9/20/2006 Pharmacist United States
Primary
Concomitant
Urinary Incontinence Required Intervention 1/1/1997 16 Male 9/20/2006 Other Health Professional Spain
Primary
Concomitant
Leukoencephalopathy Other Serious 56 Male 9/21/2006 Physician United States
Primary
Secondary
Gastric Haemorrhage Life Threatening 8/30/2006 63 Male 9/26/2006 Physician France
Primary
Secondary
Concomitant
Leukoencephalopathy Other Serious 56 Male 10/3/2006 Other Health Professional United States
Primary
Secondary
Lung Infection Pseudomonal Other Serious 50 Female 9/29/2006 Canada
Primary
Secondary
Concomitant
Musculoskeletal Chest Pain Hospitalization 11/9/2005 Male 164 lb 10/5/2006 Physician Australia
Primary
Concomitant
Pain In Extremity Hospitalization 8/24/2006 64 Male 9/29/2006 Physician
Primary
Concomitant
Leukoencephalopathy Other Serious 56 Male 10/4/2006 United States
Primary
Secondary
Tremor Hospitalization 3 Male 10/12/2006
Primary
Secondary
Concomitant
Stomatitis Other Serious 37 Female 10/17/2006 Consumer United States
Primary
Secondary
Thrombocytopenia Required Intervention 40 Male 10/6/2006 United States
Primary
Secondary
Progressive Multifocal Leukoencephalopathy Other Serious 56 Male 10/13/2006 Physician United States
Primary
Secondary
Spinal Compression Fracture Other Serious 11/1/1998 43 Male 10/17/2006 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Liver Disorder Hospitalization 10/1/2005 66 Male 10/18/2006 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Oral Intake Reduced Hospitalization 7 Female 10/13/2006 Other Health Professional United Kingdom
Primary
Secondary
Viral Load Increased Other Serious 11/1/1998 43 Male 10/19/2006 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Injection Site Necrosis Hospitalization 8/21/2006 74 Male 220 lb 10/20/2006 Physician France
Primary
Secondary
Concomitant
Transfusion Reaction Hospitalization 2/17/2006 5 Female 39 lb 10/10/2006 Canada
Primary
Concomitant
Weight Increased Required Intervention 9/18/2006 Male 36 lb 9/29/2006 Pharmacist United States
Primary
Concomitant
Respiratory Failure Required Intervention 31 Female 10/23/2006 Japan
Primary
Secondary
Concomitant
Vomiting Hospitalization 7 Female 10/23/2006 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Necrotising Colitis Hospitalization 7 Female 10/24/2006 Consumer United Kingdom
Primary
Secondary
Osteoporosis Other Serious 43 Male 10/31/2006 Other Health Professional United Kingdom
Primary
Secondary
Hyponatraemia Required Intervention 9/5/2006 8 Male 61 lb 10/4/2006 Pharmacist United States
Primary
Concomitant
Vomiting Hospitalization 8/1/2005 7 Female 10/26/2006 United Kingdom
Primary
Secondary
White Blood Cell Count Increased Other Serious 42 Female 10/27/2006 Physician Turkey
Primary
Secondary
Intestinal Ischaemia Other Serious 9/11/2006 77 Male 11/2/2006 Other Health Professional Canada
Primary
Concomitant
Parosmia Disability 63 Female 11/3/2006 Other Health Professional Germany
Primary
Secondary
Concomitant
Pancreatitis Acute Other Serious 10/11/2006 65 Male 196 lb 11/3/2006 Physician Australia
Primary
Secondary
Vomiting Hospitalization 7 Female 10/26/2006 United Kingdom
Primary
Secondary
Osteoporosis Hospitalization 9/1/1998 43 Male 11/8/2006
Primary
Secondary
Concomitant
Respiratory Failure Required Intervention 6/25/2004 31 Female 11/3/2006 Physician Japan
Primary
Secondary
Concomitant
Respiratory Failure Other Serious 6/25/2004 31 Female 11/3/2006 Japan
Primary
Secondary
Concomitant
Pleural Effusion Hospitalization 11/26/2003 61 Male 168 lb 11/6/2006 Physician United States
Primary
Secondary
Prothrombin Time Prolonged Other Serious 10/25/2004 7 Male 11/13/2006
Primary
Secondary
Weight Decreased Other Serious 63 Female 11/13/2006
Primary
Secondary
Spinal Compression Fracture Other Serious 11/1/1998 43 Male 11/14/2006 Consumer United States
Primary
Secondary
Concomitant
Rash Maculo-papular Hospitalization 11/16/2006 5 Male 46 lb 11/17/2006 Other Health Professional New Zealand
Primary
Concomitant
Thrombosis 9/29/2006 Pharmacist United States
Primary
Concomitant

Drug Data