Methotrexate combined with Vincristine Sulfate

Reports:

Reaction Outcome Event Date Age Sex Weight Reported Reporter Country Treatment
Role Name
Vomiting Other Serious 6 Male 1/6/2006 Physician Australia
Primary
Concomitant
Vomiting Other Serious 12/26/2005 Female 169 lb 1/9/2006 United States
Primary
Secondary
Stomatitis Other Serious 11/21/2005 Female 138 lb 1/17/2006 United States
Primary
Secondary
Concomitant
White Blood Cell Count Decreased Required Intervention Female 1/23/2006 United States
Primary
Secondary
Subarachnoid Haemorrhage Other Serious Female 1/30/2006 Other Health Professional France
Primary
Secondary
Drug Toxicity Death Unknown 1/25/2006 United States
Primary
Secondary
Drug Toxicity Death Unknown 1/25/2006 United States
Primary
Secondary
Drug Toxicity Death Unknown 1/25/2006 United States
Primary
Secondary
Drug Toxicity Death Unknown 1/25/2006 United States
Primary
Secondary
White Blood Cell Count Decreased Other Serious 12/22/2005 Female 138 lb 1/23/2006 United States
Primary
Secondary
Therapy Non-responder Death Female 1/27/2006 United Kingdom
Primary
Secondary
Reversible Posterior Leukoencephalopathy Syndrome Other Serious 1/1/2004 6 Male 40 lb 2/3/2006 Physician Japan
Primary
Secondary
Tachypnoea Hospitalization 2/6/2006 Female 37 lb 2/6/2006 United States
Primary
Secondary
Tachycardia Death 2/1/2006 Male 42 lb 2/8/2006 United States
Primary
Secondary
Prothrombin Time Prolonged Hospitalization 8/1/2005 10 Male 67 lb 1/31/2006 Pharmacist United States
Primary
Concomitant
Reversible Posterior Leukoencephalopathy Syndrome Other Serious 1/1/2004 6 Male 40 lb 3/2/2006 Physician Japan
Primary
Secondary
Vomiting Hospitalization 2/22/2006 Female 77 lb 2/24/2006 United States
Primary
Secondary
Weight Decreased Other Serious 2/18/2006 14 Female 40 lb 3/2/2006 United States
Primary
Secondary
Reversible Posterior Leukoencephalopathy Syndrome Other Serious 1/1/2004 6 Male 40 lb 3/8/2006 Physician Japan
Primary
Secondary
Concomitant
Reversible Posterior Leukoencephalopathy Syndrome Other Serious 1/1/2004 6 Male 40 lb 3/10/2006 Physician Japan
Primary
Secondary
Pancreatitis Acute Hospitalization 4/4/1973 4 Male 1/20/2006 Physician United States
Primary
Concomitant
Deep Vein Thrombosis Hospitalization 8/27/2005 63 Female 3/22/2006 Physician France
Primary
Secondary
Concomitant
Performance Status Decreased Other Serious 3/13/2006 Male 216 lb 3/29/2006 United States
Primary
Secondary
Sepsis Required Intervention 3/20/2006 Female 40 lb 3/23/2006 United States
Primary
Secondary
Respiratory Failure Hospitalization 3/14/2006 Male 251 lb 4/10/2006 United States
Primary
Secondary
Vomiting Other Serious 3/3/2006 Male 23 lb 4/12/2006 United States
Primary
Secondary
Thrombocytopenic Purpura Other Serious 6 Female 5/5/2006 Other Health Professional Canada
Primary
Secondary
Concomitant
Weight Increased Hospitalization 11/23/2003 5 Female 4/28/2006 Physician Japan
Primary
Secondary
Concomitant
Wound Drainage Hospitalization 4/24/2006 Male 21 lb 4/27/2006 United States
Primary
Secondary
Pulmonary Infarction Other Serious 12/10/2005 Male 178 lb 5/9/2006 United States
Primary
Secondary
White Blood Cell Count Decreased Life Threatening 3/20/2006 70 Female 117 lb 5/11/2006 Physician United States
Primary
Secondary
Concomitant
Tracheal Haemorrhage Other Serious 3/7/2006 Male 32 lb 3/20/2006 United States
Primary
Secondary
Pyrexia Other Serious 5/8/2006 Female 122 lb 6/7/2006 United States
Primary
Secondary
Haemorrhage Intracranial Hospitalization 6/7/2006 Female 109 lb 6/8/2006 United States
Primary
Secondary
Ventricular Fibrillation Death 5/9/2006 11 Male 176 lb 6/11/2006 United States
Primary
Secondary
Sepsis Hospitalization 3/20/2006 Female 40 lb 6/12/2006 United States
Primary
Secondary
Haemorrhage Intracranial Hospitalization 6/7/2006 Female 109 lb 6/16/2006 United States
Primary
Secondary
Sepsis Hospitalization 4/24/2006 Male 21 lb 6/20/2006 United States
Primary
Secondary
Pyrexia Death 5/10/2006 49 Female 212 lb 7/7/2006 Physician France
Primary
Secondary
Concomitant
Tachycardia Hospitalization 6/28/2006 Female 50 lb 7/7/2006 United States
Primary
Secondary
Muscular Weakness Hospitalization 7/2/2006 Male 109 lb 7/10/2006 United States
Primary
Secondary
Staphylococcal Infection Hospitalization 5/9/2006 Female 171 lb 7/7/2006 United States
Primary
Secondary
Urosepsis Hospitalization 6/27/2006 Female 176 lb 7/13/2006 United States
Primary
Secondary
Tuberculosis Hospitalization 6/28/2006 Male 30 lb 7/19/2006 United States
Primary
Secondary
Tachycardia Hospitalization 6/28/2006 Female 50 lb 7/27/2006 United States
Primary
Secondary
Concomitant
Treatment Related Secondary Malignancy Other Serious 3 Male 8/3/2006 Consumer United States
Primary
Secondary
Treatment Related Secondary Malignancy Death 10 Male 8/3/2006 Consumer United States
Primary
Secondary
Treatment Related Secondary Malignancy Other Serious 13 Female 8/3/2006 Consumer United States
Primary
Secondary
Treatment Related Secondary Malignancy Death 14 Male 8/3/2006 Consumer United States
Primary
Secondary
Idiopathic Thrombocytopenic Purpura Other Serious 13 Female 7/31/2006 Physician Canada
Primary
Secondary
Thrombocytopenic Purpura Other Serious 10 Female 7/31/2006 Physician Canada
Primary
Secondary
Mucosal Inflammation Hospitalization 7/31/2006 Male 168 lb 8/1/2006 United States
Primary
Secondary
Tachycardia Hospitalization 3/4/2006 Male 311 lb 8/11/2006 United States
Primary
Secondary
White Blood Cell Count Increased Hospitalization 6/2/2006 Male 33 lb 8/11/2006 United States
Primary
Secondary
Vomiting Hospitalization 8/14/2006 Female 180 lb 8/15/2006 United States
Primary
Secondary
Concomitant
Pulmonary Embolism Hospitalization 8/23/2006 Male 53 lb 8/24/2006 United States
Primary
Secondary
Therapy Non-responder Hospitalization 8/24/2006 10 Male 117 lb 8/25/2006 United States
Primary
Secondary
Urticaria Generalised Hospitalization 8/25/2006 Female 33 lb 8/29/2006 United States
Primary
Secondary
Concomitant
White Blood Cell Count Increased Hospitalization 6/2/2006 Male 33 lb 8/28/2006 United States
Primary
Secondary
Vomiting Hospitalization 8/14/2006 Female 180 lb 9/5/2006 United States
Primary
Secondary
Concomitant
Ocular Icterus Hospitalization 8/30/2006 Female 172 lb 8/31/2006 United States
Primary
Secondary
Pulmonary Embolism Hospitalization 8/23/2006 Male 53 lb 9/12/2006 United States
Primary
Secondary
Vomiting Hospitalization 9/15/2006 Male 29 lb 9/15/2006 United States
Primary
Secondary
Concomitant
Liver Disorder Hospitalization 9/1/2006 Female 143 lb 9/15/2006 United States
Primary
Secondary
Septic Shock Hospitalization 8/30/2006 Female 35 lb 9/12/2006 United States
Primary
Secondary
Vomiting Hospitalization 9/12/2006 Male 146 lb 9/18/2006 United States
Primary
Secondary
Vomiting 8/30/2006 Female 172 lb 9/20/2006 United States
Primary
Secondary
Septic Shock Hospitalization 9/1/2006 Female 188 lb 9/13/2006 Other Health Professional United States
Primary
Secondary
Therapy Non-responder Hospitalization 9/20/2006 Female 66 lb 9/22/2006 United States
Primary
Secondary
Multi-organ Failure Other Serious 5 Female 10/5/2006 Physician Japan
Primary
Concomitant
Fungal Infection Death 10/2/2006 Physician United States
Primary
Concomitant
Mucormycosis Death 10/2/2006 Physician United States
Primary
Concomitant
Pain In Extremity Other Serious 11/1/1998 43 Male 10/12/2006 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Sepsis Death 39 Male 10/17/2006 Physician United States
Primary
Concomitant
Necrotising Colitis Hospitalization 7 Female 10/19/2006 Other Health Professional United Kingdom
Primary
Secondary
Pyrexia Hospitalization 9/24/2006 Female 154 lb 10/11/2006 United States
Primary
Secondary
Mucormycosis Death 10/13/2006 Physician United States
Primary
Concomitant
Pain Hospitalization 9/21/2006 Male 168 lb 10/11/2006 United States
Primary
Secondary
Staphylococcal Infection Hospitalization 10/9/2006 Male 52 lb 10/20/2006 United States
Primary
Secondary
Multi-organ Failure Other Serious 5 Female 10/27/2006 Physician Japan
Primary
Concomitant
Septic Shock Hospitalization 9/1/2006 Female 188 lb 10/26/2006 United States
Primary
Secondary
Thrombophlebitis Other Serious 17 Male 11/6/2006 Physician Poland
Primary
Secondary
Concomitant
Multi-organ Failure Other Serious 5 Female 11/8/2006 Physician Japan
Primary
Concomitant
Venous Thrombosis Limb Other Serious 58 Female 10/26/2006 Physician United States
Primary
Secondary
Splenomegaly Hospitalization 8/30/2006 Female 172 lb 10/24/2006 United States
Primary
Secondary
Concomitant
Vomiting Hospitalization 9/15/2006 Male 29 lb 11/6/2006 United States
Primary
Secondary
Concomitant
Sepsis Hospitalization Female 87 lb 11/9/2006 United States
Primary
Secondary
Concomitant
Staphylococcal Infection Hospitalization 10/9/2006 Male 52 lb 11/22/2006 United States
Primary
Secondary
White Blood Cell Count Decreased Hospitalization 11/16/2006 Male 136 lb 11/17/2006 United States
Primary
Secondary
Gait Disturbance Hospitalization 11/20/2006 Male 121 lb 11/21/2006 United States
Primary
Secondary
Venoocclusive Liver Disease Hospitalization 11/23/2006 Female 40 lb 11/27/2006 Other Health Professional United States
Primary
Secondary
Weight Increased Hospitalization 11/23/2006 Female 40 lb 11/30/2006 Other Health Professional United States
Primary
Secondary
Pain In Extremity Other Serious 11/1/1998 43 Male 12/8/2006 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Vulval Disorder Hospitalization 11/27/2006 Female 188 lb 12/6/2006 United States
Primary
Secondary
Wheezing Hospitalization 12/1/2006 Male 38 lb 12/6/2006 United States
Primary
Secondary
Mucosal Inflammation Hospitalization 11/30/2006 Male 254 lb 12/6/2006 United States
Primary
Secondary
Tremor Hospitalization 11/20/2006 Female 216 lb 12/6/2006 United States
Primary
Secondary
White Blood Cell Count Decreased Hospitalization 10/18/2006 Female 87 lb 12/13/2006 United States
Primary
Secondary
Concomitant
Wheezing Hospitalization 12/1/2006 Male 38 lb 12/14/2006 United States
Primary
Secondary
Vomiting Hospitalization 12/10/2006 Female 100 lb 12/13/2006 United States
Primary
Secondary
Vaginal Ulceration Hospitalization 11/27/2006 Female 188 lb 12/12/2006 United States
Primary
Secondary
Concomitant
Small Intestinal Obstruction Hospitalization 12/3/2006 Female 147 lb 12/15/2006 United States
Primary
Secondary
Vulval Erythema Hospitalization 12/10/2006 Female 138 lb 12/18/2006 United States
Primary
Secondary
Ventricular Tachycardia Hospitalization 12/14/2006 Female 140 lb 12/18/2006 United States
Primary
Secondary
Vomiting Hospitalization 11/23/2006 Female 40 lb 12/18/2006 United States
Primary
Secondary
Vulval Disorder Hospitalization 12/10/2006 Female 138 lb 12/21/2006 United States
Primary
Secondary
Hemiparesis Hospitalization 11/20/2006 Male 121 lb 12/29/2006 United States
Primary
Secondary
Splenic Infarction 12/22/2006 Female 42 lb 1/2/2007 United States
Primary
Secondary
Vomiting Hospitalization 12/10/2006 Female 100 lb 1/12/2007 United States
Primary
Secondary
Hepatotoxicity Other Serious 47 Female 1/19/2007 Other Health Professional Israel
Primary
Secondary
Concomitant
Red Blood Cell Count Decreased Hospitalization 12/27/2006 Female 136 lb 1/10/2007 United States
Primary
Secondary
Ventricular Tachycardia Hospitalization 12/14/2006 Female 140 lb 1/18/2007 United States
Primary
Secondary
Jaundice Cholestatic 52 Male 1/26/2007 Israel
Primary
Secondary
Concomitant
Hepatotoxicity 47 Female 1/26/2007 Israel
Primary
Secondary
Concomitant
Tracheal Haemorrhage 12/22/2006 Female 43 lb 1/25/2007 United States
Primary
Secondary
Concomitant
Interstitial Lung Disease Hospitalization Female 2/14/2007 Consumer United States
Primary
Secondary
Renal Failure Acute Hospitalization 8/12/2006 50 Male 166 lb 2/9/2007 Other Health Professional Australia
Primary
Secondary
Concomitant
Renal Failure Acute Hospitalization 8/12/2006 51 Male 166 lb 2/20/2007 Other Health Professional Australia
Primary
Secondary
Concomitant
Aspartate Aminotransferase Increased Hospitalization 8/31/2006 Female 105 lb 2/16/2007 United States
Primary
Secondary
Concomitant
Sinusitis Fungal Hospitalization 2/22/2007 Male 227 lb United States
Primary
Secondary
Retroperitoneal Fibrosis Hospitalization 66 2/19/2007 Italy
Primary
Secondary
Headache Life Threatening 12/20/2006 49 Male 3/6/2007 Other Health Professional France
Primary
Secondary
Concomitant
Depression Hospitalization 6/24/2005 Male 157 lb 3/7/2007 Other Health Professional United States
Primary
Concomitant
Malignant Neoplasm Progression Other Serious 66 Female 3/8/2007 Other Health Professional United States
Primary
Secondary
Concomitant
Glioma Other Serious 2 Female 3/8/2007 Consumer Finland
Primary
Secondary
Glioma Other Serious 2 Male 3/9/2007 Consumer Finland
Primary
Secondary
Glioma Other Serious 2 Female 3/9/2007 Other Health Professional Finland
Primary
Secondary
Glioma Other Serious 4 Male 3/9/2007 Consumer Finland
Primary
Secondary
Glioma Other Serious 3 Female 3/9/2007 Consumer Finland
Primary
Secondary
Glioma Other Serious 5 Male 3/9/2007 Consumer Finland
Primary
Secondary
Convulsion Other Serious 11 Male 3/9/2007 Other Health Professional India
Primary
Secondary
Uv Light Therapy Other Serious 49 Male 3/9/2007 Other Health Professional United States
Primary
Secondary
Concomitant
Glioma Other Serious 2 Male 3/9/2007 Consumer Finland
Primary
Secondary
Glioma Other Serious 2 Female 3/9/2007 Consumer Finland
Primary
Secondary
Glioma Other Serious 2 Female 3/9/2007 Other Health Professional Finland
Primary
Secondary
Glioma Other Serious 3 Female 3/9/2007 Consumer Finland
Primary
Secondary
Glioma Other Serious 4 Male 3/9/2007 Consumer Finland
Primary
Secondary
Glioma Other Serious 5 Male 3/12/2007 Consumer Finland
Primary
Secondary
Malignant Neoplasm Progression Other Serious 5/13/2005 63 Female 3/13/2007 Consumer United States
Primary
Secondary
Acute Myeloid Leukaemia Other Serious 1/23/2006 64 Male 3/13/2007 Other Health Professional United States
Primary
Secondary
Acute Myeloid Leukaemia Other Serious 1/23/2006 64 Male 3/13/2007 Other Health Professional United States
Primary
Secondary
White Blood Cell Count Decreased 3/7/2007 Female 66 lb 3/9/2007 United States
Primary
Secondary
Recall Phenomenon 49 Male 3/15/2007 United States
Primary
Secondary
Concomitant
Malignant Neoplasm Progression Other Serious 5/13/2005 63 Female 3/16/2007 Consumer United States
Primary
Secondary
Acute Myeloid Leukaemia Other Serious 1/23/2006 64 Male 3/19/2007 Other Health Professional United States
Primary
Secondary
White Blood Cell Count Decreased Female 66 lb 3/20/2007 United States
Primary
Secondary
Vulval Ulceration Hospitalization 11/27/2006 Female 188 lb 3/20/2007 United States
Primary
Secondary
Concomitant
Pneumonia Hospitalization 9/2/2005 Female 170 lb 4/3/2007 Other Health Professional United States
Primary
Secondary
Spinal Cord Disorder Other Serious 26 Female 4/4/2007 Other Health Professional Australia
Primary
Secondary
Concomitant
Influenza Hospitalization 3/26/2007 Female 86 lb 4/3/2007 United States
Primary
Secondary

Drug Data