Methotrexate combined with Velcade

Reports:

Reaction Outcome Event Date Age Sex Weight Reported Reporter Country Treatment
Role Name
Somnolence Other Serious 12/12/2005 61 Female 181 lb 3/9/2006 Physician France
Primary
Secondary
Thrombocytopenia Death 5/30/2006 59 Male 143 lb 6/12/2006 Physician France
Primary
Secondary
Thrombocytopenia Hospitalization 5/19/2006 59 Male 143 lb 6/16/2006 Physician France
Primary
Secondary
Thrombocytopenia Hospitalization 5/19/2006 59 Male 143 lb 6/26/2006 Physician France
Primary
Secondary
Malignant Neoplasm Progression Hospitalization 10/2/2006 56 Female 115 lb 10/23/2006 Physician France
Primary
Secondary
Malignant Neoplasm Progression Hospitalization 10/2/2006 56 Female 115 lb 10/26/2006 Physician France
Primary
Secondary
Staphylococcal Infection Hospitalization 4/28/2006 61 Male 176 lb 12/21/2006 Physician France
Primary
Secondary
Pneumocystis Jiroveci Pneumonia Hospitalization 11/27/2006 41 Male 152 lb 12/28/2006 Physician France
Primary
Secondary
Concomitant
Oesophageal Candidiasis Hospitalization 12/23/2006 56 Female 1/8/2007 Physician France
Primary
Secondary
Concomitant
Purpura Hospitalization 12/23/2006 56 Female 104 lb 1/24/2007 Physician France
Primary
Secondary
Concomitant
Pneumocystis Jiroveci Pneumonia Hospitalization 11/27/2006 41 Male 152 lb 3/2/2007 Physician France
Primary
Secondary
Concomitant
Pneumonitis Hospitalization 2/11/2007 65 Male 157 lb 3/2/2007 Physician France
Primary
Secondary
Concomitant
Vomiting Hospitalization 3/1/2007 52 Male 3/12/2007 Physician France
Primary
Secondary
Pulmonary Mass Hospitalization 2/11/2007 65 Male 157 lb 3/23/2007 Physician France
Primary
Secondary
Concomitant
Vomiting Hospitalization 3/1/2007 52 Male 159 lb 3/23/2007 Physician France
Primary
Secondary
Ulcer Hospitalization 3/4/2007 28 Female 110 lb 3/23/2007 Physician France
Primary
Secondary
Tongue Coated Hospitalization 2/1/2007 65 Male 4/26/2007 Consumer United States
Primary
Secondary
Concomitant
Ventricular Hypokinesia Life Threatening 3/22/2007 58 Male 139 lb 4/27/2007 Physician France
Primary
Secondary
Concomitant
Ventricular Hypokinesia Life Threatening 3/22/2007 58 Male 139 lb 5/10/2007 Physician France
Primary
Secondary
Concomitant
Tongue Coated Hospitalization 2/1/2007 65 Male 5/17/2007 Consumer Japan
Primary
Secondary
Concomitant
Thrombocytopenia Hospitalization 5/19/2006 59 Male 143 lb 5/11/2007 Physician France
Primary
Secondary
Oesophageal Ulcer Hospitalization 12/21/2006 56 Female 104 lb 5/11/2007 Physician France
Primary
Secondary
Concomitant
Restrictive Pulmonary Disease Hospitalization 2/11/2007 65 Male 157 lb 5/14/2007 Physician France
Primary
Secondary
Concomitant
Tongue Disorder Hospitalization 2/11/2007 65 Male 157 lb 5/17/2007 Physician France
Primary
Secondary
Concomitant
Tongue Disorder Hospitalization 2/11/2007 65 Male 157 lb 6/18/2007 Physician France
Primary
Secondary
Concomitant
Aplasia Hospitalization 6/22/2007 43 Male 152 lb 7/16/2007 Physician France
Primary
Secondary
Tongue Haemorrhage Hospitalization 2/11/2007 65 Male 157 lb 8/21/2007 Physician France
Primary
Secondary
Concomitant
Thrombocytopenia Hospitalization 5/19/2006 59 Male 143 lb 8/22/2007 Physician France
Primary
Secondary
Pancytopenia Hospitalization 12/21/2006 56 Female 104 lb 8/22/2007 Physician France
Primary
Secondary
Concomitant
Thrombocytopenia Hospitalization 12/23/2006 56 Female 104 lb 9/20/2007 Physician France
Primary
Secondary
Concomitant
Loss Of Consciousness Hospitalization 9/12/2007 70 Male 196 lb 10/1/2007 Physician United States
Primary
Secondary
Concomitant
Respiratory Tract Infection Hospitalization 9/25/2007 29 Male 181 lb 10/22/2007 Physician France
Primary
Secondary
Pneumonitis Hospitalization 2/11/2007 65 Male 157 lb 12/6/2007 Physician France
Primary
Secondary
Concomitant
Treatment Failure Hospitalization 5/19/2006 59 Male 65 lb 12/5/2007 Physician France
Primary
Secondary
White Blood Cell Count Decreased Other Serious 1/17/2007 56 Female 104 lb 12/14/2007 Physician France
Primary
Secondary
Septic Shock Death 12/31/2007 65 Male 239 lb 1/16/2008 Physician United States
Primary
Secondary
Concomitant
Sepsis Death 12/31/2007 65 Male 239 lb 1/31/2008 Physician United States
Primary
Secondary
Concomitant
Acute Myeloid Leukaemia Other Serious 1/16/2008 35 Male 157 lb 2/8/2008 Physician France
Primary
Secondary
Thrombocytopenia Life Threatening 3/22/2007 58 Male 139 lb 2/19/2008 Physician France
Primary
Secondary
Concomitant
Opportunistic Infection Hospitalization 2/11/2007 65 Male 157 lb 2/20/2008 Physician France
Primary
Secondary
Concomitant
Respiratory Tract Infection Hospitalization 9/25/2007 29 Male 181 lb 2/21/2008 Physician France
Primary
Secondary
Acute Myeloid Leukaemia Other Serious 1/13/2008 35 Male 157 lb 2/20/2008 Physician France
Primary
Secondary
Skin Injury Hospitalization 3/6/2008 49 Male 277 lb 3/24/2008 Physician United States
Primary
Secondary
Concomitant
Toxic Epidermal Necrolysis Hospitalization 4/25/2008 60 Male 5/8/2008 Other Health Professional United States
Primary
Secondary
Concomitant
Acute Myeloid Leukaemia Other Serious 1/16/2008 35 Male 5/9/2008 Physician France
Primary
Secondary
Tachycardia Hospitalization 3/1/2007 52 Male 159 lb 5/14/2008 Physician France
Primary
Secondary
Thrombocytopenia Life Threatening 3/22/2007 58 Male 139 lb 5/15/2008 Physician France
Primary
Secondary
Concomitant
White Blood Cell Count Increased Death 3/3/2006 46 Male 148 lb 5/15/2008 Physician France
Primary
Secondary
Thrombocytopenia Other Serious 1/17/2007 56 Female 104 lb 5/15/2008 Physician France
Primary
Secondary
Thrombocytopenia Other Serious 12/23/2006 56 Female 104 lb 5/15/2008 Physician France
Primary
Secondary
Concomitant
Thrombocytopenia Hospitalization 5/19/2006 59 Male 143 lb 5/15/2008 Physician France
Primary
Secondary
Toxic Epidermal Necrolysis Hospitalization 3/25/2008 60 Male 6/3/2008 Physician United States
Primary
Secondary
Concomitant
Tachycardia Hospitalization 3/1/2007 52 Male 159 lb 7/31/2008 Physician France
Primary
Secondary
Vomiting Hospitalization 3/1/2007 52 Male 159 lb 8/15/2008 Physician France
Primary
Secondary
Wrong Drug Administered Life Threatening 9/19/2008 71 Male 9/23/2008 Physician Italy
Primary
Concomitant
Hepatitis B Hospitalization 10/3/2007 61 Male 154 lb 10/7/2008 Physician France
Primary
Secondary
Concomitant
Venous Thrombosis Limb Other Serious 9/2/2008 16 Male 145 lb 10/27/2008 Other Health Professional United States
Primary
Secondary
Concomitant
Pyrexia Hospitalization 10/17/2008 47 Male 197 lb 10/28/2008 Physician United States
Primary
Secondary
Concomitant
Somnolence Life Threatening 9/19/2008 71 Male 10/29/2008 Physician Italy
Primary
Concomitant
Acute Myeloid Leukaemia Other Serious 1/16/2008 35 Male 157 lb 10/31/2008 Physician France
Primary
Secondary
Incorrect Route Of Drug Administration Life Threatening 9/19/2008 71 Male 11/6/2008 Physician Italy
Primary
Concomitant
Somnolence Life Threatening 9/19/2008 71 Male 11/24/2008 Physician Italy
Primary
Concomitant
Splenic Infarction Other Serious 1/1/2007 16 Female 11/21/2008 Physician United States
Primary
Secondary
Respiratory Rate Increased Hospitalization 11/19/2008 47 Male 187 lb 11/26/2008 Physician United States
Primary
Secondary
Aspergilloma Hospitalization 11/13/2008 60 Female 179 lb 11/26/2008 Physician United States
Primary
Secondary
White Blood Cell Count Decreased Other Serious 8/24/2008 16 Male 145 lb 11/26/2008 Other Health Professional United States
Primary
Secondary
Concomitant
Wrong Drug Administered Life Threatening 9/19/2008 71 Male 12/4/2008 Physician Italy
Primary
Concomitant
Vomiting Other Serious 10/23/2007 16 Female 156 lb 12/16/2008 Physician United States
Primary
Secondary
Aspergillosis Hospitalization 11/13/2008 60 Female 179 lb 12/16/2008 Physician United States
Primary
Secondary
Concomitant
Wrong Drug Administered Life Threatening 9/18/2008 71 Male 12/19/2008 Physician Italy
Primary
Concomitant
Wrong Drug Administered Life Threatening 9/18/2008 71 Male 12/22/2008 Physician Italy
Primary
Concomitant
White Blood Cell Count Decreased Other Serious 8/24/2008 16 Male 145 lb 12/30/2008 Other Health Professional United States
Primary
Secondary
Concomitant
Respiratory Rate Increased Hospitalization 11/19/2008 47 Male 187 lb 1/15/2009 Physician United States
Primary
Secondary
Concomitant
Pharyngitis Hospitalization 3/4/2007 28 Female 110 lb 1/28/2009 Physician France
Primary
Secondary
White Blood Cell Count Increased Death 3/3/2006 46 Male 148 lb 1/28/2009 Other Health Professional France
Primary
Secondary
Treatment Failure Hospitalization 5/19/2006 59 Male 143 lb 1/29/2009 Physician France
Primary
Secondary
Thrombocytopenia Life Threatening 3/22/2007 58 Male 139 lb 1/28/2009 Physician France
Primary
Secondary
Concomitant
Pyrexia Other Serious 1/13/2008 35 Male 157 lb 1/30/2009 Physician France
Primary
Secondary
Vomiting Other Serious 8/24/2008 16 Male 145 lb 1/29/2009 Other Health Professional United States
Primary
Secondary
Concomitant
Vomiting Other Serious 8/24/2008 16 Male 145 lb 2/12/2009 Other Health Professional United States
Primary
Secondary
Concomitant
Respiratory Failure Other Serious 10/1/2007 Female 3/24/2009 Physician United States
Primary
Secondary
Concomitant
Pancytopenia Other Serious 56 Female 104 lb 4/8/2009 Physician France
Primary
Secondary
Concomitant
Thrombocytopenia Hospitalization 4/9/2006 59 Male 143 lb 4/8/2009 Physician France
Primary
Secondary
Weight Decreased Other Serious 1/14/2007 56 Female 104 lb 4/8/2009 Physician France
Primary
Secondary
Pancytopenia Hospitalization 6/22/2007 43 Male 152 lb 4/14/2009 Physician France
Primary
Secondary
Thrombocytopenia Hospitalization 6/22/2007 43 Male 152 lb 4/20/2009 Physician France
Primary
Secondary
Vomiting Hospitalization 3/1/2007 52 Male 159 lb 4/29/2009 Physician France
Primary
Secondary
Pyrexia Other Serious 1/13/2008 35 Male 157 lb 4/29/2009 Physician France
Primary
Secondary
Respiratory Failure Other Serious 10/1/2007 Female 6/19/2009 Physician United States
Primary
Secondary
Concomitant
Salivary Gland Mass Other Serious 1/1/2008 38 Female 6/17/2009 Other Health Professional United States
Primary
Secondary
Concomitant
Mucosal Inflammation Hospitalization 6/1/2009 Male 8/6/2009 Consumer France
Primary
Secondary
Concomitant
Cytolytic Hepatitis Hospitalization 6/14/2009 Male 8/10/2009 Other Health Professional France
Primary
Secondary
Neutropenia Other Serious Male 8/24/2009 Other Health Professional United States
Primary
Concomitant
White Blood Cell Count Increased Life Threatening 1/14/2010 Female 127 lb 2/19/2010 Physician United States
Primary
Secondary
Pneumonia Life Threatening 1/14/2010 Female 127 lb 3/2/2010 Other Health Professional United States
Primary
Secondary
Pharyngitis Hospitalization 3/4/2007 28 Female 110 lb 3/8/2010 Physician France
Primary
Secondary
Upper Airway Obstruction Hospitalization 2/11/2007 65 Male 157 lb 3/8/2010 Physician France
Primary
Secondary
Concomitant
Hepatitis B Hospitalization 10/3/2007 61 Male 154 lb 3/26/2010 Physician France
Primary
Secondary
Concomitant
Caecitis Hospitalization 3/5/2010 Male 102 lb 4/13/2010 Physician United States
Primary
Secondary
Neutropenic Infection Hospitalization 9/29/2007 5/17/2010 Physician France
Primary
Secondary
Pancytopenia Other Serious 12/23/2006 56 Female 104 lb 5/13/2010 Physician France
Primary
Secondary
Upper Airway Obstruction Hospitalization 2/11/2007 65 Male 157 lb 5/14/2010 Physician France
Primary
Secondary
Concomitant
Thrombocytopenia Hospitalization 4/9/2006 59 Male 143 lb 5/17/2010 Physician France
Primary
Secondary
Neutropenia Hospitalization 9/25/2007 29 Male 181 lb 5/17/2010 Physician France
Primary
Secondary
Hepatitis B Hospitalization 10/3/2007 61 Male 154 lb 5/14/2010 Physician France
Primary
Secondary
Concomitant
Neutropenic Infection Hospitalization 9/25/2007 29 Male 181 lb 5/25/2010 Physician France
Primary
Secondary
Zygomycosis Other Serious 10/23/2007 16 Female 156 lb 7/14/2010 Physician United States
Primary
Secondary
Zygomycosis Other Serious 10/23/2007 16 Female 156 lb 7/30/2010 Physician United States
Primary
Secondary
Viral Infection Other Serious 3/5/2010 12 Male 102 lb 8/20/2010 Physician United States
Primary
Secondary
Death Hospitalization 9/13/2010 76 Female 148 lb 9/23/2010 Other Health Professional United States
Primary
Secondary
Concomitant
Zygomycosis Other Serious 10/23/2007 16 Female 156 lb 10/5/2010 Physician United States
Primary
Secondary
Death Death 9/13/2010 76 Female 148 lb 10/5/2010 Physician United States
Primary
Secondary
Concomitant
Splenic Infarction Other Serious 10/23/2007 16 Female 156 lb 10/7/2010 Physician United States
Primary
Secondary
Sepsis Death 9/13/2010 76 Female 148 lb 10/28/2010 Physician United States
Primary
Secondary
Concomitant
Oesophageal Pain Other Serious 5/12/2010 8 Female 60 lb 11/21/2010 Physician United States
Primary
Secondary
Dengue Fever Hospitalization 62 Male 12/1/2010 Other Health Professional France
Primary
Concomitant
Neutrophil Count Decreased Hospitalization 6/22/2010 8 Female 60 lb 12/2/2010 Physician United States
Primary
Secondary
Tracheitis Hospitalization 4/2/2009 1 Male 26 lb 11/18/2010 Physician United States
Primary
Concomitant
Anxiety Death 3/8/2011 15 Female 144 lb 3/23/2011 Physician United States
Primary
Secondary
Cytomegalovirus Infection Other Serious 6 Male 5/13/2011 Other Health Professional China
Primary
Concomitant
Medulloblastoma Other Serious 5/17/2011 Other Health Professional China
Primary
Secondary
Concomitant
Pleural Effusion Death 3/8/2011 15 Female 144 lb 5/24/2011 Physician United States
Primary
Secondary
Engraft Failure Death 6/1/2011 Other Health Professional China
Primary
Secondary
Concomitant
Aplasia Pure Red Cell Other Serious 5/17/2011 56 Male 6/17/2011 Physician United States
Primary
Secondary
Concomitant
Hypoalbuminaemia Other Serious 6/28/2011 15 Male 109 lb 7/11/2011 Consumer United States
Primary
Secondary
Hypotension Other Serious 3/8/2011 15 Female 144 lb 7/21/2011 Physician United States
Primary
Secondary
Blood Bilirubin Increased Other Serious 6/28/2011 15 Male 109 lb 7/27/2011 Consumer United States
Primary
Secondary
Hypotension Other Serious 6/29/2011 20 Female 115 lb 7/22/2011 Physician United States
Primary
Secondary
Hypertriglyceridaemia Other Serious 6/28/2011 15 Male 7/27/2011 United States
Primary
Secondary
Concomitant
Anxiety Other Serious 3/8/2011 15 Female 144 lb 8/11/2011 Consumer United States
Primary
Secondary
Respiratory Failure Hospitalization 8/8/2011 43 Male 226 lb 8/11/2011 Other Health Professional United States
Primary
Secondary
Concomitant
Cardio-respiratory Arrest Hospitalization 8/8/2011 43 Male 226 lb 8/25/2011 Physician United States
Primary
Secondary
Concomitant
Enterocolitis Hospitalization 8/22/2011 4 Male 39 lb 9/6/2011 Consumer United States
Primary
Secondary
Throat Irritation Hospitalization 8/4/2011 10 Female 75 lb 8/31/2011 Other Health Professional United States
Primary
Secondary
Concomitant
Respiratory Failure Hospitalization 8/8/2011 43 Male 226 lb 9/8/2011 Other Health Professional United States
Primary
Secondary
Concomitant
Enterocolitis Hospitalization 8/22/2011 3 Male 39 lb 9/15/2011 Physician United States
Primary
Secondary
Hypertension Other Serious 8/24/2011 17 Male 282 lb 9/19/2011 Physician United States
Primary
Secondary
Pancreatic Disorder Death 8/8/2011 43 Male 226 lb 9/20/2011 Consumer United States
Primary
Secondary
Concomitant
Memory Impairment Other Serious 9/14/2011 13 Male 87 lb 10/4/2011 Physician United States
Primary
Secondary
Concomitant
Akathisia Other Serious 9/14/2011 13 Male 87 lb 10/10/2011 Physician United States
Primary
Secondary
Pruritus 9/1/2011 13 Male 87 lb 10/20/2011 Physician United States
Primary
Secondary
Concomitant
Staphylococcal Infection Hospitalization 12/27/2011 11 Male 32 lb 1/20/2012 Physician United States
Primary
Secondary
Concomitant
Caecitis Hospitalization 12/18/2011 10 Female 46 lb 1/24/2012 Physician United States
Primary
Secondary
Tracheitis Hospitalization 1/17/2012 8 Female 92 lb 1/31/2012 Physician United States
Primary
Secondary
Mucosal Infection Hospitalization 12/1/2011 11 Male 32 lb 2/1/2012 Physician United States
Primary
Secondary
Concomitant
Wheezing Hospitalization 1/17/2012 8 Female 92 lb 2/10/2012 Consumer United States
Primary
Secondary
Oesophagitis Hospitalization 1/29/2012 20 Female 191 lb 2/20/2012 Consumer United States
Primary
Secondary
Pancreatitis Hospitalization 2/7/2012 6 Male 77 lb 2/21/2012 Physician United States
Primary
Secondary
Concomitant
Herpes Zoster Hospitalization 1/23/2012 18 Male 159 lb 2/17/2012 Physician United States
Primary
Secondary
Arthralgia Hospitalization 1/29/2012 20 Female 191 lb 2/29/2012 Physician United States
Primary
Secondary

Drug Data