Methotrexate combined with Vancomycin

Reports:

Reaction Outcome Event Date Age Sex Weight Reported Reporter Country Treatment
Role Name
Splenomegaly Hospitalization 1/1/2005 16 Female 1/3/2006 Consumer France
Primary
Secondary
Concomitant
Thrombocytopenia Hospitalization 11/10/2005 79 Female 1/12/2006 Other Health Professional France
Primary
Secondary
Concomitant
Thrombocytopenia Hospitalization 11/10/2005 79 Female 1/23/2006 Other Health Professional France
Primary
Secondary
Concomitant
Speech Disorder Hospitalization 11/14/2005 20 Female 218 lb 1/26/2006 Pharmacist United Kingdom
Primary
Concomitant
Peripheral Motor Neuropathy Other Serious 1/4/2006 5 Female 35 lb 2/3/2006 Physician United States
Primary
Secondary
Concomitant
White Blood Cell Count Increased Other Serious 6/26/2004 Male 121 lb 2/17/2006 Physician United Kingdom
Primary
Concomitant
Paraesthesia Hospitalization 12/4/2005 21 Male 159 lb 2/17/2006 United Kingdom
Primary
Concomitant
Vomiting Hospitalization 2/1/2006 Male 168 lb 3/28/2006 Physician Germany
Primary
Concomitant
Thrombotic Microangiopathy Other Serious 2/22/2003 61 Male 95 lb 5/16/2006 Physician Japan
Primary
Secondary
Concomitant
Venoocclusive Liver Disease Life Threatening 6/21/2001 47 Male 148 lb 5/15/2006 Physician Japan
Primary
Secondary
Concomitant
Venoocclusive Liver Disease Life Threatening 6/21/2001 47 Male 148 lb 6/23/2006 Physician Japan
Primary
Secondary
Concomitant
Sedation Other Serious 1/1/2005 Female 8/18/2006 Consumer
Primary
Concomitant
Transaminases Increased Hospitalization 7/3/2003 35 Female 8/24/2006 Other Health Professional Japan
Primary
Secondary
Concomitant
Infection Other Serious 6/26/2004 Male 121 lb 9/18/2006 Physician United Kingdom
Primary
Concomitant
Stomatitis Other Serious 7/1/2006 Female 165 lb 10/9/2006 Physician Belgium
Primary
Concomitant
Visual Disturbance Other Serious 3/1/2006 61 Male 196 lb 8/8/2006 Pharmacist United States
Primary
Concomitant
Renal Failure Acute Hospitalization 7/6/2006 77 Male 11/10/2006 Other Health Professional Switzerland
Primary
Secondary
Concomitant
Stomatitis Other Serious 7/12/2006 Female 165 lb 12/12/2006 Physician Belgium
Primary
Concomitant
Sensory Loss Other Serious 11/1/2006 21 Female 1/17/2007 Consumer United States
Primary
Concomitant
White Blood Cell Count Decreased Life Threatening 6/20/2006 58 Male 1/17/2007 Japan
Primary
Concomitant
Peripheral Motor Neuropathy Required Intervention 1/4/2006 5 Female 35 lb 3/1/2007 Physician United States
Primary
Secondary
Concomitant
Interstitial Lung Disease Life Threatening 2/6/2007 5 Female 3/15/2007 Finland
Primary
Concomitant
White Blood Cell Count Decreased Other Serious 6/20/2006 Male 117 lb 3/22/2007 Physician Japan
Primary
Concomitant
Nephritis Interstitial Other Serious 56 5/1/2007 Consumer Australia
Primary
Concomitant
Viral Pharyngitis Other Serious 8/26/2005 19 Male 5/11/2007 Poland
Primary
Secondary
Concomitant
Serum Ferritin Increased Other Serious 12/12/2005 50 Female 141 lb 5/23/2007 Physician United States
Primary
Concomitant
Staphylococcal Infection Death 2/15/2007 Male 132 lb 6/22/2007 Other Health Professional United Kingdom
Primary
Concomitant
White Blood Cell Count Decreased Other Serious 9 Male 7/10/2007 Other Health Professional Sweden
Primary
Concomitant
Ventricular Fibrillation Hospitalization 5/21/2007 17 Male 7/18/2007 Other Health Professional France
Primary
Secondary
Concomitant
Cerebellar Syndrome Death 5/21/2007 17 Male 7/24/2007 Other Health Professional France
Primary
Secondary
Concomitant
Ventricular Fibrillation Hospitalization 4/1/2007 17 Male 7/25/2007 Consumer France
Primary
Secondary
Concomitant
White Blood Cell Count Decreased Other Serious 9 Male 8/3/2007 Other Health Professional Sweden
Primary
Concomitant
Ventricular Fibrillation Hospitalization 4/30/2007 Male 8/6/2007 Other Health Professional France
Primary
Secondary
Platelet Count Decreased Life Threatening 12/18/2006 20 Male 115 lb 8/2/2007 Physician Japan
Primary
Concomitant
Ventricular Fibrillation Hospitalization 4/30/2007 Male 8/13/2007 Other Health Professional France
Primary
Secondary
Ventricular Fibrillation Hospitalization 5/1/2007 17 Male 8/14/2007 France
Primary
Secondary
Cerebellar Syndrome Death 5/21/2007 16 Male 8/21/2007 Other Health Professional France
Primary
Secondary
Concomitant
Ventricular Fibrillation Life Threatening 4/30/2007 Male 8/30/2007 Other Health Professional France
Primary
Secondary
Leukoencephalopathy Other Serious 12/5/2006 70 Female 9/3/2007 Pharmacist Japan
Primary
Secondary
Leukoencephalopathy Hospitalization 12/5/2006 70 Female 9/6/2007 Physician Japan
Primary
Secondary
Concomitant
Oesophageal Stenosis Other Serious 3 Female 9/7/2007 Other Health Professional Denmark
Primary
Secondary
Concomitant
Ventricular Fibrillation Life Threatening 5/1/2007 17 Male 9/10/2007 United States
Primary
Secondary
Vomiting Other Serious 8 Male 10/2/2007
Primary
Secondary
Concomitant
Rheumatoid Lung Hospitalization 8/1/2007 82 Female 154 lb 10/4/2007 Consumer United States
Primary
Concomitant
White Blood Cell Count Increased Hospitalization 11/2/2002 Female 10/23/2007 Physician United States
Primary
Concomitant
Pericarditis Fungal Other Serious 11/11/2005 3 Female 10/23/2007
Primary
Secondary
Concomitant
White Blood Cell Count Decreased Hospitalization 10 Male 11/8/2007 Sweden
Primary
Secondary
Concomitant
Shock Hospitalization 10/21/2007 Male 84 lb 11/13/2007 United States
Primary
Secondary
Concomitant
Septic Shock Hospitalization 10/21/2007 Male 84 lb 11/27/2007 United States
Primary
Secondary
Concomitant
Toxic Epidermal Necrolysis Other Serious 10 Male 12/14/2007 Sweden
Primary
Secondary
Concomitant
Metastases To Skin Life Threatening 12/18/2006 20 Male 115 lb 1/4/2008 Physician Japan
Primary
Concomitant
White Blood Cell Count Increased Hospitalization 17 Male 1/18/2008 France
Primary
Secondary
Concomitant
Shock Hospitalization 11/19/2007 Female 37 lb 1/28/2008 United States
Primary
Secondary
Concomitant
Shock Hospitalization 10/21/2007 Male 84 lb 2/20/2008 United States
Primary
Secondary
Concomitant
Fungal Skin Infection Hospitalization 62 Male 2/28/2008
Primary
Secondary
Concomitant
Pneumothorax Other Serious 5/31/2006 54 Male 123 lb 2/29/2008 Physician Japan
Primary
Secondary
Concomitant
Wheezing Death 1/19/2008 49 Male 154 lb 3/29/2008 Physician France
Primary
Secondary
Concomitant
Aspergillosis Death 1/20/2008 Male 4/2/2008 Physician France
Primary
Secondary
Concomitant
Ventricular Fibrillation Death 1/1/2008 Male 4/10/2008 Other Health Professional France
Primary
Secondary
Concomitant
Weight Increased Other Serious 6/13/2006 74 Male 198 lb 4/9/2008 Other Health Professional United States
Primary
Secondary
Concomitant
Weight Decreased Life Threatening 9/29/2006 51 Female 98 lb 4/7/2008 Physician Japan
Primary
Secondary
Concomitant
Wound Secretion Other Serious 70 Male 4/17/2008 Consumer United States
Primary
Secondary
Concomitant
Protein Total Decreased Other Serious Male 176 lb 4/21/2008 Pharmacist Australia
Primary
Secondary
Concomitant
Weight Decreased Other Serious 9/29/2006 51 Female 98 lb 4/17/2008 Physician Japan
Primary
Secondary
Concomitant
Venoocclusive Liver Disease Other Serious 11/1/2007 12 Male 5/6/2008 Physician Italy
Primary
Secondary
Concomitant
Pneumothorax Other Serious 5/31/2006 54 Male 123 lb 5/9/2008 Physician Japan
Primary
Secondary
Concomitant
Virus Urine Test Positive Hospitalization 17 Male 6/5/2008
Primary
Secondary
Concomitant
Injection Site Irritation Female 145 lb 6/12/2008 Consumer United States
Primary
Concomitant
Tuberculosis Hospitalization 70 Male 6/25/2008
Primary
Concomitant
Trichosporon Infection Hospitalization 5/1/2005 11 Male 6/21/2008 Physician Canada
Primary
Secondary
Concomitant
Thrombocytopenia Other Serious 9/21/2007 25 Male 7/3/2008 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Toxic Epidermal Necrolysis Death 9 Female 7/3/2008
Primary
Secondary
Concomitant
White Blood Cell Count Increased Other Serious 10/4/2007 13 Female 71 lb 7/29/2008 Physician Japan
Primary
Secondary
Concomitant
Rales Other Serious 10/4/2007 13 Female 71 lb 7/29/2008 Physician Japan
Primary
Secondary
Concomitant
Staphylococcal Infection Other Serious 70 Male 8/4/2008 United States
Primary
Concomitant
Mycobacterium Chelonei Infection Other Serious 70 Male 8/12/2008 Physician United States
Primary
Concomitant
Organising Pneumonia Death 21 Female 10/23/2008 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Respiratory Disorder Hospitalization 4/1/2008 Female 10/24/2008 Physician United States
Primary
Secondary
Concomitant
Shock Haemorrhagic Life Threatening 5/25/2008 1 NotSpecified 22 lb 10/30/2008 Physician Japan
Primary
Concomitant
Vomiting Other Serious 5/19/2008 Male 52 lb 11/5/2008 Other Health Professional Brazil
Primary
Concomitant
Weight Increased Other Serious 5/16/2008 Female 166 lb 11/5/2008 Other Health Professional Brazil
Primary
Concomitant
Pyrexia Hospitalization 6/5/2008 27 Male 163 lb 11/6/2008 Physician United States
Primary
Secondary
Rash Morbilliform Hospitalization 9/20/2008 Female 31 lb 11/14/2008 Other Health Professional France
Primary
Secondary
Concomitant
Stem Cell Transplant Other Serious 1/17/2008 9 Male 88 lb 11/7/2008 Physician Japan
Primary
Secondary
Concomitant
Pneumonia Other Serious 7/22/2008 56 Female 11/5/2008 Physician Switzerland
Primary
Secondary
Concomitant
White Blood Cell Count Decreased Life Threatening 5/25/2008 1 Male 22 lb 11/12/2008 Physician Japan
Primary
Concomitant
Gingival Hyperplasia 7/20/2008 Male 11/24/2008 Physician United States
Primary
Secondary
Concomitant
Pneumonia Other Serious 7/22/2008 Female 11/25/2008 Consumer United Kingdom
Primary
Secondary
Concomitant
Pyrexia Hospitalization 6/5/2008 27 Male 163 lb 11/25/2008 Physician United States
Primary
Secondary
Pyrexia Hospitalization 6/5/2008 27 Male 162 lb 11/26/2008 Physician United States
Primary
Secondary
White Blood Cell Count Decreased Life Threatening 5/25/2008 1 Male 22 lb 11/17/2008 Physician Japan
Primary
Concomitant
Serotonin Syndrome Other Serious 73 Female 12/4/2008
Primary
Secondary
Withdrawal Syndrome Hospitalization 6/25/2008 27 Male 162 lb 12/1/2008 Physician United States
Primary
Secondary
Concomitant
Graft Versus Host Disease Other Serious 4/5/2007 Female 12/8/2008 Physician France
Primary
Concomitant
Interacting
Pneumonia Other Serious 7/22/2008 56 Female 11/25/2008 Physician Switzerland
Primary
Secondary
Concomitant
Insomnia Required Intervention 8/23/2008 42 Male 370 lb 12/2/2008 Physician United Kingdom
Primary
Concomitant
Withdrawal Syndrome Hospitalization 6/25/2008 27 Male 162 lb 12/10/2008 United States
Primary
Secondary
Pyrexia Hospitalization 12/6/2008 Female 18 lb 12/8/2008 United States
Primary
Secondary
Concomitant
Rash Morbilliform Hospitalization 9/20/2008 Female 31 lb 12/17/2008 Other Health Professional France
Primary
Secondary
Concomitant
Pupil Fixed Hospitalization 12/6/2008 Female 18 lb 12/17/2008 United States
Primary
Secondary
Concomitant
Graft Versus Host Disease Other Serious 4/5/2007 Female 12/23/2008 Physician France
Primary
Concomitant
Interacting
Hypertension Other Serious 1/17/2008 9 Male 88 lb 12/26/2008 Physician Japan
Primary
Secondary
Concomitant
Respiratory Rate Increased Hospitalization 11/19/2008 47 Male 187 lb 1/15/2009 Physician United States
Primary
Secondary
Concomitant
Toxic Epidermal Necrolysis Hospitalization 11/1/2008 Female 163 lb 1/28/2009 Other Health Professional France
Primary
Secondary
Concomitant
Toxic Epidermal Necrolysis Other Serious 11/28/2008 Female 163 lb 2/4/2009 Germany
Primary
Secondary
Concomitant
Thrombotic Microangiopathy Other Serious 18 Male 1/30/2009 Physician Japan
Primary
Concomitant
Respiratory Failure Other Serious 11/1/2007 3/11/2009 Other Health Professional Canada
Primary
Concomitant
Face Oedema Other Serious 11/27/2008 19 Male 3/12/2009 Other Health Professional France
Primary
Secondary
Concomitant
Thirst Other Serious 12/25/2007 49 Female 123 lb 4/3/2009 Physician Japan
Primary
Concomitant
Vomiting Other Serious 8/31/2008 5 Male 40 lb 4/14/2009 Physician Japan
Primary
Secondary
Concomitant
Respiratory Failure Other Serious 11/1/2007 43 5/25/2009 Other Health Professional Canada
Primary
Concomitant
Stomatitis Other Serious 12/19/2008 59 Male 123 lb 5/28/2009 Japan
Primary
Secondary
Concomitant
Renal Impairment Other Serious 10/20/2008 Male 154 lb 6/29/2009 Physician Japan
Primary
Secondary
Concomitant
Rash Erythematous Hospitalization 4/1/2008 Female 71 lb 7/1/2009 Physician United States
Primary
Secondary
Concomitant
Hyperammonaemic Encephalopathy Hospitalization 2/6/2009 20 Male 7/6/2009 Other Health Professional France
Primary
Secondary
Apnoea Other Serious 9/10/2008 48 Female 7/22/2009 Consumer United Kingdom
Primary
Concomitant
Vomiting Hospitalization 7/19/2009 Male 104 lb 7/22/2009 United States
Primary
Secondary
Concomitant
Stomatitis Death 3/12/2008 Male 126 lb 7/31/2009 Physician Japan
Primary
Secondary
Concomitant
Mucosal Inflammation Hospitalization 6/1/2009 Male 8/6/2009 Consumer France
Primary
Secondary
Concomitant
Cytolytic Hepatitis Hospitalization 6/14/2009 Male 8/10/2009 Other Health Professional France
Primary
Secondary
Systemic Inflammatory Response Syndrome Other Serious 40 Female 9/9/2009 Other Health Professional Korea, Republic Of
Primary
Secondary
Pancytopenia Life Threatening 1/31/2008 Male 9/10/2009 Japan
Primary
Concomitant
Umbilical Hernia Hospitalization 0 Male 5 lb 9/4/2009 Other Health Professional Poland
Primary
Secondary
Concomitant
Umbilical Hernia Hospitalization 0 Male 5 lb 9/4/2009 Other Health Professional Poland
Primary
Secondary
Concomitant
Stomatitis Hospitalization 8/30/2009 Female 133 lb 9/11/2009 Physician United States
Primary
Secondary
Concomitant
White Blood Cell Count Increased Other Serious 16 Female 9/15/2009
Primary
Secondary
Concomitant
Colitis Hospitalization 8/31/2009 Female 62 lb 9/23/2009 Other Health Professional United States
Primary
Concomitant
Stomatitis Other Serious 8/13/2009 Female 133 lb 9/25/2009 Physician United States
Primary
Secondary
Concomitant
Vasculitis Other Serious 52 Male 220 lb 10/5/2009
Primary
Secondary
Concomitant
Nausea Other Serious 1/1/2009 Female 144 lb 10/6/2009 Physician United States
Primary
Secondary
Concomitant
Weight Decreased Other Serious 1/1/2008 34 Female 10/19/2009 Physician United States
Primary
Concomitant
Ventricular Dysfunction Other Serious 7 Male 57 lb 10/28/2009 Other Health Professional Canada
Primary
Secondary
Concomitant
Drug Interaction Hospitalization 10/6/2009 15 Male 11/5/2009 Physician France
Primary
Concomitant
Interacting
Drug Interaction Hospitalization 10/6/2009 Male 11/6/2009 Other Health Professional France
Primary
Secondary
Concomitant
Pleural Effusion Hospitalization 8/18/2009 Male 11/6/2009 Other Health Professional France
Primary
Secondary
Concomitant
Stomatitis Other Serious 8/13/2009 Female 133 lb 11/11/2009 Physician United States
Primary
Secondary
Concomitant
Meningitis Listeria Hospitalization 10/21/2009 Female 11/16/2009 Consumer United States
Primary
Concomitant
Meningitis Listeria Hospitalization 10/21/2009 Female 11/20/2009 Consumer United States
Primary
Concomitant
Pancreatic Necrosis Hospitalization 12/1/2008 63 Female 11/18/2009 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Pleural Effusion Hospitalization 8/18/2009 Male 11/30/2009 Other Health Professional France
Primary
Secondary
Concomitant
Pyrexia Hospitalization 11/9/2009 3 Male 31 lb 12/16/2009 Other Health Professional United States
Primary
Secondary
Concomitant
Visual Impairment Life Threatening 7/27/2009 54 Male 135 lb 12/16/2009 Physician Japan
Primary
Secondary
Concomitant
Sepsis Other Serious 5/27/2009 65 Male 12/29/2009 Physician Japan
Primary
Concomitant
Interacting
Septic Shock Death Female 116 lb 12/31/2009 Pharmacist United States
Primary
Concomitant
Weight Decreased Hospitalization 12/14/2009 Female 18 lb 12/31/2009 Physician United States
Primary
Concomitant
Weight Decreased Hospitalization 12/14/2009 Female 18 lb 1/8/2010 Physician United States
Primary
Concomitant
Therapeutic Agent Toxicity Hospitalization 11/12/2009 Female 15 lb 12/30/2009 United States
Primary
Secondary
Concomitant
Throat Irritation Other Serious 1/1/2005 Female 153 lb 1/11/2010 Pharmacist United States
Primary
Concomitant
Fungal Infection Death 10 Female 1/11/2010 Other Health Professional India
Primary
Secondary
Concomitant
Septic Shock Death Female 116 lb 1/19/2010 Pharmacist United States
Primary
Secondary
Concomitant

Drug Data