Methotrexate combined with Valsartan

Reports:

Reaction Outcome Event Date Age Sex Weight Reported Reporter Country Treatment
Role Name
Pruritus Death 7/22/2004 Male 187 lb 1/25/2006 United Kingdom
Primary
Concomitant
Renal Failure Required Intervention 8/25/2005 61 Male 11/15/2005 Other Health Professional United States
Primary
Concomitant
Death Other Serious 6/20/2005 Male 2/9/2006 Other Health Professional United Kingdom
Primary
Concomitant
Renal Failure Hospitalization 8/25/2005 61 Male 2/8/2006 Other Health Professional United States
Primary
Secondary
Concomitant
Thrombotic Thrombocytopenic Purpura Hospitalization 5/9/2005 58 Female 150 lb 12/27/2005 Other Health Professional United States
Primary
Concomitant
Renal Failure Hospitalization 8/25/2005 61 Male 3/24/2006 Other Health Professional United States
Primary
Concomitant
Pulmonary Fibrosis Hospitalization 2/1/2006 83 Female 4/13/2006 Physician France
Primary
Secondary
Concomitant
Superinfection Lung Hospitalization 2/1/2006 Female 6/22/2006 Physician France
Primary
Secondary
Concomitant
Erythrodermic Psoriasis Hospitalization 6/17/2006 Female 6/27/2006 Physician United States
Primary
Concomitant
Myocardial Infarction Hospitalization 56 Female 7/7/2006 Physician Greece
Primary
Concomitant
Renal Failure Acute Hospitalization 6/24/2006 70 Female 112 lb 10/24/2006 Pharmacist United States
Primary
Secondary
Concomitant
Death Death 12/1/2006 81 Female 1/8/2007 Consumer Canada
Primary
Concomitant
Sleep Apnoea Syndrome Hospitalization 8/17/2006 Female 3/9/2007 Physician United States
Primary
Concomitant
Acute Myocardial Infarction Other Serious 5/6/2003 57 Female 152 lb 11/27/2006 United States
Primary
Concomitant
Rhabdomyolysis Hospitalization 83 Male 4/9/2007 Pharmacist Norway
Primary
Secondary
Concomitant
Rhabdomyolysis Hospitalization 83 Male 225 lb 4/13/2007 Pharmacist Norway
Primary
Secondary
Concomitant
Tremor Other Serious 12/1/2006 53 Female 5/4/2007 Consumer Canada
Primary
Concomitant
Rhabdomyolysis Hospitalization 5/20/2005 82 Male 225 lb 5/7/2007 Pharmacist Norway
Primary
Secondary
Concomitant
Rhabdomyolysis Hospitalization 5/20/2005 82 Male 225 lb 5/9/2007 Pharmacist Norway
Primary
Secondary
Concomitant
Tendon Rupture Disability 2/15/2007 Male 161 lb 5/9/2007 Other Health Professional United Kingdom
Primary
Concomitant
Rhabdomyolysis Hospitalization 5/20/2005 82 Male 225 lb 5/14/2007 Pharmacist Norway
Primary
Secondary
Concomitant
Oedema Peripheral Hospitalization 10/15/2006 Female 201 lb 6/8/2007 Physician Italy
Primary
Concomitant
Tremor Other Serious 12/1/2006 Female 160 lb 6/20/2007 Pharmacist Canada
Primary
Concomitant
Oedema Peripheral Hospitalization 10/15/2006 Female 201 lb 7/5/2007 Physician Italy
Primary
Concomitant
Bradycardia Other Serious 3/10/2007 63 Male 7/10/2007 Other Health Professional United Kingdom
Primary
Concomitant
Urticaria Life Threatening 44 Female 7/18/2007 Pharmacist United States
Primary
Concomitant
Incision Site Infection Hospitalization Female 130 lb 7/23/2007 Canada
Primary
Concomitant
Knee Arthroplasty Other Serious 3/7/2007 Female 187 lb 11/15/2007 Other Health Professional United Kingdom
Primary
Concomitant
Trisomy 8 Other Serious 1/1/2007 Female 200 lb 11/19/2007 Physician United States
Primary
Concomitant
Weight Decreased Other Serious Female 80 lb 12/7/2007 Canada
Primary
Concomitant
Injection Site Irritation 1/1/2007 Female 170 lb 12/14/2007 Consumer United States
Primary
Concomitant
Drug Ineffective 9/1/2007 Female 266 lb 12/14/2007 Consumer United States
Primary
Concomitant
Temperature Intolerance 6/1/2007 Female 271 lb 12/14/2007 Consumer United States
Primary
Concomitant
Drug Ineffective 9/1/2007 Female 200 lb 12/14/2007 Consumer United States
Primary
Concomitant
Rheumatoid Arthritis 8/1/2007 Female 227 lb 12/14/2007 Consumer United States
Primary
Concomitant
Skin Exfoliation 9/1/2007 Female 190 lb 12/14/2007 United States
Primary
Concomitant
Skin Cancer Other Serious 11/2/2005 Female 132 lb 12/19/2007 Physician United Kingdom
Primary
Concomitant
Weight Decreased Other Serious Female 80 lb 12/20/2007 Canada
Primary
Concomitant
Weight Decreased Other Serious Female 80 lb 1/17/2008 Canada
Primary
Concomitant
Speech Disorder Hospitalization 12/1/2007 Female 1/28/2008 Physician United States
Primary
Secondary
Concomitant
Weight Decreased Other Serious Female 80 lb 2/1/2008 Canada
Primary
Concomitant
Pneumocystis Jiroveci Pneumonia Life Threatening Female 2/22/2008 Other Health Professional United Kingdom
Primary
Concomitant
Wheezing Other Serious 2/14/2008 Female 76 lb 2/22/2008 Canada
Primary
Concomitant
Wound 9/1/2007 Female 190 lb 3/14/2008 United States
Primary
Concomitant
Accidental Exposure 11/8/2006 Female 220 lb 3/14/2008 Consumer United States
Primary
Concomitant
Nausea 12/4/2007 Female 301 lb 3/14/2008 United States
Primary
Concomitant
Drug Ineffective 6/1/2007 Female 214 lb 3/14/2008 United States
Primary
Concomitant
Underdose Male 184 lb 3/15/2008 Consumer United States
Primary
Concomitant
Nasopharyngitis 1/21/2008 Female 115 lb 3/15/2008 United States
Primary
Concomitant
Rash Pruritic 10/1/2007 Female 135 lb 3/15/2008 United States
Primary
Concomitant
Wheezing Other Serious 2/14/2008 Female 76 lb 3/28/2008 Canada
Primary
Concomitant
Oedema Peripheral Hospitalization 10/15/2006 Female 201 lb 4/16/2008 Physician Italy
Primary
Concomitant
Pneumocystis Jiroveci Pneumonia Life Threatening 1/15/2008 Female 187 lb 4/24/2008 Physician United Kingdom
Primary
Concomitant
International Normalised Ratio Decreased Other Serious 3/1/2008 74 Male 4/23/2008 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Speech Disorder Other Serious 12/1/2007 Female 5/9/2008 Physician United States
Primary
Secondary
Concomitant
Haemoglobin Decreased Hospitalization 5/2/2008 71 Female 5/19/2008 Physician Japan
Primary
Secondary
Concomitant
Injection Site Pain Female 135 lb 6/12/2008 Consumer United States
Primary
Concomitant
Overdose 3/7/2008 Female 142 lb 6/12/2008 United States
Primary
Concomitant
Procedural Complication 4/25/2008 Female 160 lb 6/13/2008 Consumer United States
Primary
Concomitant
Injection Site Haemorrhage 5/4/2008 Female 6/13/2008 United States
Primary
Concomitant
Pain 10/1/2007 Female 6/13/2008 Consumer United States
Primary
Concomitant
Drug Ineffective 3/1/2008 Female 138 lb 6/13/2008 Consumer United States
Primary
Concomitant
Nausea Male 6/13/2008 Consumer United States
Primary
Secondary
Concomitant
Tooth Infection 5/6/2008 Male 165 lb 6/13/2008 United States
Primary
Concomitant
Mobility Decreased 4/23/2008 Female 145 lb 6/13/2008 United States
Primary
Concomitant
Nephrotic Syndrome Hospitalization 3/11/2008 Male 154 lb 6/20/2008 Netherlands
Primary
Concomitant
Nephrotic Syndrome Hospitalization 3/11/2008 Male 154 lb 6/26/2008 Netherlands
Primary
Concomitant
Hyperplasia Hospitalization 8/21/2007 58 Female 6/30/2008 Germany
Primary
Secondary
Concomitant
Hyperplasia Hospitalization 8/21/2007 58 Female 7/11/2008 Germany
Primary
Secondary
Concomitant
Pneumocystis Jiroveci Pneumonia Life Threatening 1/15/2008 Female 187 lb 7/16/2008 Physician United Kingdom
Primary
Concomitant
Interstitial Lung Disease Life Threatening 5/27/2008 Male 190 lb 7/28/2008 United States
Primary
Concomitant
Pulmonary Mass Hospitalization 7/4/2008 Female 161 lb 8/1/2008 China
Primary
Concomitant
Pulmonary Mass Hospitalization 7/4/2008 Female 157 lb 8/14/2008 China
Primary
Concomitant
Death Death 6/16/2008 88 Female 8/27/2008 Physician Japan
Primary
Secondary
Concomitant
Rash 11/1/2007 Male 148 lb 8/27/2008 Other Health Professional United States
Primary
Secondary
Concomitant
Pain Hospitalization 6/1/2008 Female 173 lb 8/28/2008 Physician United States
Primary
Concomitant
Pulmonary Mass Hospitalization 7/4/2008 Female 157 lb 9/5/2008 China
Primary
Concomitant
Death Other Serious 6/16/2008 88 Female 9/15/2008 Physician Japan
Primary
Secondary
Concomitant
Cardiac Failure Death 6/16/2008 Female 9/26/2008 Physician Japan
Primary
Secondary
Concomitant
Rheumatic Heart Disease Death 7/9/2008 Female 143 lb 10/23/2008 United Kingdom
Primary
Concomitant
Hypersensitivity Other Serious 8/2/2008 Female 10/29/2008 Belgium
Primary
Concomitant
Osteoarthropathy Hospitalization 76 Female 11/7/2008 Netherlands
Primary
Concomitant
Speech Disorder Other Serious 12/1/2007 Female 11/14/2008 Physician United States
Primary
Secondary
Concomitant
Osteoarthropathy Hospitalization 76 Female 11/19/2008 Netherlands
Primary
Concomitant
Hypersensitivity Other Serious 8/2/2008 Female 11/24/2008 Belgium
Primary
Concomitant
Nephrotic Syndrome Hospitalization 3/11/2008 Male 154 lb 11/26/2008 Netherlands
Primary
Concomitant
Serotonin Syndrome Other Serious 73 Female 12/4/2008
Primary
Secondary
Rash Hospitalization 11/13/2008 Female 151 lb 12/9/2008 Japan
Primary
Concomitant
Interstitial Lung Disease Life Threatening 5/27/2008 Male 190 lb 12/12/2008 United States
Primary
Concomitant
Thrombosis 8/1/2008 Female 145 lb 12/12/2008 Consumer United States
Primary
Concomitant
Breast Cancer Other Serious 10/22/2007 Female 130 lb 2/4/2009 Other Health Professional United Kingdom
Primary
Concomitant
Rheumatic Heart Disease Death 7/9/2008 Female 143 lb 2/5/2009 United Kingdom
Primary
Concomitant
Hypersensitivity Hospitalization 11/13/2008 Female 151 lb 2/5/2009 Japan
Primary
Concomitant
Toxic Epidermal Necrolysis Hospitalization 11/25/2008 62 Female 163 lb 1/28/2009 Other Health Professional France
Primary
Concomitant
Hypersensitivity Hospitalization 11/13/2008 Female 151 lb 2/12/2009 Japan
Primary
Concomitant
Hypersensitivity Hospitalization 11/13/2008 Female 151 lb 3/11/2009 Japan
Primary
Concomitant
Vomiting Hospitalization 1/1/2007 Female 99 lb 4/17/2009 Physician Japan
Primary
Secondary
Concomitant
Vomiting Hospitalization 1/1/2007 Female 99 lb 4/30/2009 Physician Japan
Primary
Secondary
Concomitant
Pulmonary Mass Hospitalization 7/4/2008 Female 157 lb 5/8/2009 China
Primary
Concomitant
Impetigo Hospitalization 4/1/2009 63 Male 5/15/2009 Physician Mexico
Primary
Concomitant
Osteoarthropathy Hospitalization 9/1/2005 Male 6/30/2009 Other Health Professional Netherlands
Primary
Concomitant
Vomiting Other Serious 1/1/2007 Female 99 lb 7/6/2009 Physician Japan
Primary
Concomitant
Vomiting Other Serious 1/1/2007 Female 99 lb 7/16/2009 Physician Japan
Primary
Concomitant
Acute Myocardial Infarction Death 70 Female 7/21/2009 Physician Argentina
Primary
Concomitant
Vomiting Other Serious 1/1/2007 Female 99 lb 7/27/2009 Physician Japan
Primary
Concomitant
Incorrect Dose Administered 2/6/2007 Female 199 lb 9/11/2009 Consumer United States
Primary
Concomitant
Incorrect Dose Administered 4/18/2007 Female 158 lb 9/11/2009 Consumer United States
Primary
Concomitant
Wrong Technique In Drug Usage Process 7/20/2007 Female 158 lb 9/11/2009 Consumer United States
Primary
Concomitant
Injection Site Urticaria 1/1/2007 Female 110 lb 9/12/2009 Consumer United States
Primary
Concomitant
Accidental Needle Stick 11/8/2006 Female 220 lb 9/12/2009 Consumer United States
Primary
Concomitant
Injection Site Extravasation 3/1/2008 Female 138 lb 9/12/2009 Consumer United States
Primary
Concomitant
Toxic Skin Eruption Hospitalization 7/2/2009 Male 116 lb 9/22/2009 Japan
Primary
Secondary
Concomitant
Vasculitis Hospitalization 2/1/2009 Female 98 lb 9/25/2009 Japan
Primary
Concomitant
White Blood Cell Count Decreased Other Serious 4/24/2009 68 Female 104 lb 10/14/2009 Other Health Professional Japan
Primary
Secondary
Concomitant
Vasculitis Hospitalization 2/1/2009 Female 98 lb 10/19/2009 Japan
Primary
Concomitant
Toxic Skin Eruption Hospitalization 7/2/2009 Male 116 lb 11/23/2009 Japan
Primary
Secondary
Concomitant
Vasculitis Hospitalization 2/1/2009 Female 98 lb 12/3/2009 Japan
Primary
Concomitant
White Blood Cell Count Decreased Other Serious 4/24/2009 68 Female 104 lb 12/15/2009 Other Health Professional Japan
Primary
Secondary
Concomitant
Toxic Skin Eruption Hospitalization 7/2/2009 Male 116 lb 12/21/2009 Japan
Primary
Secondary
Concomitant
Vasculitis Hospitalization 2/1/2009 Female 98 lb 12/30/2009 Japan
Primary
Secondary
Concomitant
Decreased Appetite Hospitalization 6/9/2009 Male 130 lb 1/12/2010 Japan
Primary
Concomitant
White Blood Cell Count Decreased Other Serious 11/15/2009 Female 1/29/2010 Japan
Primary
Secondary
Concomitant
Vasculitis Other Serious 2/1/2009 Female 98 lb 1/29/2010 Japan
Primary
Secondary
Concomitant
Decreased Appetite Hospitalization 6/9/2009 Male 130 lb 2/1/2010 Japan
Primary
Concomitant
Respiratory Tract Congestion Disability 1/5/2010 Male 212 lb 2/18/2010 Physician United Kingdom
Primary
Concomitant
Rheumatoid Arthritis Life Threatening 1/21/2010 Male 138 lb 3/5/2010 Japan
Primary
Secondary
Concomitant
White Blood Cell Count Decreased Other Serious 11/15/2009 Female 3/11/2010 Japan
Primary
Secondary
Concomitant
Endometrial Cancer Life Threatening 5/29/2009 Female 201 lb 3/12/2010 United States
Primary
Concomitant
Muscular Weakness Hospitalization 2/21/2010 Male 187 lb 3/15/2010 Physician Spain
Primary
Concomitant
Cerebrovascular Accident Hospitalization 1/23/2009 Female 231 lb 3/26/2010 Germany
Primary
Concomitant
Cerebrovascular Accident Hospitalization 1/23/2009 73 Female 231 lb 4/8/2010 Germany
Primary
Concomitant
Muscular Weakness Hospitalization 2/21/2010 58 Male 187 lb 4/13/2010 Physician Spain
Primary
Concomitant
White Blood Cell Count Decreased Other Serious 4/24/2009 68 Female 104 lb 4/19/2010 Physician Japan
Primary
Secondary
Concomitant
Muscular Weakness Hospitalization 2/21/2010 58 Male 187 lb 4/22/2010 Physician Spain
Primary
Concomitant
Endometrial Cancer Life Threatening 5/29/2009 57 Female 201 lb 4/30/2010 United States
Primary
Concomitant
Pyrexia Hospitalization 4/28/2010 85 Female 126 lb 5/28/2010 Physician Japan
Primary
Concomitant
Renal Failure Other Serious 1/25/2010 72 Female 126 lb 6/4/2010 Physician Belgium
Primary
Concomitant
Pyrexia Hospitalization 4/28/2010 85 Female 126 lb 6/10/2010 Physician Japan
Primary
Secondary
Concomitant
Pyrexia Hospitalization 4/28/2010 85 Female 126 lb 6/17/2010 Physician Japan
Primary
Secondary
Concomitant
Lip Swelling Other Serious 5/21/2010 24 Female 6/17/2010 Other Health Professional South Africa
Primary
Concomitant
Leukopenia Hospitalization 4/6/2010 53 Female 245 lb 6/18/2010 Physician Germany
Primary
Secondary
Concomitant
Muscular Weakness Other Serious 11/5/2009 67 Male 115 lb 6/24/2010 Physician Japan
Primary
Concomitant
Rheumatoid Arthritis Life Threatening 1/21/2010 68 Male 138 lb 7/1/2010 Physician Japan
Primary
Secondary
Concomitant
Rheumatoid Arthritis Life Threatening 1/21/2010 68 Male 138 lb 7/16/2010 Physician Japan
Primary
Secondary
Concomitant
Staphylococcal Sepsis Other Serious 11/5/2009 67 Male 115 lb 7/19/2010 Physician Japan
Primary
Concomitant
Pyrexia Hospitalization 4/28/2010 85 Female 126 lb 7/26/2010 Physician Japan
Primary
Secondary
Concomitant
Dyskinesia Other Serious Female 5/17/2010 Physician United States
Primary
Concomitant
Endometrial Cancer Recurrent Life Threatening 5/29/2009 57 Female 201 lb 8/2/2010 Physician United States
Primary
Concomitant
Pain Other Serious 3/1/2010 47 Male 203 lb 8/3/2010 Consumer Brazil
Primary
Concomitant
White Blood Cell Count Decreased Other Serious 11/15/2009 79 Female 8/5/2010 Physician Japan
Primary
Secondary
Concomitant

Drug Data