Methotrexate combined with Valproate Sodium

Reports:

Reaction Outcome Event Date Age Sex Weight Reported Reporter Country Treatment
Role Name
Weight Decreased Hospitalization 11/4/2005 Female 2/9/2006 United Kingdom
Primary
Concomitant
Breast Cancer Required Intervention 2/1/2005 55 Female 159 lb 2/27/2006 Consumer United States
Primary
Concomitant
Thrombotic Microangiopathy Other Serious 2/22/2003 61 Male 95 lb 5/16/2006 Physician Japan
Primary
Secondary
Concomitant
Venoocclusive Liver Disease Disability 1/1/2004 61 Female 98 lb 6/7/2006 Physician Japan
Primary
Secondary
Concomitant
Multiple Drug Overdose Hospitalization 12/4/2006 Other Health Professional United States
Primary
Secondary
Neutropenia Other Serious 12/14/2006 60 Female 128 lb 2/15/2007 Other Health Professional United Kingdom
Primary
Concomitant
Vomiting Disability 1/30/2007 7 Female 3/13/2007 Japan
Primary
Concomitant
Vomiting Hospitalization 12/16/2006 54 Female 4/19/2007 Japan
Primary
Secondary
Concomitant
Vomiting Hospitalization 12/16/2006 54 Female 6/11/2007 Other Health Professional Japan
Primary
Secondary
Concomitant
Weight Increased Life Threatening 4/5/2007 51 Female 7/16/2007 Other Health Professional Japan
Primary
Concomitant
Stomatitis Life Threatening 1/8/2007 40 Female 7/19/2007 Japan
Primary
Secondary
Concomitant
Weight Decreased Hospitalization 11/4/2005 Male 7/26/2007 Other Health Professional United Kingdom
Primary
Concomitant
Vomiting Death 2/25/2007 13 Female 8/1/2007 Japan
Primary
Concomitant
Vomiting Other Serious 1/30/2007 7 Female 8/16/2007 Japan
Primary
Concomitant
Clavicle Fracture Hospitalization 12/21/2006 Male 130 lb 9/14/2007 United Kingdom
Primary
Concomitant
Stomatitis Life Threatening 5/6/2007 56 Female 9/18/2007 Japan
Primary
Secondary
Concomitant
Upper Gastrointestinal Haemorrhage Life Threatening 3/21/2007 20 Male 9/18/2007 Japan
Primary
Concomitant
Stenotrophomonas Infection Death 4/12/2007 33 Male 9/18/2007 Japan
Primary
Concomitant
Thrombocytopenia Life Threatening 1/24/2007 21 Male 9/18/2007 Japan
Primary
Concomitant
Transplant Rejection Life Threatening 5/23/2007 60 Male 9/20/2007 Other Health Professional Japan
Primary
Concomitant
Thrombotic Microangiopathy Other Serious 8/10/2007 30 Female 9/20/2007 Other Health Professional Japan
Primary
Concomitant
Staphylococcal Sepsis Life Threatening 12/18/2006 50 Male 9/20/2007 Other Health Professional Japan
Primary
Concomitant
Weight Decreased Hospitalization 11/4/2005 Male 10/29/2007 Other Health Professional United Kingdom
Primary
Concomitant
Venoocclusive Liver Disease 7/30/2007 51 Male 10/26/2007 Japan
Primary
Concomitant
Stomatitis 6/10/2007 21 Female 10/26/2007 Japan
Primary
Concomitant
Streptococcal Sepsis Other Serious 4/6/2007 21 Male 11/16/2007 Japan
Primary
Secondary
Concomitant
Stomatitis Life Threatening 5/2/2007 25 Male 11/16/2007 Japan
Primary
Concomitant
Injection Site Pruritus 9/17/2007 Male 208 lb 12/14/2007 United States
Primary
Concomitant
Ear Infection 10/27/2007 Male 188 lb 12/14/2007 United States
Primary
Concomitant
Upper Gastrointestinal Haemorrhage Life Threatening 3/21/2007 20 Male 1/3/2008 Japan
Primary
Concomitant
Staphylococcal Infection Other Serious 11/12/2007 53 Male 2/15/2008 Physician Japan
Primary
Secondary
Concomitant
Staphylococcal Infection Other Serious 11/12/2007 53 Male 2/25/2008 Physician Japan
Primary
Secondary
Concomitant
Epilepsy Other Serious 12/13/2007 39 Male 2/29/2008 Other Health Professional United Kingdom
Primary
Interacting
Vomiting Life Threatening 10/16/2007 54 Female 3/6/2008 Japan
Primary
Concomitant
Vomiting Hospitalization 10/31/2007 65 Female 3/6/2008 Japan
Primary
Concomitant
Wolff-parkinson-white Syndrome Hospitalization 8/6/2007 80 Male 3/6/2008 Japan
Primary
Secondary
Concomitant
Drug Administration Error 2/25/2008 50 Female 133 lb 3/15/2008 United States
Primary
Concomitant
Injection Site Irritation 2/11/2008 Female 185 lb 3/15/2008 United States
Primary
Concomitant
Venoocclusive Liver Disease 10/23/2007 29 Female 4/2/2008 Japan
Primary
Concomitant
Venoocclusive Liver Disease Other Serious 11/1/2007 12 Male 5/6/2008 Physician Italy
Primary
Secondary
Concomitant
Vomiting Hospitalization 10/26/2007 65 Female 4/30/2008 Japan
Primary
Concomitant
Stomatitis Life Threatening 7/3/2007 51 Female 4/30/2008 Japan
Primary
Concomitant
Thrombotic Microangiopathy Life Threatening 2/6/2007 23 Male 4/30/2008 Japan
Primary
Concomitant
Tumour Associated Fever Hospitalization 11/13/2006 58 Male 4/30/2008 Japan
Primary
Secondary
Concomitant
Vomiting Life Threatening 10/28/2007 58 Male 4/30/2008 Japan
Primary
Concomitant
Sepsis Life Threatening 10/8/2007 57 Female 5/15/2008 Other Health Professional Japan
Primary
Concomitant
White Blood Cell Count Increased Life Threatening 10/21/2007 46 Male 5/15/2008 Physician Japan
Primary
Secondary
Concomitant
Vomiting Other Serious 9/30/2007 67 Female 5/15/2008 Physician Japan
Primary
Concomitant
Stomatitis Life Threatening 12/13/2006 30 Male 5/15/2008 Japan
Primary
Secondary
Concomitant
Tuberculous Pleurisy Other Serious 5/22/2008 Female 6/12/2008 Physician Netherlands
Primary
Concomitant
Mania 2/1/2008 Male 6/12/2008 Physician United States
Primary
Concomitant
Stomatitis Hospitalization 3/1/2007 62 Female 6/9/2008 Physician Japan
Primary
Concomitant
Vomiting 9/1/2007 18 Female 6/9/2008 Other Health Professional Japan
Primary
Concomitant
Vomiting Life Threatening 5/1/2008 17 Male 6/18/2008 Japan
Primary
Concomitant
Vomiting Life Threatening 7/9/2007 50 Female 6/27/2008 Other Health Professional Japan
Primary
Concomitant
Pneumonia Disability 10/3/2007 37 Male 6/27/2008 Other Health Professional Japan
Primary
Concomitant
Oral Disorder Death 45 Female 6/27/2008 Other Health Professional Japan
Primary
Concomitant
Staphylococcal Sepsis Hospitalization 10/22/2007 32 Female 7/8/2008 Japan
Primary
Concomitant
Vomiting Hospitalization 7/24/2007 58 Male 7/8/2008 Japan
Primary
Concomitant
Stomatitis Life Threatening 8/1/2007 53 Male 7/1/2008 Japan
Primary
Secondary
Concomitant
Stomatitis 11/4/2007 53 Male 7/10/2008 Japan
Primary
Concomitant
Staphylococcal Sepsis 12/2/2006 67 Male 7/10/2008 Japan
Primary
Concomitant
Stomatitis 2/3/2008 3 Female 7/16/2008 Japan
Primary
Concomitant
Stomatitis Life Threatening 11/30/2007 50 Male 7/16/2008 Japan
Primary
Concomitant
Vomiting 5/5/2008 12 Female 7/17/2008 Japan
Primary
Concomitant
Nausea Death 6/27/2007 47 Female 7/17/2008 Other Health Professional Japan
Primary
Concomitant
Viral Haemorrhagic Cystitis Life Threatening 9/10/2007 51 Male 7/16/2008 Japan
Primary
Concomitant
Vomiting Death 2/25/2007 9 Female 7/16/2008 Japan
Primary
Concomitant
Vomiting Hospitalization 5/27/2007 52 Male 7/16/2008 Japan
Primary
Concomitant
Vomiting Hospitalization 6/12/2007 51 Male 7/17/2008 Other Health Professional Japan
Primary
Concomitant
Stomatitis Life Threatening 12/5/2007 42 Male 7/25/2008 Japan
Primary
Concomitant
Stomatitis Hospitalization 5/30/2007 58 Male 8/1/2008 Japan
Primary
Concomitant
Stomatitis Life Threatening 4/5/2007 42 Male 8/5/2008 Japan
Primary
Concomitant
Febrile Neutropenia Life Threatening 4/5/2007 28 Male 8/5/2008 Japan
Primary
Concomitant
Stomatitis Life Threatening 7/30/2007 60 Male 8/5/2008 Japan
Primary
Concomitant
Vomiting Life Threatening 4/17/2007 40 Female 8/14/2008 Other Health Professional Japan
Primary
Concomitant
Stomatitis Life Threatening 10/10/2007 34 Male 8/18/2008 Japan
Primary
Concomitant
Urine Output Decreased Life Threatening 8/13/2007 64 Female 8/19/2008 Japan
Primary
Concomitant
Vomiting Hospitalization 46 Male 8/25/2008 Japan
Primary
Concomitant
Stomatitis Life Threatening 10/22/2007 57 Female 8/29/2008 Japan
Primary
Concomitant
Vomiting Death 3/28/2007 2 Female 9/4/2008 Japan
Primary
Concomitant
Venoocclusive Liver Disease Hospitalization 2 Female 9/4/2008 Japan
Primary
Concomitant
Staphylococcal Sepsis Life Threatening 4/19/2007 17 Male 9/5/2008 Japan
Primary
Secondary
Concomitant
Vomiting Life Threatening 3/3/2006 9 Female 9/8/2008 Japan
Primary
Concomitant
Urticaria 7/17/2008 Male 80 lb 9/12/2008 United States
Primary
Concomitant
Vomiting Life Threatening 12/16/2006 50 Male 9/9/2008 Japan
Primary
Concomitant
Vomiting Life Threatening 10/28/2007 58 Male 9/9/2008 Japan
Primary
Concomitant
White Blood Cell Count Decreased Life Threatening 6/15/2007 52 Male 9/11/2008 Other Health Professional Japan
Primary
Concomitant
Thrombotic Microangiopathy Life Threatening 9/25/2007 48 Female 9/11/2008 Other Health Professional Japan
Primary
Secondary
Concomitant
Stomatitis Life Threatening 11/20/2007 3 Male 9/11/2008 Japan
Primary
Concomitant
Stomatitis Life Threatening 2/3/2008 3 Female 9/11/2008 Other Health Professional Japan
Primary
Concomitant
Stomatitis Life Threatening 9/18/2007 65 Male 9/12/2008 Other Health Professional Japan
Primary
Concomitant
Mallory-weiss Syndrome Death 4/27/2007 47 Male 9/16/2008 Japan
Primary
Concomitant
Stomatitis Death 1/15/2008 47 Male 9/15/2008 Japan
Primary
Concomitant
Urine Output Decreased Life Threatening 8/13/2007 64 Female 9/15/2008 Japan
Primary
Secondary
Concomitant
Vomiting Life Threatening 12/8/2006 51 Female 9/17/2008 Japan
Primary
Concomitant
Vomiting Life Threatening 10/18/2007 53 Female 9/17/2008 Japan
Primary
Secondary
Concomitant
Stem Cell Transplant Life Threatening 7/26/2007 49 Male 9/17/2008 Japan
Primary
Concomitant
Stomatitis Life Threatening 11/22/2007 50 Male 9/19/2008 Japan
Primary
Concomitant
Sepsis Death 57 Female 9/19/2008 Japan
Primary
Concomitant
Weight Increased Life Threatening 9/27/2007 67 Female 9/25/2008 Japan
Primary
Concomitant
Stomatitis Life Threatening 31 Female 9/25/2008 Japan
Primary
Concomitant
Stomatitis Life Threatening 8/3/2007 57 Male 10/3/2008 Japan
Primary
Concomitant
Vomiting Hospitalization 4/28/2008 16 Male 10/10/2008 Japan
Primary
Concomitant
Transplant Rejection Hospitalization 3/13/2007 33 Male 11/6/2008 Japan
Primary
Concomitant
Vomiting Life Threatening 12/16/2006 50 Male 11/14/2008 Japan
Primary
Concomitant
Vomiting Life Threatening 4/25/2007 16 Male 11/14/2008 Japan
Primary
Secondary
Concomitant
Vomiting Life Threatening 4/16/2008 12 Female 11/24/2008 Japan
Primary
Concomitant
Nausea Death 6/27/2007 47 Female 11/25/2008 Japan
Primary
Concomitant
Stomatitis Life Threatening 6/1/2007 61 Male 12/4/2008 Japan
Primary
Concomitant
Vision Blurred 8/1/2007 Male 250 lb 12/12/2008 Consumer United States
Primary
Secondary
Concomitant
White Blood Cell Count Decreased Life Threatening 6/15/2007 52 Male 12/11/2008 Japan
Primary
Secondary
Concomitant
Stomatitis Life Threatening 12/28/2007 43 Female 12/16/2008 Japan
Primary
Secondary
Concomitant
Stomatitis Life Threatening 9/18/2007 65 Male 1/5/2009 Japan
Primary
Concomitant
Xerosis Other Serious 1/1/2000 11 Male 77 lb 12/3/2008 United States
Primary
Secondary
Concomitant
Xerosis Other Serious 1/1/2000 11 Male 77 lb 12/3/2008 United States
Primary
Secondary
Concomitant
Thrombotic Microangiopathy Life Threatening 6/8/2006 60 Male 1/29/2009 Japan
Primary
Concomitant
White Blood Cell Count Decreased Life Threatening 6/15/2007 52 Male 2/3/2009 Japan
Primary
Secondary
Concomitant
Toxic Encephalopathy Life Threatening 7/4/2007 51 Male 2/3/2009 Japan
Primary
Secondary
Concomitant
Nausea Life Threatening 6/27/2007 47 Female 2/6/2009 Japan
Primary
Concomitant
Sepsis Other Serious 10/3/2008 60 Female 106 lb 3/12/2009 Physician Japan
Primary
Concomitant
Vomiting Other Serious 8/20/2008 45 Male 128 lb 3/12/2009 Physician Japan
Primary
Secondary
Concomitant
Pain Other Serious 1/1/2006 Female 240 lb 3/14/2009 Consumer United States
Primary
Concomitant
Nausea Life Threatening 9/28/2008 59 Female 123 lb 3/16/2009 Physician Japan
Primary
Secondary
Concomitant
Pyrexia Other Serious 1/16/2009 53 Male 112 lb 5/28/2009 Japan
Primary
Concomitant
Myelodysplastic Syndrome Other Serious 6/28/2008 65 Male 148 lb 6/1/2009 Physician Japan
Primary
Secondary
Concomitant
Gingival Ulceration Other Serious Female 158 lb 6/3/2009 Canada
Primary
Concomitant
Tremor Disability 1/1/2009 70 6/4/2009 Other Health Professional France
Primary
Concomitant
Pancytopenia Other Serious 1/1/2007 Female 6/5/2009 Physician United Kingdom
Primary
Concomitant
Pyrexia Hospitalization 1/22/2009 69 Female 6/11/2009 Other Health Professional United Kingdom
Primary
Concomitant
Tooth Fracture Other Serious Female 158 lb 6/19/2009 Canada
Primary
Concomitant
Urinary Incontinence Other Serious 5/27/2009 59 Male 7/28/2009 Physician Belgium
Primary
Concomitant
Stomatitis Life Threatening 9/23/2008 59 Female 123 lb 8/6/2009 Physician Japan
Primary
Secondary
Concomitant
Myocardial Ischaemia Death Male 130 lb 8/11/2009 United Kingdom
Primary
Concomitant
Stomatitis Life Threatening 9/28/2008 59 Female 123 lb 9/15/2009 Physician Japan
Primary
Secondary
Concomitant
Thrombocytopenia Other Serious 8/4/2009 10 Male 9/18/2009 Physician United Kingdom
Primary
Concomitant
Pancytopenia Other Serious 1/1/2007 Female 12/1/2009 Physician United Kingdom
Primary
Concomitant
Staphylococcal Infection Life Threatening 5/1/2007 65 Male 99 lb 5/26/2010 Consumer Japan
Primary
Concomitant
Pancytopenia Other Serious 12/27/2008 52 Male 152 lb 5/27/2010 Physician Japan
Primary
Concomitant
Pulmonary Oedema Hospitalization 6/25/2010 52 Male 274 lb 7/7/2010 Other Health Professional Canada
Primary
Concomitant
Tumour Necrosis Hospitalization 12/17/2009 67 Female 7/1/2010 Japan
Primary
Concomitant
Renal Tuberculosis Hospitalization 12/17/2009 67 Female 7/13/2010 Japan
Primary
Concomitant
Venoocclusive Liver Disease Other Serious 10/20/2009 50 Female 97 lb 8/3/2010 Physician Japan
Primary
Concomitant
Transplant Failure Other Serious 12/1/2009 60 Male 126 lb 8/4/2010 Physician Japan
Primary
Concomitant
Fall Hospitalization 12/17/2009 67 Female 7/29/2010 Japan
Primary
Concomitant
Necrosis Hospitalization 12/17/2009 67 Female 8/6/2010 Other Health Professional Japan
Primary
Concomitant
Drug Level Increased Hospitalization 8/1/2010 52 Male 250 lb 10/8/2010 Other Health Professional Canada
Primary
Secondary
Concomitant
Staphylococcal Sepsis Life Threatening 1/14/2009 67 Male 99 lb 10/26/2010 Consumer Japan
Primary
Concomitant
Transplant Failure Other Serious 12/27/2008 52 Male 152 lb 10/28/2010 Physician Japan
Primary
Secondary
Concomitant
Pancytopenia Other Serious 12/27/2008 52 Male 152 lb 10/26/2010 Physician Japan
Primary
Concomitant

Drug Data