Methotrexate combined with Urso 250

Reports:

Reaction Outcome Event Date Age Sex Weight Reported Reporter Country Treatment
Role Name
White Blood Cell Count Decreased Hospitalization 3/4/2007 Female 146 lb 6/11/2007 Physician Japan
Primary
Secondary
Concomitant
White Blood Cell Count Decreased Other Serious 6/27/2006 30 Female 90 lb 7/3/2007 Japan
Primary
Secondary
Concomitant
White Blood Cell Count Decreased Other Serious 6/27/2006 30 Female 90 lb 7/3/2007 Japan
Primary
Secondary
Concomitant
White Blood Cell Count Decreased Other Serious 6/27/2006 30 Female 90 lb 7/12/2007 Japan
Primary
Secondary
Concomitant
White Blood Cell Count Decreased Other Serious 2/27/2007 8 Male 44 lb 8/27/2007 Physician Japan
Primary
Secondary
Concomitant
Melaena Other Serious 3/2/2007 43 Male 132 lb 9/17/2007 Physician Japan
Primary
Concomitant
Pneumocystis Jiroveci Pneumonia Hospitalization 1/14/2005 Male 104 lb 9/20/2007 Physician Japan
Primary
Secondary
Concomitant
Cardiac Failure Other Serious 6/29/2006 2 Male 10/18/2007 Consumer United States
Primary
Secondary
Concomitant
Status Epilepticus Life Threatening 2/10/2005 39 Male 10/26/2007 Japan
Primary
Secondary
Concomitant
Skin Disorder Other Serious Female 12/3/2007 Other Health Professional Canada
Primary
Concomitant
Cardiac Failure Other Serious 6/29/2006 2 Male 12/7/2007 Consumer United States
Primary
Secondary
Concomitant
Skin Disorder Other Serious Female 1/23/2008 Other Health Professional Canada
Primary
Concomitant
Skin Disorder Other Serious 8/1/2007 Female 2/7/2008 Other Health Professional Canada
Primary
Concomitant
Pneumothorax Other Serious 5/31/2006 54 Male 123 lb 2/29/2008 Physician Japan
Primary
Secondary
Concomitant
Interstitial Lung Disease Death 7/17/2007 65 Male 161 lb 2/29/2008 Physician Japan
Primary
Secondary
Concomitant
Portal Vein Thrombosis Hospitalization 11/10/2006 69 Male 3/4/2008 Japan
Primary
Secondary
Concomitant
Portal Vein Thrombosis Hospitalization 11/10/2006 69 Male 4/2/2008 Japan
Primary
Secondary
Concomitant
Cardiac Failure Congestive Disability 4/16/2007 46 Female 108 lb 4/17/2008 Physician Japan
Primary
Secondary
Concomitant
Cardiac Failure Congestive Disability 4/16/2007 46 Female 108 lb 4/22/2008 Physician Japan
Primary
Concomitant
Pneumothorax Other Serious 5/31/2006 54 Male 123 lb 5/9/2008 Physician Japan
Primary
Secondary
Concomitant
Pyrexia Death 7/17/2007 65 Male 161 lb 5/20/2008 Physician Japan
Primary
Secondary
Concomitant
Cardiomegaly Disability 4/16/2007 46 Female 108 lb 7/15/2008 Physician Japan
Primary
Concomitant
White Blood Cell Count Decreased Other Serious 4/2/2008 19 Male 110 lb 7/16/2008 Physician Japan
Primary
Secondary
Concomitant
Weight Increased Life Threatening 8/6/2007 23 Female 121 lb 8/25/2008 Physician Japan
Primary
Secondary
Concomitant
Cardiomegaly Disability 4/16/2007 46 Female 108 lb 9/19/2008 Physician Japan
Primary
Secondary
Concomitant
Weight Increased Life Threatening 8/6/2007 23 Female 121 lb 11/4/2008 Physician Japan
Primary
Secondary
Concomitant
Reflux Oesophagitis Hospitalization 3/4/2007 Female 146 lb 11/7/2008 Physician Japan
Primary
Secondary
Concomitant
Rash Other Serious 12/27/2007 Female 44 lb 12/5/2008 Physician Japan
Primary
Secondary
Concomitant
Rash Other Serious 12/27/2007 Female 44 lb 12/5/2008 Physician Japan
Primary
Secondary
Concomitant
White Blood Cell Count Decreased Other Serious 2/27/2007 8 Male 44 lb 12/9/2008 Physician Japan
Primary
Secondary
Concomitant
Rash Other Serious 12/27/2007 Female 44 lb 12/24/2008 Physician Japan
Primary
Secondary
Concomitant
Weight Increased Life Threatening 8/6/2007 23 Female 121 lb 1/9/2009 Physician Japan
Primary
Secondary
Concomitant
Sepsis Other Serious 8/16/2008 51 Male 97 lb 2/13/2009 Physician Japan
Primary
Secondary
Concomitant
Sepsis Other Serious 10/3/2008 60 Female 106 lb 3/12/2009 Physician Japan
Primary
Concomitant
Vomiting Other Serious 8/20/2008 45 Male 128 lb 3/12/2009 Physician Japan
Primary
Secondary
Concomitant
Nausea Life Threatening 9/28/2008 59 Female 123 lb 3/16/2009 Physician Japan
Primary
Secondary
Concomitant
Skin Ulcer Other Serious Female 225 lb 3/16/2009 Canada
Primary
Concomitant
White Blood Cell Count Decreased Other Serious 4/2/2008 19 Male 110 lb 3/20/2009 Physician Japan
Primary
Secondary
Concomitant
Renal Impairment Life Threatening 6/26/2008 49 4/6/2009 Physician Japan
Primary
Secondary
Concomitant
Venoocclusive Liver Disease Life Threatening 7/21/2008 56 Male 132 lb 4/15/2009 Physician Japan
Primary
Concomitant
Pyrexia Other Serious 1/16/2009 53 Male 112 lb 5/28/2009 Japan
Primary
Concomitant
White Blood Cell Count Decreased Other Serious 2/27/2007 8 Male 44 lb 7/27/2009 Physician Japan
Primary
Secondary
Concomitant
Stomatitis Death 3/12/2008 Male 126 lb 7/31/2009 Physician Japan
Primary
Secondary
Concomitant
Platelet Count Decreased Other Serious 8/18/2008 26 Female 117 lb 8/5/2009 Physician Japan
Primary
Secondary
Concomitant
Stomatitis Life Threatening 9/23/2008 59 Female 123 lb 8/6/2009 Physician Japan
Primary
Secondary
Concomitant
Sepsis Other Serious 8/8/2008 51 Male 97 lb 9/3/2009 Physician Japan
Primary
Secondary
Concomitant
Renal Impairment Life Threatening 7/2/2008 49 Male 141 lb 9/11/2009 Physician Japan
Primary
Secondary
Concomitant
Muscular Weakness Hospitalization 8/2/2009 64 Female 9/15/2009 Physician Japan
Primary
Concomitant
Stomatitis Life Threatening 9/28/2008 59 Female 123 lb 9/15/2009 Physician Japan
Primary
Secondary
Concomitant
Venoocclusive Liver Disease Life Threatening 7/11/2008 56 Male 132 lb 9/24/2009 Physician Japan
Primary
Concomitant
Renal Impairment Life Threatening 7/2/2008 49 Male 141 lb 9/25/2009 Physician Japan
Primary
Secondary
Concomitant
Pseudomembranous Colitis Other Serious 8/25/2008 18 Male 128 lb 10/1/2009 Physician Japan
Primary
Secondary
Concomitant
Optic Neuritis Hospitalization 8/2/2009 Female 112 lb 10/14/2009 Physician Japan
Primary
Concomitant
Sepsis Other Serious 8/8/2008 51 Male 97 lb 10/14/2009 Physician Japan
Primary
Secondary
Concomitant
Urticaria Other Serious 12/9/2008 7 Female 10/15/2009 Physician Japan
Primary
Concomitant
Weight Increased Other Serious 1/1/2008 48 Female 12/18/2009 Other Health Professional Japan
Primary
Concomitant
Urinary Tract Infection Other Serious Female 163 lb 12/22/2009 United Kingdom
Primary
Concomitant
Optic Neuritis Hospitalization 8/2/2009 Female 112 lb 1/15/2010 Other Health Professional Japan
Primary
Concomitant
Tonsillitis Hospitalization 9/5/2008 Female 2/23/2010 Physician Japan
Primary
Secondary
Concomitant
Stomatitis Death 3/12/2008 Male 126 lb 3/9/2010 Physician Japan
Primary
Secondary
Concomitant
Pyrexia Hospitalization 1/3/2010 Female 90 lb 3/12/2010 Physician Japan
Primary
Secondary
Concomitant
Interacting
Gait Disturbance Other Serious 11/1/2009 84 Male 3/15/2010 Physician Japan
Primary
Secondary
Concomitant
Organising Pneumonia Hospitalization 4/16/2009 Male 3/25/2010 Other Health Professional Japan
Primary
Secondary
Concomitant
Pyrexia Hospitalization 1/3/2010 61 Female 90 lb 4/6/2010 Physician Japan
Primary
Secondary
Concomitant
Interacting
Pancreatitis Acute Other Serious 3/10/2010 13 Female 88 lb 4/23/2010 Physician Japan
Primary
Secondary
Concomitant
Pancreatitis Acute Other Serious 3/10/2010 13 Female 88 lb 5/6/2010 Physician Japan
Primary
Secondary
Concomitant
Refractoriness To Platelet Transfusion Other Serious 7/20/2008 2 Female 24 lb 5/13/2010 Physician Japan
Primary
Concomitant
White Blood Cell Count Decreased Other Serious 2/27/2007 8 Male 44 lb 5/19/2010 Physician Japan
Primary
Secondary
Concomitant
Vestibular Disorder Congenital Anomaly 11/1/2009 84 Male 6/11/2010 Physician Japan
Primary
Secondary
Concomitant
Stem Cell Transplant Other Serious 7/20/2008 2 Female 24 lb 6/15/2010 Physician Japan
Primary
Concomitant
Vestibular Disorder 11/1/2009 84 Male 6/28/2010 Physician Japan
Primary
Secondary
Concomitant
Stem Cell Transplant Other Serious 8/31/2008 33 Male 7/14/2010 Physician Japan
Primary
Secondary
Concomitant
Pneumonia Hospitalization 8/13/2009 15 Female 97 lb 10/13/2010 Physician Japan
Primary
Secondary
Concomitant
Erysipelas Hospitalization 9/30/2010 39 Female 103 lb 11/11/2010 Physician Japan
Primary
Secondary
Concomitant
Sepsis Life Threatening 11/8/2009 15 Male 157 lb 11/11/2010 Physician Japan
Primary
Secondary
Concomitant
Respiratory Disorder Life Threatening 10/8/2009 12 Male 92 lb 11/11/2010 Physician Japan
Primary
Concomitant
Refractoriness To Platelet Transfusion Other Serious 7/20/2008 2 Female 24 lb 11/4/2010 Physician Japan
Primary
Concomitant
Shock Life Threatening 11/11/2007 12 Female 80 lb 11/15/2010 Physician Japan
Primary
Secondary
Concomitant
Encephalitis Fungal Death Male 139 lb 11/15/2010 Physician Japan
Primary
Secondary
Concomitant
Memory Impairment Hospitalization 8/25/2010 11/17/2010 Physician Japan
Primary
Secondary
Concomitant
Shock Life Threatening 11/11/2007 12 Female 80 lb 12/6/2010 Physician Japan
Primary
Secondary
Concomitant
Sepsis Life Threatening 11/8/2009 15 Male 157 lb 12/6/2010 Physician Japan
Primary
Secondary
Concomitant
Respiratory Disorder Life Threatening 10/10/2009 12 Male 92 lb 12/6/2010 Physician Japan
Primary
Concomitant
Mouth Haemorrhage Death 4/25/2009 4 Female 32 lb 12/8/2010 Physician Japan
Primary
Secondary
Concomitant
Thrombotic Microangiopathy Hospitalization 9/18/2010 5 Female 53 lb 12/21/2010 Physician Japan
Primary
Concomitant
Multi-organ Failure Life Threatening 9/15/2001 32 Female 88 lb 12/28/2010 Physician Japan
Primary
Secondary
Concomitant
Acute Respiratory Distress Syndrome Life Threatening 11/11/2007 12 Female 80 lb 1/6/2011 Physician Japan
Primary
Secondary
Concomitant
Sepsis Life Threatening 11/8/2009 15 Male 157 lb 1/6/2011 Physician Japan
Primary
Secondary
Concomitant
Circulatory Collapse Life Threatening 9/15/2001 32 Female 88 lb 1/12/2011 Physician Japan
Primary
Secondary
Concomitant
Infection Death 4/25/2009 4 Female 32 lb 1/24/2011 Physician Japan
Primary
Secondary
Concomitant
Pneumonia Life Threatening 4/22/2007 41 Male 132 lb 2/4/2011 Physician Japan
Primary
Secondary
Concomitant
Cardiac Failure Life Threatening 2/14/2008 17 Female 134 lb 2/9/2011 Physician Japan
Primary
Secondary
Concomitant
Renal Failure Death 7/18/2010 29 Female 82 lb 2/9/2011 Physician Japan
Primary
Secondary
Concomitant
Cardiac Failure Death 7/25/2010 60 Female 93 lb 2/14/2011 Physician Japan
Primary
Secondary
Concomitant
Thrombotic Microangiopathy Hospitalization 9/18/2010 5 Female 53 lb 2/23/2011 Physician Japan
Primary
Concomitant
Venoocclusive Liver Disease Other Serious 8/3/2010 1 Male 24 lb 2/28/2011 Physician Japan
Primary
Secondary
Concomitant
Systemic Mycosis Hospitalization 4/22/2007 41 Male 132 lb 3/2/2011 Physician Japan
Primary
Secondary
Concomitant
Blood Alkaline Phosphatase Increased Death 3/12/2009 16 Male 82 lb 3/2/2011 Physician Japan
Primary
Secondary
Concomitant
Acute Graft Versus Host Disease Hospitalization 2/1/2009 41 Female 152 lb 3/8/2011 Physician Japan
Primary
Secondary
Concomitant
Alanine Aminotransferase Increased Life Threatening 1/24/2005 50 Male 121 lb 3/11/2011 Physician Japan
Primary
Secondary
Concomitant
Gamma-glutamyltransferase Increased Life Threatening 11/7/2008 59 Male 148 lb 3/11/2011 Physician Japan
Primary
Concomitant
Enterococcal Sepsis Life Threatening 3/9/2009 16 Male 82 lb 3/14/2011 Physician Japan
Primary
Secondary
Concomitant
Staphylococcal Sepsis Life Threatening 3/9/2009 16 Male 82 lb 3/14/2011 Physician Japan
Primary
Secondary
Concomitant
Cardiac Disorder Disability 1/19/2010 2 Female 22 lb 3/24/2011 Physician Japan
Primary
Secondary
Concomitant
Febrile Neutropenia Hospitalization 7/22/2007 54 Female 99 lb 3/31/2011 Physician Japan
Primary
Secondary
Concomitant
Febrile Neutropenia Hospitalization 7/22/2007 54 Female 99 lb 4/5/2011 Physician Japan
Primary
Secondary
Concomitant
Encephalitis Viral Other Serious 4/15/2008 7 Female 50 lb 4/5/2011 Physician Japan
Primary
Secondary
Concomitant
Blood Urea Increased Hospitalization 1/24/2005 50 Male 121 lb 4/7/2011 Physician Japan
Primary
Secondary
Concomitant
Interstitial Lung Disease Hospitalization 8/30/2007 57 Female 82 lb 4/7/2011 Physician Japan
Primary
Secondary
Concomitant
Pseudomonas Infection Hospitalization 8/4/2006 48 Male 165 lb 4/12/2011 Physician Japan
Primary
Concomitant
Diarrhoea Disability 11/24/2008 11 Male 93 lb 4/13/2011 Physician Japan
Primary
Secondary
Concomitant
Acute Graft Versus Host Disease Death 8/30/2002 6 Male 35 lb 4/13/2011 Physician Japan
Primary
Secondary
Concomitant
Reye's Syndrome Life Threatening 9/15/2001 32 Female 88 lb 4/15/2011 Physician Japan
Primary
Secondary
Concomitant
Melaena Other Serious 10/18/2009 48 Female 97 lb 4/15/2011 Physician Japan
Primary
Secondary
Concomitant
Thrombotic Microangiopathy Life Threatening 12/7/2009 1 Female 22 lb 4/19/2011 Physician Japan
Primary
Secondary
Concomitant
Thrombotic Microangiopathy Life Threatening 12/7/2009 1 Female 22 lb 4/19/2011 Physician Japan
Primary
Secondary
Concomitant
Renal Disorder Hospitalization 7/25/2010 60 Female 93 lb 4/20/2011 Physician Japan
Primary
Secondary
Concomitant
Renal Disorder Death 7/17/2010 29 Female 82 lb 4/20/2011 Physician Japan
Primary
Secondary
Concomitant
Febrile Neutropenia Other Serious 7/21/2008 38 Female 123 lb 4/20/2011 Physician Japan
Primary
Secondary
Concomitant
Glucose Tolerance Impaired Disability 6/5/2009 59 Male 146 lb 4/22/2011 Physician Japan
Primary
Secondary
Concomitant
Cystitis Disability 1/11/2005 7 Male 55 lb 4/28/2011 Physician Japan
Primary
Secondary
Concomitant
Febrile Neutropenia Hospitalization 3/10/2007 40 Male 126 lb 4/29/2011 Physician Japan
Primary
Secondary
Concomitant
Febrile Neutropenia Hospitalization 3/20/2008 58 Male 119 lb 4/29/2011 Physician Japan
Primary
Secondary
Concomitant
Renal Impairment Hospitalization 5/2/2007 56 Female 95 lb 5/2/2011 Physician Japan
Primary
Secondary
Concomitant
Thrombotic Microangiopathy Other Serious 8/9/2008 7 Female 33 lb 5/4/2011 Physician Japan
Primary
Secondary
Concomitant
Pleural Effusion Hospitalization 11/8/2010 2 Male 31 lb 5/4/2011 Physician Japan
Primary
Concomitant
Anaphylactic Reaction Hospitalization 4/3/2010 16 Female 95 lb 5/4/2011 Physician Japan
Primary
Secondary
Concomitant
Histiocytosis Haematophagic Death 8/30/2002 6 Male 35 lb 5/5/2011 Physician Japan
Primary
Secondary
Concomitant
Sepsis Other Serious 10/12/2010 56 Male 130 lb 5/5/2011 Physician Japan
Primary
Concomitant
Systemic Candida Death 4/24/2009 38 Male 157 lb 5/5/2011 Physician Japan
Primary
Secondary
Concomitant
Staphylococcal Sepsis Hospitalization 4/22/2007 41 Male 132 lb 5/6/2011 Physician Japan
Primary
Secondary
Concomitant
Venoocclusive Liver Disease Hospitalization 7/25/2010 12 Female 80 lb 5/13/2011 Physician Japan
Primary
Secondary
Concomitant
Renal Disorder Life Threatening 7/25/2010 60 Female 93 lb 5/24/2011 Physician Japan
Primary
Secondary
Concomitant
Cytomegalovirus Infection Disability 10/14/2005 8 Male 55 lb 5/26/2011 Physician Japan
Primary
Secondary
Concomitant
Gamma-glutamyltransferase Increased Life Threatening 12/6/2010 53 Male 165 lb 5/27/2011 Physician Japan
Primary
Concomitant
Oral Herpes Other Serious 5/20/2010 65 Male 110 lb 5/26/2011 Physician Japan
Primary
Concomitant
Bacterial Infection Life Threatening 11/29/2008 8 Male 46 lb 6/2/2011 Physician Japan
Primary
Concomitant
Decreased Appetite Hospitalization 1/17/2010 55 Male 168 lb 6/6/2011 Consumer Japan
Primary
Secondary
Concomitant
Aspartate Aminotransferase Increased Hospitalization 12/20/2003 27 Female 108 lb 6/16/2011 Physician Japan
Primary
Secondary
Concomitant
Acute Graft Versus Host Disease Hospitalization 2/1/2009 41 Female 152 lb 6/22/2011 Physician Japan
Primary
Secondary
Concomitant
Febrile Neutropenia Hospitalization 7/22/2007 54 Female 99 lb 6/24/2011 Physician Japan
Primary
Secondary
Concomitant
Constipation Hospitalization 12/10/2003 27 Female 108 lb 6/24/2011 Physician Japan
Primary
Secondary
Concomitant
Hepatic Failure Death 8/30/2002 6 Male 35 lb 6/27/2011 Physician Japan
Primary
Secondary
Concomitant
Stomatitis Disability 11/24/2008 11 Male 93 lb 6/28/2011 Physician Japan
Primary
Secondary
Concomitant
Chronic Graft Versus Host Disease Other Serious 3/16/2010 58 Female 106 lb 6/29/2011 Physician Japan
Primary
Secondary
Concomitant
Drug Ineffective Other Serious 3/16/2010 58 Female 106 lb 6/29/2011 Physician Japan
Primary
Secondary
Concomitant
Encephalitis Viral Other Serious 4/15/2008 7 Female 50 lb 7/1/2011 Physician Japan
Primary
Secondary
Concomitant
Respiratory Failure Hospitalization 1/1/2011 61 Female 95 lb 7/5/2011 Other Health Professional Japan
Primary
Secondary
Concomitant
Acute Respiratory Distress Syndrome Life Threatening 11/11/2007 12 Female 80 lb 7/5/2011 Physician Japan
Primary
Secondary
Concomitant
Bacterial Infection Life Threatening 11/8/2009 15 Male 157 lb 7/5/2011 Physician Japan
Primary
Secondary
Concomitant

Drug Data