Methotrexate combined with Tylenol-500

Reports:

Reaction Outcome Event Date Age Sex Weight Reported Reporter Country Treatment
Role Name
Prothrombin Time Prolonged Hospitalization 74 Female 1/20/2010 United States
Primary
Concomitant
Unresponsive To Stimuli Other Serious 12/15/2009 Female 150 lb 1/29/2010 Other Health Professional United States
Primary
Concomitant
Pyrexia 5/1/2009 Female 214 lb 1/29/2010 Physician United States
Primary
Concomitant
Drug Dose Omission 9/6/2009 Female 120 lb 1/29/2010 United States
Primary
Concomitant
Sinusitis 5/1/2009 Female 160 lb 1/29/2010 Other Health Professional United States
Primary
Concomitant
Ovarian Cyst 7/1/2009 Female 180 lb 1/29/2010 United States
Primary
Concomitant
Herpes Zoster 9/27/2009 Female 135 lb 1/29/2010 Consumer United States
Primary
Concomitant
Rheumatoid Arthritis 11/2/2009 Female 132 lb 1/30/2010 Consumer United States
Primary
Concomitant
Paraesthesia 10/20/2009 Female 1/30/2010 United States
Primary
Concomitant
Vision Blurred Other Serious 1/1/2005 Female 153 lb 1/30/2010 Pharmacist United States
Primary
Concomitant
Pneumonia Hospitalization 3/12/2008 Female 194 lb 2/3/2010 Physician United States
Primary
Secondary
Concomitant
Respiratory Failure Hospitalization 8/6/2009 Male 130 lb 2/8/2010 Canada
Primary
Concomitant
Rheumatoid Arthritis Hospitalization 5/19/2009 Female 2/8/2010 Brazil
Primary
Concomitant
Vision Blurred Other Serious 1/1/2005 Female 153 lb 2/8/2010 Pharmacist United States
Primary
Concomitant
Serum Sickness Other Serious 10/1/2009 Female 166 lb 2/10/2010 Physician United States
Primary
Concomitant
Infusion Related Reaction Other Serious 1/1/2009 Female 2/12/2010 Other Health Professional United States
Primary
Concomitant
Pneumonia Hospitalization 3/12/2008 Female 194 lb 2/12/2010 Physician United States
Primary
Secondary
Concomitant
Pneumonia Respiratory Syncytial Viral Hospitalization 2/2/2010 Female 18 lb 2/12/2010 Physician United States
Primary
Secondary
Concomitant
Mental Impairment Other Serious 1/1/2009 Male 287 lb 2/19/2010 Consumer Canada
Primary
Concomitant
Vascular Dementia Hospitalization 68 Male 2/5/2010 United States
Primary
Concomitant
Vitamin D Decreased Hospitalization 8/11/2008 48 Female 212 lb 2/26/2010 Physician United States
Primary
Concomitant
Intramedullary Rod Insertion Hospitalization 12/3/2009 Female 3/3/2010 Canada
Primary
Concomitant
Coombs Negative Haemolytic Anaemia Hospitalization 9/28/2009 44 Female 157 lb 3/5/2010 Physician United States
Primary
Concomitant
Pneumonia Respiratory Syncytial Viral Hospitalization 2/2/2010 Female 18 lb 3/8/2010 Physician United States
Primary
Secondary
Concomitant
Respiratory Moniliasis Hospitalization 12/8/2009 Female 153 lb 3/10/2010 Physician United States
Primary
Concomitant
Pain In Extremity Other Serious 6/9/2009 Female 205 lb 3/12/2010 Other Health Professional Canada
Primary
Concomitant
Coombs Negative Haemolytic Anaemia Hospitalization 9/28/2009 44 Female 157 lb 3/15/2010 Physician United States
Primary
Concomitant
Urticaria Other Serious 13 Female 119 lb 3/17/2010 Consumer United States
Primary
Secondary
Concomitant
Upper Respiratory Tract Infection Other Serious 3/3/2009 13 Female 152 lb 3/17/2010 Other Health Professional United States
Primary
Concomitant
Treatment Noncompliance Hospitalization 74 Female 3/5/2010 Lawyer United States
Primary
Concomitant
Colon Cancer Hospitalization 10/29/2009 Female 3/19/2010 United States
Primary
Concomitant
Diabetic Foot Hospitalization 1/5/2010 Female 148 lb 3/22/2010 Physician United States
Primary
Secondary
Concomitant
Wrist Fracture Other Serious 1/1/2002 Female 3/25/2010 Other Health Professional United States
Primary
Concomitant
Inflammatory Bowel Disease Hospitalization 2/11/2010 3 Male 31 lb 4/2/2010 Physician United States
Primary
Concomitant
Pyrexia Hospitalization 3/20/2010 2 Female 18 lb 4/2/2010 Physician United States
Primary
Concomitant
Lung Neoplasm Other Serious 6/1/2009 66 Female 255 lb 4/6/2010 Physician United States
Primary
Concomitant
Mental Impairment Other Serious 1/1/2009 23 Male 287 lb 4/6/2010 Consumer Canada
Primary
Concomitant
Wrist Fracture Other Serious 1/1/2002 42 Female 4/9/2010 Other Health Professional United States
Primary
Concomitant
Ventricular Fibrillation Other Serious 1/1/2010 71 Male 260 lb 4/14/2010 Physician United States
Primary
Concomitant
Urinary Tract Neoplasm Other Serious 11/9/2009 65 Female 158 lb 4/16/2010 Physician United States
Primary
Concomitant
Pyrexia Hospitalization 3/20/2010 2 Female 18 lb 4/16/2010 Physician United States
Primary
Concomitant
Inflammatory Bowel Disease Hospitalization 2/11/2010 3 Male 31 lb 4/16/2010 Physician United States
Primary
Concomitant
Rheumatoid Arthritis Hospitalization 5/19/2009 61 Female 4/21/2010 Brazil
Primary
Concomitant
Vision Blurred Other Serious Male 144 lb 4/23/2010 Other Health Professional Canada
Primary
Concomitant
Lung Neoplasm Other Serious 6/1/2009 66 Female 255 lb 4/30/2010 Physician United States
Primary
Concomitant
Vomiting Hospitalization 4/1/2009 51 Male 355 lb 4/30/2010 Physician United States
Primary
Concomitant
Tooth Extraction Other Serious 4/8/2010 71 Male 240 lb 4/30/2010 Canada
Primary
Concomitant
Pulmonary Mass Hospitalization 6/1/2009 32 Male 189 lb 5/3/2010 Other Health Professional Canada
Primary
Concomitant
Colon Cancer Hospitalization 10/29/2009 80 Female 5/4/2010 United States
Primary
Concomitant
Raynaud's Phenomenon Other Serious 1/1/1999 66 Female 126 lb 5/6/2010 Physician United States
Primary
Concomitant
Vomiting Other Serious 11/1/2008 55 Female 208 lb 5/6/2010 United States
Primary
Concomitant
Ventricular Fibrillation Other Serious 1/1/2010 71 Male 260 lb 5/6/2010 Physician United States
Primary
Concomitant
Syncope Other Serious 73 Female 5/7/2010 Consumer United States
Primary
Concomitant
Renal Failure Acute Other Serious 4/12/2010 76 Male 256 lb 5/11/2010 Physician United States
Primary
Concomitant
Thrombocytopenia Other Serious Male 223 lb 5/11/2010 Physician United States
Primary
Concomitant
Renal Failure Acute Other Serious 4/12/2010 76 Male 256 lb 5/13/2010 Physician United States
Primary
Concomitant
Pneumonia Hospitalization 3/12/2008 67 Female 194 lb 5/12/2010 Physician United States
Primary
Secondary
Concomitant
Respiratory Failure Death 8/11/2009 66 Female 126 lb 5/20/2010 Other Health Professional United States
Primary
Concomitant
Gastrointestinal Infection Hospitalization 1/1/2008 75 Female 141 lb 7/13/2010 Consumer Brazil
Primary
Secondary
Concomitant
Vomiting Other Serious 8/1/2010 78 Female 174 lb 8/27/2010 Physician Canada
Primary
Concomitant
Tachycardia Other Serious 9/20/2007 50 Male 194 lb 8/27/2010 Other Health Professional United States
Primary
Secondary
Concomitant
Prostate Cancer Life Threatening 5/24/2010 68 Male 155 lb 8/30/2010 Physician United States
Primary
Secondary
Concomitant
Prostate Cancer Life Threatening 5/24/2010 68 Male 155 lb 9/1/2010 Physician United States
Primary
Secondary
Concomitant
Fatigue Other Serious Female 133 lb 10/20/2010 Physician United States
Primary
Concomitant
Oesophageal Adenocarcinoma Other Serious 3/18/2010 61 Male 193 lb 11/24/2010 Physician United States
Primary
Concomitant
Vision Blurred Other Serious 1/1/2005 64 Female 153 lb 12/2/2010 United States
Primary
Concomitant
Purpura 84 Female 118 lb 12/8/2010 Physician Canada
Primary
Concomitant
Duodenitis Hospitalization 12/1/2008 61 Male 234 lb 1/7/2011 Other Health Professional Canada
Primary
Secondary
Concomitant
Headache Other Serious 9/1/2007 50 Male 194 lb 1/12/2011 Other Health Professional United States
Primary
Secondary
Concomitant
Malaise Other Serious 11/30/2010 75 Female 205 lb 1/24/2011 Physician United States
Primary
Concomitant
Hernia Other Serious 1/1/2009 53 Male 270 lb 1/25/2011 Physician United States
Primary
Concomitant
Platelet Count Decreased Hospitalization 12/1/2010 59 Female 129 lb 1/27/2011 United States
Primary
Concomitant
Nasal Congestion Other Serious 8/9/2010 69 Female 119 lb 1/28/2011 Other Health Professional Canada
Primary
Concomitant
Nausea 1/5/2010 47 Female 125 lb 1/28/2011 Consumer United States
Primary
Concomitant
Skin Exfoliation 1/1/2008 64 Female 1/28/2011 United States
Primary
Concomitant
Arthralgia Female 200 lb 1/28/2011 United States
Primary
Concomitant
Injection Site Pain Female 135 lb 1/28/2011 Consumer United States
Primary
Concomitant
Sinus Congestion Female 150 lb 1/28/2011 Other Health Professional United States
Primary
Concomitant
Pain 2/12/2010 62 Female 210 lb 1/28/2011 Consumer United States
Primary
Concomitant
Drug Effect Decreased 2/1/2010 53 Female 190 lb 1/29/2011 Consumer United States
Primary
Concomitant
Injection Site Nodule 5/19/2010 Female 1/29/2011 Consumer United States
Primary
Concomitant
Upper Respiratory Tract Infection 1/1/2009 54 Female 1/29/2011 Consumer United States
Primary
Concomitant
Injection Site Pain 5/1/2010 60 Female 1/29/2011 Consumer United States
Primary
Concomitant
Fungal Infection 6/7/2010 51 Female 1/29/2011 Consumer United States
Primary
Concomitant
Paraesthesia Other Serious 1/1/2009 78 Female 153 lb 1/29/2011 Consumer United States
Primary
Concomitant
Nausea 5/16/2010 50 Female 1/29/2011 Consumer United States
Primary
Concomitant
Drug Ineffective 2/1/2010 80 Male 140 lb 1/29/2011 Other Health Professional United States
Primary
Concomitant
Malaise 9/5/2010 62 Female 1/30/2011 Consumer United States
Primary
Concomitant
Decreased Appetite 6/1/2010 53 Male 195 lb 1/30/2011 Physician United States
Primary
Concomitant
Headache 9/18/2010 59 Female 1/30/2011 Consumer United States
Primary
Concomitant
Visual Acuity Reduced 10/1/2010 76 Female 1/30/2011 Consumer United States
Primary
Secondary
Concomitant
Nasopharyngitis 50 Female 1/30/2011 Consumer United States
Primary
Concomitant
Urine Odour Abnormal 8/1/2010 58 Female 1/30/2011 Consumer United States
Primary
Concomitant
Muscle Spasms 9/1/2009 67 Male 1/30/2011 Consumer United States
Primary
Concomitant
Burning Sensation 8/1/2010 67 Female 1/30/2011 Consumer United States
Primary
Secondary
Concomitant
Rheumatoid Arthritis Hospitalization 1/1/2006 84 Female 110 lb 1/30/2011 Consumer United States
Primary
Concomitant
Drug Ineffective Female 125 lb 1/30/2011 Consumer United States
Primary
Concomitant
Drug Ineffective 1/1/2010 15 Female 1/30/2011 Consumer United States
Primary
Concomitant
Myalgia Hospitalization 11/1/2005 60 Female 245 lb 2/1/2011 United States
Primary
Secondary
Concomitant
Respiratory Rate Increased Other Serious 11/2/2010 17 Female 176 lb 2/2/2011 Physician United States
Primary
Concomitant
Chills Other Serious 9/23/2010 27 Male 179 lb 2/3/2011 Other Health Professional Canada
Primary
Concomitant
Cerebrovascular Disorder Hospitalization 12/18/2010 70 Female 2/3/2011 Other Health Professional United States
Primary
Secondary
Concomitant
Intestinal Perforation Hospitalization 10/1/2010 53 Female 160 lb 2/4/2011 Physician United States
Primary
Concomitant
Renal Mass Other Serious Male 2/4/2011 Other Health Professional United States
Primary
Secondary
Concomitant
Dysphagia Hospitalization 12/25/2010 82 Female 95 lb 2/7/2011 Other Health Professional Canada
Primary
Concomitant
Local Swelling Hospitalization 12/25/2010 82 Female 95 lb 2/8/2011 Other Health Professional Canada
Primary
Concomitant
Fatigue Other Serious 3/16/2009 54 Female 258 lb 2/9/2011 Consumer United States
Primary
Concomitant
Renal Atrophy Other Serious 5/30/1996 48 Female 2/10/2011 United States
Primary
Secondary
Concomitant
Pancytopenia Death 2/8/2011 85 Male 169 lb 3/16/2011 Physician United States
Primary
Concomitant
Depression Hospitalization 3/30/2011 46 Female 181 lb 6/3/2011 Other Health Professional Canada
Primary
Concomitant
Pneumonia Hospitalization 2/15/2011 59 Female 179 lb 6/3/2011 Physician United States
Primary
Secondary
Concomitant
Cognitive Disorder Other Serious Female 6/3/2011 Pharmacist United States
Primary
Concomitant
Pain In Extremity Hospitalization 1/1/2010 76 Female 118 lb 6/6/2011 Physician Canada
Primary
Concomitant
Micturition Urgency Other Serious 1/1/2003 53 Female 6/6/2011 Lawyer United States
Primary
Secondary
Concomitant
Interacting
Joint Swelling Hospitalization Male 309 lb 6/8/2011 Consumer South Africa
Primary
Concomitant
Lung Disorder Hospitalization 7/9/2008 50 Female 6/13/2011 Lawyer United States
Primary
Concomitant
Hepatectomy Hospitalization 12/25/2010 71 Female 159 lb 6/13/2011 Consumer Canada
Primary
Concomitant
Dysphonia Other Serious 9/15/2009 58 Female 198 lb 6/15/2011 Consumer United Kingdom
Primary
Secondary
Concomitant
Urinary Incontinence Death 7/9/2008 50 Female 6/20/2011 Physician United States
Primary
Concomitant
Skin Hyperpigmentation Other Serious 1/1/2003 53 Female 6/21/2011 Physician United States
Primary
Secondary
Concomitant
Interacting
Memory Impairment Other Serious 1/1/2011 52 Male 6/22/2011 Consumer Canada
Primary
Concomitant
Thrombocytopenia Hospitalization 7/17/2010 86 Male 6/22/2011 Consumer United States
Primary
Secondary
Concomitant
Basal Cell Carcinoma 4/18/2011 56 Female 175 lb 6/27/2011 Physician United States
Primary
Secondary
Concomitant
Cardiac Disorder Other Serious 6/16/2011 64 Female 135 lb 6/29/2011 Other Health Professional Canada
Primary
Concomitant
Memory Impairment Other Serious 1/1/2011 52 Male 7/6/2011 Consumer Canada
Primary
Concomitant
Chills Hospitalization 6/29/2011 64 Male 185 lb 7/1/2011 Other Health Professional United States
Primary
Concomitant
Interacting
Basal Cell Carcinoma 4/18/2011 56 Female 175 lb 7/8/2011 Physician United States
Primary
Secondary
Concomitant
Oedema Peripheral Other Serious Male 185 lb 7/18/2011 Other Health Professional Canada
Primary
Concomitant
Blood Glucose Increased Other Serious 1/1/2008 70 Female 170 lb 7/19/2011 Consumer Brazil
Primary
Concomitant
Basal Cell Carcinoma 4/18/2011 56 Female 175 lb 7/22/2011 Physician United States
Primary
Secondary
Concomitant
Hydronephrosis Other Serious 1/1/2003 53 Female 7/22/2011 Lawyer United States
Primary
Secondary
Concomitant
Interacting
Cerebral Infarction Hospitalization 7/19/2011 14 Female 96 lb 7/21/2011 United States
Primary
Secondary
Concomitant
Nausea Other Serious 3/28/2011 71 Male 213 lb 8/1/2011 Other Health Professional Canada
Primary
Concomitant
Dehydration Hospitalization 7/1/2011 26 Male 8/1/2011 Other Health Professional Canada
Primary
Concomitant
Stevens-johnson Syndrome Hospitalization Female 8/2/2011 Other Health Professional Japan
Primary
Secondary
Concomitant
Painful Respiration Other Serious 1/1/2007 72 Female 155 lb 8/4/2011 Physician United States
Primary
Concomitant
Night Sweats Other Serious 11/1/2005 60 Female 245 lb 8/4/2011 Physician United States
Primary
Secondary
Concomitant
Myalgia Male 200 lb 8/5/2011 Consumer United States
Primary
Concomitant
Fatigue 6/3/2011 58 Female 170 lb 8/6/2011 Consumer United States
Primary
Concomitant
Infection Hospitalization 1/1/2007 72 Female 155 lb 8/8/2011 Physician United States
Primary
Concomitant
Ischaemic Cerebral Infarction Hospitalization 4/18/2011 13 Female 96 lb 8/5/2011 Physician United States
Primary
Secondary
Concomitant
Pyrexia Hospitalization 3/20/2010 2 Female 18 lb 8/11/2011 Physician United States
Primary
Concomitant
Ulcer Haemorrhage Hospitalization 12/1/2010 50 Male 8/11/2011 Consumer United Kingdom
Primary
Secondary
Concomitant
Cerebral Ischaemia Other Serious 5/1/2010 63 Male 8/12/2011 Consumer United Kingdom
Primary
Concomitant
Depression Hospitalization 3/30/2011 46 Female 181 lb 8/15/2011 Other Health Professional Canada
Primary
Concomitant
Depression Hospitalization 3/30/2011 46 Female 181 lb 8/15/2011 Physician Canada
Primary
Concomitant
Cardiomegaly Hospitalization 11/1/2005 60 Female 245 lb 8/16/2011 United States
Primary
Secondary
Concomitant
Aortic Aneurysm Hospitalization 4/1/2009 78 Female 215 lb 8/18/2011 Physician United States
Primary
Secondary
Concomitant
Upper Respiratory Tract Infection Other Serious 6/7/2011 60 Female 233 lb 8/22/2011 Physician United States
Primary
Secondary
Concomitant
Cellulitis Hospitalization 7/30/2011 50 Male 269 lb 8/25/2011 Physician United States
Primary
Concomitant

Drug Data