Methotrexate combined with Tramadol

Reports:

Reaction Outcome Event Date Age Sex Weight Reported Reporter Country Treatment
Role Name
Muscle Spasms Hospitalization 1/4/2006 Male 2/7/2006 United Kingdom
Primary
Concomitant
Osteoporosis Hospitalization 2/15/2004 Female 112 lb 2/9/2006 United Kingdom
Primary
Concomitant
Peritoneal Tuberculosis Hospitalization Female 2/13/2006 Physician United Kingdom
Primary
Secondary
Concomitant
Palpitations Other Serious 1/13/2006 Female 216 lb 2/16/2006 Other Health Professional United Kingdom
Primary
Concomitant
Atrial Fibrillation Other Serious 7/15/2005 Female 216 lb 2/16/2006 Other Health Professional United Kingdom
Primary
Concomitant
Impaired Healing Hospitalization 5/4/2005 65 Male 2/21/2006 Other Health Professional Germany
Primary
Secondary
Concomitant
Peritoneal Tuberculosis Hospitalization 10/17/2005 Female 185 lb 2/23/2006 Physician United Kingdom
Primary
Secondary
Concomitant
Skin Exfoliation Other Serious 1/1/2005 Female 163 lb 4/13/2006 Physician United States
Primary
Secondary
Concomitant
Lower Respiratory Tract Infection Hospitalization 3/10/2006 61 Male 4/13/2006 Consumer United Kingdom
Primary
Concomitant
Joint Stiffness Other Serious 9/30/2003 Male 276 lb 4/14/2006 Other Health Professional United Kingdom
Primary
Concomitant
Pericarditis Other Serious 1/6/2006 Female 96 lb 10/5/2006 Other Health Professional United Kingdom
Primary
Concomitant
Cardiac Failure Congestive Other Serious 9/24/2008 78 Male 12/30/2008 Other Health Professional United States
Primary
Secondary
Concomitant
Malignant Melanoma Life Threatening 1/1/2007 59 Female 119 lb 12/31/2008 Consumer United States
Primary
Secondary
Concomitant
Rash 55 Female 12/31/2008 Physician United States
Primary
Secondary
Peripheral Sensory Neuropathy Other Serious 84 Female 2/13/2009 Physician United States
Primary
Secondary
Concomitant
Lower Respiratory Tract Infection Other Serious 11/21/2005 Female 132 lb 2/13/2009 Other Health Professional United Kingdom
Primary
Concomitant
Progressive Multifocal Leukoencephalopathy Life Threatening 11/1/2008 Female 3/10/2009 Physician United States
Primary
Secondary
Concomitant
Sudden Death Death 9/9/2008 Female 4/3/2009 United States
Primary
Concomitant
Panic Reaction Other Serious 3/1/2009 43 Male 4/13/2009 Other Health Professional United Kingdom
Primary
Concomitant
Haematuria Other Serious 9/15/2008 Male 176 lb 4/15/2009 United Kingdom
Primary
Secondary
Concomitant
Acute Myocardial Infarction Death 1/3/2009 75 Male 163 lb 5/12/2009 Other Health Professional United Kingdom
Primary
Concomitant
Rheumatoid Arthritis Other Serious 1/1/2008 Female 125 lb 5/12/2009 Physician United States
Primary
Concomitant
Application Site Burn Other Serious 5/3/2009 59 Female 197 lb 5/13/2009 Consumer United States
Primary
Concomitant
Mucosal Inflammation Hospitalization 3/1/2008 Female 5/14/2009 Consumer United Kingdom
Primary
Secondary
Concomitant
Hyperkeratosis Other Serious 10/14/2003 Female 126 lb 7/6/2009 Other Health Professional United Kingdom
Primary
Concomitant
Arthritis Infective Hospitalization 1/11/2009 Female 7/6/2009 Physician New Zealand
Primary
Secondary
Concomitant
Polyuria Other Serious 58 Female 7/9/2009 Consumer United States
Primary
Concomitant
Sepsis Other Serious 1/20/2008 Female 110 lb 7/9/2009 Spain
Primary
Concomitant
Post Procedural Complication Other Serious 6/15/2008 Female 143 lb 7/27/2009 Other Health Professional United Kingdom
Primary
Concomitant
Total Lung Capacity Decreased Hospitalization Male 7/28/2009 Consumer United Kingdom
Primary
Concomitant
Pancreatitis Hospitalization 7/10/2009 Female 7/31/2009 Australia
Primary
Concomitant
Vomiting Other Serious 12/31/2008 Female 119 lb 8/10/2009 United Kingdom
Primary
Concomitant
Rash Pustular Other Serious Male 187 lb 8/12/2009 Physician South Africa
Primary
Secondary
Concomitant
Post Procedural Complication Other Serious 6/15/2008 Female 143 lb 8/14/2009 Other Health Professional United Kingdom
Primary
Concomitant
Pancreatitis Hospitalization 7/10/2009 Female 8/14/2009 Australia
Primary
Concomitant
Upper Gastrointestinal Haemorrhage Other Serious 4/1/2008 64 8/14/2009 Physician Philippines
Primary
Secondary
Concomitant
Lung Neoplasm Malignant Death 6/15/2008 Female 8/14/2009 Consumer United Kingdom
Primary
Secondary
Concomitant
Herpes Zoster Ophthalmic Other Serious 4/1/2009 Female 187 lb 8/21/2009 Consumer United States
Primary
Concomitant
Renal Failure Hospitalization 73 Female 8/21/2009 Other Health Professional United Kingdom
Primary
Concomitant
Mitral Valve Incompetence Other Serious 1/1/2007 Male 194 lb 8/21/2009 Brazil
Primary
Concomitant
Vomiting Other Serious 1/1/2003 Female 141 lb 8/21/2009 Physician United States
Primary
Concomitant
Pleural Effusion Hospitalization Male 8/21/2009 Consumer United States
Primary
Concomitant
Myocardial Ischaemia Death 75 Male 163 lb 8/24/2009 Other Health Professional United Kingdom
Primary
Concomitant
Pancreatitis Hospitalization 7/10/2009 Female 9/24/2009 Australia
Primary
Concomitant
Chest Pain Hospitalization 6/8/2009 Female 9/24/2009 Consumer United Kingdom
Primary
Concomitant
Bronchial Carcinoma Death Female 11/17/2009 United Kingdom
Primary
Concomitant
Rheumatoid Arthritis Other Serious 5/9/2009 Female 106 lb 11/17/2009 United Kingdom
Primary
Concomitant
Pituitary Tumour Benign Other Serious 5/1/2008 51 Female 146 lb 11/19/2009 Other Health Professional United Kingdom
Primary
Concomitant
Anal Cancer Other Serious 3/18/2009 78 Female 236 lb 11/19/2009 Other Health Professional United Kingdom
Primary
Concomitant
Spinal Disorder Other Serious 6/1/2008 Female 192 lb 11/19/2009 Physician United States
Primary
Concomitant
Dyspepsia Other Serious 7/1/2008 Male 331 lb 11/19/2009 Physician United States
Primary
Concomitant
Squamous Cell Carcinoma Other Serious 9/4/2007 Male 11/19/2009 United Kingdom
Primary
Concomitant
Breast Cancer Stage Ii Other Serious 11/3/2009 Female 168 lb 12/12/2009 Other Health Professional Hungary
Primary
Concomitant
Febrile Neutropenia Life Threatening 12/15/2008 Male 12/31/2009 Consumer United Kingdom
Primary
Secondary
Concomitant
Non-hodgkin's Lymphoma Life Threatening 10/13/2009 Male 181 lb 1/8/2010 United States
Primary
Concomitant
Subcutaneous Abscess Hospitalization Female 1/14/2010 United Kingdom
Primary
Concomitant
Necrosis Disability Female 181 lb 1/18/2010 Consumer Argentina
Primary
Concomitant
Weight Decreased 11/1/2009 Female 119 lb 1/15/2010 Consumer United States
Primary
Secondary
Concomitant
Vomiting Other Serious 1/1/2003 Female 141 lb 1/21/2010 Physician United States
Primary
Concomitant
Febrile Neutropenia Life Threatening 12/15/2008 Male 123 lb 1/26/2010 Consumer United Kingdom
Primary
Secondary
Concomitant
Drug Dose Omission 9/1/2009 Female 160 lb 1/29/2010 Consumer United States
Primary
Concomitant
Drug Ineffective 9/15/2009 Female 135 lb 1/29/2010 Consumer United States
Primary
Concomitant
Injection Site Pain 11/3/2008 Male 1/29/2010 Consumer United States
Primary
Concomitant
Vomiting 9/23/2009 Female 146 lb 1/29/2010 United States
Primary
Concomitant
Headache 9/18/2009 Male 170 lb 1/29/2010 United States
Primary
Concomitant
Pruritus Generalised Female 1/29/2010 Pharmacist United States
Primary
Concomitant
Throat Irritation 10/23/2009 Female 275 lb 1/30/2010 United States
Primary
Concomitant
Injection Site Haemorrhage 12/3/2009 Male 207 lb 1/30/2010 United States
Primary
Concomitant
Meningioma Hospitalization 9/1/2007 Male 185 lb 2/2/2010 Other Health Professional France
Primary
Secondary
Concomitant
Hypercalcaemia Hospitalization 10/3/2009 Female 2/2/2010 Physician Netherlands
Primary
Concomitant
Sputum Discoloured Hospitalization 10/22/2009 Female 2/5/2010 United Kingdom
Primary
Concomitant
Rheumatoid Arthritis Other Serious 11/25/2009 50 Female 275 lb 2/8/2010 Other Health Professional United States
Primary
Concomitant
White Blood Cell Count Increased Death 11/6/2009 Female 163 lb 2/12/2010 United Kingdom
Primary
Concomitant
Melaena Hospitalization 12/15/2009 Male 2/15/2010 United Kingdom
Primary
Concomitant
Myalgia Hospitalization 12/12/2009 63 Male 2/16/2010 Other Health Professional Sweden
Primary
Concomitant
Spindle Cell Sarcoma Life Threatening 3/13/2008 Female 328 lb 2/17/2010 Physician Australia
Primary
Secondary
Concomitant
Cholecystitis Hospitalization 1/24/2010 Female 2/18/2010 Physician United Kingdom
Primary
Secondary
Concomitant
Rheumatoid Arthritis 64 Male 2/22/2010 Consumer United States
Primary
Concomitant
Pain 4/1/2009 37 Female 302 lb 2/22/2010 Consumer United States
Primary
Concomitant
Influenza Hospitalization 10/5/2009 Female 167 lb 3/8/2010 United States
Primary
Concomitant
Thrombophlebitis Superficial Hospitalization 1/5/2010 Female 204 lb 3/22/2010 Consumer Spain
Primary
Concomitant
C-reactive Protein Increased Other Serious Male 3/22/2010 Other Health Professional United Kingdom
Primary
Concomitant
Skin Cancer Other Serious 10/1/2007 Female 159 lb 3/24/2010 Consumer United Kingdom
Primary
Concomitant
Fall Other Serious 2/11/2010 67 Female 5/28/2010 Physician United States
Primary
Concomitant
Tongue Disorder Other Serious 57 Female 6/1/2010 Consumer United States
Primary
Secondary
Concomitant
Nasopharyngitis 3/1/2010 54 Female 165 lb 5/11/2010 Consumer United States
Primary
Concomitant
Polyarthritis Hospitalization 11/30/2009 68 Female 196 lb 6/2/2010 Argentina
Primary
Concomitant
Pelvic Abscess Hospitalization 5/11/2010 52 Male 213 lb 6/11/2010 Physician United Kingdom
Primary
Secondary
Concomitant
Pneumonia Primary Atypical Hospitalization 3/24/2010 67 Female 115 lb 6/14/2010 Physician Korea, Republic Of
Primary
Secondary
Concomitant
Urinary Tract Infection Hospitalization 50 Female 6/10/2010 Consumer United States
Primary
Concomitant
Death Death Female 100 lb 6/16/2010 United States
Primary
Concomitant
No Therapeutic Response Other Serious 2/3/2010 55 Male 203 lb 6/16/2010 Consumer United Kingdom
Primary
Concomitant
Disseminated Tuberculosis Hospitalization 4/22/2010 67 Female 115 lb 6/18/2010 Physician Korea, Republic Of
Primary
Secondary
Concomitant
Vomiting Other Serious 3/1/2010 80 Female 160 lb 6/18/2010 Consumer United States
Primary
Concomitant
Appendicitis Hospitalization 5/10/2010 61 Male 6/20/2010 Other Health Professional United States
Primary
Secondary
Concomitant
Pulmonary Tuberculosis Hospitalization 6/22/2009 67 Female 99 lb 6/21/2010 Other Health Professional Korea, Republic Of
Primary
Concomitant
Neutropenia Life Threatening 3/1/2008 73 Female 6/21/2010 Consumer United Kingdom
Primary
Secondary
Concomitant
Cerebrovascular Accident Hospitalization 4/3/2010 71 Male 152 lb 6/23/2010 Other Health Professional United States
Primary
Secondary
Concomitant
Vomiting Life Threatening 6/18/2010 70 Male 115 lb 7/6/2010 Consumer United States
Primary
Secondary
Concomitant
Respiratory Failure Death 6/6/2009 69 Male 7/9/2010 Physician United Kingdom
Primary
Concomitant
Vomiting Hospitalization 6/23/2010 57 Female 7/12/2010 Other Health Professional Poland
Primary
Secondary
Concomitant
Pyrexia Life Threatening 3/1/2007 50 Female 123 lb 7/12/2010 Physician United Kingdom
Primary
Concomitant
Transaminases Increased Other Serious 12/1/2009 46 Male 7/13/2010 Consumer France
Primary
Secondary
Concomitant
Interacting
Septic Shock Hospitalization 4/22/2010 67 Female 115 lb 7/16/2010 Physician Korea, Republic Of
Primary
Secondary
Concomitant
Urosepsis Hospitalization 6/23/2010 57 Female 7/16/2010 Other Health Professional Poland
Primary
Secondary
Concomitant
Pyrexia Hospitalization 2/1/2009 59 Male 185 lb 7/16/2010 Physician United States
Primary
Concomitant
Urinary Tract Infection Hospitalization 50 Female 7/15/2010 Physician United States
Primary
Concomitant
Vein Pain Other Serious 2/11/2010 62 Female 199 lb 7/22/2010 Physician United States
Primary
Concomitant
Pneumonia Hospitalization 7/10/2010 76 Male 224 lb 8/17/2010 Physician United States
Primary
Secondary
Concomitant
Pneumonia Hospitalization 7/29/2010 55 Female 8/17/2010 Physician Thailand
Primary
Secondary
Concomitant
Sepsis Other Serious 1/20/2008 89 Female 110 lb 8/17/2010 Physician Spain
Primary
Concomitant
Weight Increased Other Serious 1/1/2003 32 Female 141 lb 8/17/2010 Physician United States
Primary
Concomitant
Throat Irritation Other Serious 7/1/2010 51 Female 188 lb 8/18/2010 Other Health Professional United States
Primary
Concomitant
Retching Hospitalization 4/1/2009 86 Female 8/20/2010 Other Health Professional United States
Primary
Secondary
Concomitant
Pyrexia Other Serious 7/16/2010 58 Female 8/20/2010 Other Health Professional United States
Primary
Concomitant
Migraine Other Serious 10/1/2007 50 Female 8/23/2010 Other Health Professional United States
Primary
Concomitant
Migraine Other Serious 1/1/2010 26 Female 8/23/2010 Other Health Professional United States
Primary
Concomitant
Migraine Other Serious 6/1/2010 35 Female 8/23/2010 Other Health Professional United States
Primary
Concomitant
Urinary Tract Infection Hospitalization 50 Female 8/20/2010 Physician United States
Primary
Concomitant
Sinusitis 2/1/2010 51 Female 175 lb 8/16/2010 Other Health Professional United States
Primary
Concomitant
Vomiting Life Threatening 10/4/2009 76 Female 130 lb 9/2/2010 Other Health Professional Argentina
Primary
Concomitant
Gastroenteritis Viral Hospitalization 9/1/2010 55 Female 186 lb 9/20/2010 Physician United States
Primary
Concomitant
Weight Increased Other Serious 1/1/2003 32 Female 141 lb 9/21/2010 Physician United States
Primary
Concomitant
Weight Increased Other Serious 1/1/2003 32 Female 141 lb 9/22/2010 Physician United States
Primary
Concomitant
Intervertebral Disc Protrusion Hospitalization 9/1/2010 55 Female 186 lb 9/23/2010 Physician United States
Primary
Concomitant
Vision Blurred Other Serious 9/6/2010 41 Female 196 lb 9/23/2010 Other Health Professional United Kingdom
Primary
Concomitant
Progressive Multifocal Leukoencephalopathy Life Threatening 11/1/2008 41 Female 9/23/2010 Physician United States
Primary
Secondary
Concomitant
Weight Increased Other Serious 9/15/2009 58 Female 190 lb 9/24/2010 Physician United Kingdom
Primary
Concomitant
Spider Vein Other Serious 2/1/2010 61 Female 183 lb 9/27/2010 Physician United States
Primary
Concomitant
Rheumatoid Arthritis Hospitalization 1/4/2007 75 Female 207 lb 9/28/2010 Other Health Professional United Kingdom
Primary
Concomitant
Small Intestinal Perforation Other Serious 8/1/2010 68 Female 286 lb 9/28/2010 Consumer United States
Primary
Concomitant
Upper Gastrointestinal Haemorrhage Other Serious 4/1/2008 64 Female 121 lb 10/7/2010 Physician Philippines
Primary
Secondary
Concomitant
Weight Increased Other Serious 1/1/2003 32 Female 141 lb 10/13/2010 Other Health Professional
Primary
Concomitant
Rectosigmoid Cancer Recurrent Hospitalization 3/30/2005 10/25/2010 Physician United Kingdom
Primary
Concomitant
Weight Increased Other Serious 9/15/2009 58 Female 190 lb 10/29/2010 Physician United Kingdom
Primary
Concomitant
Cerebral Infarction Hospitalization 10/4/2010 87 Female 143 lb 11/1/2010 Physician Finland
Primary
Secondary
Concomitant
Unevaluable Event Hospitalization 2/13/2008 66 Male 210 lb 11/5/2010 Lawyer United States
Primary
Concomitant
Weight Increased Other Serious 1/1/2010 49 Female 11/24/2010 Consumer United States
Primary
Secondary
Concomitant
Pneumonia Hospitalization 9/1/2009 69 Male 165 lb 12/13/2010 Consumer Netherlands
Primary
Concomitant
Somnolence Other Serious 1/1/2010 12/14/2010 Consumer Brazil
Primary
Secondary
Concomitant
Sinusitis Female 175 lb 11/5/2010 Other Health Professional United States
Primary
Concomitant
Sleep Disorder 12/1/2009 12/16/2010 Physician United States
Primary
Concomitant
Nasopharyngitis Other Serious 1/1/2010 73 Female 153 lb 12/17/2010 Physician United States
Primary
Concomitant
Therapeutic Response Decreased Other Serious 1/1/2010 54 Female 132 lb 12/17/2010 Other Health Professional Brazil
Primary
Concomitant
Pain In Extremity 1/1/2010 12/21/2010 Physician United States
Primary
Concomitant
Off Label Use 1/1/2008 63 Female 194 lb 11/6/2010 Consumer United States
Primary
Secondary
Concomitant
Pulmonary Embolism Hospitalization 11/1/2010 68 Female 240 lb 12/22/2010 Consumer United States
Primary
Concomitant
Acne 1/1/2010 12/22/2010 Consumer United States
Primary
Concomitant
Pneumonia Hospitalization 11/4/2010 63 Male 158 lb 12/23/2010 Physician South Africa
Primary
Concomitant
Breast Cancer Other Serious 7/2/2007 60 Female 106 lb 12/23/2010 Other Health Professional United Kingdom
Primary
Concomitant

Drug Data