Methotrexate combined with Tramadol Hydrochloride

Reports:

Reaction Outcome Event Date Age Sex Weight Reported Reporter Country Treatment
Role Name
Blood Pressure Decreased Death 2/13/2005 64 Male 223 lb 3/7/2006 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Toothache Other Serious 63 Female 132 lb 5/24/2006 Portugal
Primary
Concomitant
Swelling Other Serious 4/13/2006 51 Female 5/24/2006 Physician Portugal
Primary
Concomitant
Vomiting Hospitalization 6/1/2004 48 Female 163 lb 6/5/2006 Other Health Professional United Kingdom
Primary
Secondary
Toothache Other Serious 8/1/2005 63 Female 132 lb 6/8/2006 Portugal
Primary
Concomitant
Pericardial Effusion Hospitalization 10/1/2005 72 Female 6/27/2006 Other Health Professional Sweden
Primary
Secondary
Concomitant
Tooth Disorder Hospitalization 45 Female 154 lb 10/17/2007 Other Health Professional United Kingdom
Primary
Concomitant
Tooth Disorder Hospitalization 45 Female 154 lb 3/6/2008 Other Health Professional United Kingdom
Primary
Concomitant
Breast Cancer Other Serious 67 Female 7/9/2008 Physician United Kingdom
Primary
Secondary
Concomitant
Impaired Healing Hospitalization 1/1/2004 61 Male 8/6/2008 Physician Switzerland
Primary
Secondary
Concomitant
Meningitis Meningococcal Other Serious 10/1/2008 Male 176 lb 11/14/2008 United States
Primary
Concomitant
Meningitis Meningococcal Other Serious 10/1/2008 Male 176 lb 12/1/2008 United States
Primary
Concomitant
Osteolysis Hospitalization 3/14/2008 82 Female 12/8/2008 Other Health Professional Italy
Primary
Concomitant
Accidental Exposure 9/5/2008 Male 185 lb 12/12/2008 Consumer United States
Primary
Concomitant
Urticaria 10/15/2008 Female 12/12/2008 Physician United States
Primary
Concomitant
Urinary Tract Infection 11/1/2005 Female 12/12/2008 Consumer United States
Primary
Concomitant
Osteolysis Hospitalization 3/14/2008 82 Female 12/26/2008 Other Health Professional Italy
Primary
Concomitant
Hyperglycaemia Life Threatening 1/3/2009 67 Female 3/13/2009 Other Health Professional Germany
Primary
Secondary
Concomitant
Vaginal Infection Other Serious Female 135 lb 3/14/2009 Physician United States
Primary
Concomitant
Malaise 11/26/2008 Female 3/14/2009 United States
Primary
Concomitant
Injection Site Discomfort 6/1/2006 Female 193 lb 3/14/2009 United States
Primary
Concomitant
Pain In Extremity 11/1/2008 Female 3/14/2009 Consumer United States
Primary
Concomitant
Rheumatoid Arthritis Hospitalization 1/1/2008 44 Female 3/16/2009 Physician Israel
Primary
Concomitant
Haematuria Life Threatening 11/18/2007 Male 206 lb 4/9/2009 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Supraventricular Tachycardia Hospitalization 3/16/2009 57 Male 4/15/2009 Other Health Professional United Kingdom
Primary
Concomitant
Haematuria Other Serious 9/15/2008 Male 176 lb 4/15/2009 United Kingdom
Primary
Secondary
Concomitant
Haematuria Other Serious 9/15/2008 Male 206 lb 4/27/2009 United Kingdom
Primary
Secondary
Concomitant
Type 2 Diabetes Mellitus Other Serious 1/1/2004 53 Female 145 lb 7/14/2009 United States
Primary
Concomitant
Impaired Healing Hospitalization 1/1/2004 61 Male 9/11/2009 Physician Switzerland
Primary
Secondary
Concomitant
Surgery Hospitalization 1/1/2008 53 Female 10/22/2009 Consumer Germany
Primary
Concomitant
Syncope Other Serious 10/9/2009 84 Female 10/27/2009 Consumer Australia
Primary
Concomitant
Hypotension Hospitalization 8/1/2009 Female 119 lb 11/2/2009 Brazil
Primary
Secondary
Concomitant
Hemiplegia Other Serious 8/11/2009 16 Male 11/6/2009 Other Health Professional France
Primary
Secondary
Concomitant
Viith Nerve Injury Other Serious 52 Female 11/25/2009 United States
Primary
Secondary
Concomitant
Endometrial Cancer Life Threatening 5/29/2009 Female 201 lb 3/12/2010 United States
Primary
Concomitant
Endometrial Cancer Life Threatening 5/29/2009 57 Female 201 lb 4/30/2010 United States
Primary
Concomitant
Rheumatoid Arthritis Hospitalization 2/19/2008 64 Male 194 lb 5/20/2010 Consumer United Kingdom
Primary
Secondary
Concomitant
Progressive Multifocal Leukoencephalopathy Life Threatening 11/1/2008 41 Female 5/21/2010 Physician United States
Primary
Concomitant
Vision Blurred Other Serious 2/1/2010 52 Female 154 lb 5/27/2010 Brazil
Primary
Concomitant
Vision Blurred Other Serious 2/1/2010 52 Female 154 lb 5/28/2010 Brazil
Primary
Concomitant
Pneumonia Other Serious 5/1/2010 73 Female 158 lb 7/27/2010 Physician United States
Primary
Concomitant
Weight Decreased Other Serious 11/1/2008 76 Female 100 lb 7/27/2010 Consumer United States
Primary
Concomitant
Spinal Osteoarthritis Hospitalization 7/10/2010 76 Male 224 lb 7/28/2010 Physician United States
Primary
Secondary
Concomitant
Hemiparesis Hospitalization 6/4/2009 59 Male 112 lb 7/27/2010 Other Health Professional United Kingdom
Primary
Concomitant
Therapeutic Response Decreased Other Serious 1/1/2010 54 Female 132 lb 7/29/2010 Other Health Professional Brazil
Primary
Concomitant
Vein Pain Other Serious 2/11/2010 62 Female 199 lb 8/3/2010 Physician United States
Primary
Concomitant
Pulmonary Mass Hospitalization 6/3/2010 55 Female 8/3/2010 Physician Thailand
Primary
Secondary
Concomitant
Pneumonitis Life Threatening 5/1/2010 Female 125 lb 8/3/2010 Other Health Professional United Kingdom
Primary
Concomitant
Headache 5/3/2008 61 Female 238 lb 8/3/2010 Consumer United States
Primary
Concomitant
Weight Increased 1/1/2008 60 Female 142 lb 8/3/2010 Other Health Professional United States
Primary
Concomitant
Vomiting Other Serious 3/1/2010 80 Female 160 lb 8/4/2010 Consumer United States
Primary
Concomitant
Death Death 6/25/2010 84 Male 168 lb 8/11/2010 Physician United Kingdom
Primary
Secondary
Concomitant
Neoplasm Malignant Other Serious Female 8/23/2010 Other Health Professional Netherlands
Primary
Concomitant
Rheumatoid Arthritis Hospitalization 2/19/2008 64 Male 185 lb 8/26/2010 Consumer United Kingdom
Primary
Secondary
Concomitant
Pancreatitis Relapsing Other Serious 1/1/1998 51 Male 179 lb 9/17/2010 United States
Primary
Concomitant
Osteomyelitis Other Serious 7/27/2010 58 Female 150 lb 10/8/2010 Physician Canada
Primary
Concomitant
Endometrial Cancer Recurrent Life Threatening 5/29/2009 57 Female 201 lb 11/19/2010 Physician United States
Primary
Concomitant
Salivary Gland Adenoma Hospitalization 1/28/2006 64 Female 11/30/2010 Other Health Professional Austria
Primary
Concomitant
Endometrial Cancer Recurrent Life Threatening 5/29/2009 57 Female 201 lb 12/10/2010 Physician United States
Primary
Concomitant
Sinusitis 10/23/2009 12/13/2010 Consumer United States
Primary
Concomitant
Tooth Fracture 11/9/2009 12/14/2010 Consumer United States
Primary
Concomitant
Blister 11/24/2009 12/14/2010 Physician United States
Primary
Concomitant
Injection Site Swelling 10/1/2009 12/15/2010 Consumer United States
Primary
Concomitant
Therapeutic Response Decreased 10/1/2009 12/15/2010 Physician United States
Primary
Concomitant
Nodule On Extremity Hospitalization 2/25/2010 12/19/2010 Physician United States
Primary
Secondary
Concomitant
Sinusitis 3/8/2010 12/19/2010 Consumer United States
Primary
Concomitant
Pyrexia 3/9/2010 12/19/2010 Consumer United States
Primary
Concomitant
Rash Erythematous 12/19/2010 Consumer United States
Primary
Concomitant
Injection Site Pain 3/23/2010 12/21/2010 Consumer United States
Primary
Concomitant
Fatigue 4/19/2010 12/21/2010 Consumer United States
Primary
Concomitant
Injection Site Swelling 5/23/2010 12/22/2010 Consumer United States
Primary
Concomitant
Injection Site Reaction 1/7/2010 12/22/2010 Consumer United States
Primary
Concomitant
Abdominal Pain 4/17/2010 12/22/2010 Consumer United States
Primary
Concomitant
Nausea 6/22/2010 12/22/2010 Consumer United States
Primary
Concomitant
Injection Site Swelling 7/19/2010 12/22/2010 Consumer United States
Primary
Concomitant
Rash 6/22/2010 12/22/2010 Consumer United States
Primary
Concomitant
Sinusitis 5/27/2010 12/22/2010 Consumer United States
Primary
Concomitant
Pain In Extremity 7/23/2010 12/23/2010 Consumer United States
Primary
Concomitant
Injection Site Swelling 9/1/2010 12/23/2010 Consumer United States
Primary
Concomitant
Rash 9/13/2010 12/23/2010 Consumer United States
Primary
Concomitant
Hot Flush 9/16/2010 12/23/2010 Consumer United States
Primary
Concomitant
Tooth Abscess 12/23/2010 Consumer United States
Primary
Concomitant
Hyperglycaemia Life Threatening 1/1/2009 67 Female 256 lb 12/28/2010 Other Health Professional Germany
Primary
Secondary
Concomitant
Diverticular Perforation Hospitalization 3/7/2008 71 Male 176 lb 3/23/2011 Consumer United Kingdom
Primary
Concomitant
Dizziness Hospitalization 3/16/2011 37 Male 4/15/2011 Other Health Professional Japan
Primary
Secondary
Anaemia Hospitalization 8/4/2010 52 Male 4/15/2011 Other Health Professional France
Primary
Secondary
Concomitant
Constipation Life Threatening 3/25/2011 89 Male 102 lb 4/18/2011 Other Health Professional United Kingdom
Primary
Concomitant
Dizziness Hospitalization 3/16/2011 37 Male 4/19/2011 Other Health Professional Japan
Primary
Secondary
Cholecystitis Acute Life Threatening 8/4/2010 52 Male 4/19/2011 Other Health Professional France
Primary
Secondary
Concomitant
Injection Site Erythema 8/1/2010 45 Female 137 lb 5/11/2011 Consumer United States
Primary
Concomitant
Progressive Multifocal Leukoencephalopathy Disability 11/1/2008 41 Female 5/13/2011 Physician United States
Primary
Secondary
Concomitant
Loss Of Consciousness Death 1/1/2011 87 Female 5/17/2011 Consumer United States
Primary
Concomitant
Decreased Appetite Hospitalization 5/20/2011 62 Female 6/2/2011 Physician United States
Primary
Secondary
Concomitant
Pulmonary Thrombosis Hospitalization 4/20/2011 52 Female 6/3/2011 Physician Belgium
Primary
Concomitant
Influenza Like Illness Other Serious 9/19/2010 53 Male 6/3/2011 Consumer Canada
Primary
Concomitant
Pain Other Serious 3/25/2011 56 Male 7/7/2011 Physician United States
Primary
Secondary
Concomitant
Spinal Column Stenosis Life Threatening 4/1/2011 58 Male 154 lb 7/20/2011 Physician Germany
Primary
Concomitant
Erysipelas Other Serious 1/1/2010 70 Male 176 lb 7/27/2011 Consumer Brazil
Primary
Concomitant
Loss Of Consciousness Hospitalization 5/17/2011 25 Male 8/10/2011 Other Health Professional France
Primary
Concomitant
Urinary Tract Infection Other Serious 1/1/2011 56 Female 117 lb 8/25/2011 Consumer United Kingdom
Primary
Concomitant
Failure To Thrive Other Serious 7/25/2011 67 Male 182 lb 9/2/2011 Physician United States
Primary
Concomitant
Swelling Face Other Serious 8/24/2011 54 Male 176 lb 9/2/2011 Physician United States
Primary
Secondary
Concomitant
Somnolence Other Serious 8/1/2008 56 Female 141 lb 9/6/2011 Consumer United States
Primary
Secondary
Concomitant
Fatigue 9/30/2010 60 Female 9/7/2011 Physician Canada
Primary
Secondary
Concomitant
Blood Pressure Fluctuation Other Serious 8/1/2010 57 Female 128 lb 9/7/2011 Consumer Brazil
Primary
Secondary
Concomitant
Asthenia Other Serious 1/1/2008 71 Female 9/7/2011 Consumer United States
Primary
Concomitant
Respiratory Alkalosis Hospitalization 8/19/2011 29 Female 183 lb 9/7/2011 Consumer Brazil
Primary
Concomitant
Syncope Other Serious 78 Female 9/8/2011 Consumer United States
Primary
Concomitant
Drug Dose Omission Other Serious 11/22/2010 66 Female 164 lb 9/8/2011 Physician United States
Primary
Concomitant
Arthropathy Hospitalization 8/1/2010 57 Female 128 lb 9/13/2011 Physician Brazil
Primary
Secondary
Concomitant
Respiratory Tract Infection Other Serious 1/1/2008 76 Female 9/26/2011 Consumer Australia
Primary
Concomitant
Hyperglycaemia Life Threatening 1/3/2009 67 Female 256 lb 9/27/2011 Other Health Professional Germany
Primary
Secondary
Concomitant
Pain Hospitalization 8/1/2010 57 Female 128 lb 10/17/2011 Brazil
Primary
Secondary
Concomitant
Varicose Vein Ruptured Hospitalization 1/1/2010 70 Male 176 lb 11/10/2011 Consumer Brazil
Primary
Concomitant
Depression Other Serious 9/27/2011 40 Female 176 lb 11/23/2011 Physician Brazil
Primary
Concomitant
Fracture Other Serious 9/27/2011 40 Female 176 lb 12/1/2011 Physician Brazil
Primary
Concomitant
Colorectal Cancer Metastatic Life Threatening 11/8/2011 79 Female 187 lb 1/6/2012 Physician Netherlands
Primary
Secondary
Concomitant
Intervertebral Disc Protrusion Hospitalization 1/1/2011 56 Female 117 lb 1/20/2012 Consumer Brazil
Primary
Concomitant
Pneumonia Other Serious 65 Female 2/9/2012 Consumer Brazil
Primary
Secondary
Concomitant
Aphonia Hospitalization 1/1/2010 70 Male 176 lb 4/13/2012 Physician Brazil
Primary
Concomitant
Herpes Zoster Other Serious 1/1/2011 65 Female 171 lb 4/20/2012 Consumer United States
Primary
Concomitant
Laboratory Test Abnormal Death Male 183 lb 5/9/2012 Consumer United States
Primary
Concomitant
Myocardial Infarction Hospitalization 12/4/2007 59 Female 186 lb 5/9/2012 Lawyer United States
Primary
Concomitant
Hypertensive Crisis Other Serious 5/24/2011 48 Female 165 lb 5/10/2012 Physician Germany
Primary
Secondary
Concomitant
Tooth Extraction Hospitalization 10/1/2011 59 Female 135 lb 5/11/2012 Consumer United States
Primary
Concomitant
Urticaria Other Serious 3/19/2012 77 Female 5/11/2012 Physician France
Primary
Concomitant
Pleural Mesothelioma Other Serious 3/26/2011 54 Male 190 lb 5/15/2012 Physician Denmark
Primary
Secondary
Concomitant
Drug Interaction Other Serious 5/16/2012 Pharmacist Australia
Primary
Interacting
Nervousness Other Serious 1/1/2012 51 Female 172 lb 5/17/2012 Other Health Professional United States
Primary
Concomitant
Ovarian Mass Other Serious 6/29/2011 61 Female 185 lb 5/18/2012 Consumer United States
Primary
Secondary
Concomitant
Pleural Mesothelioma Other Serious 3/26/2011 54 Male 190 lb 5/21/2012 Other Health Professional Denmark
Primary
Secondary
Concomitant
Tendon Rupture Hospitalization 1/1/2012 47 Female 235 lb 5/22/2012 Physician United Kingdom
Primary
Concomitant
Rheumatoid Arthritis 5/22/2012 Consumer United States
Primary
Concomitant
Immunodeficiency Other Serious 12/1/2011 68 Female 5/23/2012 Other Health Professional Colombia
Primary
Concomitant
Abscess Limb Other Serious Female 5/24/2012 Other Health Professional United Kingdom
Primary
Concomitant
Constipation Other Serious Female 5/24/2012 Other Health Professional Poland
Primary
Secondary
Muscle Rigidity Other Serious 3/1/2012 43 Female 123 lb 5/29/2012 Consumer Brazil
Primary
Concomitant
Arthritis Other Serious 11/18/1998 57 Female 174 lb 6/25/2012 Physician United States
Primary
Secondary
Concomitant
Breast Cancer Hospitalization 2/24/2012 54 Female 251 lb 6/26/2012 Physician Germany
Primary
Concomitant
Adverse Reaction Hospitalization 1/1/2011 56 Female 148 lb 7/5/2012 Physician United States
Primary
Concomitant
General Physical Health Deterioration Hospitalization 5/15/2012 29 Female 180 lb 7/3/2012 United States
Primary
Concomitant
Cytomegalovirus Test Positive Hospitalization 4/1/2012 66 Female 7/19/2012 Physician Switzerland
Primary
Secondary
Concomitant
Interacting
Hypertensive Crisis Other Serious 5/24/2011 48 Female 165 lb 7/19/2012 Physician Germany
Primary
Secondary
Concomitant
Renal Failure Acute Death 6/2/2012 79 Female 122 lb 7/19/2012 Pharmacist United Kingdom
Primary
Secondary
Concomitant
Lymphadenopathy Hospitalization 1/1/2012 54 Female 307 lb 7/19/2012 Physician United States
Primary
Concomitant
Fatigue Hospitalization 5/28/2012 62 Male 7/20/2012 Consumer Germany
Primary
Secondary
Concomitant
Renal Failure Acute Death 6/2/2012 79 Female 122 lb 7/24/2012 Pharmacist United Kingdom
Primary
Secondary
Concomitant
Haemoglobin Decreased Death 6/2/2012 79 Female 122 lb 7/25/2012 Pharmacist United Kingdom
Primary
Secondary
Concomitant
Stevens-johnson Syndrome Death 6/2/2012 79 Female 122 lb 7/25/2012 Pharmacist United Kingdom
Primary
Secondary
Concomitant
Haemoglobin Decreased Death 6/2/2012 79 Female 122 lb 7/25/2012 Pharmacist United Kingdom
Primary
Secondary
Concomitant

Drug Data