Methotrexate combined with Toprol-XL

Reports:

Reaction Outcome Event Date Age Sex Weight Reported Reporter Country Treatment
Role Name
Pulmonary Oedema Death 1/1/2005 Male 215 lb 1/9/2006 Other Health Professional United States
Primary
Concomitant
Treatment Noncompliance Other Serious 1/1/2005 44 Female 1/4/2006 Other Health Professional United States
Primary
Concomitant
Weight Decreased Other Serious 11/10/1999 39 Female 139 lb 1/10/2006 Physician United States
Primary
Concomitant
Skin Cancer Other Serious 4/1/2004 Female 148 lb 1/26/2006 Physician United States
Primary
Concomitant
Pleural Effusion Death 1/1/2005 Male 215 lb 1/31/2006 Other Health Professional United States
Primary
Concomitant
Vasospasm Other Serious 7/1/2002 42 Female 161 lb 2/6/2006 Physician United States
Primary
Concomitant
Myocardial Infarction Other Serious 1/1/2002 57 Male 225 lb 2/22/2006 Lawyer United States
Primary
Concomitant
Pneumonia Other Serious 1/1/2002 57 Male 225 lb 2/27/2006 Physician United States
Primary
Concomitant
Coronary Artery Disease Death Female 3/1/2006 Physician United States
Primary
Concomitant
Sleep Disorder Other Serious 1/1/2003 54 Male 201 lb 3/13/2006 Lawyer United States
Primary
Concomitant
Vision Blurred Hospitalization 10/29/2005 54 Male 21 lb 3/8/2006 Other Health Professional United States
Primary
Concomitant
Vision Blurred Other Serious 10/29/2005 54 Male 210 lb 3/8/2006 Other Health Professional United States
Primary
Concomitant
Sleep Disorder Other Serious 1/1/2003 54 Male 201 lb 3/23/2006 Lawyer United States
Primary
Concomitant
Staphylococcal Infection Hospitalization 1/1/2002 61 Female 198 lb 3/20/2006 Consumer United States
Primary
Concomitant
Urinary Incontinence Hospitalization 1/1/2000 58 Female 141 lb 3/28/2006 Physician United States
Primary
Concomitant
Pneumonia Other Serious 1/1/2002 57 Male 225 lb 3/29/2006 Physician United States
Primary
Concomitant
Myocardial Infarction Other Serious 4/10/2003 77 Female 154 lb 4/4/2006 Lawyer United States
Primary
Concomitant
Urinary Incontinence Hospitalization 54 Male 4/5/2006 Physician United States
Primary
Concomitant
Basal Cell Carcinoma Other Serious 7/1/2005 Female 4/14/2006 Physician United States
Primary
Concomitant
Systemic Lupus Erythematosus Other Serious 5/9/2005 Female 4/17/2006 Physician United States
Primary
Concomitant
Sleep Disorder Other Serious 1/1/2003 54 Male 201 lb 4/20/2006 Lawyer United States
Primary
Concomitant
Vasospasm Other Serious 7/1/2002 42 Female 148 lb 4/20/2006 Physician United States
Primary
Concomitant
White Blood Cell Count Decreased Hospitalization 3/23/2006 Female 4/21/2006 Physician United States
Primary
Secondary
Concomitant
Supraventricular Tachycardia Hospitalization 6/3/2002 70 Male 130 lb 4/25/2006 Physician United States
Primary
Secondary
Concomitant
Sudden Cardiac Death Death 8/20/2001 63 Female 198 lb 4/26/2006 Lawyer United States
Primary
Concomitant
Pulpitis Dental Other Serious 77 Female 5/4/2006 Other Health Professional United States
Primary
Concomitant
Yellow Skin Other Serious 4/1/1997 Female 5/10/2006 Consumer United States
Primary
Secondary
Concomitant
Thrombosis Hospitalization 8/22/2002 63 Male 198 lb 5/10/2006 Lawyer United States
Primary
Concomitant
Staphylococcal Infection Hospitalization 3/23/2006 Female 5/11/2006 Physician United States
Primary
Secondary
Concomitant
Pulmonary Congestion Other Serious 3/10/2003 44 Male 238 lb 5/12/2006 Physician United States
Primary
Concomitant
White Blood Cell Count Decreased Hospitalization 3/23/2006 Female 5/19/2006 Physician United States
Primary
Secondary
Concomitant
Hair Texture Abnormal 10/1/2005 58 Female 3/23/2006 Consumer United States
Primary
Concomitant
Yellow Skin Other Serious 4/1/1997 Female 5/31/2006 Physician United States
Primary
Secondary
Concomitant
Cryptococcosis Hospitalization 11/3/2005 72 Male 195 lb 5/30/2006 Other Health Professional United States
Primary
Concomitant
Infusion Related Reaction Hospitalization 1/3/2006 Female 338 lb 6/2/2006 Physician United States
Primary
Concomitant
Squamous Cell Carcinoma Other Serious 11/1/2005 Male 6/9/2006 Physician United States
Primary
Concomitant
Colitis Hospitalization 11/1/2005 Female 6/9/2006 Physician United States
Primary
Concomitant
Tongue Disorder 1/1/2006 56 Female 6/21/2006 Consumer United States
Primary
Concomitant
Vasculitic Rash Other Serious 12/18/2001 Female 118 lb 6/28/2006 Physician United States
Primary
Concomitant
Lipase Increased Other Serious 4/1/2006 Female 6/30/2006 Consumer United States
Primary
Secondary
Concomitant
Weight Increased Other Serious 1/1/2006 66 Female 6/5/2006 United States
Primary
Secondary
Concomitant
Punctate Keratitis Other Serious 5/23/2006 Female 8/1/2006 Physician United States
Primary
Secondary
Concomitant
Tachycardia Other Serious 2/1/2006 Female 8/18/2006 Physician United States
Primary
Concomitant
Small Intestinal Obstruction Hospitalization 7/23/2006 84 Female 135 lb 8/14/2006 Consumer United States
Primary
Concomitant
Small Intestinal Obstruction Hospitalization 7/23/2006 84 Female 135 lb 8/24/2006 Physician United States
Primary
Concomitant
Pleural Effusion Other Serious 2/1/2006 Male 9/11/2006 Physician United States
Primary
Concomitant
Lipase Increased Other Serious 4/1/2006 68 Female 9/21/2006 Consumer United States
Primary
Secondary
Concomitant
Rheumatoid Arthritis Other Serious Female 150 lb 10/16/2006 United States
Primary
Secondary
Concomitant
Pyrexia 1/1/2003 Male 8/22/2006 United States
Primary
Concomitant
Gastrointestinal Haemorrhage Hospitalization 6/11/2006 70 Male 12/6/2006 Consumer United States
Primary
Secondary
Concomitant
Myelodysplastic Syndrome Unclassifiable Death Female 12/8/2006 Physician United States
Primary
Concomitant
Renal Artery Stent Placement Hospitalization 5/1/2006 Female 157 lb 12/8/2006 Physician United States
Primary
Concomitant
Pneumonia Hospitalization 5/1/2006 Female 12/11/2006 Physician United States
Primary
Concomitant
Myocardial Infarction Hospitalization 5/15/2005 Male 248 lb 12/13/2006 Physician United States
Primary
Concomitant
Myocardial Infarction Hospitalization 4/7/2006 Male 12/13/2006 Other Health Professional United States
Primary
Concomitant
Skin Cancer Other Serious 2/1/2006 Male 12/21/2006 Physician United States
Primary
Concomitant
Psoriasis Female 245 lb 12/21/2006 Other Health Professional United States
Primary
Concomitant
Muscle Spasms 9/1/2006 78 Female 159 lb 12/22/2006 Consumer United States
Primary
Concomitant
Lipase Increased Other Serious 4/1/2006 68 Female 12/19/2006 Consumer United States
Primary
Secondary
Concomitant
Therapeutic Response Unexpected With Drug Substitution Other Serious 1/1/2006 Female 134 lb 12/28/2006 Other Health Professional United States
Primary
Concomitant
Lipase Increased Other Serious 4/1/2006 68 Female 12/19/2006 Consumer United States
Primary
Secondary
Concomitant
Pneumonitis Other Serious 3/7/2006 76 Female 10/7/2006 Other Health Professional United States
Primary
Concomitant
Sick Sinus Syndrome Other Serious 8/14/2006 Female 199 lb 1/10/2007 Physician United States
Primary
Concomitant
Bladder Cancer Other Serious 10/23/2006 57 Male 1/10/2007 Other Health Professional United States
Primary
Secondary
Concomitant
Injection Site Reaction Other Serious 5/3/2006 59 Female 130 lb 6/30/2006 Consumer United States
Primary
Concomitant
Osteonecrosis Other Serious 2/9/2005 69 Female 130 lb 11/28/2006 Other Health Professional United States
Primary
Concomitant
Basal Cell Carcinoma Other Serious 3/1/2006 Male 260 lb 1/25/2007 Physician United States
Primary
Concomitant
Lung Infiltration Hospitalization 1/1/2006 Female 127 lb 1/25/2007 Physician United States
Primary
Concomitant
Vomiting Hospitalization 2/26/2006 Female 171 lb 1/25/2007 Physician United States
Primary
Concomitant
Tremor Other Serious 1/1/2006 Female 1/25/2007 Physician United States
Primary
Secondary
Concomitant
Coronary Artery Disease Hospitalization 3/19/2006 Male 200 lb 1/26/2007 Physician United States
Primary
Concomitant
Rheumatoid Arthritis Hospitalization 1/1/2006 Female 168 lb 2/15/2007 Consumer United States
Primary
Concomitant
Splenomegaly Other Serious 2/24/2007 51 Male 300 lb 3/8/2007 Physician United States
Primary
Concomitant
Gastrointestinal Haemorrhage Hospitalization 6/11/2006 70 Male 3/13/2007 Consumer United States
Primary
Secondary
Concomitant
Coronary Artery Occlusion Life Threatening 1/12/2007 72 Female 226 lb 3/8/2007 Physician United States
Primary
Concomitant
Urticaria Other Serious 1/1/2005 56 Female 270 lb 3/31/2006 United States
Primary
Concomitant
Sweat Discolouration 64 Male 3/27/2007 Physician United States
Primary
Concomitant
Hyperhidrosis 62 Male 185 lb 3/27/2007 Physician United States
Primary
Concomitant
Pre-existing Condition Improved 1/1/2007 50 Female 201 lb 3/27/2007 Consumer United States
Primary
Concomitant
Palpitations 54 Female 196 lb 3/27/2007 Consumer United States
Primary
Concomitant
Respiratory Disorder Hospitalization 10/9/2006 Female 3/28/2007 Physician United States
Primary
Concomitant
Coronary Artery Occlusion Life Threatening 1/12/2007 72 Female 226 lb 3/21/2007 Other Health Professional United States
Primary
Concomitant
Dyspnoea Hospitalization 12/5/2006 Female 4/5/2007 Physician United States
Primary
Concomitant
Vomiting Other Serious 11/29/2006 75 Male 4/26/2007 Consumer United States
Primary
Concomitant
Gastrointestinal Haemorrhage Hospitalization 6/11/2006 70 Male 5/10/2007 Consumer United States
Primary
Secondary
Concomitant
Small Intestinal Obstruction Hospitalization 1/1/2007 Female 5/15/2007 Physician United States
Primary
Secondary
Concomitant
Somnolence Other Serious 5/1/2007 53 Female 210 lb 5/24/2007 Consumer United States
Primary
Concomitant
Procedural Complication Hospitalization 3/1/2007 Female 187 lb 6/14/2007 Physician United States
Primary
Concomitant
Lung Neoplasm Hospitalization 3/27/2007 Male 205 lb 6/18/2007 Physician United States
Primary
Secondary
Concomitant
Palpitations 2/23/2007 54 Female 196 lb 6/25/2007 Consumer United States
Primary
Concomitant
Fatigue 38 Female 249 lb 6/25/2007 Consumer United States
Primary
Concomitant
Intention Tremor 1/13/2007 75 Female 5/7/2007 Pharmacist United States
Primary
Concomitant
Bowen's Disease Other Serious 6/1/2005 83 Female 7/5/2007 Other Health Professional United States
Primary
Concomitant
Chest Pain Hospitalization 2/14/2005 44 Male 262 lb 8/3/2007 Physician United States
Primary
Concomitant
Cerebrovascular Accident Other Serious 12/5/2004 70 Female 7/9/2007 Consumer United States
Primary
Concomitant
Liver Function Test Abnormal Other Serious 2/28/2006 Female 171 lb 9/10/2007 Physician United States
Primary
Concomitant
Cough 1/1/2004 Female 9/19/2007 Physician United States
Primary
Concomitant
Rash Other Serious 9/6/2007 Female 148 lb 9/12/2007 Other Health Professional United States
Primary
Concomitant
Rheumatoid Lung Hospitalization 8/1/2007 82 Female 154 lb 10/4/2007 Consumer United States
Primary
Concomitant
Headache 2/1/2004 Male 10/12/2007 Consumer United States
Primary
Concomitant
Headache 2/1/2004 Male 11/2/2007 Consumer United States
Primary
Concomitant
Pulmonary Embolism Other Serious 150 lb 11/15/2007 Physician United States
Primary
Concomitant
Lung Infiltration Hospitalization 3/27/2007 Male 205 lb 11/20/2007 Physician United States
Primary
Secondary
Concomitant
Pulmonary Embolism Other Serious 9/1/2007 Female 150 lb 11/29/2007 Physician United States
Primary
Concomitant
Rash Other Serious 11/10/2006 Female 221 lb 12/6/2007 Physician United States
Primary
Concomitant
Squamous Cell Carcinoma Of Skin Other Serious 8/8/2007 Female 144 lb 12/6/2007 Physician United States
Primary
Concomitant
Prostate Cancer Other Serious 1/1/2007 Male 267 lb 12/6/2007 Physician United States
Primary
Concomitant
Weight Increased Female 12/11/2007 Consumer United States
Primary
Concomitant
Spinal Fracture 5/1/2007 Male 159 lb 12/12/2007 Physician United States
Primary
Concomitant
Sinusitis 1/1/2006 Female 12/15/2007 Physician United States
Primary
Secondary
Concomitant
Bowen's Disease Other Serious 4/1/2007 83 Female 12/17/2007 Other Health Professional United States
Primary
Concomitant
Drug Ineffective 8/22/2007 68 Female 201 lb 12/21/2007 Consumer United States
Primary
Concomitant
Skin Hyperpigmentation 10/1/2007 48 Male 209 lb 12/21/2007 Consumer United States
Primary
Concomitant
Urticaria 10/16/2007 48 Male 209 lb 12/21/2007 Consumer United States
Primary
Concomitant
Osteonecrosis Other Serious 2/9/2005 69 Female 130 lb 11/28/2007 Other Health Professional United States
Primary
Concomitant
Myocardial Infarction Death 12/26/2007 Female 254 lb 1/14/2008 Other Health Professional United States
Primary
Concomitant
Splenomegaly Other Serious 6/1/2007 Female 144 lb 1/24/2008 Physician United States
Primary
Secondary
Concomitant
Bowen's Disease Other Serious 4/1/2007 85 Female 2/5/2008 Other Health Professional United States
Primary
Concomitant
Small Intestinal Obstruction Other Serious 12/19/2007 72 Female 150 lb 2/6/2008 Physician United States
Primary
Concomitant
Ventricular Extrasystoles Hospitalization 9/5/2007 48 Male 200 lb 3/27/2008 Physician United States
Primary
Concomitant
Hemiparesis Hospitalization 1/30/2008 57 Female 249 lb 4/3/2008 Other Health Professional United States
Primary
Concomitant
Drug Screen Positive 4/18/2008 Consumer United States
Primary
Concomitant
Weight Decreased Life Threatening 10/1/2007 Male 4/23/2008 Consumer United States
Primary
Secondary
Concomitant
Stent Placement Hospitalization Male 4/24/2008 Physician United States
Primary
Concomitant
Incorrect Route Of Drug Administration 4/25/2007 45 Female 4/28/2008 Consumer United States
Primary
Concomitant
Withdrawal Syndrome 9/21/2007 5/13/2008 Consumer United States
Primary
Concomitant
Sinusitis Other Serious 5/1/1999 Female 5/28/2008 Physician United States
Primary
Concomitant
Muscle Spasms 5/1/2008 58 Female 240 lb 6/30/2008 Other Health Professional United States
Primary
Concomitant
Tremor Other Serious Female 7/2/2008 Physician United States
Primary
Secondary
Concomitant
Amyotrophic Lateral Sclerosis Death 7/3/2008 Female 162 lb 7/13/2008 Physician United States
Primary
Concomitant
Hypoaesthesia Hospitalization Male 7/18/2008 Consumer United States
Primary
Concomitant
Squamous Cell Carcinoma Of Skin Other Serious 8/8/2007 Female 144 lb 8/4/2008 Physician United States
Primary
Concomitant
Squamous Cell Carcinoma Of Skin Other Serious 8/8/2007 Female 143 lb 8/12/2008 Physician United States
Primary
Concomitant
Extradural Abscess Hospitalization Female 8/15/2008 Physician United States
Primary
Secondary
Concomitant
Lower Gastrointestinal Haemorrhage Hospitalization 3/30/2008 63 Male 148 lb 6/24/2008 Pharmacist United States
Primary
Concomitant
Endocrine Ophthalmopathy Other Serious 7/1/2008 Female 242 lb 9/15/2008 Physician United States
Primary
Concomitant
Infusion Related Reaction Hospitalization 11/12/2007 Male 275 lb 9/22/2008 Physician United States
Primary
Concomitant
Muscle Spasms 5/15/2008 58 Female 240 lb 9/25/2008 Other Health Professional United States
Primary
Concomitant
Wound Dehiscence Other Serious 6/1/2008 Female 10/2/2008 Physician United States
Primary
Concomitant
Dementia Other Serious 1/1/2006 Female 126 lb 11/4/2008 Physician United States
Primary
Concomitant
Squamous Cell Carcinoma Of Skin Other Serious 11/28/2005 Male 11/25/2008 Physician United States
Primary
Concomitant
Weight Increased Hospitalization 2/28/2005 Female 167 lb 12/5/2008 Physician United States
Primary
Concomitant
Sarcoidosis Hospitalization 8/5/2008 Female 197 lb 12/8/2008 Physician United States
Primary
Concomitant
Stress 4/29/2008 Male 200 lb 12/11/2008 Physician United States
Primary
Concomitant
Alopecia 5/1/2008 68 Female 12/17/2008 United States
Primary
Concomitant
Weight Increased Hospitalization 2/28/2005 Female 167 lb 12/23/2008 Physician United States
Primary
Concomitant
Rheumatoid Arthritis Other Serious 9/9/2008 66 Female 12/31/2008 Consumer United States
Primary
Concomitant
Carpal Tunnel Syndrome Other Serious 11/1/2008 Female 125 lb 1/27/2009 Physician United States
Primary
Concomitant
Tricuspid Valve Incompetence Other Serious 1/1/2008 Male 185 lb 2/9/2009 Physician United States
Primary
Concomitant
Pyrexia Hospitalization 83 Male 2/13/2009 Pharmacist United States
Primary
Concomitant

Drug Data