Methotrexate combined with Tocilizumab

Reports:

Reaction Outcome Event Date Age Sex Weight Reported Reporter Country Treatment
Role Name
Pulmonary Embolism Hospitalization 12/14/2005 58 Female 138 lb 3/3/2006 Physician China
Primary
Secondary
Vomiting Hospitalization 7/28/2006 64 Female 157 lb 8/18/2006 Physician Canada
Primary
Secondary
Concomitant
Thalamic Infarction Hospitalization 11/29/2005 53 Female 159 lb 9/15/2006 Physician Japan
Primary
Secondary
Concomitant
Vomiting Other Serious 10/5/2006 9 Female 40 lb 12/2/2007 United Kingdom
Primary
Secondary
Concomitant
Vomiting Hospitalization 10/5/2006 9 Female 41 lb 11/29/2007 United Kingdom
Primary
Concomitant
Vomiting Other Serious 10/5/2006 9 Female 41 lb 12/1/2007 Consumer United Kingdom
Primary
Secondary
Concomitant
Vomiting Other Serious 10/5/2006 9 Female 41 lb 11/30/2007 United Kingdom
Primary
Secondary
Concomitant
Pulmonary Embolism Death 11/21/2007 Female 143 lb 1/8/2008 Physician United Kingdom
Primary
Concomitant
Spinal Fracture Hospitalization 12/31/2006 73 Female 2/8/2008 Germany
Primary
Secondary
Concomitant
Aspergillosis Hospitalization 7/19/2007 65 Male 5/15/2008 Other Health Professional United Kingdom
Primary
Secondary
Aspergillosis Hospitalization 7/19/2007 65 Male 8/20/2008 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Pancytopenia Hospitalization 4/29/2009 Female 137 lb 5/14/2009 Physician France
Primary
Secondary
Concomitant
Pancytopenia Hospitalization 4/29/2009 Female 137 lb 6/5/2009 Physician France
Primary
Secondary
Concomitant
Non-hodgkin's Lymphoma Hospitalization 5/7/2009 Male 274 lb 6/18/2009 Physician United States
Primary
Secondary
Concomitant
Tuberculosis Test Positive Other Serious 6/29/2008 Female 115 lb 7/9/2009 Physician Japan
Primary
Secondary
Concomitant
Non-hodgkin's Lymphoma Hospitalization 5/7/2009 Male 274 lb 8/7/2009 Physician United States
Primary
Secondary
Concomitant
Respiratory Failure Death 11/21/2007 Female 9/11/2009 Germany
Primary
Concomitant
Respiratory Failure Death 11/21/2007 Female 9/14/2009 Germany
Primary
Concomitant
Respiratory Failure Death 11/21/2007 Female 143 lb 9/15/2009 Physician Germany
Primary
Concomitant
Respiratory Failure Hospitalization 11/21/2007 Female 10/13/2009 Germany
Primary
Concomitant
Alveolitis Other Serious 3/1/2009 Female 164 lb 10/27/2009 Physician United States
Primary
Secondary
Concomitant
Endometrial Cancer Metastatic Other Serious Female 261 lb 10/30/2009 Physician United States
Primary
Secondary
Concomitant
Malignant Pleural Effusion Hospitalization 10/20/2009 Female 150 lb 1/5/2010 Physician United States
Primary
Secondary
Concomitant
Osteomyelitis Hospitalization 12/15/2009 Female 158 lb 1/14/2010 Physician United States
Primary
Secondary
Concomitant
Tremor Hospitalization 10/1/2009 Female 176 lb 1/15/2010 Physician Bulgaria
Primary
Secondary
Concomitant
Quadriparesis Hospitalization 1/1/2010 Female 1/15/2010 Physician Japan
Primary
Secondary
Concomitant
Cytolytic Hepatitis Hospitalization 3/12/2009 38 Female 1/15/2010 Physician France
Primary
Concomitant
Breast Cancer Other Serious 12/14/2009 Female 205 lb 1/15/2010 Physician Greece
Primary
Concomitant
Pyrexia Hospitalization 8/1/2009 Male 154 lb 1/18/2010 Physician Brazil
Primary
Secondary
Concomitant
Pyelonephritis Hospitalization 12/14/2009 Female 1/18/2010 Physician Japan
Primary
Concomitant
Tremor Hospitalization 10/1/2009 Female 176 lb 1/18/2010 Physician Bulgaria
Primary
Secondary
Concomitant
Calculus Urinary Hospitalization 3/1/2007 Female 159 lb 1/21/2010 Physician Argentina
Primary
Secondary
Concomitant
Cerebral Haemorrhage Other Serious 11/16/2009 Female 1/21/2010 Physician Japan
Primary
Concomitant
Pyrexia Hospitalization 8/1/2009 Male 154 lb 1/21/2010 Physician United Kingdom
Primary
Secondary
Concomitant
Oesophageal Neoplasm Life Threatening 10/15/2009 Female 84 lb 1/22/2010 Physician Argentina
Primary
Secondary
Cardiac Arrest Death 10/16/2009 Male 245 lb 1/22/2010 Physician Greece
Primary
Concomitant
Laboratory Test Abnormal Other Serious 1/6/2010 Female 148 lb 1/22/2010 Physician United States
Primary
Secondary
Concomitant
Renal Impairment Other Serious 8/7/2008 Male 117 lb 1/22/2010 Physician Japan
Primary
Secondary
Concomitant
Subdural Haematoma Hospitalization 12/6/2009 Female 117 lb 1/25/2010 Physician Mexico
Primary
Secondary
Concomitant
Breast Cancer Hospitalization 12/14/2009 Female 205 lb 1/25/2010 Physician Greece
Primary
Concomitant
Renal Disorder Other Serious 7/28/2009 Female 154 lb 1/25/2010 Consumer Brazil
Primary
Concomitant
Pyrexia Hospitalization 1/1/2009 Male 154 lb 1/25/2010 Physician Brazil
Primary
Secondary
Concomitant
Bronchopneumonia Other Serious 7/6/2009 Female 1/25/2010 Physician Japan
Primary
Secondary
Concomitant
Pharyngeal Ulceration Hospitalization 12/1/2009 Male 142 lb 1/26/2010 Physician United States
Primary
Concomitant
Calculus Urinary Hospitalization 3/1/2007 Female 159 lb 1/27/2010 Physician Argentina
Primary
Secondary
Concomitant
Upper Respiratory Tract Inflammation Hospitalization 9/29/2008 Female 130 lb 1/27/2010 Physician Japan
Primary
Concomitant
Bladder Cancer Other Serious 12/3/2009 Male 176 lb 1/27/2010 Physician Italy
Primary
Secondary
Concomitant
Subdural Haematoma Hospitalization 12/6/2009 Female 117 lb 1/29/2010 Physician Mexico
Primary
Secondary
Concomitant
Intestinal Ulcer Other Serious 6/29/2008 Male 2/1/2010 Physician Japan
Primary
Secondary
Concomitant
Upper Respiratory Tract Inflammation Hospitalization 6/6/2008 Female 49 lb 2/1/2010 Physician Japan
Primary
Concomitant
White Blood Cell Count Decreased Other Serious 4/21/2009 Female 2/1/2010 Physician Japan
Primary
Concomitant
Lung Neoplasm Life Threatening 10/16/2009 Female 150 lb 2/1/2010 Physician Brazil
Primary
Concomitant
Tremor Hospitalization 10/1/2009 Female 176 lb 2/1/2010 Physician Bulgaria
Primary
Secondary
Concomitant
Pyrexia Hospitalization 1/1/2009 Male 154 lb 2/1/2010 Physician United Kingdom
Primary
Secondary
Concomitant
Streptococcal Infection Other Serious 8/6/2008 Female 180 lb 2/2/2010 Physician United States
Primary
Concomitant
Renal Neoplasm Other Serious 10/15/2009 Female 161 lb 2/2/2010 Physician United Kingdom
Primary
Secondary
Concomitant
Pneumonia Hospitalization 6/26/2009 Female 2/2/2010 Physician Japan
Primary
Secondary
Concomitant
Interstitial Lung Disease Hospitalization Female 2/2/2010 Physician Japan
Primary
Secondary
Lung Neoplasm Other Serious 11/25/2009 Male 196 lb 2/2/2010 Physician United Kingdom
Primary
Secondary
Concomitant
Renal Impairment Other Serious 8/7/2008 Male 117 lb 2/2/2010 Physician Japan
Primary
Secondary
Concomitant
Carpal Tunnel Syndrome Hospitalization 2/15/2009 48 Female 2/3/2010 Germany
Primary
Concomitant
Pneumonia Hospitalization 3/12/2008 Female 194 lb 2/3/2010 Physician United States
Primary
Secondary
Concomitant
Pyrexia Hospitalization 1/1/2009 Male 154 lb 2/4/2010 Physician Brazil
Primary
Secondary
Concomitant
Aortic Aneurysm Hospitalization Female 200 lb 2/4/2010 Physician United States
Primary
Concomitant
Renal Neoplasm Other Serious 10/12/2009 Female 161 lb 2/5/2010 Physician United Kingdom
Primary
Secondary
Concomitant
Breast Cancer Hospitalization 12/14/2009 Female 205 lb 2/5/2010 Physician Greece
Primary
Concomitant
Respiratory Failure Hospitalization 11/21/2007 Female 2/5/2010 Germany
Primary
Concomitant
Cholelithiasis Hospitalization 12/17/2009 Male 224 lb 2/8/2010 Physician Canada
Primary
Concomitant
Pulmonary Embolism Hospitalization 11/21/2009 Female 481 lb 2/8/2010 Physician United States
Primary
Secondary
Concomitant
Respiratory Failure Hospitalization 11/21/2007 Female 2/8/2010 Germany
Primary
Concomitant
Bursitis Infective Hospitalization 8/1/2009 Female 148 lb 2/9/2010 Physician Netherlands
Primary
Concomitant
Lymphoma Hospitalization 9/22/2009 Female 99 lb 2/9/2010 Physician Japan
Primary
Secondary
Concomitant
Asphyxia Death 6/27/2009 Female 2/9/2010 Physician Japan
Primary
Concomitant
Respiratory Failure Hospitalization 11/21/2007 Female 2/9/2010 Germany
Primary
Concomitant
Gastric Ulcer Hospitalization 8/2/2006 Female 187 lb 2/10/2010 Physician Russian Federation
Primary
Secondary
Concomitant
Respiratory Failure Life Threatening 1/22/2010 Male 187 lb 2/10/2010 Physician Mexico
Primary
Secondary
Concomitant
Pyrexia Hospitalization 1/1/2009 Male 154 lb 2/10/2010 Physician United Kingdom
Primary
Secondary
Concomitant
Prostate Cancer Life Threatening 12/9/2008 Male 212 lb 2/11/2010 Physician United States
Primary
Concomitant
Renal Impairment Other Serious 8/7/2008 Male 117 lb 2/11/2010 Physician Japan
Primary
Secondary
Concomitant
Tremor Hospitalization 1/29/2010 Female 215 lb 2/11/2010 Physician United States
Primary
Concomitant
Tuberculosis Hospitalization 10/4/2008 Female 2/11/2010 Physician Japan
Primary
Concomitant
Pyothorax Hospitalization 10/7/2009 61 Female 2/12/2010 Physician Japan
Primary
Concomitant
Pneumonia Hospitalization 3/12/2008 Female 194 lb 2/12/2010 Physician United States
Primary
Secondary
Concomitant
Lung Neoplasm Other Serious 11/1/2009 Male 196 lb 2/12/2010 Physician United Kingdom
Primary
Secondary
Concomitant
Renal Mass Other Serious 10/12/2009 Female 161 lb 2/12/2010 Physician United Kingdom
Primary
Secondary
Concomitant
Oestrogen Receptor Assay Positive Hospitalization 12/14/2009 Female 205 lb 2/12/2010 Physician Greece
Primary
Concomitant
Myasthenia Gravis Hospitalization 4/16/2009 Female 257 lb 2/16/2010 Physician South Africa
Primary
Secondary
Concomitant
Cellulitis Other Serious 8/6/2008 Female 180 lb 2/16/2010 Physician United States
Primary
Concomitant
Syncope Hospitalization 10/15/2009 Female 111 lb 2/16/2010 Physician United States
Primary
Concomitant
Respiratory Failure Life Threatening 1/22/2010 Male 187 lb 2/16/2010 Physician Mexico
Primary
Secondary
Concomitant
Tuberculosis Hospitalization 10/4/2008 Female 2/16/2010 Physician Japan
Primary
Concomitant
Tremor Hospitalization 10/1/2009 Female 176 lb 2/17/2010 Physician Bulgaria
Primary
Secondary
Concomitant
Cholecystitis Acute Hospitalization 11/16/2009 Female 2/17/2010 Physician India
Primary
Concomitant
Lymphoproliferative Disorder Other Serious 1/20/2010 Female 99 lb 2/17/2010 Physician Japan
Primary
Secondary
Concomitant
Interstitial Lung Disease Other Serious 1/18/2010 Male 216 lb 2/17/2010 Physician Canada
Primary
Secondary
Concomitant
Spindle Cell Sarcoma Life Threatening 3/13/2008 Female 328 lb 2/17/2010 Physician Australia
Primary
Secondary
Concomitant
Fasciitis Hospitalization 4/18/2007 Male 208 lb 2/18/2010 Physician Canada
Primary
Secondary
Concomitant
Demyelination Life Threatening 2/2/2010 Female 150 lb 2/18/2010 Physician China
Primary
Concomitant
Pneumonia Hospitalization 6/20/2008 Female 90 lb 2/19/2010 Physician Japan
Primary
Secondary
Concomitant
Upper Respiratory Tract Infection Other Serious 1/18/2010 Male 216 lb 2/19/2010 Physician Canada
Primary
Secondary
Concomitant
Rheumatoid Arthritis Hospitalization 7/2/2009 Female 88 lb 2/22/2010 Physician France
Primary
Secondary
Concomitant
Transient Ischaemic Attack Hospitalization 8/8/2009 Male 183 lb 2/22/2010 Physician France
Primary
Secondary
Tachycardia Hospitalization 1/25/2010 Female 115 lb 2/22/2010 Physician Brazil
Primary
Secondary
Concomitant
Asphyxia Death 6/27/2009 Female 2/23/2010 Physician Japan
Primary
Concomitant
Cervix Carcinoma Hospitalization 1/22/2010 Female 152 lb 2/23/2010 Physician Bulgaria
Primary
Secondary
Tonsillitis Hospitalization 9/5/2008 Female 2/23/2010 Physician Japan
Primary
Secondary
Concomitant
Pyelonephritis Hospitalization 12/14/2009 Female 2/23/2010 Physician Japan
Primary
Concomitant
Pulmonary Fibrosis Hospitalization 11/21/2007 74 Female 2/10/2010 Other Health Professional Germany
Primary
Concomitant
Aortic Aneurysm Hospitalization 9/18/2009 Female 200 lb 2/24/2010 Physician United States
Primary
Concomitant
Respiratory Failure Hospitalization 1/22/2010 Male 187 lb 2/24/2010 Physician Mexico
Primary
Secondary
Concomitant
Cervix Carcinoma Hospitalization 1/22/2010 Female 152 lb 2/24/2010 Physician Bulgaria
Primary
Secondary
Pyrexia Hospitalization 3/24/2009 Female 149 lb 2/25/2010 Physician Greece
Primary
Secondary
Concomitant
Tongue Neoplasm Malignant Stage Unspecified Hospitalization 8/12/2008 Female 2/25/2010 Physician Spain
Primary
Concomitant
Rheumatoid Arthritis Hospitalization 7/2/2009 Female 88 lb 2/25/2010 Physician France
Primary
Secondary
Concomitant
Calculus Urinary Hospitalization 3/1/2007 Female 159 lb 2/25/2010 Physician Argentina
Primary
Secondary
Concomitant
Subcutaneous Abscess Other Serious 10/16/2009 Female 2/25/2010 Other Health Professional Japan
Primary
Concomitant
Interstitial Lung Disease Other Serious 1/18/2010 Male 216 lb 2/26/2010 Physician Canada
Primary
Secondary
Concomitant
Skin Ulcer Hospitalization 10/20/2008 Female 2/26/2010 Physician Japan
Primary
Secondary
Concomitant
Pneumonia Hospitalization 10/7/2009 61 Female 91 lb 2/26/2010 Physician Japan
Primary
Concomitant
Erysipelas Hospitalization 10/16/2008 Male 3/1/2010 Physician France
Primary
Concomitant
Pulmonary Tuberculosis Hospitalization 1/1/2008 69 Female 3/2/2010 Physician Japan
Primary
Secondary
Concomitant
Cellulitis Hospitalization 12/29/2007 Female 209 lb 3/2/2010 Physician United States
Primary
Secondary
Concomitant
Cerebrovascular Accident Hospitalization 1/5/2010 Female 194 lb 3/2/2010 Physician United States
Primary
Secondary
Concomitant
Stress Cardiomyopathy Hospitalization 1/25/2010 Female 115 lb 3/2/2010 Physician Brazil
Primary
Secondary
Concomitant
Cholelithiasis Hospitalization 12/17/2009 Male 224 lb 3/3/2010 Physician Canada
Primary
Concomitant
Pneumocystis Jiroveci Pneumonia Other Serious 1/1/2009 Female 3/3/2010 Physician Japan
Primary
Secondary
Concomitant
Lung Neoplasm Other Serious 11/1/2009 Male 196 lb 3/3/2010 Physician United Kingdom
Primary
Secondary
Concomitant
Oedema Peripheral Hospitalization 10/2/2008 28 Female 112 lb 3/4/2010 Physician Japan
Primary
Secondary
Concomitant
Gallbladder Perforation Hospitalization 9/21/2009 Female 172 lb 3/4/2010 Physician United States
Primary
Secondary
Concomitant
Lymphocyte Count Decreased Other Serious 10/7/2008 Female 117 lb 3/4/2010 Physician Japan
Primary
Secondary
Concomitant
Respiratory Failure Hospitalization 1/22/2010 Male 187 lb 3/4/2010 Physician Mexico
Primary
Secondary
Concomitant
Demyelination Life Threatening 2/2/2010 Female 150 lb 3/4/2010 Physician China
Primary
Concomitant
Cholecystitis Acute Hospitalization 11/16/2009 Female 130 lb 3/5/2010 Physician India
Primary
Concomitant
Malignant Muscle Neoplasm Other Serious 3/19/2009 Male 291 lb 3/5/2010 Physician Canada
Primary
Concomitant
Tuberculosis Test Positive Other Serious 6/29/2008 Female 115 lb 3/8/2010 Physician Japan
Primary
Secondary
Concomitant
Atrial Flutter Hospitalization 1/30/2010 Female 187 lb 3/8/2010 Physician Portugal
Primary
Concomitant
Vaginal Haemorrhage Hospitalization 9/10/2006 Female 118 lb 3/10/2010 Physician Mexico
Primary
Secondary
Concomitant
Respiratory Failure Hospitalization 1/22/2010 Male 187 lb 3/10/2010 Physician Mexico
Primary
Secondary
Concomitant
Pseudomonas Infection Life Threatening 9/10/2006 Female 118 lb 3/11/2010 Physician Mexico
Primary
Secondary
Concomitant
Gastric Perforation Life Threatening 5/14/2009 Female 95 lb 3/11/2010 Physician Japan
Primary
Secondary
Concomitant
Abortion Spontaneous Other Serious 2/12/2010 Female 3/11/2010 Physician France
Primary
Concomitant
Subdural Haematoma Life Threatening 12/6/2009 Female 118 lb 3/11/2010 Physician Mexico
Primary
Secondary
Concomitant
Uterine Cancer Hospitalization 12/21/2009 Female 99 lb 3/11/2010 Other Health Professional Japan
Primary
Secondary
Endometrial Cancer Stage Ii Life Threatening 4/29/2008 Female 199 lb 3/11/2010 Physician United States
Primary
Concomitant
Pulmonary Tuberculosis Hospitalization 1/1/2008 69 Female 3/12/2010 Physician Japan
Primary
Concomitant
Spindle Cell Sarcoma Life Threatening 3/13/2008 Female 328 lb 3/12/2010 Physician Australia
Primary
Secondary
Concomitant
Oesophageal Carcinoma Life Threatening 10/15/2009 Female 84 lb 3/12/2010 Physician Argentina
Primary
Secondary
Cerebrovascular Accident Hospitalization 1/5/2010 Female 194 lb 3/15/2010 Physician United States
Primary
Concomitant
Pulmonary Haemorrhage Hospitalization 7/29/2009 Male 185 lb 3/15/2010 Physician Poland
Primary
Secondary
Concomitant
Small Intestine Ulcer Hospitalization 3/13/2009 Male 117 lb 3/16/2010 Physician Japan
Primary
Secondary
Concomitant

Drug Data