Methotrexate combined with Thiotepa

Reports:

Reaction Outcome Event Date Age Sex Weight Reported Reporter Country Treatment
Role Name
Neurotoxicity Other Serious 26 Female 3/4/2006 Physician United States
Primary
Concomitant
Thrombotic Microangiopathy Other Serious 38 Female 3/4/2006 Physician United States
Primary
Concomitant
Vomiting Death 2/25/2007 13 Female 8/1/2007 Japan
Primary
Concomitant
Tooth Abscess Other Serious 1/1/2004 53 Female 9/29/2007 France
Primary
Secondary
Concomitant
Sinus Tachycardia Other Serious 57 Male 10/24/2007 Japan
Primary
Concomitant
Sepsis Hospitalization 2/3/2008 Male 167 lb 2/6/2008 United States
Primary
Secondary
Serositis Death 1 3/6/2008 Consumer Japan
Primary
Concomitant
Cystitis Haemorrhagic Other Serious 11 3/11/2008 Consumer Japan
Primary
Concomitant
Venoocclusive Disease Other Serious 13 3/11/2008 Consumer Japan
Primary
Concomitant
Inappropriate Antidiuretic Hormone Secretion Other Serious 14 3/11/2008 Consumer Japan
Primary
Concomitant
Venous Occlusion Life Threatening 5 Female 3/18/2008 Consumer United States
Primary
Secondary
Stem Cell Transplant Death 1 3/13/2008 Japan
Primary
Concomitant
Venous Occlusion Life Threatening 5 Female 3/24/2008 Consumer United States
Primary
Secondary
Serositis Death 1 3/24/2008 Physician Japan
Primary
Concomitant
Cystitis Haemorrhagic Other Serious 11 3/24/2008 Physician Japan
Primary
Concomitant
Venoocclusive Disease Other Serious 13 3/24/2008 Physician Japan
Primary
Concomitant
Inappropriate Antidiuretic Hormone Secretion Other Serious 14 3/24/2008 Physician Japan
Primary
Concomitant
Venoocclusive Disease Hospitalization 2/12/2008 Male 231 lb 3/17/2008 United States
Primary
Secondary
Venoocclusive Disease Hospitalization 2/12/2008 Male 231 lb 4/16/2008 United States
Primary
Secondary
Serositis Hospitalization 12/15/2007 Female 104 lb 5/2/2008 United States
Primary
Secondary
Concomitant
Serositis Hospitalization 12/15/2007 Female 104 lb 5/9/2008 United States
Primary
Secondary
Concomitant
Oral Herpes Other Serious 16 Female 6/18/2008 Other Health Professional Germany
Primary
Secondary
Concomitant
Pulmonary Sepsis Life Threatening 6/1/2004 51 Male 7/7/2008 Other Health Professional Italy
Primary
Secondary
Concomitant
White Blood Cell Count Decreased Life Threatening 6/10/2008 Female 7/8/2008 Japan
Primary
Secondary
Concomitant
Respiratory Failure Hospitalization 6/10/2008 15 Female 8/1/2008 Japan
Primary
Secondary
Concomitant
Infection Other Serious 44 Male 181 lb 9/15/2008 United States
Primary
Concomitant
Bone Sarcoma Other Serious 8 Male 12/1/2008 Consumer Japan
Primary
Secondary
Bone Sarcoma Other Serious 8 Male 12/1/2008 Other Health Professional Japan
Primary
Secondary
Concomitant
Surgical Procedure Repeated Other Serious 15 Male 11/27/2008 Physician United States
Primary
Secondary
Concomitant
Unresponsive To Stimuli Other Serious 14 Male 11/27/2008 Physician United States
Primary
Secondary
Concomitant
Bone Sarcoma Other Serious 8 Male 12/2/2008 Other Health Professional Japan
Primary
Secondary
Concomitant
Neuropathy Peripheral Other Serious 15 Male 12/29/2008 Other Health Professional United States
Primary
Secondary
Treatment Failure Other Serious 15 Male 12/23/2008 Other Health Professional United States
Primary
Secondary
Unresponsive To Stimuli Death 14 Male 12/23/2008 Other Health Professional United States
Primary
Secondary
Bone Sarcoma Life Threatening 5/1/2007 7 Male 1/5/2009 Other Health Professional Japan
Primary
Secondary
Basal Cell Carcinoma Other Serious 1/1/2004 4 Female 1/7/2009 Italy
Primary
Secondary
Progressive Multifocal Leukoencephalopathy Other Serious 15 Male 1/5/2009 Other Health Professional United States
Primary
Secondary
Sudden Death Hospitalization 14 Male 1/5/2009 Other Health Professional United States
Primary
Secondary
Myelitis Transverse Other Serious 14 Male 1/9/2009 Other Health Professional United States
Primary
Secondary
Concomitant
Myelitis Transverse Other Serious 15 Male 1/9/2009 Other Health Professional United States
Primary
Secondary
Concomitant
Scleroderma Other Serious 1/1/2004 Female 1/19/2009 Other Health Professional Italy
Primary
Secondary
Hypothyroidism Other Serious 1/1/2004 Female 1/19/2009 Other Health Professional Italy
Primary
Secondary
Somnolence Hospitalization 1/30/2009 Male 166 lb 2/6/2009 United States
Primary
Secondary
Concomitant
Renal Failure Hospitalization 1/30/2009 Male 166 lb 2/17/2009 United States
Primary
Secondary
Concomitant
Renal Failure Hospitalization 1/30/2009 Male 166 lb 2/19/2009 United States
Primary
Secondary
Somnolence Hospitalization 1/30/2009 Male 166 lb 3/10/2009 United States
Primary
Secondary
Concomitant
Zygomycosis Other Serious 46 Male 3/17/2009 Other Health Professional Italy
Primary
Concomitant
Somnolence Hospitalization 1/30/2009 Male 166 lb 3/20/2009 United States
Primary
Secondary
Concomitant
Thrombotic Microangiopathy Other Serious 23 Male 4/7/2009 Physician Japan
Primary
Concomitant
Visual Impairment Other Serious 31 Female 5/5/2009 Other Health Professional Canada
Primary
Secondary
Visual Impairment Other Serious 31 Female 5/12/2009 Consumer United Kingdom
Primary
Secondary
Concomitant
Tuberculosis Other Serious 12/1/2007 19 Male 7/3/2009 Other Health Professional Brazil
Primary
Secondary
Concomitant
Tuberculosis Other Serious 12/1/2007 19 Male 7/7/2009 Consumer United Kingdom
Primary
Secondary
Concomitant
Rash Maculo-papular Other Serious 5/7/2009 1 Male 7/8/2009 Physician United States
Primary
Secondary
Concomitant
Pain In Extremity Other Serious 11 Male 7/23/2009 Consumer Japan
Primary
Secondary
Bone Sarcoma Other Serious 11 Male 8/14/2009 Consumer Japan
Primary
Secondary
Mucosal Inflammation Other Serious 16 Male 8/21/2009 Other Health Professional Germany
Primary
Secondary
Concomitant
Rash Other Serious 41 Female 10/23/2009 Other Health Professional Italy
Primary
Concomitant
Somnolence Life Threatening 9/16/2009 Male 120 lb 11/2/2009 Physician Netherlands
Primary
Concomitant
Somnolence Life Threatening 9/15/2009 Male 120 lb 11/11/2009 Physician Netherlands
Primary
Concomitant
Venoocclusive Disease Death 18 Male 12/7/2009 Physician United States
Primary
Concomitant
Venoocclusive Disease Other Serious 6 Male 12/7/2009 Physician United States
Primary
Concomitant
Venoocclusive Disease Other Serious 20 Female 12/7/2009 Physician United States
Primary
Concomitant
Thrombotic Microangiopathy Other Serious 18 Female 12/7/2009 Physician United States
Primary
Concomitant
Venoocclusive Disease Other Serious 9 Male 12/7/2009 Physician United States
Primary
Concomitant
Venoocclusive Disease Death 11 Male 12/7/2009 Physician United States
Primary
Concomitant
Venoocclusive Disease Death 7 Male 12/7/2009 Physician United States
Primary
Concomitant
Interstitial Lung Disease Other Serious 10 Female 12/7/2009 Physician United States
Primary
Concomitant
Pleural Effusion Other Serious 10 Male 12/7/2009 Physician United States
Primary
Concomitant
Venoocclusive Disease Death 1 Female 12/7/2009 Physician United States
Primary
Concomitant
Tachypnoea Hospitalization 11/12/2009 Female 15 lb 12/4/2009 United States
Primary
Secondary
Tachypnoea Hospitalization 11/12/2009 Female 15 lb 12/23/2009 United States
Primary
Secondary
Therapeutic Agent Toxicity Hospitalization 11/12/2009 Female 15 lb 12/30/2009 United States
Primary
Secondary
Concomitant
Respiratory Failure Death 12/8/2009 29 Female 1/13/2010 Physician Italy
Primary
Secondary
Tachypnoea Hospitalization 11/12/2009 Female 15 lb 1/12/2010 United States
Primary
Secondary
Concomitant
Zygomycosis Other Serious 1/1/2006 Male 2/12/2010 Physician Italy
Primary
Concomitant
Intracranial Hypotension Hospitalization 2/23/2010 51 Male 3/17/2010 Physician Italy
Primary
Secondary
Concomitant
Intracranial Hypotension Hospitalization 2/23/2010 51 Male 3/19/2010 Physician Italy
Primary
Secondary
Concomitant
Neuropathy Peripheral Other Serious 48 Female 3/23/2010 Other Health Professional Spain
Primary
Secondary
Concomitant
Acute Graft Versus Host Disease Death 3/25/2010 Italy
Primary
Secondary
Concomitant
Thrombotic Microangiopathy Other Serious 13 Male 3/30/2010 Physician Japan
Primary
Concomitant
Wernicke's Encephalopathy Disability 5/9/2008 4/13/2010 Physician United States
Primary
Secondary
Weight Decreased Other Serious 1/1/2004 4/16/2010 United States
Primary
Concomitant
Wernicke's Encephalopathy Disability 5/9/2008 4/20/2010 Physician United States
Primary
Secondary
Weight Decreased Other Serious 1/1/2004 4/20/2010 United States
Primary
Concomitant
Weight Decreased Other Serious 1/1/2004 5/10/2010 United States
Primary
Concomitant
Intracranial Hypotension Hospitalization 2/23/2010 51 Male 5/12/2010 Physician United States
Primary
Secondary
Concomitant
Renal Failure Hospitalization 4/25/2010 43 Male 5/17/2010 Other Health Professional United States
Primary
Secondary
Concomitant
Weight Increased Hospitalization 4/2/2010 6 Female 55 lb 5/11/2010 United States
Primary
Secondary
Tracheomalacia Other Serious 5/7/2009 1 Male 5/14/2010 Physician United States
Primary
Secondary
Concomitant
Tracheomalacia Other Serious 5/7/2009 1 Male 5/18/2010 Physician United States
Primary
Secondary
Concomitant
Salpingo-oophorectomy Bilateral Hospitalization 58 Female 6/2/2010 Other Health Professional United States
Primary
Secondary
Burkitt's Lymphoma Other Serious 58 Female 6/4/2010 Physician United States
Primary
Secondary
Viral Test Positive Other Serious 5/7/2009 1 Male 6/1/2010 Physician United States
Primary
Secondary
Concomitant
Renal Failure Hospitalization 4/25/2010 43 Male 6/7/2010 Other Health Professional United States
Primary
Secondary
Concomitant
Weight Decreased Other Serious 1/1/2004 6/15/2010 United States
Primary
Concomitant
Uterine Cancer Other Serious 7/1/2004 58 Female 6/15/2010 Other Health Professional United States
Primary
Secondary
Weight Decreased Other Serious 1/1/2004 6/17/2010 United States
Primary
Concomitant
Urinary Incontinence Hospitalization 1/1/2009 61 Female 6/15/2010 Physician Germany
Primary
Secondary
Concomitant
Urosepsis Hospitalization 4/2/2009 58 Male 220 lb 6/29/2010 Physician France
Primary
Secondary
Concomitant
Viith Nerve Paralysis Other Serious 10 Male 8/9/2010 Other Health Professional United States
Primary
Secondary
Concomitant
Viith Nerve Paralysis Other Serious 10 Male 8/13/2010 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Venoocclusive Liver Disease Other Serious 13 Female 8/13/2010 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Tracheomalacia Other Serious 5/7/2009 1 Male 8/13/2010 Physician United States
Primary
Secondary
Concomitant
Urinary Incontinence Other Serious 1/1/2009 59 Female 132 lb 8/23/2010 Consumer United States
Primary
Secondary
Concomitant
Urinary Incontinence Other Serious 6/1/2009 59 Female 132 lb 9/1/2010 Physician Germany
Primary
Secondary
Concomitant
Venoocclusive Liver Disease Other Serious 8/30/2010 Physician Italy
Primary
Concomitant
Unevaluable Event Other Serious Male 8/30/2010 Physician Italy
Primary
Concomitant
Stomatitis Other Serious 1 Male 9/21/2010 Other Health Professional Japan
Primary
Secondary
Concomitant
Stomatitis Other Serious 1 Male 9/21/2010 Other Health Professional Japan
Primary
Secondary
Concomitant
Malignant Neoplasm Progression Death 9/22/2010 Physician Spain
Primary
Concomitant
Malignant Neoplasm Progression Death 9/22/2010 Physician Spain
Primary
Concomitant
Mucosal Inflammation Other Serious 9 Female 9/30/2010 Physician Italy
Primary
Concomitant
Somnolence Hospitalization 6/16/2010 61 Male 10/21/2010 Physician Germany
Primary
Secondary
Concomitant
Ureteric Stenosis Death 10/20/2010 Physician Italy
Primary
Concomitant
Venoocclusive Disease Death 11/8/2010 Other Health Professional Germany
Primary
Secondary
Enterococcal Sepsis Death 11 Female 12/17/2010 Physician Italy
Primary
Secondary
Concomitant
Pancytopenia Death 11 Female 12/21/2010 United States
Primary
Secondary
Concomitant
Bone Sarcoma Other Serious 9 Male 12/22/2010 Consumer Japan
Primary
Secondary
Bone Sarcoma Other Serious 11 Male 12/22/2010 Other Health Professional Japan
Primary
Secondary
Aplasia Pure Red Cell Other Serious 23 Female 12/19/2010 Physician Italy
Primary
Concomitant
Bone Sarcoma Other Serious 11 Male 1/3/2011 Physician Japan
Primary
Secondary
Infection Death 1/17/2011 Physician United States
Primary
Secondary
Concomitant
Graft Versus Host Disease Death 1/17/2011 Physician United States
Primary
Secondary
Concomitant
Bk Virus Infection Death 20 Female 1/24/2011 Other Health Professional Singapore
Primary
Secondary
Pneumonia Hospitalization 11 Male 1/27/2011 Other Health Professional Japan
Primary
Secondary
Systemic Candida Death 20 Female 1/31/2011 Other Health Professional United Kingdom
Primary
Secondary
Stevens-johnson Syndrome Hospitalization 20 Female 2/8/2011 Other Health Professional Singapore
Primary
Secondary
Concomitant
Posterior Reversible Encephalopathy Syndrome Hospitalization 20 Female 2/8/2011 Other Health Professional Singapore
Primary
Secondary
Concomitant
Central Nervous System Lymphoma Hospitalization 20 Female 2/8/2011 Other Health Professional Singapore
Primary
Secondary
Concomitant
Febrile Neutropenia Hospitalization 20 Female 2/8/2011 Other Health Professional Singapore
Primary
Secondary
Concomitant
Sepsis Death 20 Female 2/8/2011 Other Health Professional Singapore
Primary
Secondary
Haematuria Other Serious 20 Female 2/11/2011 Other Health Professional Singapore
Primary
Secondary
Stevens-johnson Syndrome Other Serious 20 Female 2/16/2011 Other Health Professional Singapore
Primary
Secondary
Concomitant
Multi-organ Failure Death 4/25/2010 43 Male 168 lb 2/23/2011 Physician United States
Primary
Secondary
Concomitant
Sepsis Hospitalization 20 Female 2/15/2011
Primary
Secondary
Metastases To Meninges Other Serious 1/1/2004 3/25/2011 Physician United States
Primary
Concomitant
Venoocclusive Liver Disease Death 4/25/2010 43 Male 168 lb 4/1/2011 Physician United States
Primary
Secondary
Concomitant
Multi-organ Failure Death 4/25/2010 43 Male 168 lb 4/13/2011 Other Health Professional United States
Primary
Secondary
Concomitant
Influenza Other Serious 5/7/2009 1 Male 29 lb 4/12/2011 Physician United States
Primary
Secondary
Concomitant
Pneumonia Disability 7/18/2002 12 Male 139 lb 4/28/2011 Physician Japan
Primary
Secondary
Concomitant
Venoocclusive Liver Disease Hospitalization 7/18/2002 12 Male 139 lb 5/5/2011 Physician Japan
Primary
Secondary
Concomitant
Hyperbilirubinaemia Other Serious 11/16/2010 58 Female 117 lb 5/13/2011 Consumer United States
Primary
Secondary
Concomitant
Diabetes Mellitus Other Serious 18 Female 5/27/2011 Physician Germany
Primary
Secondary
Concomitant
Cytomegalovirus Infection Life Threatening Female 6/15/2011 Pharmacist United Kingdom
Primary
Concomitant
Mucosal Inflammation Hospitalization 8 Female 6/21/2011 Pharmacist United Kingdom
Primary
Concomitant
Venoocclusive Disease Hospitalization 6/21/2011 Pharmacist United Kingdom
Primary
Concomitant
Weight Decreased Hospitalization Male 6/22/2011 Pharmacist United Kingdom
Primary
Concomitant
Neoplasm Malignant Death 5 6/25/2011 Other Health Professional Korea, Republic Of
Primary
Concomitant
Acute Graft Versus Host Disease Death 3 6/25/2011 Other Health Professional Korea, Republic Of
Primary
Concomitant

Drug Data