Methotrexate combined with Thioguanine

Reports:

Reaction Outcome Event Date Age Sex Weight Reported Reporter Country Treatment
Role Name
Disseminated Intravascular Coagulation Other Serious 12/21/2005 Female 42 lb 12/27/2005 United States
Primary
Secondary
Weight Decreased Death 6 Male 1/27/2006 United States
Primary
Secondary
Concomitant
Weight Decreased Other Serious 6 Female 1/28/2006 Physician United States
Primary
Secondary
Peripheral Motor Neuropathy Other Serious 1/4/2006 5 Female 35 lb 2/3/2006 Physician United States
Primary
Secondary
Concomitant
Thrombocytopenic Purpura Other Serious 6 Female 5/5/2006 Other Health Professional Canada
Primary
Secondary
Concomitant
Thrombocytopenic Purpura Other Serious 10 Female 5/5/2006 Other Health Professional Canada
Primary
Secondary
Concomitant
Idiopathic Thrombocytopenic Purpura Other Serious 10 Female 6/3/2006 Physician Canada
Primary
Secondary
Tachycardia Hospitalization 6/28/2006 Female 50 lb 7/7/2006 United States
Primary
Secondary
Urosepsis Hospitalization 6/27/2006 Female 176 lb 7/13/2006 United States
Primary
Secondary
Tachycardia Hospitalization 6/28/2006 Female 50 lb 7/27/2006 United States
Primary
Secondary
Concomitant
Blood Growth Hormone Decreased Other Serious 12 Female 8/4/2006 Other Health Professional United States
Primary
Secondary
Epiphyseal Disorder Other Serious 15 Male 8/4/2006 Other Health Professional United States
Primary
Secondary
Idiopathic Thrombocytopenic Purpura Other Serious 13 Female 7/31/2006 Physician Canada
Primary
Secondary
Thrombocytopenic Purpura Other Serious 10 Female 7/31/2006 Physician Canada
Primary
Secondary
Weight Increased Life Threatening 8/9/2006 4 Male 43 lb 8/11/2006 Physician United States
Primary
Concomitant
Pulmonary Embolism Hospitalization 8/23/2006 Male 53 lb 8/24/2006 United States
Primary
Secondary
Pulmonary Embolism Hospitalization 8/23/2006 Male 53 lb 9/12/2006 United States
Primary
Secondary
Sepsis Hospitalization Female 87 lb 11/9/2006 United States
Primary
Secondary
Concomitant
Venoocclusive Liver Disease Hospitalization 11/23/2006 Female 40 lb 11/27/2006 Other Health Professional United States
Primary
Secondary
Weight Increased Hospitalization 11/23/2006 Female 40 lb 11/30/2006 Other Health Professional United States
Primary
Secondary
Vulval Disorder Hospitalization 11/27/2006 Female 188 lb 12/6/2006 United States
Primary
Secondary
White Blood Cell Count Decreased Hospitalization 10/18/2006 Female 87 lb 12/13/2006 United States
Primary
Secondary
Concomitant
Vomiting Hospitalization 12/10/2006 Female 100 lb 12/13/2006 United States
Primary
Secondary
Vaginal Ulceration Hospitalization 11/27/2006 Female 188 lb 12/12/2006 United States
Primary
Secondary
Concomitant
Vomiting Hospitalization 11/23/2006 Female 40 lb 12/18/2006 United States
Primary
Secondary
Neurotoxicity Other Serious 15 Female 10/7/2006 United States
Primary
Concomitant
Vomiting Hospitalization 12/10/2006 Female 100 lb 1/12/2007 United States
Primary
Secondary
Metastasis Death 11 Male 3/5/2007
Primary
Secondary
Metastasis Death 15 Female 3/5/2007
Primary
Secondary
Metastasis Death 13 Female 3/5/2007
Primary
Secondary
Metastasis Death 12 Male 3/5/2007
Primary
Secondary
Metastasis Death 15 Male 3/5/2007
Primary
Secondary
Blood Creatinine Increased Other Serious 73 Female 3/8/2007 Other Health Professional United States
Primary
Secondary
Concomitant
Glioma Other Serious 2 Male 3/9/2007 Consumer Finland
Primary
Secondary
Glioma Other Serious 2 Female 3/9/2007 Other Health Professional Finland
Primary
Secondary
Glioma Other Serious 4 Male 3/9/2007 Consumer Finland
Primary
Secondary
Glioma Other Serious 3 Female 3/9/2007 Consumer Finland
Primary
Secondary
Glioma Other Serious 5 Male 3/9/2007 Consumer Finland
Primary
Secondary
Glioma Other Serious 2 Male 3/9/2007 Consumer Finland
Primary
Secondary
Glioma Other Serious 2 Female 3/9/2007 Other Health Professional Finland
Primary
Secondary
Glioma Other Serious 3 Female 3/9/2007 Consumer Finland
Primary
Secondary
Glioma Other Serious 4 Male 3/9/2007 Consumer Finland
Primary
Secondary
Glioma Other Serious 5 Male 3/12/2007 Consumer Finland
Primary
Secondary
Peripheral Motor Neuropathy Required Intervention 1/4/2006 5 Female 35 lb 3/1/2007 Physician United States
Primary
Secondary
Concomitant
Vulval Ulceration Hospitalization 11/27/2006 Female 188 lb 3/20/2007 United States
Primary
Secondary
Concomitant
Neoplasm Malignant Death 15 Female 3/30/2007 Germany
Primary
Secondary
Concomitant
Neoplasm Malignant Death 13 Female 3/30/2007 Germany
Primary
Secondary
Concomitant
Neoplasm Malignant Death 11 Male 3/30/2007 Germany
Primary
Secondary
Concomitant
Neoplasm Malignant Death 15 Male 3/30/2007 Germany
Primary
Secondary
Concomitant
Neoplasm Malignant Death 12 Male 3/30/2007 Germany
Primary
Secondary
Concomitant
Pleural Fibrosis Disability 2/1/1994 29 Male 79 lb 6/26/2007 Other Health Professional France
Primary
Secondary
Concomitant
Pleural Fibrosis Disability 2/1/1994 29 Male 79 lb 6/29/2007 Consumer United States
Primary
Secondary
Concomitant
Trichostasis Spinulosa Other Serious 6 Male 6/30/2007 Physician Australia
Primary
Secondary
Precocious Puberty Other Serious Female 9/14/2007 Other Health Professional United States
Primary
Secondary
Concomitant
Glioma Death 15 Male 11/21/2007 Germany
Primary
Secondary
Glioma Death 13 Female 11/21/2007 Germany
Primary
Secondary
Nervous System Disorder Death 12 Male 11/21/2007 Physician Germany
Primary
Secondary
Glioma Death 11 Male 11/21/2007 Germany
Primary
Secondary
Concomitant
Stress Other Serious 28 Male 12/14/2007 Australia
Primary
Secondary
Tachycardia Hospitalization 12/12/2007 Male 139 lb 12/13/2007 United States
Primary
Secondary
Supraventricular Extrasystoles Hospitalization 12/12/2007 Male 139 lb 12/19/2007 United States
Primary
Secondary
Vomiting Other Serious 2 Female 2/7/2008 Physician Canada
Primary
Secondary
Concomitant
Urinary Tract Infection Enterococcal Hospitalization 3/17/2008 Female 31 lb 3/21/2008 United States
Primary
Secondary
Vomiting Hospitalization 11 Male 6/20/2008 Consumer Korea, Republic Of
Primary
Secondary
Concomitant
Chronic Myeloid Leukaemia Life Threatening 54 Male 6/26/2008 United Kingdom
Primary
Secondary
Chronic Myeloid Leukaemia Life Threatening 54 Male 6/30/2008 Consumer United States
Primary
Secondary
Chronic Myeloid Leukaemia Life Threatening 54 Male 7/9/2008 Consumer United Kingdom
Primary
Secondary
Chronic Myeloid Leukaemia Life Threatening 54 Male 7/15/2008 United Kingdom
Primary
Secondary
Neoplasm Malignant Life Threatening 54 Male 7/16/2008 United Kingdom
Primary
Secondary
Chronic Myeloid Leukaemia Life Threatening 54 Male 7/17/2008 Consumer United Kingdom
Primary
Secondary
Neoplasm Malignant Life Threatening 54 Male 7/17/2008 United Kingdom
Primary
Secondary
Chronic Myeloid Leukaemia Life Threatening 54 Male 7/22/2008 Other Health Professional United Kingdom
Primary
Secondary
Chronic Myeloid Leukaemia Life Threatening 54 Male 7/24/2008 Other Health Professional United Kingdom
Primary
Secondary
Neoplasm Malignant Life Threatening 54 Male 7/25/2008 United Kingdom
Primary
Secondary
Concomitant
Chronic Myeloid Leukaemia Life Threatening 54 Male 7/28/2008 United Kingdom
Primary
Secondary
Rash Vesicular Death 2 Male 7/19/2008 Other Health Professional United Kingdom
Primary
Secondary
Promyelocyte Count Increased Life Threatening 54 Male 7/22/2008 Other Health Professional United Kingdom
Primary
Secondary
Pancytopenia Other Serious 2 Male 8/12/2008 Other Health Professional United Kingdom
Primary
Secondary
Hepatic Encephalopathy Death 2 Male 8/14/2008 United Kingdom
Primary
Secondary
Concomitant
Chronic Myeloid Leukaemia Life Threatening 54 Male 8/18/2008 Other Health Professional United Kingdom
Primary
Secondary
Viral Infection Hospitalization 2 Male 8/19/2008 United Kingdom
Primary
Secondary
Renal Impairment Hospitalization 8/29/2008 Female 139 lb 9/3/2008 United States
Primary
Secondary
Concomitant
Chronic Myeloid Leukaemia Other Serious 54 Male 9/29/2008 United Kingdom
Primary
Secondary
Chronic Myeloid Leukaemia Life Threatening 54 Male 8/15/2008 United Kingdom
Primary
Secondary
Stem Cell Transplant Other Serious 30 Female 12/30/2008 Other Health Professional Netherlands
Primary
Secondary
White Blood Cell Disorder Other Serious 4 Male 2/6/2009
Primary
Secondary
Concomitant
Nuclear Magnetic Resonance Imaging Brain Abnormal Other Serious 16 Male 2/17/2009 Physician United States
Primary
Concomitant
Neurotoxicity Other Serious 16 Male 2/25/2009
Primary
Secondary
Neurotoxicity Hospitalization 16 Male 4/28/2009 Physician United States
Primary
Concomitant
Thymus Enlargement Required Intervention 14 Male 6/26/2009 Physician China
Primary
Secondary
Thymus Enlargement Other Serious 11 Female 6/26/2009 Other Health Professional China
Primary
Secondary
Thymus Enlargement Other Serious 15 Male 6/26/2009 Other Health Professional China
Primary
Secondary
Thymus Enlargement Other Serious 12 Male 6/26/2009 Other Health Professional China
Primary
Secondary
Thymus Enlargement Required Intervention 6 Male 6/26/2009 Other Health Professional China
Primary
Secondary
Thymus Enlargement Required Intervention 9 Male 6/26/2009 Other Health Professional China
Primary
Secondary
Hemiparesis Hospitalization 7/27/2008 13 Male 134 lb 8/5/2009 Pharmacist Belgium
Primary
Secondary
Concomitant
Transplant Other Serious 13 Male 7/31/2009 Consumer United Kingdom
Primary
Secondary
Concomitant
Neutropenia Hospitalization 8/11/2009 Male 219 lb 8/14/2009 United States
Primary
Secondary
Tumour Lysis Syndrome Other Serious 13 Male 8/19/2009 Physician United Kingdom
Primary
Secondary
Concomitant
Pancreatitis Hospitalization 9/2/2009 Male 222 lb 9/2/2009 United States
Primary
Secondary
Vasculitis Other Serious 7/27/2008 13 Male 134 lb 9/10/2009 Other Health Professional United States
Primary
Secondary
Weight Increased Hospitalization 9/8/2009 Male 58 lb 9/18/2009 United States
Primary
Secondary
Leukoencephalopathy Other Serious 4 Male 9/25/2009 Other Health Professional Germany
Primary
Secondary
Low Density Lipoprotein Increased Hospitalization 7/10/2009 Female 33 lb 9/22/2009 United States
Primary
Secondary
Lipase Increased Other Serious 7/10/2009 3 Female 33 lb 9/29/2009 Physician United States
Primary
Secondary
Concomitant
Weight Increased Hospitalization 9/8/2009 Male 58 lb 10/7/2009 United States
Primary
Secondary
Ventricular Tachycardia Hospitalization 10/3/2009 Male 201 lb 10/8/2009 United States
Primary
Secondary
Neuropathy Peripheral Disability 12 Male 10/15/2009 Other Health Professional Canada
Primary
Concomitant
Febrile Neutropenia Hospitalization 10/14/2009 Male 170 lb 10/15/2009 United States
Primary
Secondary
Concomitant
Low Density Lipoprotein Increased Other Serious 7/10/2009 3 Female 33 lb 10/19/2009 Physician United States
Primary
Secondary
Concomitant
Vomiting Hospitalization 10/29/2009 Female 99 lb 11/2/2009 Other Health Professional United States
Primary
Secondary
Concomitant
Pyrexia Hospitalization 10/23/2009 Female 119 lb 10/30/2009 United States
Primary
Secondary
Insulin-like Growth Factor Decreased Other Serious 12 Female 11/17/2009 Other Health Professional United States
Primary
Secondary
Epiphysiolysis Other Serious 15 Male 11/17/2009 Other Health Professional United States
Primary
Secondary
Concomitant
Vomiting Hospitalization 10/29/2009 Female 99 lb 11/13/2009 United States
Primary
Secondary
Concomitant
Neurotoxicity Other Serious 10 Male 12/7/2009
Primary
Secondary
Concomitant
Neutropenia Other Serious 17 Male 12/24/2009 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Burkitt's Leukaemia Hospitalization 13 Male 12/23/2009 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Neutropenia Other Serious 17 Male 1/4/2010 Consumer United Kingdom
Primary
Secondary
Concomitant
Chronic Myeloid Leukaemia Other Serious 54 Male 1/8/2010 Consumer United Kingdom
Primary
Secondary
Platelet Disorder Life Threatening 1/12/2005 11 Male 79 lb 1/18/2010 Consumer United Kingdom
Primary
Concomitant
Tic Other Serious 13 Male 1/20/2010 Other Health Professional United Kingdom
Primary
Secondary
Tic Other Serious 13 Male 1/20/2010 Other Health Professional United Kingdom
Primary
Secondary
Tic Other Serious 14 Male 1/21/2010 Consumer United Kingdom
Primary
Secondary
Renal Impairment Other Serious 17 Male 1/22/2010 Other Health Professional United Kingdom
Primary
Secondary
Staphylococcal Bacteraemia Other Serious 13 Male 1/22/2010 Other Health Professional United Kingdom
Primary
Secondary
Neutropenia Other Serious 17 Male 1/15/2010 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Chronic Myeloid Leukaemia Life Threatening 54 Male 1/15/2010 Other Health Professional United Kingdom
Primary
Secondary
Renal Impairment Other Serious 17 Male 1/26/2010 Consumer United Kingdom
Primary
Secondary
Concomitant
Weight Bearing Difficulty Hospitalization 12/11/2009 Male 177 lb 1/21/2010 United States
Primary
Secondary
Renal Impairment Other Serious 17 Male 1/28/2010 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Pyrexia Hospitalization 1/16/2010 Male 137 lb 1/26/2010 Other Health Professional United States
Primary
Secondary
Low Density Lipoprotein Increased 7/10/2009 Female 33 lb 1/20/2010 United States
Primary
Secondary
Renal Impairment Other Serious 17 Male 2/1/2010 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Hypertriglyceridaemia Other Serious 7/10/2009 3 Female 33 lb 1/29/2010 Physician United States
Primary
Secondary
Concomitant
Renal Impairment Other Serious 17 Male 2/22/2010 Other Health Professional United Kingdom
Primary
Secondary
Renal Impairment Other Serious 17 Male 2/25/2010 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Renal Impairment Other Serious 17 Male 2/25/2010 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Renal Impairment Other Serious 17 Male 2/25/2010 Consumer United Kingdom
Primary
Secondary
Concomitant
Renal Impairment Other Serious 17 Male 2/26/2010 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Renal Impairment Other Serious 17 Male 2/22/2010 Physician United Kingdom
Primary
Secondary
Concomitant
Renal Impairment Other Serious 17 Male 3/10/2010 Consumer United Kingdom
Primary
Secondary
Concomitant
Renal Impairment Other Serious 17 Male 3/12/2010 Consumer United Kingdom
Primary
Secondary
Concomitant
Tachypnoea Hospitalization 2 Male 3/9/2010 Australia
Primary
Secondary
Concomitant
Renal Impairment Other Serious 17 Male 3/16/2010 Consumer United Kingdom
Primary
Secondary
Concomitant
Tic Other Serious 14 Male 3/19/2010 Consumer United Kingdom
Primary
Secondary
Tic Other Serious 13 Male 3/22/2010 Other Health Professional United Kingdom
Primary
Secondary
Pyrexia Hospitalization 3/14/2010 Male 180 lb 3/18/2010 United States
Primary
Secondary
Concomitant
Tic Other Serious 13 Male 3/29/2010 Other Health Professional United Kingdom
Primary
Secondary
Renal Impairment Other Serious 17 Male 3/29/2010 Consumer United Kingdom
Primary
Secondary
Concomitant

Drug Data