Methotrexate combined with Teprenone

Reports:

Reaction Outcome Event Date Age Sex Weight Reported Reporter Country Treatment
Role Name
Scleritis Other Serious 9/14/2006 Female 1/8/2007 Physician Japan
Primary
Concomitant
Petechiae Hospitalization 8/9/2007 Male 159 lb 3/7/2008 Japan
Primary
Secondary
Concomitant
Meningitis Other Serious 9/27/2008 Female 93 lb 11/14/2008 Japan
Primary
Secondary
Concomitant
Speech Disorder Hospitalization 9/27/2008 Female 93 lb 12/11/2008 Japan
Primary
Secondary
Concomitant
Speech Disorder Hospitalization 9/27/2008 Female 93 lb 12/18/2008 Japan
Primary
Secondary
Concomitant
Speech Disorder Hospitalization 9/25/2008 Female 93 lb 12/26/2008 Japan
Primary
Secondary
Concomitant
Speech Disorder Hospitalization 9/25/2008 Female 93 lb 2/4/2009 Japan
Primary
Secondary
Concomitant
Speech Disorder Hospitalization 9/25/2008 Female 93 lb 3/10/2009 Japan
Primary
Secondary
Concomitant
Speech Disorder Hospitalization 9/25/2008 Female 93 lb 3/18/2009 Japan
Primary
Secondary
Concomitant
Speech Disorder Hospitalization 9/25/2008 Female 93 lb 6/11/2009 Japan
Primary
Secondary
Concomitant
Speech Disorder Hospitalization 9/25/2008 Female 93 lb 6/17/2009 Japan
Primary
Secondary
Concomitant
Vomiting Hospitalization 5/28/2009 61 Female 6/11/2009 Physician Japan
Primary
Secondary
Concomitant
Vomiting Hospitalization 5/28/2009 61 Female 111 lb 6/19/2009 Consumer Japan
Primary
Secondary
Concomitant
Pyrexia Hospitalization 9/22/2008 Female 94 lb 7/8/2009 Japan
Primary
Concomitant
Vomiting Hospitalization 5/28/2009 61 Female 111 lb 7/6/2009 Physician Japan
Primary
Secondary
Concomitant
Pyrexia Hospitalization 9/22/2008 Female 94 lb 8/21/2009 Japan
Primary
Concomitant
Nodule Other Serious 10/16/2008 Female 9/14/2009 Japan
Primary
Secondary
Concomitant
Tachycardia Other Serious 6/25/2009 Female 86 lb 9/22/2009 Japan
Primary
Secondary
Concomitant
Nodule Other Serious Female 9/24/2009 Japan
Primary
Secondary
Concomitant
Vomiting Hospitalization 5/28/2009 61 Female 111 lb 10/20/2009 Physician Japan
Primary
Secondary
Concomitant
Swelling Hospitalization 10/21/2009 30 Female 11/10/2009 Japan
Primary
Concomitant
Tachycardia Other Serious 6/25/2009 Female 86 lb 11/17/2009 Japan
Primary
Secondary
Concomitant
Purulent Discharge Hospitalization 10/21/2009 30 Female 11/25/2009 Other Health Professional Japan
Primary
Concomitant
Swelling Hospitalization 10/21/2009 30 Female 12/1/2009 Japan
Primary
Concomitant
Swelling Hospitalization 10/21/2009 Female 12/30/2009 Japan
Primary
Concomitant
Staphylococcal Infection Hospitalization 10/21/2009 Female 1/19/2010 Japan
Primary
Concomitant
Tachycardia Other Serious 6/25/2009 Female 86 lb 2/3/2010 Japan
Primary
Secondary
Concomitant
Hyponatraemia Hospitalization 12/11/2009 Female 139 lb 2/24/2010 Physician Japan
Primary
Secondary
Concomitant
Hyponatraemia Hospitalization 12/11/2009 Female 139 lb 2/24/2010 Physician Japan
Primary
Secondary
Concomitant
Hyponatraemia Hospitalization 12/11/2009 Female 139 lb 3/5/2010 Physician Japan
Primary
Secondary
Concomitant
Rheumatoid Arthritis Life Threatening 1/21/2010 Male 138 lb 3/5/2010 Japan
Primary
Secondary
Concomitant
Rectal Cancer Other Serious 11/25/2009 Female 117 lb 3/12/2010 Japan
Primary
Concomitant
Vomiting Hospitalization 5/28/2009 Female 111 lb 3/12/2010 Physician Japan
Primary
Concomitant
White Blood Cell Count Decreased Hospitalization 2/5/2010 Female 3/15/2010 Other Health Professional Japan
Primary
Secondary
Concomitant
Sick Sinus Syndrome Other Serious 2/1/2010 Male 126 lb 3/25/2010 Japan
Primary
Secondary
Concomitant
Sick Sinus Syndrome Other Serious 2/1/2010 61 Male 126 lb 4/5/2010 Japan
Primary
Secondary
Concomitant
Duodenal Stenosis Other Serious 9/19/2009 83 Male 120 lb 4/9/2010 Japan
Primary
Concomitant
Sick Sinus Syndrome Other Serious 2/1/2010 61 Male 126 lb 4/15/2010 Japan
Primary
Secondary
Concomitant
Tachycardia Other Serious 6/25/2009 71 Female 86 lb 4/22/2010 Japan
Primary
Secondary
Concomitant
Vomiting Hospitalization 2/5/2010 63 Female 4/15/2010 Japan
Primary
Secondary
Concomitant
White Blood Cell Count Increased Hospitalization 4/4/2010 57 Female 4/27/2010 Physician Japan
Primary
Concomitant
Rectal Cancer Other Serious 11/25/2009 68 Female 117 lb 4/28/2010 Japan
Primary
Concomitant
White Blood Cell Count Increased Hospitalization 4/4/2010 57 Female 5/5/2010 Physician Japan
Primary
Concomitant
White Blood Cell Count Decreased Hospitalization 2/5/2010 63 Female 5/12/2010 Japan
Primary
Secondary
Concomitant
Rectal Cancer Other Serious 11/25/2009 68 Female 117 lb 5/21/2010 Japan
Primary
Concomitant
White Blood Cell Count Increased Hospitalization 4/4/2010 57 Female 95 lb 5/21/2010 Physician Japan
Primary
Concomitant
Bile Duct Cancer Death Female 5/24/2010 Physician Japan
Primary
Concomitant
Melaena Hospitalization 11/21/2009 69 Female 115 lb 5/25/2010 Japan
Primary
Concomitant
Cerebral Infarction Hospitalization Female 6/3/2010 Physician Japan
Primary
Concomitant
White Blood Cell Count Decreased Hospitalization 2/5/2010 63 Female 5/31/2010 Japan
Primary
Secondary
Concomitant
Cerebral Infarction Hospitalization 3/28/2010 74 Female 6/16/2010 Physician Japan
Primary
Concomitant
Vomiting Hospitalization 5/28/2009 61 Female 111 lb 6/10/2010 Physician Japan
Primary
Concomitant
Rheumatoid Arthritis Life Threatening 1/21/2010 68 Male 138 lb 7/1/2010 Physician Japan
Primary
Secondary
Concomitant
White Blood Cell Count Increased Hospitalization 4/4/2010 57 Female 95 lb 7/2/2010 Physician Japan
Primary
Concomitant
Pyrexia Hospitalization 6/17/2010 40 Female 7/6/2010 Japan
Primary
Concomitant
Nasopharyngitis Other Serious 7/1/2009 83 Male 120 lb 7/12/2010 Physician Japan
Primary
Concomitant
Pyelonephritis Hospitalization 6/17/2010 40 Female 7/8/2010 Japan
Primary
Concomitant
Rheumatoid Arthritis Life Threatening 1/21/2010 68 Male 138 lb 7/16/2010 Physician Japan
Primary
Secondary
Concomitant
Pyelonephritis Hospitalization 6/17/2010 40 Female 7/13/2010 Physician Japan
Primary
Concomitant
Memory Impairment Other Serious Female 101 lb 7/29/2010 Physician Japan
Primary
Concomitant
Tachycardia Other Serious 6/25/2009 71 Female 86 lb 8/2/2010 Physician Japan
Primary
Secondary
Concomitant
Hydrocele Hospitalization 7/20/2010 71 Male 116 lb 8/2/2010 Physician Japan
Primary
Secondary
Concomitant
Pyrexia Hospitalization 5/21/2010 55 Female 168 lb 8/2/2010 Physician Japan
Primary
Concomitant
Organising Pneumonia Hospitalization 6/23/2010 66 Female 90 lb 8/5/2010 Physician Japan
Primary
Secondary
Concomitant
Tachycardia Other Serious 6/25/2009 71 Female 86 lb 8/17/2010 Physician Japan
Primary
Secondary
Concomitant
Rheumatoid Arthritis Life Threatening 1/21/2010 68 Male 138 lb 8/17/2010 Physician Japan
Primary
Secondary
Concomitant
Renal Abscess Hospitalization 6/17/2010 40 Female 8/12/2010 Japan
Primary
Concomitant
White Blood Cell Count Increased Hospitalization 4/4/2010 57 Female 95 lb 8/26/2010 Physician Japan
Primary
Concomitant
Subarachnoid Haemorrhage Hospitalization 8/10/2010 57 Female 8/20/2010 Other Health Professional Japan
Primary
Concomitant
Renal Abscess Hospitalization 6/17/2010 40 Female 8/20/2010 Japan
Primary
Concomitant
Subarachnoid Haemorrhage Hospitalization 8/10/2010 57 Female 146 lb 8/26/2010 Other Health Professional Japan
Primary
Concomitant
Cerebral Infarction Hospitalization 3/28/2010 74 Female 9/2/2010 Physician Japan
Primary
Concomitant
Hydrocele Hospitalization 7/20/2010 71 Male 116 lb 9/7/2010 Physician Japan
Primary
Secondary
Concomitant
Subarachnoid Haemorrhage Hospitalization 8/10/2010 57 Female 146 lb 9/7/2010 Other Health Professional Japan
Primary
Concomitant
Amnesia Other Serious 2/5/2010 61 Female 101 lb 9/16/2010 Physician Japan
Primary
Concomitant
Respiratory Disorder Death 4/15/2010 54 Male 132 lb 9/20/2010 Physician Japan
Primary
Secondary
Concomitant
Subarachnoid Haemorrhage Hospitalization 8/10/2010 57 Female 146 lb 9/14/2010 Other Health Professional Japan
Primary
Concomitant
Vomiting Hospitalization 8/10/2010 57 Female 146 lb 9/23/2010 Other Health Professional Japan
Primary
Concomitant
Subarachnoid Haemorrhage Hospitalization 8/10/2010 57 Female 146 lb 9/23/2010 Physician Japan
Primary
Concomitant
White Blood Cell Count Increased Hospitalization 4/4/2010 57 Female 95 lb 10/1/2010 Physician Japan
Primary
Concomitant
Streptococcus Test Positive Death 4/15/2010 54 Male 132 lb 10/4/2010 Physician Japan
Primary
Secondary
Concomitant
Osteonecrosis Hospitalization 7/8/2009 65 Female 99 lb 10/6/2010 Physician Japan
Primary
Secondary
Concomitant
Vomiting Hospitalization 5/28/2009 61 Female 111 lb 10/5/2010 Consumer Japan
Primary
Secondary
Concomitant
Osteonecrosis Hospitalization 7/8/2009 65 Female 99 lb 10/26/2010 Physician Japan
Primary
Secondary
Concomitant
Subarachnoid Haemorrhage Hospitalization 8/10/2010 57 Female 146 lb 10/14/2010 Other Health Professional Japan
Primary
Concomitant
Subarachnoid Haemorrhage Hospitalization 8/10/2010 57 Female 146 lb 10/20/2010 Other Health Professional Japan
Primary
Concomitant
Melaena Hospitalization 11/21/2009 69 Female 115 lb 11/3/2010 Physician Japan
Primary
Concomitant
Renal Abscess Hospitalization 6/17/2010 40 Female 10/25/2010 Other Health Professional Japan
Primary
Secondary
Concomitant
Vomiting Hospitalization 8/10/2010 57 Female 146 lb 10/25/2010 Other Health Professional Japan
Primary
Concomitant
Vasculitis Other Serious 4/1/2010 61 Male 172 lb 11/4/2010 Physician Japan
Primary
Concomitant
Hydrocele Hospitalization 1/1/2010 70 Male 116 lb 11/11/2010 Physician Japan
Primary
Secondary
Concomitant
Vasculitis Other Serious 4/1/2010 61 Male 172 lb 11/18/2010 Physician Japan
Primary
Concomitant
Lymphadenopathy Other Serious 7/16/2010 66 Male 11/19/2010 Physician Japan
Primary
Concomitant
Vasculitis Other Serious 4/1/2010 61 Male 172 lb 11/23/2010 Physician Japan
Primary
Concomitant
Renal Hypertrophy Hospitalization Female 11/9/2010 Other Health Professional Japan
Primary
Secondary
Concomitant
Lymphadenopathy Other Serious 7/16/2010 66 Male 11/30/2010 Physician Japan
Primary
Concomitant
Renal Abscess Hospitalization 6/17/2010 40 Female 11/17/2010 Other Health Professional Japan
Primary
Secondary
Concomitant
Sick Sinus Syndrome Other Serious 2/1/2010 61 Male 126 lb 12/13/2010 Physician Japan
Primary
Secondary
Concomitant
Renal Impairment Hospitalization 8/1/2010 79 Female 83 lb 12/13/2010 Physician Japan
Primary
Concomitant
Renal Hypertrophy Hospitalization 6/17/2010 40 Female 11/30/2010 Other Health Professional Japan
Primary
Secondary
Concomitant
Hydrocele Hospitalization 1/1/2010 70 Male 116 lb 12/16/2010 Physician Japan
Primary
Secondary
Concomitant
Renal Hypertrophy Hospitalization 6/17/2010 40 Female 12/6/2010 Other Health Professional Japan
Primary
Secondary
Concomitant
Renal Hypertrophy Hospitalization 6/17/2010 40 Female 12/16/2010 Other Health Professional Japan
Primary
Secondary
Concomitant
Pneumocystis Jiroveci Pneumonia Hospitalization 8/23/2010 1/3/2011 Other Health Professional Japan
Primary
Concomitant
Hepatomegaly Hospitalization 2/5/2010 63 Female 12/28/2010 Other Health Professional Japan
Primary
Secondary
Concomitant
Cerebral Infarction Hospitalization 12/9/2010 41 Male 170 lb 1/14/2011 Physician Japan
Primary
Secondary
Concomitant
Cerebral Infarction Hospitalization 12/9/2010 41 Male 170 lb 1/24/2011 Physician Japan
Primary
Secondary
Concomitant
Cerebral Infarction Hospitalization 3/28/2010 74 Female 2/9/2011 Physician Japan
Primary
Concomitant
Urinary Tract Infection Death 3/28/2010 74 Female 2/11/2011 Physician Japan
Primary
Concomitant
Cardio-respiratory Arrest Death 8/1/2010 79 Female 83 lb 2/17/2011 Physician Japan
Primary
Concomitant
Lymphoma Other Serious 3/15/2011 59 Male 3/23/2011 Physician Japan
Primary
Secondary
Concomitant
Pyrexia Hospitalization 11/19/2009 87 Female 84 lb 3/25/2011 Physician Japan
Primary
Concomitant
Pyrexia Hospitalization 11/19/2009 87 Female 84 lb 3/31/2011 Physician Japan
Primary
Secondary
Concomitant
Lymphoma Other Serious 3/15/2011 59 Male 143 lb 4/4/2011 Physician Japan
Primary
Secondary
Concomitant
Gaze Palsy Hospitalization 8/10/2010 57 Female 146 lb 3/30/2011 Other Health Professional Japan
Primary
Concomitant
Thrombotic Microangiopathy Life Threatening 12/7/2009 1 Female 22 lb 4/19/2011 Physician Japan
Primary
Secondary
Concomitant
Thrombotic Microangiopathy Life Threatening 12/7/2009 1 Female 22 lb 4/19/2011 Physician Japan
Primary
Secondary
Concomitant
Nasopharyngitis Hospitalization 1/8/2011 88 Female 84 lb 4/20/2011 Physician Japan
Primary
Concomitant
Diabetes Mellitus Hospitalization 5/28/2010 54 Female 104 lb 5/6/2011 Other Health Professional Japan
Primary
Secondary
Concomitant
Convulsion Hospitalization 8/10/2010 57 Female 146 lb 5/24/2011 Physician Japan
Primary
Concomitant
Lymphoma Hospitalization 12/9/2010 58 Male 143 lb 5/31/2011 Physician Japan
Primary
Secondary
Concomitant
Lymphoma Hospitalization 12/9/2010 58 Male 143 lb 6/2/2011 Physician Japan
Primary
Secondary
Concomitant
Lymphoma Hospitalization 12/9/2010 58 Male 143 lb 6/10/2011 Physician Japan
Primary
Secondary
Concomitant
Bone Tuberculosis Other Serious 7/30/2010 66 Male 7/18/2011 Physician Japan
Primary
Concomitant
Gastric Cancer Other Serious 6/24/2011 72 Male 116 lb 7/27/2011 Physician Japan
Primary
Secondary
Concomitant
Lymphoma Hospitalization 12/9/2010 58 Male 143 lb 8/15/2011 Physician Japan
Primary
Secondary
Concomitant
Glomerulonephritis Membranous Hospitalization 2/17/2011 53 Male 181 lb 8/15/2011 Other Health Professional Japan
Primary
Secondary
Concomitant
Maternal Exposure During Pregnancy Other Serious 11/1/2010 Female 8/25/2011 Physician Korea, Republic Of
Primary
Concomitant
Computerised Tomogram Thorax Abnormal Other Serious 7/16/2010 66 Male 108 lb 8/29/2011 Physician Japan
Primary
Concomitant
Small Intestine Ulcer Other Serious Female 9/7/2011 Other Health Professional Japan
Primary
Concomitant
Bone Tuberculosis Other Serious 7/16/2010 66 Male 108 lb 9/7/2011 Physician Japan
Primary
Concomitant
Idiopathic Thrombocytopenic Purpura Death 11/17/2009 6 Male 33 lb 9/19/2011 Physician Japan
Primary
Concomitant
Organising Pneumonia Hospitalization 6/23/2010 66 Female 90 lb 9/20/2011 Physician Japan
Primary
Secondary
Concomitant
Liver Disorder Death 4/15/2010 54 Male 132 lb 9/21/2011 Physician Japan
Primary
Secondary
Concomitant
Herpes Zoster Hospitalization 3/14/2011 85 Female 90 lb 9/29/2011 Physician Japan
Primary
Concomitant
Cerebral Infarction Hospitalization 3/14/2011 85 Female 90 lb 10/3/2011 Physician Japan
Primary
Concomitant
Liver Disorder Death 4/15/2010 54 Male 132 lb 10/7/2011 Physician Japan
Primary
Secondary
Concomitant
Gastrointestinal Erosion Other Serious Female 10/14/2011 Other Health Professional Japan
Primary
Concomitant
Respiratory Disorder Death 4/15/2010 54 Male 132 lb 10/17/2011 Physician Japan
Primary
Secondary
Concomitant
Hyperkalaemia Other Serious 2/1/2010 61 Male 126 lb 10/21/2011 Physician Japan
Primary
Secondary
Concomitant
Cerebral Infarction Hospitalization 3/14/2011 85 Female 90 lb 10/21/2011 Physician Japan
Primary
Concomitant
Small Intestine Ulcer Other Serious Female 10/28/2011 Other Health Professional Japan
Primary
Concomitant
Nephropathy Other Serious 8/23/2010 82 Female 75 lb 10/31/2011 Physician Japan
Primary
Concomitant
Pneumothorax Other Serious 2/1/2010 61 Male 126 lb 11/2/2011 Physician Japan
Primary
Secondary
Concomitant
Herpes Zoster Hospitalization 3/14/2011 85 Female 90 lb 11/4/2011 Physician Japan
Primary
Concomitant
Staphylococcal Sepsis Death 8/23/2010 82 Female 75 lb 11/7/2011 Physician Japan
Primary
Concomitant
Staphylococcal Sepsis Death 8/23/2010 82 Female 75 lb 11/18/2011 Physician Japan
Primary
Concomitant
Gastric Cancer Other Serious 6/21/2011 72 Male 116 lb 11/30/2011 Japan
Primary
Secondary
Concomitant
Hepatic Steatosis Other Serious 11/28/2011 71 Female 143 lb 12/30/2011 Physician Japan
Primary
Secondary
Concomitant
Haemolytic Anaemia Life Threatening 11/17/2009 6 Male 33 lb 12/30/2011 Physician Japan
Primary
Concomitant

Drug Data