Methotrexate combined with Spironolactone

Reports:

Reaction Outcome Event Date Age Sex Weight Reported Reporter Country Treatment
Role Name
Spinal Fusion Surgery Other Serious 6/9/2003 Female 142 lb 2/10/2006 Physician United States
Primary
Secondary
Concomitant
Sinus Tachycardia Other Serious 1/1/2003 43 Female 181 lb 2/27/2006 Physician United States
Primary
Concomitant
Vein Disorder Other Serious 9/7/2005 20 Female 121 lb 2/27/2006 Physician United States
Primary
Concomitant
Tinnitus Other Serious 1/1/2003 43 Female 181 lb 3/21/2006 Physician United States
Primary
Concomitant
Tinnitus Other Serious 1/1/2003 43 Female 181 lb 3/24/2006 Physician United States
Primary
Concomitant
Skin Nodule Hospitalization 10/1/2003 Female 119 lb 6/22/2006 Germany
Primary
Concomitant
Pericarditis Constrictive Hospitalization 10/1/2003 Female 119 lb 7/20/2006 Germany
Primary
Concomitant
Optic Neuritis Other Serious Female 210 lb 9/29/2006 Consumer United States
Primary
Concomitant
Pharmaceutical Product Complaint Other Serious 9/30/2006 60 Female 10/9/2006 Consumer United States
Primary
Concomitant
Vomiting Hospitalization 7/16/2006 Female 227 lb 11/14/2006 Physician Germany
Primary
Concomitant
Vomiting Hospitalization 7/16/2006 Female 227 lb 11/14/2006 Physician Germany
Primary
Concomitant
Pulmonary Tuberculosis Hospitalization 7/1/2005 Male 11/16/2006 Other Health Professional Finland
Primary
Secondary
Concomitant
Tonsil Cancer Other Serious 1/1/2006 Female 182 lb 12/13/2006 Physician United States
Primary
Concomitant
Death Death 12/7/2006 70 Female 12/15/2006 Consumer Canada
Primary
Concomitant
Death Death 12/6/2006 70 Female 12/19/2006 Physician Canada
Primary
Concomitant
Somnolence Other Serious 1/1/2006 61 Female 120 lb 1/2/2007 Other Health Professional United States
Primary
Concomitant
Pharmaceutical Product Complaint Other Serious 9/30/2006 60 Female 1/8/2007 Consumer United States
Primary
Concomitant
Gingival Bleeding 7/18/2006 40 Female 235 lb 10/24/2006 United States
Primary
Secondary
Concomitant
Dry Throat 59 Female 205 lb 10/24/2006 Qatar
Primary
Concomitant
Atrial Fibrillation Hospitalization 5/1/2006 Female 120 lb 1/25/2007 Physician United States
Primary
Concomitant
Vomiting Hospitalization 3/16/2006 Male 198 lb 2/23/2007 Other Health Professional United Kingdom
Primary
Concomitant
Pharyngolaryngeal Pain 10/2/2006 40 Female 235 lb 1/23/2007 Consumer United States
Primary
Concomitant
Fall Hospitalization 1/26/2007 Male 229 lb 5/15/2007 Consumer United States
Primary
Concomitant
Post Herpetic Neuralgia Other Serious 4/12/2006 73 Female 170 lb 5/30/2007 Other Health Professional United Kingdom
Primary
Concomitant
Ventricular Fibrillation Hospitalization 12/4/2006 Female 198 lb 7/12/2007 Physician Germany
Primary
Secondary
Concomitant
Pain 78 Female 8/3/2007 Consumer United States
Primary
Concomitant
Somnolence 3/1/2007 Female 300 lb 8/29/2007 Physician United States
Primary
Secondary
Concomitant
Pyrexia Hospitalization 10/29/2007 Female 180 lb 11/12/2007 United States
Primary
Concomitant
White Blood Cell Count Decreased Other Serious 11/4/2006 58 Female 95 lb 11/14/2007 Physician Japan
Primary
Secondary
Concomitant
Skin Disorder Other Serious Female 12/3/2007 Other Health Professional Canada
Primary
Concomitant
Lung Neoplasm Malignant Other Serious Female 143 lb 12/4/2007 Other Health Professional United Kingdom
Primary
Concomitant
Syncope Other Serious 1/1/2004 Female 103 lb 12/13/2007 United States
Primary
Secondary
Concomitant
Drug Ineffective 1/1/2005 Female 223 lb 12/14/2007 Consumer United States
Primary
Concomitant
Pseudomonal Sepsis Hospitalization 79 Female 1/15/2008 Physician United Kingdom
Primary
Concomitant
Skin Disorder Other Serious Female 1/23/2008 Other Health Professional Canada
Primary
Concomitant
Tuberculosis Hospitalization 10/7/2003 57 Female 152 lb 1/30/2008 Physician Spain
Primary
Concomitant
Pseudomonal Sepsis Hospitalization Female 1/31/2008 Physician United Kingdom
Primary
Concomitant
Thoracic Vertebral Fracture Hospitalization 1/3/2008 83 Female 1/25/2008 Belgium
Primary
Concomitant
Thoracic Vertebral Fracture Hospitalization 1/3/2008 83 Female 2/6/2008 Belgium
Primary
Concomitant
Pancytopenia Other Serious 11/4/2006 58 Female 95 lb 2/11/2008 Japan
Primary
Secondary
Concomitant
Thoracic Vertebral Fracture Hospitalization 1/3/2008 83 Female 4/8/2008 Physician Belgium
Primary
Concomitant
Renal Failure Acute Hospitalization 2/22/2006 79 Female 5/19/2008 Physician United States
Primary
Secondary
Concomitant
Nausea Other Serious 1/1/2008 Female 199 lb 5/21/2008 Physician United States
Primary
Concomitant
Breast Cancer Hospitalization 1/1/2008 Female 245 lb 5/22/2008 Physician United Kingdom
Primary
Concomitant
Nausea Other Serious 1/1/2008 Female 199 lb 6/2/2008 Physician United States
Primary
Concomitant
Thoracic Vertebral Fracture Hospitalization 1/3/2008 83 Female 5/29/2008 Belgium
Primary
Concomitant
Injection Site Pain 4/9/2008 Female 145 lb 6/13/2008 United States
Primary
Concomitant
Mobility Decreased 4/23/2008 Female 145 lb 6/13/2008 United States
Primary
Concomitant
Thoracic Vertebral Fracture Hospitalization 1/3/2008 83 Female 6/24/2008 Belgium
Primary
Concomitant
Pain Hospitalization 7/13/2007 77 Female 7/3/2008 Physician Belgium
Primary
Concomitant
Weight Decreased Hospitalization 1/1/2008 81 Female 7/3/2008 Consumer Canada
Primary
Concomitant
Pyrexia Other Serious 1/1/2007 69 Female 132 lb 7/14/2008 Physician Netherlands
Primary
Secondary
Concomitant
White Blood Cell Count Decreased 8/9/2007 Female 142 lb 7/25/2008 Consumer United States
Primary
Concomitant
Vomiting 7/21/2008 Female 150 lb 9/12/2008 United States
Primary
Concomitant
Sepsis Death 9/26/2008 Female 10/27/2008 Other Health Professional Norway
Primary
Concomitant
Thrombosis Hospitalization 5/15/2008 Male 205 lb 10/29/2008 United Kingdom
Primary
Concomitant
Pulmonary Thrombosis Hospitalization 5/15/2008 Male 205 lb 10/31/2008 United Kingdom
Primary
Concomitant
Dyspnoea Other Serious 3/1/2008 Female 154 lb 11/7/2008 Germany
Primary
Concomitant
Renal Failure Acute Hospitalization 59 Female 11/26/2008 Pharmacist United States
Primary
Concomitant
Injection Site Pain 9/9/2008 Female 162 lb 12/12/2008 Consumer United States
Primary
Concomitant
Injection Site Pain 10/15/2008 Female 275 lb 12/12/2008 Physician United States
Primary
Concomitant
White Blood Cell Count Decreased Hospitalization 11/6/2008 2 Male 29 lb 12/29/2008 Other Health Professional United States
Primary
Concomitant
Renal Failure Acute Hospitalization 59 Female 216 lb 1/12/2009
Primary
Secondary
Concomitant
Renal Failure Death 1/1/2009 Female 1/22/2009 Physician United States
Primary
Concomitant
Renal Failure Acute Hospitalization 12/16/2008 66 Female 3/2/2009 Physician Romania
Primary
Concomitant
Rectal Polyp Hospitalization 1/30/2009 Male 3/4/2009 Consumer United States
Primary
Concomitant
Urinary Tract Infection Life Threatening 10/29/2002 Female 3/9/2009 Other Health Professional Netherlands
Primary
Secondary
Concomitant
Tooth Infection Other Serious 1/1/2008 Female 175 lb 3/24/2009 Physician United States
Primary
Secondary
Concomitant
Tremor Hospitalization 2/4/2009 2 Male 29 lb 5/1/2009 Other Health Professional United States
Primary
Secondary
Concomitant
Dizziness Other Serious 4/2/2009 Female 130 lb 5/6/2009 Physician United States
Primary
Concomitant
Memory Impairment Other Serious 4/1/2009 Female 124 lb 5/6/2009 Consumer United States
Primary
Concomitant
Application Site Burn Other Serious 5/3/2009 59 Female 197 lb 5/13/2009 Consumer United States
Primary
Concomitant
Pancytopenia Other Serious 11/4/2006 58 Female 95 lb 5/14/2009 Japan
Primary
Secondary
Concomitant
Upper Limb Fracture Hospitalization 2/4/2009 2 Male 29 lb 5/18/2009 Other Health Professional United States
Primary
Secondary
Concomitant
Respiratory Distress Other Serious 4/30/2009 0 Female 5/21/2009 Physician United Kingdom
Primary
Concomitant
Sinus Tachycardia Hospitalization 83 Male 6/3/2009 Physician United States
Primary
Concomitant
Viral Infection Hospitalization 5/2/2009 Female 207 lb 6/12/2009 United States
Primary
Concomitant
Pneumonia Other Serious 12/1/2008 Female 180 lb 6/15/2009 United States
Primary
Concomitant
Sepsis Other Serious 2/3/2003 69 Male 6/17/2009 Other Health Professional United Kingdom
Primary
Concomitant
Pneumonia Other Serious 12/1/2008 Female 180 lb 6/25/2009 United States
Primary
Concomitant
Upper Limb Fracture Hospitalization 2/4/2009 2 Male 29 lb 6/26/2009 Other Health Professional United States
Primary
Secondary
Concomitant
Lethargy Other Serious 6/12/2009 53 Male 220 lb 7/16/2009 Other Health Professional United Kingdom
Primary
Concomitant
Vomiting Hospitalization 2/4/2009 2 Male 29 lb 7/14/2009 Other Health Professional United States
Primary
Secondary
Concomitant
Cardiomyopathy Hospitalization 4/25/2009 Male 7/31/2009 Physician United Kingdom
Primary
Concomitant
Vomiting Hospitalization 2/4/2009 3 Male 30 lb 8/17/2009 Other Health Professional United States
Primary
Secondary
Concomitant
Therapeutic Response Decreased Other Serious 1/14/2009 Female 132 lb 8/26/2009 Japan
Primary
Secondary
Concomitant
Wheezing Hospitalization 2/4/2009 3 Male 30 lb 8/25/2009 Other Health Professional United States
Primary
Secondary
Concomitant
Urinary Tract Infection Other Serious 12/1/2008 Female 188 lb 9/11/2009 United States
Primary
Concomitant
Injection Site Pain 4/9/2008 Female 145 lb 9/12/2009 United States
Primary
Concomitant
Injection Site Pain 9/9/2008 Female 162 lb 9/12/2009 Consumer United States
Primary
Concomitant
Urinary Tract Infection Other Serious 12/1/2008 Female 188 lb 9/14/2009 United States
Primary
Concomitant
Incorrect Dose Administered 5/1/2009 Female 185 lb 9/18/2009 Consumer United States
Primary
Concomitant
Vomiting 5/26/2009 Female 230 lb 9/18/2009 United States
Primary
Concomitant
Injection Site Pain 7/25/2009 Female 250 lb 9/19/2009 Consumer United States
Primary
Concomitant
Vitamin D Decreased 8/19/2008 Female 85 lb 9/19/2009 United States
Primary
Concomitant
Wound Dehiscence Life Threatening 10/17/2005 67 Male 9/28/2009 Other Health Professional Germany
Primary
Secondary
Concomitant
Urinary Tract Infection Other Serious 12/1/2008 Female 188 lb 9/30/2009 United States
Primary
Concomitant
Wheezing Other Serious 2/24/2009 Female 9/30/2009 Other Health Professional Canada
Primary
Concomitant
Tuberculosis Gastrointestinal Hospitalization 4/16/2009 Female 132 lb 10/8/2009 Physician Japan
Primary
Concomitant
White Blood Cell Count Decreased Other Serious 4/24/2009 68 Female 104 lb 10/14/2009 Other Health Professional Japan
Primary
Secondary
Concomitant
Wrist Fracture Hospitalization 9/2/2009 75 Female 130 lb 10/13/2009 Physician New Zealand
Primary
Concomitant
Urinary Tract Infection Hospitalization 7/23/2009 68 Female 226 lb 10/30/2009 Physician United States
Primary
Concomitant
Wrist Fracture Hospitalization 9/2/2009 75 Female 130 lb 11/4/2009 Physician New Zealand
Primary
Concomitant
Weight Decreased Hospitalization 1/1/2009 Male 198 lb 11/12/2009 Brazil
Primary
Concomitant
Sepsis Death Male 11/13/2009 Consumer United States
Primary
Concomitant
Urinary Tract Infection Other Serious 12/1/2008 Female 188 lb 11/18/2009 United States
Primary
Concomitant
Pneumonia Hospitalization 4/1/2008 61 Female 11/19/2009 Physician United States
Primary
Secondary
Concomitant
Dyspepsia Other Serious 7/1/2008 Male 331 lb 11/19/2009 Physician United States
Primary
Concomitant
Infusion Related Reaction Other Serious 10/13/2009 Male 147 lb 11/20/2009 Consumer United States
Primary
Concomitant
Vomiting Hospitalization 7/23/2009 68 Female 226 lb 11/25/2009 Physician United States
Primary
Concomitant
Hypoaesthesia 10/1/2009 Female 12/9/2009 Other Health Professional United States
Primary
Concomitant
Sinus Congestion 6/15/2009 12/9/2009 Physician United States
Primary
Concomitant
Pneumonia Hospitalization 4/1/2008 61 Female 12/10/2009 Physician United States
Primary
Secondary
Concomitant
White Blood Cell Count Decreased Other Serious 4/24/2009 68 Female 104 lb 12/15/2009 Other Health Professional Japan
Primary
Secondary
Concomitant
Pyrexia Hospitalization 11/9/2009 3 Male 31 lb 12/16/2009 Other Health Professional United States
Primary
Secondary
Concomitant
Infusion Related Reaction Other Serious 10/13/2009 Male 147 lb 12/23/2009 Consumer United States
Primary
Concomitant
Pain Other Serious 5/15/2009 Female 141 lb 1/22/2010 Brazil
Primary
Concomitant
Vomiting Other Serious 1/1/2007 63 Male 1/25/2010 Lawyer United States
Primary
Secondary
Concomitant
Arthralgia 6/1/2008 Male 280 lb 1/29/2010 United States
Primary
Concomitant
Wound Dehiscence Life Threatening 10/17/2005 67 Male 2/5/2010 Other Health Professional Germany
Primary
Secondary
Concomitant
Gastric Ulcer Hospitalization 8/2/2006 Female 187 lb 2/10/2010 Physician Russian Federation
Primary
Secondary
Concomitant
White Blood Cell Count Decreased Other Serious 5/27/2009 64 Female 123 lb 2/11/2010 Physician Japan
Primary
Secondary
Concomitant
Nausea 9/15/2008 62 Female 134 lb 2/25/2010 Other Health Professional United States
Primary
Concomitant
Decreased Appetite Hospitalization 1/23/2010 80 Female 3/12/2010 Physician Japan
Primary
Concomitant
Pulmonary Haemorrhage Hospitalization 7/29/2009 Male 185 lb 3/15/2010 Physician Poland
Primary
Secondary
Concomitant
Leukopenia Hospitalization 3/3/2010 68 Female 117 lb 3/18/2010 Physician Germany
Primary
Concomitant
Renal Impairment Hospitalization 1/1/2008 Female 209 lb 3/19/2010 Brazil
Primary
Concomitant
Leukopenia Hospitalization 3/3/2010 68 Female 117 lb 3/24/2010 Other Health Professional Germany
Primary
Concomitant
Pulmonary Haemorrhage Hospitalization 8/5/2009 Male 185 lb 3/31/2010 Physician Poland
Primary
Secondary
Concomitant
Wrist Fracture Hospitalization 9/2/2009 Female 130 lb 3/25/2010 Physician New Zealand
Primary
Concomitant
Renal Impairment Hospitalization 1/1/2008 67 Female 209 lb 4/14/2010 Brazil
Primary
Concomitant
White Blood Cell Count Decreased Other Serious 4/24/2009 68 Female 104 lb 4/19/2010 Physician Japan
Primary
Secondary
Concomitant
Vomiting Other Serious 1/1/2007 63 Male 192 lb 4/26/2010 Lawyer United States
Primary
Secondary
Concomitant
Cerebrovascular Accident Life Threatening 10/19/2009 66 Male 200 lb 4/30/2010 Physician United States
Primary
Concomitant
Mixed Hepatocellular Cholangiocarcinoma Life Threatening Male 5/10/2010 Other Health Professional Germany
Primary
Concomitant
Upper Limb Fracture Hospitalization 2/4/2009 3 Male 32 lb 5/5/2010 Other Health Professional United States
Primary
Concomitant
Urine Output Decreased Other Serious 10/1/2007 63 Male 193 lb 5/14/2010 Lawyer United States
Primary
Secondary
Concomitant
Pneumonia Hospitalization 11/5/2009 46 Male 183 lb 5/13/2010 United States
Primary
Secondary
Concomitant
Pseudomonal Sepsis Hospitalization 11/17/2007 79 Female 123 lb 5/27/2010 Physician France
Primary
Secondary
Concomitant
Renal Failure Hospitalization 62 Male 6/17/2010 Physician United Kingdom
Primary
Concomitant
Pulmonary Tuberculosis Hospitalization 6/22/2009 67 Female 99 lb 6/21/2010 Other Health Professional Korea, Republic Of
Primary
Concomitant
Pancreatitis Hospitalization Female 6/24/2010 Consumer United States
Primary
Concomitant
Vaginal Haemorrhage Other Serious 9/1/2009 42 Female 6/25/2010 Physician United States
Primary
Concomitant
Sudden Death Death 6/23/2010 51 Female 269 lb 6/29/2010 Physician Egypt
Primary
Secondary
Concomitant
Renal Failure Hospitalization 62 Male 7/2/2010 Physician United Kingdom
Primary
Concomitant
Vaginal Haemorrhage Other Serious 9/1/2009 42 Female 7/8/2010 Physician United States
Primary
Concomitant
C-reactive Protein Increased Other Serious 6/14/2010 47 Female 265 lb 7/16/2010 Physician Egypt
Primary
Secondary
Concomitant
Rheumatoid Arthritis Hospitalization 11/1/2007 63 Female 170 lb 7/23/2010 Consumer United States
Primary
Concomitant
Venoocclusive Disease Other Serious 6/1/2010 13 Male 120 lb 8/3/2010 Physician Netherlands
Primary
Concomitant
Venoocclusive Disease Other Serious 6/1/2010 13 Male 120 lb 8/12/2010 Physician Netherlands
Primary
Concomitant

Drug Data