Methotrexate combined with Spiriva

Reports:

Reaction Outcome Event Date Age Sex Weight Reported Reporter Country Treatment
Role Name
Pulmonary Tuberculosis Other Serious 11/4/2005 Male 255 lb 1/13/2006 Physician United States
Primary
Concomitant
Colitis Ischaemic Death 12/2/2005 Male 4/24/2006 Physician United States
Primary
Concomitant
Urinary Retention 57 Female 4/28/2006 Consumer United States
Primary
Secondary
Concomitant
Dysgeusia 11/30/2005 66 Female 2/21/2006 Pharmacist United States
Primary
Concomitant
Dyspnoea 9/20/2005 77 Male 2/21/2006 United States
Primary
Concomitant
Vomiting Hospitalization 6/21/2006 82 Male 174 lb 7/6/2006 Physician United States
Primary
Concomitant
Ventricular Tachycardia Hospitalization 12/25/2005 Female 115 lb 7/7/2006 Physician United States
Primary
Concomitant
Dysgeusia 11/30/2005 66 Female 5/19/2006 Pharmacist United States
Primary
Concomitant
Wheezing Hospitalization 6/21/2006 82 Male 174 lb 7/20/2006 Physician United States
Primary
Concomitant
Wheezing Hospitalization 6/21/2006 82 Male 174 lb 7/28/2006 Physician United States
Primary
Concomitant
Drug Ineffective 4/1/2005 61 Female 8/10/2006 Consumer United States
Primary
Concomitant
Vomiting Hospitalization 9/1/2005 Female 180 lb 9/8/2006 Physician United States
Primary
Concomitant
Visual Disturbance Other Serious 3/1/2006 61 Male 196 lb 8/8/2006 Pharmacist United States
Primary
Concomitant
Feeling Abnormal 5/1/2006 62 Female 8/22/2006 United States
Primary
Concomitant
Pyrexia 1/1/2003 Male 8/22/2006 United States
Primary
Concomitant
Tooth Discolouration Other Serious 6/1/2006 12/13/2006 Physician
Primary
Concomitant
Osteonecrosis Other Serious 6/29/2006 57 Female 11/28/2006 Pharmacist United States
Primary
Concomitant
Spinal Column Stenosis Other Serious 11/1/2005 Female 183 lb 2/2/2007 Physician United States
Primary
Concomitant
Feeling Abnormal 5/1/2006 62 Female 11/21/2006 United States
Primary
Concomitant
White Blood Cell Count Increased Other Serious 11/1/2005 Female 183 lb 2/14/2007 Physician United States
Primary
Secondary
Concomitant
Limb Injury 1/1/2006 Female 11/21/2006 United States
Primary
Concomitant
Vasculitis Hospitalization 1/1/2006 68 Female 4/9/2007 Physician United States
Primary
Concomitant
Pneumocystis Jiroveci Pneumonia Hospitalization 7/31/2006 Female 126 lb 4/17/2007 Physician Japan
Primary
Secondary
Concomitant
Vasculitis Hospitalization 1/1/2006 68 Female 4/18/2007 Physician United States
Primary
Concomitant
Weight Decreased Other Serious 5/1/2007 Female 229 lb 8/13/2007 Consumer United States
Primary
Secondary
Concomitant
Myocardial Ischaemia Other Serious 8/1/2004 Female 9/4/2007 United States
Primary
Secondary
Concomitant
Vasculitis Hospitalization 1/1/2006 68 Female 10/23/2007 Physician United States
Primary
Concomitant
Weight Decreased Other Serious 5/1/2007 Female 229 lb 10/30/2007 Consumer United States
Primary
Secondary
Concomitant
Injection Site Pain 3/1/2007 Female 200 lb 12/8/2007 Other Health Professional United States
Primary
Concomitant
Osteonecrosis Other Serious 1/1/2003 57 Female 11/28/2007 United States
Primary
Concomitant
Vasculitis Hospitalization 1/1/2006 68 Female 2/5/2008 Physician United States
Primary
Concomitant
Vasculitis Hospitalization 3/14/2005 68 Female 119 lb 2/15/2008 Physician United States
Primary
Concomitant
Lymphoma Other Serious Female 3/11/2008 Physician United States
Primary
Concomitant
Asthma Other Serious 12/6/2007 Female 160 lb 3/26/2008 Other Health Professional United States
Primary
Concomitant
Weight Decreased Other Serious 1/1/2007 Female 113 lb 4/22/2008 Physician United States
Primary
Secondary
Concomitant
Raynaud's Phenomenon 2/1/2006 54 Female 4/3/2007 Physician United States
Primary
Concomitant
Lymphoma Other Serious 68 Female 4/25/2008 Other Health Professional United States
Primary
Concomitant
Anaphylactic Reaction Other Serious 3/31/2008 64 Male 5/13/2008 Physician
Primary
Concomitant
Non-hodgkin's Lymphoma Other Serious 1/1/2008 Female 98 lb 5/15/2008 Other Health Professional United States
Primary
Concomitant
Pneumonia Hospitalization 1/1/2006 Female 5/23/2008 Consumer United States
Primary
Concomitant
Medication Residue 3/1/2007 5/13/2008 Consumer United States
Primary
Concomitant
Syncope 4/22/2008 Female 119 lb 5/30/2008 Other Health Professional United States
Primary
Concomitant
Infarction Other Serious 4/26/2008 55 Female 143 lb 6/13/2008 Physician United States
Primary
Concomitant
Pneumonia Hospitalization 1/1/2006 Female 6/30/2008 Consumer United States
Primary
Concomitant
Staphylococcal Infection Other Serious 2/1/2008 Female 7/2/2008 Other Health Professional United States
Primary
Concomitant
Pharyngeal Oedema Other Serious 6/6/2008 69 Male 9/26/2008 Other Health Professional
Primary
Concomitant
Pharyngeal Oedema Other Serious 6/6/2008 69 Male 176 lb 10/1/2008 Other Health Professional
Primary
Concomitant
Weight Decreased Other Serious 11/1/2006 10/31/2008 Physician Finland
Primary
Concomitant
Pneumonia Hospitalization 8/1/2008 65 Male 173 lb 11/24/2008 Other Health Professional Canada
Primary
Concomitant
Oedema Peripheral Other Serious 8/21/2008 Female 138 lb 12/2/2008 Physician United States
Primary
Secondary
Concomitant
Uterine Cancer Other Serious 10/5/2008 Female 276 lb 12/12/2008 Consumer United States
Primary
Concomitant
Throat Irritation 1/1/2008 77 Female 141 lb 12/22/2008 Physician
Primary
Concomitant
Sensation Of Heaviness 9/1/2008 Female 1/6/2009 Consumer
Primary
Concomitant
Upper Respiratory Tract Infection Other Serious 12/24/2008 71 Female 114 lb 1/15/2009 Physician United States
Primary
Concomitant
Sensation Of Heaviness 9/1/2008 Female 1/16/2009 Consumer
Primary
Concomitant
Systemic Candida Hospitalization 11/10/2008 Female 115 lb 1/30/2009 Belgium
Primary
Secondary
Concomitant
Urinary Retention Hospitalization Male 2/23/2009 Other Health Professional
Primary
Concomitant
Rectal Polyp Hospitalization 1/30/2009 Male 3/4/2009 Consumer United States
Primary
Concomitant
Lung Adenocarcinoma Stage Iii Death 5/1/2008 Female 143 lb 3/9/2009 Physician Netherlands
Primary
Secondary
Concomitant
Systemic Candida Hospitalization 11/10/2008 Female 115 lb 3/9/2009 Belgium
Primary
Secondary
Concomitant
Rotator Cuff Syndrome Other Serious 1/1/2007 Female 180 lb 3/10/2009 Consumer United States
Primary
Concomitant
Nausea Other Serious Female 107 lb 3/11/2009 Canada
Primary
Secondary
Concomitant
Upper Respiratory Tract Infection Other Serious 4/1/2006 Female 114 lb 3/13/2009 Other Health Professional United States
Primary
Concomitant
Urinary Tract Infection Hospitalization Female 112 lb 3/13/2009 Canada
Primary
Secondary
Concomitant
Oliguria Life Threatening 2/1/2009 58 Female 3/16/2009 Physician Switzerland
Primary
Secondary
Concomitant
Lung Adenocarcinoma Stage Iii Death 5/1/2008 Female 143 lb 3/26/2009 Physician Netherlands
Primary
Secondary
Concomitant
Urinary Tract Infection Hospitalization Female 112 lb 4/3/2009 Canada
Primary
Concomitant
Interacting
Nocturia 3/18/2009 83 Female 4/6/2009 Consumer
Primary
Concomitant
Galactorrhoea Other Serious 4/3/2009 Female 207 lb 4/14/2009 Physician United States
Primary
Concomitant
Oedematous Pancreatitis Hospitalization 3/24/2009 Female 187 lb 5/12/2009 Physician France
Primary
Concomitant
Systemic Candida Hospitalization 11/10/2008 Female 115 lb 6/1/2009 Belgium
Primary
Secondary
Concomitant
Injection Site Irritation 1/1/2005 Female 159 lb 6/12/2009 Other Health Professional United States
Primary
Concomitant
Sinusitis 11/1/2005 Female 175 lb 6/12/2009 Consumer United States
Primary
Concomitant
Ill-defined Disorder 5/1/2009 Female 170 lb 6/12/2009 Consumer United States
Primary
Concomitant
Rheumatoid Arthritis 1/1/2005 Female 155 lb 6/15/2009 Other Health Professional United States
Primary
Concomitant
Death Death Female 7/7/2009 Consumer United States
Primary
Concomitant
Lung Disorder Hospitalization Female 219 lb 7/13/2009 Physician United States
Primary
Concomitant
Systemic Candida Hospitalization 11/10/2008 Female 115 lb 7/24/2009 Belgium
Primary
Secondary
Concomitant
Rheumatoid Arthritis Disability 6/14/2009 60 7/24/2009 Pharmacist Canada
Primary
Concomitant
Renal Atrophy Other Serious 3/30/2009 Male 158 lb 7/28/2009 Physician United States
Primary
Concomitant
Chronic Obstructive Pulmonary Disease Hospitalization 11/15/2008 Female 8/13/2009 Germany
Primary
Secondary
Concomitant
Respiratory Failure Hospitalization 11/10/2008 Female 115 lb 8/13/2009 Belgium
Primary
Secondary
Concomitant
Osteoarthritis Other Serious 79 Female 137 lb 8/24/2009 Consumer United States
Primary
Concomitant
Multi-organ Failure Death 3/19/2009 80 Female 185 lb 8/20/2009 United Kingdom
Primary
Concomitant
Weight Increased Hospitalization 7/15/2008 Male 243 lb 9/3/2009 Physician Australia
Primary
Secondary
Concomitant
Hernia Hospitalization 3/18/2005 Male 196 lb 9/10/2009 United Kingdom
Primary
Concomitant
Somnolence 6/1/2008 Female 166 lb 9/19/2009 United States
Primary
Concomitant
Drug Dose Omission 6/25/2009 Female 135 lb 9/19/2009 Consumer United States
Primary
Concomitant
Wound Dehiscence Life Threatening 10/17/2005 67 Male 9/28/2009 Other Health Professional Germany
Primary
Secondary
Concomitant
Dyspnoea 9/1/2009 Female 9/28/2009 Consumer
Primary
Concomitant
Pain Other Serious Female 164 lb 10/1/2009 Canada
Primary
Concomitant
Hepatic Fibrosis Other Serious 10/1/2007 Male 10/9/2009 Other Health Professional United States
Primary
Concomitant
Dyspnoea 1/1/2006 Female 10/12/2009 Consumer
Primary
Concomitant
Tooth Fracture Other Serious 9/1/2009 Female 155 lb 10/14/2009 Canada
Primary
Concomitant
Drug Ineffective 2/1/2009 Female 10/15/2009 Consumer
Primary
Concomitant
Dyspnoea 9/9/2009 Female 10/19/2009 Consumer
Primary
Concomitant
Pneumonia Hospitalization 8/6/2009 Male 130 lb 10/21/2009 Canada
Primary
Concomitant
Cough 5/1/2009 Female 10/22/2009 Consumer
Primary
Secondary
Concomitant
Nasopharyngitis 5/1/2009 Female 10/23/2009 Consumer
Primary
Concomitant
Pneumonia Hospitalization 8/27/2009 72 Female 228 lb 10/20/2009 Other Health Professional United States
Primary
Secondary
Concomitant
Tooth Fracture Other Serious 9/1/2009 Female 155 lb 10/27/2009 Canada
Primary
Concomitant
Tooth Fracture Other Serious 9/1/2009 Female 155 lb 11/4/2009 Canada
Primary
Concomitant
Tooth Fracture Other Serious 9/1/2009 Female 155 lb 11/4/2009 Canada
Primary
Concomitant
Vomiting Hospitalization 1/1/2006 Female 138 lb 11/6/2009 United States
Primary
Concomitant
Stress Cardiomyopathy Hospitalization 11/10/2008 Female 115 lb 11/6/2009 Belgium
Primary
Secondary
Concomitant
Intestinal Obstruction Hospitalization 9/9/2009 Female 122 lb 11/9/2009 United States
Primary
Concomitant
Respiratory Failure Hospitalization 11/10/2008 Female 115 lb 11/9/2009 Belgium
Primary
Secondary
Concomitant
Lung Neoplasm Malignant Other Serious 10/28/2009 Male 177 lb 11/11/2009 Physician Canada
Primary
Secondary
Concomitant
Throat Irritation Other Serious 1/1/2005 Female 153 lb 11/16/2009 Pharmacist United States
Primary
Concomitant
Respiratory Failure Hospitalization 11/10/2008 Female 115 lb 11/16/2009 Belgium
Primary
Secondary
Concomitant
Vomiting Hospitalization 9/9/2009 Female 122 lb 11/16/2009 Other Health Professional United States
Primary
Concomitant
Renal Failure Hospitalization 6/15/2008 72 Male 11/18/2009 United States
Primary
Concomitant
Tooth Fracture Other Serious 1/1/2007 Female 155 lb 11/19/2009 Canada
Primary
Concomitant
Syncope Hospitalization 10/8/2009 65 Female 11/20/2009 Physician Czech Republic
Primary
Concomitant
Renal Failure Hospitalization 6/15/2008 72 Male 11/23/2009 United States
Primary
Concomitant
Respiratory Failure Hospitalization 11/10/2008 Female 115 lb 11/25/2009 Belgium
Primary
Secondary
Concomitant
Syncope Other Serious 11/16/2009 Male 200 lb 11/25/2009 Canada
Primary
Concomitant
Vascular Dementia Hospitalization 68 Male 11/17/2009 Lawyer United States
Primary
Concomitant
Volvulus Other Serious 11/17/2009 Male 225 lb 12/1/2009 Canada
Primary
Concomitant
Tooth Fracture Other Serious 1/1/2007 Female 155 lb 12/8/2009 Canada
Primary
Concomitant
Pulmonary Embolism Other Serious 11/18/2009 77 Female 12/9/2009 Other Health Professional United States
Primary
Secondary
Concomitant
Sepsis Death 10/15/2009 66 Male 240 lb 12/11/2009 Physician United States
Primary
Concomitant
Pain Other Serious 11/18/2009 Female 140 lb 12/14/2009 Canada
Primary
Concomitant
Lung Neoplasm Malignant Other Serious 10/28/2009 Male 177 lb 12/16/2009 Physician Canada
Primary
Secondary
Concomitant
Streptococcal Infection Other Serious 5/1/2009 Female 220 lb 12/18/2009 Physician United States
Primary
Concomitant
Urine Output Decreased Life Threatening 9/1/2001 67 Female 12/18/2009 Other Health Professional Sweden
Primary
Secondary
Concomitant
Wound Infection Staphylococcal Other Serious 1/1/2008 Female 110 lb 12/29/2009 Other Health Professional United States
Primary
Secondary
Concomitant
Paraesthesia Other Serious 11/18/2009 Female 140 lb 12/29/2009 Canada
Primary
Concomitant
Tooth Fracture Other Serious 1/1/2007 Female 155 lb 12/29/2009 Canada
Primary
Concomitant
Syncope Hospitalization 10/8/2009 65 Female 12/30/2009 Physician Czech Republic
Primary
Concomitant
Glucose Tolerance Impaired Hospitalization 12/1/2009 Female 12/24/2009 Consumer United States
Primary
Concomitant
Pneumonia Hospitalization 8/6/2009 Male 130 lb 1/7/2010 Canada
Primary
Concomitant
Lung Neoplasm Malignant Other Serious 10/28/2009 Male 177 lb 1/11/2010 Physician Canada
Primary
Secondary
Concomitant
Throat Irritation Other Serious 1/1/2005 Female 153 lb 1/11/2010 Pharmacist United States
Primary
Concomitant
Pulmonary Embolism Other Serious 11/18/2009 77 Female 1/11/2010 Other Health Professional United States
Primary
Secondary
Concomitant
Throat Irritation Other Serious 1/1/2005 Female 153 lb 1/21/2010 Pharmacist United States
Primary
Concomitant
Arthropathy 10/1/2009 Female 134 lb 1/30/2010 Physician United States
Primary
Concomitant
Paraesthesia 6/1/2009 Male 204 lb 1/30/2010 Consumer United States
Primary
Concomitant
Urinary Tract Infection Hospitalization 10/23/2009 Female 188 lb 1/30/2010 United States
Primary
Secondary
Concomitant
Vision Blurred Other Serious 1/1/2005 Female 153 lb 1/30/2010 Pharmacist United States
Primary
Concomitant
Chronic Obstructive Pulmonary Disease Hospitalization 11/15/2008 Female 2/3/2010 Germany
Primary
Secondary
Concomitant
Gallbladder Operation Hospitalization 1/20/2010 Female 2/3/2010 Consumer United States
Primary
Concomitant
Pulmonary Embolism Other Serious 11/18/2009 77 Female 2/4/2010 Other Health Professional United States
Primary
Secondary
Concomitant
Aortic Aneurysm Hospitalization Female 200 lb 2/4/2010 Physician United States
Primary
Concomitant
Dyspnoea 1/1/2006 Female 2/4/2010 Consumer
Primary
Concomitant
Sudden Cardiac Death Death 12/3/2008 Male 2/4/2010 Germany
Primary
Concomitant
Wound Dehiscence Life Threatening 10/17/2005 67 Male 2/5/2010 Other Health Professional Germany
Primary
Secondary
Concomitant
Respiratory Failure Hospitalization 8/6/2009 Male 130 lb 2/8/2010 Canada
Primary
Concomitant
Vision Blurred Other Serious 1/1/2005 Female 153 lb 2/8/2010 Pharmacist United States
Primary
Concomitant
Death Death Male 190 lb 2/15/2010 Consumer United States
Primary
Concomitant

Drug Data