Methotrexate combined with Solu-Medrol

Reports:

Reaction Outcome Event Date Age Sex Weight Reported Reporter Country Treatment
Role Name
Venoocclusive Liver Disease Life Threatening 6/6/2005 2 Male 26 lb 1/3/2006 Physician Japan
Primary
Secondary
Concomitant
Splenomegaly Hospitalization 1/1/2005 16 Female 1/3/2006 Consumer France
Primary
Secondary
Concomitant
Ventricular Fibrillation Life Threatening 6/30/2005 Female 99 lb 1/6/2006 Physician Japan
Primary
Concomitant
Weight Increased Hospitalization 3/1/2005 7 Female 55 lb 12/30/2005 Physician Japan
Primary
Concomitant
Respiratory Distress Hospitalization 12/9/2005 72 Male 163 lb 1/13/2006 Consumer United States
Primary
Secondary
Concomitant
Thrombocytopenia Hospitalization 11/12/2004 61 Male 181 lb 1/18/2006 Consumer United States
Primary
Secondary
Concomitant
Febrile Bone Marrow Aplasia Hospitalization 11/12/2004 69 Male 181 lb 1/17/2006 Physician France
Primary
Secondary
Concomitant
Renal Impairment Required Intervention 11/5/2005 54 Female 11/15/2005 Other Health Professional United States
Primary
Concomitant
Vomiting Other Serious 8/5/2002 8 Male 2/7/2006 Japan
Primary
Secondary
Concomitant
Renal Impairment Hospitalization 11/5/2005 54 Female 2/8/2006 Other Health Professional United States
Primary
Concomitant
Vomiting Other Serious 6/1/2005 8 Male 104 lb 2/10/2006 Physician Japan
Primary
Secondary
Concomitant
Peritonitis Other Serious 12/1/1998 Female 110 lb 2/17/2006 Physician United States
Primary
Concomitant
Tonic Convulsion Other Serious 6/1/2005 8 Male 104 lb 2/17/2006 Physician Japan
Primary
Secondary
Concomitant
Renal Impairment Hospitalization 11/5/2005 54 Female 2/21/2006 Other Health Professional United States
Primary
Concomitant
Vomiting Disability 11/4/2005 9 Male 53 lb 3/29/2006 Physician Japan
Primary
Concomitant
Thrombocytopenia Life Threatening 2/7/2006 40 Female 209 lb 3/28/2006 Physician France
Primary
Secondary
Concomitant
Septic Shock Life Threatening 2/4/2006 40 Female 209 lb 3/28/2006 Consumer France
Primary
Secondary
Concomitant
Venoocclusive Liver Disease Life Threatening 1/1/2001 47 Male 3/20/2006 Physician Japan
Primary
Concomitant
Thrombocytopenia Life Threatening 2/4/2006 40 Female 209 lb 4/13/2006 Physician France
Primary
Secondary
Concomitant
Thrombocytopenia Life Threatening 2/7/2006 40 Female 209 lb 4/14/2006 Physician France
Primary
Secondary
Concomitant
Vomiting Hospitalization 9/14/2001 Female 253 lb 4/26/2006 Physician United States
Primary
Secondary
Concomitant
Renal Failure Acute Hospitalization 3/22/2006 49 Male 165 lb 4/18/2006 Physician France
Primary
Concomitant
Weight Decreased Other Serious 3/14/2006 49 Male 165 lb 5/1/2006 Physician France
Primary
Concomitant
Thrombocytopenia Life Threatening 2/4/2006 40 Female 209 lb 5/9/2006 Consumer United States
Primary
Secondary
Concomitant
Septic Shock Life Threatening 2/4/2006 40 Female 209 lb 5/8/2006 Physician France
Primary
Secondary
Concomitant
Peritonitis Other Serious 12/1/1998 Female 113 lb 5/19/2006 Physician United States
Primary
Concomitant
Thrombocytopenia Other Serious 1/1/2006 40 Female 5/19/2006 Consumer Japan
Primary
Secondary
Concomitant
Septic Shock Life Threatening 2/7/2006 40 Female 209 lb 5/15/2006 Physician France
Primary
Secondary
Concomitant
Venoocclusive Liver Disease Life Threatening 6/5/2002 42 Female 112 lb 5/15/2006 Physician Japan
Primary
Secondary
Concomitant
Venoocclusive Liver Disease Life Threatening 6/21/2001 47 Male 148 lb 5/15/2006 Physician Japan
Primary
Secondary
Concomitant
Renal Failure Acute Other Serious 3/14/2006 49 Male 165 lb 6/12/2006 Physician France
Primary
Concomitant
Venoocclusive Liver Disease Life Threatening 6/5/2002 42 Female 112 lb 6/7/2006 Physician Japan
Primary
Secondary
Concomitant
Venoocclusive Liver Disease Life Threatening 6/21/2001 47 Male 148 lb 6/23/2006 Physician Japan
Primary
Secondary
Concomitant
Weight Decreased Other Serious 3/14/2006 49 Male 165 lb 7/13/2006 Physician France
Primary
Concomitant
Mucous Membrane Disorder Hospitalization 8/26/2004 8 Male 51 lb 7/21/2006 Physician Japan
Primary
Concomitant
Renal Tubular Acidosis Other Serious 5/5/2005 20 Male 8/3/2006 Consumer United States
Primary
Secondary
Concomitant
Pneumonia Legionella Life Threatening 6/2/2006 Male 163 lb 8/15/2006 Physician United States
Primary
Secondary
Concomitant
Renal Tubular Acidosis Other Serious 5/5/2005 20 Male 8/30/2006 Consumer United States
Primary
Secondary
Concomitant
Oral Mucosal Disorder Hospitalization 2/9/2006 10 Male 8/30/2006 Consumer United States
Primary
Secondary
Concomitant
Pneumonia Legionella Life Threatening 6/2/2006 Male 151 lb 9/6/2006 Physician United States
Primary
Secondary
Concomitant
Vasculitis Other Serious 52 Male 9/11/2006 United States
Primary
Secondary
Concomitant
Vomiting Other Serious 9/13/2006 35 Female 205 lb 11/20/2006 Physician United States
Primary
Secondary
Concomitant
Pulmonary Fibrosis Death 4/9/1986 70 Male 12/6/2006 Other Health Professional Japan
Primary
Secondary
Concomitant
Muscle Spasms Other Serious Female 211 lb 12/27/2006 Consumer United States
Primary
Concomitant
Panic Attack Other Serious Female 211 lb 1/26/2007 Consumer United States
Primary
Concomitant
Tendonitis Other Serious 3/14/2006 49 Male 165 lb 2/7/2007 Physician
Primary
Concomitant
Pneumothorax Other Serious 5/31/2006 54 Male 123 lb 2/26/2007 Physician Japan
Primary
Secondary
Concomitant
Vomiting Hospitalization 3/1/2007 52 Male 3/12/2007 Physician France
Primary
Secondary
Vomiting Other Serious 8/5/2002 8 Male 3/23/2007 Japan
Primary
Secondary
Concomitant
Reversible Posterior Leukoencephalopathy Syndrome Other Serious 6/1/2005 Male 104 lb 3/27/2007 Japan
Primary
Secondary
Concomitant
Vomiting Hospitalization 3/1/2007 52 Male 159 lb 3/23/2007 Physician France
Primary
Secondary
Vomiting Other Serious 8/5/2002 8 Male 4/3/2007 Japan
Primary
Secondary
Concomitant
Polyneuropathy Other Serious 9/30/1999 5 Female 4/5/2007 Physician Sweden
Primary
Concomitant
Interacting
Wheezing Other Serious 12/15/2005 Male 228 lb 4/6/2007 Other Health Professional Canada
Primary
Concomitant
White Blood Cell Count Decreased Other Serious 5/30/2005 48 Male 4/2/2007 Pharmacist Japan
Primary
Secondary
Concomitant
Tendonitis Other Serious 3/14/2006 49 Male 165 lb 4/19/2007 Physician
Primary
Concomitant
Status Epilepticus Hospitalization Male 4/20/2007 Physician France
Primary
Concomitant
Subcutaneous Nodule Other Serious 2/1/2007 Female 5/7/2007 Consumer United States
Primary
Secondary
Concomitant
Status Epilepticus Life Threatening Male 5/18/2007 Other Health Professional France
Primary
Secondary
Concomitant
Drug Ineffective Hospitalization 1/1/2000 21 Female 5/24/2007 Consumer United States
Primary
Secondary
Concomitant
Rheumatoid Arthritis Other Serious 9/13/2006 Female 205 lb 5/25/2007 Other Health Professional United States
Primary
Secondary
Concomitant
Cardiomyopathy Hospitalization 4/17/2007 8 Male 57 lb 6/5/2007
Primary
Secondary
Cardiomyopathy Hospitalization 4/17/2007 8 Male 57 lb 6/11/2007 Other Health Professional France
Primary
Secondary
Concomitant
Renal Impairment Hospitalization 9/30/2005 63 Female 139 lb 6/15/2007 Other Health Professional Japan
Primary
Secondary
Concomitant
Pleural Effusion Hospitalization 10/1/2005 Male 176 lb 6/21/2007 Physician Denmark
Primary
Secondary
Concomitant
Platelet Count Decreased Life Threatening 12/18/2006 20 Male 115 lb 8/2/2007 Physician Japan
Primary
Concomitant
Weight Decreased Other Serious 31 Female 8/16/2007 Czech Republic
Primary
Concomitant
Pulmonary Fibrosis Other Serious 9/20/2006 Female 88 lb 8/30/2007 Physician Japan
Primary
Secondary
Concomitant
Weight Increased Other Serious 31 Female 9/6/2007 Czech Republic
Primary
Secondary
Concomitant
Melaena Other Serious 3/2/2007 43 Male 132 lb 9/17/2007 Physician Japan
Primary
Concomitant
Tremor Hospitalization 5/8/2000 52 Female 291 lb 9/24/2007 Physician United States
Primary
Concomitant
Pneumonia Bacterial Hospitalization 8/26/2007 59 Female 146 lb 10/26/2007 Consumer United States
Primary
Concomitant
Syncope Life Threatening 7/11/2007 Female 190 lb 11/21/2007 Physician United States
Primary
Concomitant
Skin Necrosis Hospitalization 46 Female 12/14/2007 Physician Brazil
Primary
Concomitant
Metastases To Skin Life Threatening 12/18/2006 20 Male 115 lb 1/4/2008 Physician Japan
Primary
Concomitant
Pyrexia Hospitalization 1/1/2007 33 Female 1/23/2008 Consumer United States
Primary
Secondary
Concomitant
Arachnoiditis Hospitalization 1/11/2008 Female 36 lb 1/18/2008 United States
Primary
Secondary
Concomitant
White Blood Cell Count Decreased Hospitalization 9/10/2001 32 Male 1/17/2008 Physician Japan
Primary
Secondary
Concomitant
Pyrexia Hospitalization 1/1/2007 33 Female 2/5/2008 Consumer United States
Primary
Secondary
Concomitant
Wheezing Death 1/19/2008 49 Male 154 lb 2/8/2008 Physician France
Primary
Secondary
Pruritus Hospitalization 11/14/2007 Female 143 lb 2/14/2008 Physician Denmark
Primary
Concomitant
Pneumothorax Other Serious 5/31/2006 54 Male 123 lb 2/29/2008 Physician Japan
Primary
Secondary
Concomitant
Interstitial Lung Disease Death 7/17/2007 65 Male 161 lb 2/29/2008 Physician Japan
Primary
Secondary
Concomitant
Urticaria Other Serious 12/21/2006 Female 179 lb 3/28/2008 Physician United States
Primary
Concomitant
Wheezing Death 1/19/2008 49 Male 154 lb 3/29/2008 Physician France
Primary
Secondary
Concomitant
Thrombocytopenia Other Serious 7/20/2007 74 152 lb 4/1/2008 Physician France
Primary
Secondary
Concomitant
Ventricular Fibrillation Death 1/1/2008 Male 4/10/2008 Other Health Professional France
Primary
Secondary
Concomitant
Alanine Aminotransferase Increased Other Serious 1/10/2008 63 Male 130 lb 4/11/2008 Physician France
Primary
Secondary
Weight Decreased Life Threatening 9/29/2006 51 Female 98 lb 4/7/2008 Physician Japan
Primary
Secondary
Concomitant
Weight Decreased Other Serious 9/29/2006 51 Female 98 lb 4/17/2008 Physician Japan
Primary
Secondary
Concomitant
Sinusitis Disability 10/4/2007 55 Female 4/25/2008 France
Primary
Secondary
Pyrexia Other Serious 8/11/2002 3 Male 31 lb 4/23/2008 Physician Japan
Primary
Concomitant
Pneumothorax Other Serious 5/31/2006 54 Male 123 lb 5/9/2008 Physician Japan
Primary
Secondary
Concomitant
Osteonecrosis Disability 10/4/2007 55 Female 5/9/2008 Physician United Kingdom
Primary
Secondary
Tachycardia Hospitalization 3/1/2007 52 Male 159 lb 5/14/2008 Physician France
Primary
Secondary
Pyrexia Death 7/17/2007 65 Male 161 lb 5/20/2008 Physician Japan
Primary
Secondary
Concomitant
Eyelid Ptosis Hospitalization 3/15/2008 70 Female 5/23/2008 Physician France
Primary
Secondary
Concomitant
Strabismus Hospitalization 3/15/2008 70 Female 5/28/2008 Consumer France
Primary
Secondary
Concomitant
Eyelid Ptosis Hospitalization 3/15/2008 70 Female 5/30/2008 Other Health Professional France
Primary
Secondary
Concomitant
Arthritis Other Serious 5/14/2008 17 Male 6/5/2008 Physician United Kingdom
Primary
Concomitant
Hip Fracture Hospitalization 3/27/2008 Female 6/17/2008 Consumer United Kingdom
Primary
Concomitant
Eyelid Ptosis Hospitalization 3/15/2008 70 Female 6/17/2008 Physician France
Primary
Secondary
Concomitant
Toxic Skin Eruption Hospitalization 5/1/2008 14 Male 143 lb 6/19/2008 Consumer United States
Primary
Secondary
Concomitant
Eyelid Ptosis Hospitalization 3/15/2008 70 Female 6/26/2008 Other Health Professional France
Primary
Secondary
Concomitant
No Adverse Event 3/15/2008 70 Female 6/27/2008 Physician France
Primary
Secondary
Concomitant
X-ray Dental Other Serious 12/28/2007 Female 7/31/2008 Other Health Professional France
Primary
Concomitant
White Blood Cell Count Increased Other Serious 10/4/2007 13 Female 71 lb 7/29/2008 Physician Japan
Primary
Secondary
Concomitant
Rales Other Serious 10/4/2007 13 Female 71 lb 7/29/2008 Physician Japan
Primary
Secondary
Concomitant
Lymphoma Hospitalization 7/3/2008 80 Male 168 lb 8/1/2008 Physician France
Primary
Secondary
Concomitant
Tachycardia Hospitalization 3/1/2007 52 Male 159 lb 7/31/2008 Physician France
Primary
Secondary
Septic Shock Life Threatening 8/1/2008 78 Male 143 lb 8/5/2008 Physician France
Primary
Secondary
Concomitant
Vomiting Hospitalization 7/22/2007 Male 97 lb 8/13/2008 Other Health Professional Brazil
Primary
Concomitant
Vomiting Other Serious 5/19/2008 Male 52 lb 8/15/2008 Other Health Professional Brazil
Primary
Secondary
Concomitant
Vomiting Hospitalization 3/1/2007 52 Male 159 lb 8/15/2008 Physician France
Primary
Secondary
Septic Shock Life Threatening 8/1/2008 78 Male 143 lb 8/18/2008 Physician France
Primary
Secondary
Concomitant
Neutropenia Hospitalization 8/7/2008 44 Male 148 lb 8/21/2008 Belgium
Primary
Secondary
Concomitant
Pyrexia Hospitalization 7/25/2008 Female 130 lb 9/17/2008 Physician Canada
Primary
Concomitant
Urinary Tract Infection Pseudomonal Life Threatening 8/1/2008 78 Male 143 lb 9/16/2008 Physician France
Primary
Secondary
Concomitant
Renal Failure Hospitalization 7/1/2008 69 Male 154 lb 9/17/2008 Physician France
Primary
Secondary
Concomitant
Neoplasm Recurrence Hospitalization 7/30/2008 80 Male 168 lb 9/17/2008 Physician France
Primary
Secondary
Concomitant
Stevens-johnson Syndrome Hospitalization 1/1/2008 14 Male 143 lb 9/26/2008 Consumer United States
Primary
Secondary
Concomitant
Vomiting Hospitalization 7/22/2007 Male 97 lb 10/10/2008 Other Health Professional Brazil
Primary
Concomitant
Cerebral Thrombosis Hospitalization 9/6/2008 Male 172 lb 10/16/2008 Other Health Professional France
Primary
Secondary
Concomitant
Vomiting Other Serious 5/19/2008 Male 52 lb 10/16/2008 Other Health Professional Brazil
Primary
Secondary
Concomitant
Renal Impairment Other Serious 8/3/2007 24 Male 126 lb 10/20/2008 Consumer Japan
Primary
Secondary
Concomitant
Tremor Other Serious 1/1/2008 Female 10/24/2008 Other Health Professional United States
Primary
Concomitant
Swelling Face Other Serious 8/26/2008 18 Female 201 lb 10/24/2008 United States
Primary
Secondary
Concomitant
Stomatitis Other Serious 6/1/2007 54 Male 106 lb 10/31/2008 Japan
Primary
Secondary
Visual Acuity Reduced Other Serious 4/18/2008 Male 57 lb 11/4/2008 Other Health Professional Brazil
Primary
Concomitant
Vision Blurred Hospitalization 12/14/2007 Male 52 lb 11/4/2008 Other Health Professional Brazil
Primary
Concomitant
Vomiting Hospitalization 7/22/2007 Male 97 lb 11/4/2008 Other Health Professional Brazil
Primary
Concomitant
Vomiting Other Serious 5/19/2008 Male 52 lb 11/5/2008 Other Health Professional Brazil
Primary
Concomitant
Pupils Unequal Hospitalization 12/1/2007 7 Male 11/10/2008 Consumer France
Primary
Secondary
Concomitant
Pneumatosis Intestinalis Hospitalization 10/19/2008 Male 11/13/2008 Consumer United Kingdom
Primary
Secondary
Weight Increased Life Threatening 9/20/2007 48 Female 11/7/2008 Physician Japan
Primary
Secondary
Concomitant
Urinary Tract Infection Other Serious 5/1/2008 Female 151 lb 11/17/2008 Physician United States
Primary
Concomitant
Thrombotic Microangiopathy Death 5/21/2008 9 Female 46 lb 11/13/2008 Physician Japan
Primary
Secondary
Concomitant
Ventricular Extrasystoles 9/26/2008 53 Female 11/26/2008 Consumer United States
Primary
Concomitant
Febrile Bone Marrow Aplasia Life Threatening 10/30/2008 Male 11/26/2008 Consumer United Kingdom
Primary
Secondary
Pupils Unequal Hospitalization 12/1/2007 7 Male 12/1/2008 Other Health Professional France
Primary
Secondary
Concomitant
Febrile Bone Marrow Aplasia Hospitalization 10/30/2008 Male 12/3/2008 Consumer United Kingdom
Primary
Secondary
Concomitant
Renal Failure Hospitalization 9/13/2008 Male 12/4/2008 Physician United Kingdom
Primary
Secondary
Concomitant
Graft Versus Host Disease Other Serious 4/5/2007 Female 12/8/2008 Physician France
Primary
Concomitant
Interacting
Respiratory Syncytial Virus Infection Life Threatening 2/23/2008 1 Female 10 lb 11/26/2008 Physician Japan
Primary
Secondary
Concomitant
Rash Other Serious 12/27/2007 Female 44 lb 12/5/2008 Physician Japan
Primary
Secondary
Concomitant
Rash Other Serious 12/27/2007 Female 44 lb 12/5/2008 Physician Japan
Primary
Secondary
Concomitant
Pneumoperitoneum Hospitalization 8/30/2004 72 Female 12/12/2008 Other Health Professional France
Primary
Secondary
Concomitant
Graft Versus Host Disease Other Serious 4/5/2007 Female 12/23/2008 Physician France
Primary
Concomitant
Interacting
Viral Haemorrhagic Cystitis Other Serious 10/6/2004 Male 143 lb 12/23/2008 Physician Japan
Primary
Secondary
Concomitant
Osteolysis Hospitalization 2/9/2007 Male 160 lb 12/26/2008 United States
Primary
Concomitant

Drug Data