Methotrexate combined with Sodium Bicarbonate

Reports:

Reaction Outcome Event Date Age Sex Weight Reported Reporter Country Treatment
Role Name
Syncope Required Intervention 9/20/2005 Female 114 lb 5/11/2006 Other Health Professional United States
Primary
Secondary
Concomitant
Pulmonary Oedema Life Threatening 3/27/2006 Female 116 lb 6/9/2006 Physician United States
Primary
Secondary
Concomitant
Vaginal Exfoliation Hospitalization 5/23/2006 Female 139 lb 7/13/2006 Physician United Kingdom
Primary
Concomitant
Drug Clearance Decreased Required Intervention 2/24/2004 17 Male 152 lb 7/12/2006 Pharmacist United States
Primary
Concomitant
Pulmonary Oedema Life Threatening 4/7/2006 Female 116 lb 8/10/2006 Physician United States
Primary
Secondary
Concomitant
Aspartate Aminotransferase Increased Hospitalization 7/30/2006 57 Male 149 lb 8/10/2006 Pharmacist United States
Primary
Concomitant
Septic Shock Life Threatening 8/29/2006 50 Male 9/18/2006 Physician Israel
Primary
Concomitant
Vascular Bypass Graft Other Serious 7/21/2005 Male 216 lb 12/11/2006 Other Health Professional United Kingdom
Primary
Concomitant
Death Other Serious 11/12/2006 Male 216 lb 12/22/2006 Other Health Professional United Kingdom
Primary
Concomitant
Death Other Serious 11/12/2006 Male 216 lb 1/9/2007 Other Health Professional United Kingdom
Primary
Concomitant
Peripheral Ischaemia Other Serious 7/21/2005 Male 216 lb 2/27/2007 Other Health Professional United Kingdom
Primary
Concomitant
Ventricular Dysfunction Other Serious 2/26/2007 Male 173 lb 4/11/2007 Physician United States
Primary
Concomitant
Interstitial Lung Disease Other Serious Male 216 lb 4/19/2007 Other Health Professional United Kingdom
Primary
Concomitant
Renal Failure Other Serious Male 4/13/2007 Other Health Professional France
Primary
Secondary
Concomitant
Weight Increased Other Serious 67 Male 6/11/2007 Consumer United States
Primary
Secondary
Concomitant
Xerosis Hospitalization 11 Male 6/13/2007 Physician United States
Primary
Concomitant
Nephropathy Toxic Other Serious 4/1/2005 13 Male 7/2/2007 Other Health Professional United States
Primary
Secondary
Neutrophil Count Decreased 6/18/2007 Male 198 lb 7/3/2007 United States
Primary
Secondary
Concomitant
Venous Thrombosis Hospitalization 11 Male 10/30/2007 Physician United States
Primary
Concomitant
Malignant Melanoma Other Serious 5/15/2007 Male 165 lb 12/3/2007 Other Health Professional United Kingdom
Primary
Concomitant
Viral Infection Other Serious 12/9/2004 Female 141 lb 1/2/2008 Physician United States
Primary
Concomitant
Petechiae Other Serious 7/23/2007 Female 179 lb 3/10/2008 Physician Germany
Primary
Concomitant
Musculoskeletal Stiffness Other Serious Male 36 lb 3/12/2008 Pharmacist United States
Primary
Secondary
Neurotoxicity Other Serious 35 Female 3/27/2008 Pharmacist United States
Primary
Concomitant
Weight Increased Other Serious 6/13/2006 74 Male 198 lb 4/9/2008 Other Health Professional United States
Primary
Secondary
Concomitant
Cardiac Failure Congestive Disability 4/16/2007 46 Female 108 lb 4/22/2008 Physician Japan
Primary
Concomitant
White Blood Cell Count Decreased Hospitalization 4/1/2008 28 Male 123 lb 5/6/2008 Physician United States
Primary
Secondary
Concomitant
Vomiting Death 35 Female 5/20/2008 Pharmacist United States
Primary
Concomitant
Xerosis Other Serious 1/1/2000 11 Male 77 lb 6/19/2008 Lawyer United States
Primary
Secondary
Concomitant
Xerosis Other Serious 1/1/2000 11 Male 77 lb 6/23/2008 Lawyer United States
Primary
Secondary
Concomitant
Cardiomegaly Disability 4/16/2007 46 Female 108 lb 7/15/2008 Physician Japan
Primary
Concomitant
White Blood Cell Count Decreased Hospitalization 4/1/2008 28 Male 123 lb 7/18/2008 Physician United States
Primary
Secondary
Concomitant
Thyroid Neoplasm Other Serious 5/19/2004 Female 184 lb 8/8/2008 Physician United States
Primary
Concomitant
Cardiomegaly Disability 4/16/2007 46 Female 108 lb 9/19/2008 Physician Japan
Primary
Secondary
Concomitant
Renal Failure Acute Other Serious 11/1/2007 43 Male 10/7/2008 Physician United States
Primary
Concomitant
Renal Failure Acute Other Serious 11/1/2007 56 Male 10/7/2008 Physician United States
Primary
Concomitant
Renal Failure Acute Other Serious 12/1/2007 53 Male 10/7/2008 Physician United States
Primary
Concomitant
Gingival Hyperplasia 7/20/2008 Male 11/24/2008 Physician United States
Primary
Secondary
Concomitant
Gamma-glutamyltransferase Increased Hospitalization 12/21/2008 4 Male 44 lb 1/7/2009 Physician Germany
Primary
Secondary
Concomitant
Renal Failure Acute Other Serious 64 Female 1/13/2009
Primary
Secondary
Concomitant
Puncture Site Infection Hospitalization 12/21/2008 4 Male 44 lb 1/22/2009 Physician Germany
Primary
Secondary
Concomitant
Transaminases Increased Hospitalization 12/21/2008 4 Male 44 lb 2/2/2009 Physician Germany
Primary
Secondary
Concomitant
Renal Failure Other Serious 60 Male 4/3/2009 Consumer United Kingdom
Primary
Secondary
Concomitant
Renal Impairment Life Threatening 6/26/2008 49 4/6/2009 Physician Japan
Primary
Secondary
Concomitant
White Blood Cell Count Decreased Other Serious 2/1/2008 27 Male 123 lb 4/17/2009 Physician United States
Primary
Secondary
Concomitant
White Blood Cell Count Decreased Other Serious 2/1/2008 27 Male 123 lb 4/21/2009 Physician United States
Primary
Secondary
Concomitant
Transaminases Increased Hospitalization 12/21/2008 4 Male 44 lb 6/26/2009 Physician Germany
Primary
Secondary
Concomitant
Urticaria Other Serious 12/9/2008 7 Female 7/13/2009 Other Health Professional Japan
Primary
Concomitant
Neutropenia Other Serious 57 Male 8/6/2009
Primary
Secondary
Concomitant
Urticaria Other Serious 12/9/2008 7 Female 10/15/2009 Physician Japan
Primary
Concomitant
Infusion Related Reaction Other Serious 10/13/2009 Male 147 lb 12/23/2009 Consumer United States
Primary
Concomitant
Pyrexia Other Serious 3/22/2009 15 Male 110 lb 2/26/2010 Physician Japan
Primary
Concomitant
Uterine Enlargement Other Serious 32 Female 5/6/2010 Physician Greece
Primary
Secondary
Red Blood Cell Sedimentation Rate Increased 10/6/2009 15 Male 5/13/2010 Other Health Professional France
Primary
Concomitant
Interacting
Stomatitis Other Serious 16 Female 5/21/2010
Primary
Secondary
Uterine Enlargement Other Serious 32 Female 5/27/2010 Physician Greece
Primary
Secondary
Uterine Enlargement Other Serious 32 Female 5/28/2010 Physician Greece
Primary
Secondary
Drug Interaction Hospitalization 10/6/2009 15 Male 6/1/2010 Other Health Professional France
Primary
Concomitant
Interacting
Syncope Other Serious 10/6/2007 50 Male 194 lb 6/30/2010 Lawyer United States
Primary
Concomitant
Sepsis Other Serious 11/1/2009 74 Male 7/6/2010 Physician Japan
Primary
Secondary
Concomitant
Visual Impairment Hospitalization 4 Female 7/8/2010 Other Health Professional Poland
Primary
Secondary
Concomitant
Reversible Posterior Leukoencephalopathy Syndrome Other Serious 4 Female 8/2/2010
Primary
Secondary
Nephropathy Toxic Other Serious 14 Male 8/5/2010
Primary
Secondary
Urinary Incontinence Other Serious 1/1/2009 59 Female 132 lb 8/23/2010 Consumer United States
Primary
Secondary
Concomitant
Tachycardia Other Serious 9/20/2007 50 Male 194 lb 8/27/2010 Other Health Professional United States
Primary
Secondary
Concomitant
Urinary Incontinence Other Serious 6/1/2009 59 Female 132 lb 9/1/2010 Physician Germany
Primary
Secondary
Concomitant
Urinary Tract Infection Other Serious 8/1/2010 69 Female 169 lb 11/24/2010 Physician United States
Primary
Concomitant
Renal Failure Acute Other Serious 56 Male 165 lb 12/29/2010 Pharmacist France
Primary
Concomitant
Therapeutic Response Decreased Other Serious 7/1/2009 48 Female 115 lb 1/6/2011 Physician Japan
Primary
Concomitant
Blood Pressure Increased Other Serious 8/9/2009 48 Female 115 lb 1/10/2011 Physician Japan
Primary
Secondary
Concomitant
Headache Other Serious 9/1/2007 50 Male 194 lb 1/12/2011 Other Health Professional United States
Primary
Secondary
Concomitant
Renal Impairment Other Serious 2/1/2009 35 Female 1/21/2011 Other Health Professional Tunisia
Primary
Concomitant
Interacting
Haemolytic Uraemic Syndrome Other Serious 1/25/2010 10 Female 60 lb 2/4/2011 Physician Japan
Primary
Secondary
Concomitant
Metastases To Liver Other Serious 10/1/2010 70 Female 2/28/2011 Physician Ireland
Primary
Secondary
Concomitant
Acute Graft Versus Host Disease Life Threatening 1/25/2010 10 Female 60 lb 2/16/2011 Physician Japan
Primary
Secondary
Concomitant
Hyponatraemia Other Serious 2/17/2009 35 Female 3/7/2011 Other Health Professional Tunisia
Primary
Secondary
Deep Vein Thrombosis Death 1/1/2010 61 Female 3/11/2011 Physician Netherlands
Primary
Secondary
Concomitant
Intestinal Stenosis Other Serious 10/1/2010 70 Female 3/21/2011 Other Health Professional Ireland
Primary
Secondary
Concomitant
Intestinal Stenosis Hospitalization 10/1/2010 70 Female 3/24/2011 Other Health Professional Ireland
Primary
Secondary
Concomitant
Uterine Cyst Other Serious 10/1/2010 70 Female 4/7/2011 Other Health Professional Ireland
Primary
Secondary
Concomitant
Delirium Other Serious 6/16/2010 53 Male 154 lb 4/8/2011 Physician Japan
Primary
Concomitant
Anaemia Hospitalization 56 Male 3/31/2011 Physician France
Primary
Concomitant
Renal Failure Acute Hospitalization 5/4/2011 16 Male 169 lb 5/11/2011 Physician United States
Primary
Concomitant
Dehydration Hospitalization 4/7/2010 61 Female 6/10/2011 Physician Netherlands
Primary
Secondary
Concomitant
Wegener's Granulomatosis Hospitalization Female 209 lb 6/30/2011 Consumer United Kingdom
Primary
Concomitant
Acute Respiratory Distress Syndrome Life Threatening 11/11/2007 12 Female 80 lb 7/5/2011 Physician Japan
Primary
Secondary
Concomitant
Bacterial Infection Life Threatening 11/8/2009 15 Male 157 lb 7/5/2011 Physician Japan
Primary
Secondary
Concomitant
Hypertension Life Threatening 4/22/2010 13 Male 90 lb 7/5/2011 Physician Japan
Primary
Concomitant
Pneumonia Fungal Death 5/29/2007 47 Male 119 lb 7/8/2011 Physician Japan
Primary
Secondary
Concomitant
Wegener's Granulomatosis Hospitalization Female 209 lb 7/13/2011 Other Health Professional United Kingdom
Primary
Concomitant
Cystitis Haemorrhagic Other Serious 17 Male 7/14/2011 Other Health Professional China
Primary
Concomitant
Cystitis Haemorrhagic Other Serious 43 Male 7/14/2011 Other Health Professional China
Primary
Concomitant
Cystitis Haemorrhagic Other Serious 32 Female 7/14/2011 Other Health Professional China
Primary
Concomitant
Acute Graft Versus Host Disease Other Serious 38 Male 7/14/2011 Other Health Professional China
Primary
Concomitant
Acute Graft Versus Host Disease Other Serious 18 Male 7/14/2011 Physician China
Primary
Concomitant
Chronic Graft Versus Host Disease Other Serious 32 Male 7/14/2011 Other Health Professional China
Primary
Concomitant
Encephalitis Fungal Death Male 139 lb 8/1/2011 Physician Japan
Primary
Secondary
Concomitant
Dysstasia Other Serious 10/1/2006 58 Male 145 lb 8/5/2011 Other Health Professional United States
Primary
Secondary
Concomitant
Colitis Other Serious 7/25/2011 67 Male 182 lb 8/5/2011 Physician United States
Primary
Concomitant
Failure To Thrive Other Serious 7/25/2011 67 Male 182 lb 8/8/2011 Physician United States
Primary
Concomitant
Aortic Valve Replacement Other Serious 1/1/2010 60 Male 157 lb 8/17/2011 Other Health Professional United Kingdom
Primary
Concomitant
Renal Failure Hospitalization 53 Female 8/18/2011 Other Health Professional France
Primary
Concomitant
Interacting
Renal Failure Hospitalization 53 Female 8/18/2011 Other Health Professional France
Primary
Concomitant
Interacting
Renal Failure Hospitalization 53 Female 8/18/2011 Other Health Professional France
Primary
Concomitant
Interacting
Wegener's Granulomatosis Hospitalization Female 176 lb 8/26/2011 Physician United Kingdom
Primary
Concomitant
Dyspnoea Other Serious 7/25/2011 67 Male 182 lb 8/28/2011 Physician United States
Primary
Concomitant
Colitis Other Serious 7/25/2011 67 Male 182 lb 8/30/2011 Physician United States
Primary
Concomitant
Failure To Thrive Other Serious 7/25/2011 67 Male 182 lb 9/2/2011 Physician United States
Primary
Concomitant
Pulmonary Granuloma Hospitalization 6/1/2009 Female 209 lb 9/7/2011 Other Health Professional United Kingdom
Primary
Concomitant
Drug Clearance Decreased Hospitalization 53 Female 9/12/2011 Physician France
Primary
Secondary
Concomitant
Wegener's Granulomatosis Hospitalization 22 Female 176 lb 9/13/2011 Other Health Professional United Kingdom
Primary
Concomitant
Graft Versus Host Disease Disability 6/6/2011 13 Female 88 lb 9/20/2011 Physician Japan
Primary
Concomitant
Drug Clearance Decreased Hospitalization 53 Female 9/23/2011 Other Health Professional France
Primary
Secondary
Concomitant
Myocardial Fibrosis Disability 1/1/2000 11 Male 77 lb 9/27/2011 Other Health Professional United States
Primary
Secondary
Concomitant
Hypertension Other Serious 6/12/2010 53 Male 154 lb 10/5/2011 Physician Japan
Primary
Concomitant
Lymphocyte Count Decreased Other Serious 6/1/2009 22 Female 176 lb 10/12/2011 Other Health Professional United Kingdom
Primary
Concomitant
Condition Aggravated Hospitalization Female 176 lb 10/14/2011 Physician United Kingdom
Primary
Concomitant
Chronic Graft Versus Host Disease Other Serious 10/24/2004 17 Male 10/24/2011 Physician China
Primary
Concomitant
Cystitis Haemorrhagic Other Serious 43 Male 10/24/2011 Other Health Professional China
Primary
Concomitant
Cystitis Haemorrhagic Other Serious 1/8/2008 32 Female 10/24/2011 Other Health Professional China
Primary
Concomitant
Acute Graft Versus Host Disease Other Serious 11/29/2006 38 Male 10/24/2011 Physician China
Primary
Concomitant
Acute Graft Versus Host Disease Other Serious 1/16/2009 32 Male 10/25/2011 Other Health Professional China
Primary
Concomitant
Acute Graft Versus Host Disease Other Serious 4/21/2008 18 Male 10/25/2011 Other Health Professional China
Primary
Concomitant
Drug Interaction Other Serious 8/23/2011 13 Male 92 lb 11/3/2011 Pharmacist Brazil
Primary
Secondary
Concomitant
Interacting
Visual Impairment Death 6/6/2011 13 Female 88 lb 11/8/2011 Physician Japan
Primary
Concomitant
Urinary Tract Infection Pseudomonal Life Threatening 6/9/2010 73 Female 128 lb 11/9/2011 Physician Japan
Primary
Concomitant
Pyrexia Hospitalization 10/25/2010 11 Male 66 lb 12/12/2011 Physician Japan
Primary
Concomitant
Venoocclusive Liver Disease Death 2/7/2009 57 Male 139 lb 12/14/2011 Physician Japan
Primary
Concomitant
Leukopenia Other Serious 2/26/2007 68 Male 173 lb 12/20/2011 Consumer United States
Primary
Secondary
Concomitant
Stomatitis Other Serious 8/13/2009 48 Female 133 lb 12/20/2011 Physician United States
Primary
Secondary
Concomitant
Left Ventricular Dysfunction Other Serious 2/26/2007 68 Male 173 lb 12/27/2011 Consumer United States
Primary
Secondary
Concomitant
Left Ventricular Dysfunction Other Serious 2/26/2007 68 Male 173 lb 12/29/2011 Physician United States
Primary
Secondary
Concomitant
Graft Versus Host Disease In Skin Other Serious 4/22/2010 13 Male 90 lb 1/9/2012 Physician Japan
Primary
Concomitant
Venoocclusive Liver Disease Death 2/7/2009 57 Male 139 lb 2/7/2012 Physician Japan
Primary
Concomitant
Infection Hospitalization 1/29/2009 3 Female 35 lb 2/10/2012 Physician Japan
Primary
Concomitant
Toxic Encephalopathy Other Serious 2/2/2011 26 Male 119 lb 3/9/2012 Japan
Primary
Concomitant
Nausea Other Serious 6/12/2010 53 Male 154 lb 3/15/2012 Physician Japan
Primary
Concomitant
Graft Versus Host Disease In Skin Death 4/20/2010 13 Male 90 lb 3/26/2012 Physician Japan
Primary
Concomitant
Pyrexia Hospitalization 10/25/2010 11 Male 66 lb 3/26/2012 Physician Japan
Primary
Concomitant
Skin Infection Other Serious 4/2/2011 27 Female 112 lb 4/9/2012 Physician Japan
Primary
Concomitant
Blood Lactate Dehydrogenase Increased Disability 3/14/2012 37 Female 119 lb 5/25/2012 Physician Japan
Primary
Concomitant
Decreased Appetite Hospitalization 4/2/2011 27 Female 112 lb 5/30/2012 Physician Japan
Primary
Concomitant
Dry Eye Other Serious 6/12/2010 53 Male 154 lb 5/30/2012 Physician Japan
Primary
Concomitant
Graft Versus Host Disease In Skin Death 4/20/2010 13 Male 90 lb 6/1/2012 Physician Japan
Primary
Secondary
Concomitant
Weight Increased Other Serious 3/14/2012 37 Female 119 lb 6/8/2012 Physician Japan
Primary
Concomitant
Haemolytic Uraemic Syndrome Death 1/29/2009 3 Female 35 lb 7/5/2012 Physician Japan
Primary
Concomitant
Pancytopenia Hospitalization 8/21/2010 77 Male 126 lb 7/6/2012 Consumer Japan
Primary
Secondary
Concomitant
Coagulation Time Abnormal Life Threatening 4/24/2011 10 Female 87 lb 7/10/2012 Physician Japan
Primary
Secondary
Concomitant
Feeling Hot Other Serious 6/2/2012 79 Female 122 lb 7/14/2012 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Scab Other Serious 5/8/2012 79 Female 122 lb 7/16/2012 Pharmacist United Kingdom
Primary
Secondary
Concomitant

Drug Data