Methotrexate combined with Simvastatin

Reports:

Reaction Outcome Event Date Age Sex Weight Reported Reporter Country Treatment
Role Name
Sepsis Other Serious 9/25/2001 Male 1/4/2006 Physician Italy
Primary
Concomitant
Breast Cancer Stage Iii Hospitalization 9/19/2005 Female 1/5/2006 Other Health Professional United Kingdom
Primary
Concomitant
Adverse Event Other Serious 11/11/2005 68 Female 1/10/2006 Physician Sweden
Primary
Concomitant
Skin Graft Infection Other Serious 9/15/2005 Male 192 lb 1/11/2006 Other Health Professional United Kingdom
Primary
Concomitant
Palpitations Other Serious 11/18/2005 Female 1/11/2006 Other Health Professional United Kingdom
Primary
Concomitant
Skin Graft Rejection Other Serious 9/15/2005 Male 192 lb 1/19/2006 Other Health Professional United Kingdom
Primary
Concomitant
Adverse Event Other Serious 8/3/2005 68 Female 1/25/2006 Physician Sweden
Primary
Concomitant
Abdominal Abscess Hospitalization 11/8/2004 Female 148 lb 1/25/2006 Netherlands
Primary
Concomitant
Peripheral Embolism Other Serious 12/15/2004 Female 1/27/2006 Other Health Professional United Kingdom
Primary
Concomitant
Subcutaneous Emphysema Other Serious 10/1/2003 Male 203 lb 2/9/2006 United Kingdom
Primary
Secondary
Concomitant
Facial Palsy Other Serious 12/18/2005 67 Female 143 lb 2/15/2006 Other Health Professional United Kingdom
Primary
Concomitant
Visual Acuity Reduced Other Serious 1/1/2006 Female 151 lb 2/17/2006 Physician Germany
Primary
Concomitant
Sepsis Hospitalization 50 Female 2/21/2006 Other Health Professional United Kingdom
Primary
Concomitant
Gastrointestinal Haemorrhage Life Threatening 7/18/2005 56 Female 2/22/2006 Consumer United Kingdom
Primary
Secondary
Concomitant
Ulcer Haemorrhage Life Threatening 7/18/2003 61 Male 2/23/2006 Other Health Professional Norway
Primary
Concomitant
Cerebrovascular Accident Hospitalization 2/4/2006 61 Male 2/17/2006 Physician Thailand
Primary
Concomitant
Septic Shock Other Serious 8/3/2005 68 Female 3/9/2006 Physician Sweden
Primary
Concomitant
Visual Disturbance Hospitalization 8/14/2003 60 Male 3/8/2006 Canada
Primary
Concomitant
Vomiting Other Serious 2/6/2006 85 Male 137 lb 2/6/2006 Pharmacist United States
Primary
Concomitant
Visual Acuity Reduced Other Serious 1/1/2006 Female 151 lb 3/27/2006 Physician Germany
Primary
Concomitant
Optic Neuritis Retrobulbar Hospitalization 55 Male 4/7/2006 United States
Primary
Concomitant
Haemoptysis Hospitalization 3/27/2006 Male 148 lb 4/14/2006 Norway
Primary
Concomitant
Thalamic Infarction Other Serious 2/1/2006 Female 151 lb 4/14/2006 Physician Germany
Primary
Concomitant
Haemoptysis Hospitalization 3/27/2006 Male 148 lb 4/28/2006 Norway
Primary
Concomitant
Lymphoma Death 1/1/2005 86 Female 5/9/2006 Other Health Professional United Kingdom
Primary
Concomitant
Metastasis Other Serious 10/15/2001 60 Male 5/12/2006 United States
Primary
Secondary
Concomitant
Tooth Extraction Other Serious 10/3/2005 39 Female 128 lb 5/24/2006 Physician United Kingdom
Primary
Concomitant
Bladder Cancer Hospitalization 9/1/2005 Male 5/26/2006 Physician United States
Primary
Concomitant
Carotid Artery Occlusion Other Serious 5/14/2006 Male 156 lb 6/5/2006 Consumer United States
Primary
Concomitant
Soft Tissue Necrosis Hospitalization 1/1/2005 Male 132 lb 6/9/2006 Physician United States
Primary
Concomitant
Osteomyelitis Hospitalization 10/15/2005 Male 176 lb 6/12/2006 Other Health Professional United Kingdom
Primary
Concomitant
Septic Shock Other Serious 11/11/2005 68 Female 6/15/2006 Physician Sweden
Primary
Secondary
Concomitant
Pyrexia Other Serious 11/1/2003 Female 197 lb 6/22/2006 Physician United States
Primary
Secondary
Concomitant
Migraine Other Serious 3/10/2006 Female 155 lb 6/26/2006 Other Health Professional United Kingdom
Primary
Concomitant
Pyrexia Other Serious 11/1/2003 Female 197 lb 6/30/2006 Physician United States
Primary
Secondary
Concomitant
Vomiting Hospitalization 6/21/2006 82 Male 174 lb 7/6/2006 Physician United States
Primary
Concomitant
Therapy Non-responder Hospitalization 3/27/2006 Male 148 lb 7/7/2006 Norway
Primary
Concomitant
Haemoptysis Hospitalization 3/27/2006 Male 148 lb 7/7/2006 Norway
Primary
Concomitant
Neutropenic Sepsis Hospitalization 4/4/2006 74 Female 7/12/2006 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Gastrointestinal Haemorrhage Other Serious 7/6/2006 63 Female 7/19/2006 Consumer Spain
Primary
Concomitant
Convulsion Hospitalization 6/14/2006 Male 150 lb 7/19/2006 Physician United States
Primary
Concomitant
Wheezing Hospitalization 6/21/2006 82 Male 174 lb 7/20/2006 Physician United States
Primary
Concomitant
Urinary Tract Infection Hospitalization 9/7/2005 83 Male 165 lb 7/17/2006 Denmark
Primary
Secondary
Concomitant
Wheezing Hospitalization 6/21/2006 82 Male 174 lb 7/28/2006 Physician United States
Primary
Concomitant
Transient Ischaemic Attack Other Serious 7/30/2004 Female 8/25/2006 Other Health Professional Sweden
Primary
Concomitant
Sepsis Hospitalization 12/29/2005 50 Female 8/31/2006 Other Health Professional United Kingdom
Primary
Concomitant
Ulna Fracture Hospitalization 7/24/2006 Female 8/31/2006 Other Health Professional United Kingdom
Primary
Concomitant
Transient Ischaemic Attack Other Serious 7/30/2004 Female 9/8/2006 Other Health Professional Sweden
Primary
Concomitant
Transient Ischaemic Attack Other Serious 7/30/2004 Female 9/8/2006 Other Health Professional Sweden
Primary
Concomitant
Pulmonary Embolism Hospitalization 6/6/2006 Female 163 lb 9/13/2006 Physician United States
Primary
Concomitant
Obstruction Other Serious 6/28/2006 Female 205 lb 9/22/2006 Other Health Professional United Kingdom
Primary
Concomitant
Septic Shock Other Serious 9/25/2001 Male 10/9/2006 Physician Italy
Primary
Concomitant
Pulmonary Granuloma Life Threatening 1/1/2006 40 Male 10/25/2006 Physician Iceland
Primary
Secondary
Concomitant
Pyelonephritis Acute Other Serious 10/23/2006 46 Female 11/1/2006 Other Health Professional Thailand
Primary
Concomitant
Subcorneal Pustular Dermatosis Hospitalization 6/1/2006 Female 11/6/2006 Other Health Professional Norway
Primary
Concomitant
Neoplasm Malignant Other Serious Female 205 lb 11/9/2006 Other Health Professional United Kingdom
Primary
Concomitant
Respiratory Rate Increased Other Serious 10/23/2006 46 Female 11/13/2006 Other Health Professional Thailand
Primary
Concomitant
Cerebral Infarction Hospitalization 5/15/2006 55 Male 216 lb 11/20/2006 Other Health Professional United Kingdom
Primary
Concomitant
Sarcoidosis Life Threatening 1/1/2006 40 Male 11/27/2006 Physician Switzerland
Primary
Secondary
Concomitant
Tremor Other Serious 10/24/2006 Female 11/27/2006 Other Health Professional United Kingdom
Primary
Concomitant
Tremor Other Serious 10/24/2006 Female 11/29/2006 Other Health Professional United Kingdom
Primary
Concomitant
Tooth Extraction Other Serious 10/3/2005 39 Female 128 lb 12/12/2006 Physician United Kingdom
Primary
Concomitant
Tooth Discolouration Other Serious 6/1/2006 12/13/2006 Physician
Primary
Concomitant
Sepsis Syndrome Required Intervention 5/31/2006 70 Female 12/15/2006 Pharmacist United States
Primary
Concomitant
Headache 9/20/2006 53 Female 150 lb 12/22/2006 Consumer United States
Primary
Concomitant
Synovial Fluid Analysis Hospitalization 8/26/2006 Male 12/22/2006 Other Health Professional Belgium
Primary
Concomitant
Urine Ketone Body Present Other Serious 12/1/2005 Female 12/26/2006 Other Health Professional United Kingdom
Primary
Concomitant
Pulmonary Embolism Hospitalization 6/6/2006 Female 163 lb 12/28/2006 Physician United States
Primary
Concomitant
Sick Sinus Syndrome Other Serious 8/14/2006 Female 199 lb 1/10/2007 Physician United States
Primary
Concomitant
Pneumonia Other Serious 7/5/2006 152 lb 1/13/2007 Other Health Professional United Kingdom
Primary
Concomitant
Oligodendroglioma Hospitalization 3/18/2005 66 Female 181 lb 1/12/2007 Other Health Professional United States
Primary
Secondary
Concomitant
Subcutaneous Emphysema Hospitalization 10/1/2003 66 Male 1/27/2007 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Ulcer Other Serious 7/5/2006 Female 119 lb 1/27/2007 Consumer Brazil
Primary
Concomitant
Femoral Neck Fracture Hospitalization 3/1/2004 Female 2/2/2007 Other Health Professional Germany
Primary
Concomitant
Subcutaneous Emphysema Other Serious 10/1/2003 66 Male 2/1/2007 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Lower Respiratory Tract Infection Other Serious 7/5/2006 152 lb 2/8/2007 Other Health Professional United Kingdom
Primary
Concomitant
Pneumonia Hospitalization 1/3/2007 53 Male 179 lb 2/12/2007 Physician Israel
Primary
Secondary
Concomitant
Dyspnoea Disability 12/1/2006 78 Female 2/13/2007 United States
Primary
Concomitant
Gynaecomastia Other Serious 1/29/2007 Male 212 lb 2/22/2007 Other Health Professional United Kingdom
Primary
Concomitant
Plasma Cells Increased Other Serious 12/1/2006 74 Male 2/13/2007 Physician United States
Primary
Secondary
Concomitant
Plasma Cells Increased Other Serious 12/1/2006 74 Male 2/28/2007 Physician United States
Primary
Secondary
Concomitant
Pancreatic Carcinoma Other Serious 11/1/2006 60 Female 154 lb 3/1/2007 Other Health Professional United Kingdom
Primary
Concomitant
Transient Ischaemic Attack Other Serious 7/30/2004 Female 3/8/2007 Other Health Professional Sweden
Primary
Concomitant
Supraventricular Tachycardia Hospitalization 12/21/2005 Female 123 lb 3/8/2007 Other Health Professional United Kingdom
Primary
Concomitant
Pulmonary Embolism Hospitalization 9/15/2006 Female 176 lb 3/8/2007 Other Health Professional United Kingdom
Primary
Concomitant
Systemic Lupus Erythematosus Other Serious 11/1/2006 Male 179 lb 3/12/2007 Physician United States
Primary
Concomitant
Wound Other Serious 8/14/2006 Female 137 lb 3/23/2007 Other Health Professional United Kingdom
Primary
Concomitant
Joint Swelling Other Serious 11/1/2006 61 Female 269 lb 3/23/2007 United Kingdom
Primary
Secondary
Concomitant
Joint Swelling Other Serious 11/1/2006 61 Female 269 lb 3/23/2007 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Joint Swelling Required Intervention 11/1/2006 61 Female 3/26/2007 United Kingdom
Primary
Secondary
Concomitant
Systemic Lupus Erythematosus Other Serious 11/1/2006 Male 179 lb 4/11/2007 Physician United States
Primary
Concomitant
Gallbladder Disorder Hospitalization 8/17/2006 Female 134 lb 4/13/2007 Physician United States
Primary
Concomitant
Prostatic Disorder Other Serious 7/5/2006 Male 163 lb 4/16/2007 Consumer United Kingdom
Primary
Concomitant
Upper Limb Fracture Other Serious 1/1/1998 Female 4/17/2007 Physician United States
Primary
Concomitant
Skin Test Positive Hospitalization 12/8/2006 83 Female 4/6/2007 France
Primary
Concomitant
Rash Hospitalization 6/6/2006 Female 163 lb 4/18/2007 Physician United States
Primary
Concomitant
Delirium Other Serious 3/13/2007 70 Male 169 lb 3/28/2007 Pharmacist United States
Primary
Concomitant
Vomiting Other Serious 8/25/2006 Female 139 lb 5/4/2007 Other Health Professional United Kingdom
Primary
Concomitant
Transient Ischaemic Attack Other Serious 7/30/2004 Female 5/4/2007 Other Health Professional Sweden
Primary
Concomitant
Myocardial Infarction Death Male 174 lb 5/4/2007 Other Health Professional United Kingdom
Primary
Concomitant
Musculoskeletal Chest Pain Hospitalization 12/5/2006 Female 269 lb 5/9/2007 Other Health Professional United Kingdom
Primary
Concomitant
Tooth Extraction Other Serious 10/3/2005 39 Female 128 lb 5/12/2007 Physician United Kingdom
Primary
Concomitant
Heart Rate Irregular Other Serious 4/1/2007 Male 5/16/2007 Physician United States
Primary
Concomitant
Rash Hospitalization 6/6/2006 Female 163 lb 5/17/2007 Physician United States
Primary
Concomitant
Lower Respiratory Tract Infection Other Serious 1/1/2007 Female 157 lb 5/24/2007 Other Health Professional United Kingdom
Primary
Concomitant
Weight Decreased Hospitalization 83 Male 225 lb 6/7/2007 Physician Norway
Primary
Secondary
Concomitant
Musculoskeletal Chest Pain Hospitalization 12/5/2005 Female 269 lb 6/19/2007 Other Health Professional United Kingdom
Primary
Concomitant
Staphylococcal Infection Death 2/15/2007 Male 132 lb 6/22/2007 Other Health Professional United Kingdom
Primary
Concomitant
Breast Cancer Stage Iii Hospitalization 9/19/2005 Female 212 lb 6/22/2007 Physician United Kingdom
Primary
Concomitant
Stomatitis Life Threatening 4/2/2007 81 Male 220 lb 6/29/2007 Other Health Professional Switzerland
Primary
Secondary
Concomitant
Type 2 Diabetes Mellitus Other Serious 1/1/2005 54 Female 125 lb 6/30/2007 Physician United States
Primary
Concomitant
Liver Function Test Abnormal Other Serious 1/1/2007 68 Female 152 lb 6/22/2007 Physician United Kingdom
Primary
Secondary
Concomitant
Weight Decreased Hospitalization 83 Male 225 lb 6/26/2007 Physician Norway
Primary
Secondary
Concomitant
Staphylococcal Infection Death 2/15/2007 Male 132 lb 7/11/2007 Other Health Professional United Kingdom
Primary
Concomitant
Liver Function Test Abnormal Other Serious 5/21/2007 68 Female 152 lb 6/29/2007 Physician United Kingdom
Primary
Secondary
Concomitant
Ventricular Fibrillation Hospitalization 12/4/2006 Female 198 lb 7/12/2007 Physician Germany
Primary
Secondary
Concomitant
Sepsis Hospitalization 6/11/2007 Male 101 lb 7/13/2007 Physician United Kingdom
Primary
Concomitant
Vomiting Hospitalization 1/1/2007 Male 7/13/2007 Other Health Professional United Kingdom
Primary
Concomitant
Weight Decreased Hospitalization 83 Male 225 lb 7/16/2007
Primary
Secondary
Gastric Ulcer Other Serious 6/16/2005 63 Male 7/20/2007 Physician Sweden
Primary
Secondary
Concomitant
Lower Respiratory Tract Infection Other Serious 7/5/2006 Male 152 lb 7/20/2007 Other Health Professional United Kingdom
Primary
Concomitant
Incision Site Infection Hospitalization Female 130 lb 7/23/2007 Canada
Primary
Concomitant
Prostatic Specific Antigen Increased Other Serious 6/1/2007 Male 180 lb 7/23/2007 Physician United States
Primary
Concomitant
Musculoskeletal Chest Pain Hospitalization 11/15/2006 Female 269 lb 7/27/2007 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Musculoskeletal Chest Pain Hospitalization 12/5/2006 Female 269 lb 7/27/2007 Other Health Professional United Kingdom
Primary
Concomitant
Myocardial Infarction Other Serious Male 190 lb 7/30/2007 Other Health Professional Canada
Primary
Concomitant
Rheumatoid Arthritis Hospitalization Male 8/6/2007 Physician United States
Primary
Concomitant
Myocardial Infarction Death 3/20/2007 Female 165 lb 8/16/2007 Physician Canada
Primary
Concomitant
Pancreatitis Hospitalization 11/21/2006 Male 8/21/2007 Pharmacist United Kingdom
Primary
Secondary
Concomitant
Transient Ischaemic Attack Other Serious 7/30/2004 Female 8/27/2007 Other Health Professional Sweden
Primary
Concomitant
Swelling Hospitalization 8/1/2007 Female 184 lb 8/30/2007 Consumer United States
Primary
Concomitant
Circulatory Collapse Hospitalization 7/24/2007 67 Male 192 lb 9/1/2007 Other Health Professional United Kingdom
Primary
Concomitant
Circulatory Collapse Hospitalization 7/24/2007 67 Male 192 lb 9/6/2007 Other Health Professional United Kingdom
Primary
Concomitant
Atrial Flutter Hospitalization 8/22/2007 65 Male 9/24/2007 Other Health Professional United Kingdom
Primary
Concomitant
Pelvic Pain 7/27/2007 63 Female 159 lb 9/26/2007 Consumer United States
Primary
Concomitant
Ischaemic Cerebral Infarction Other Serious 5/16/2006 66 Female 9/28/2007 Physician Germany
Primary
Concomitant
Rash Maculo-papular Hospitalization 9/13/2007 65 Female 10/10/2007 Other Health Professional United Kingdom
Primary
Concomitant
Syncope Hospitalization 7/24/2007 67 Male 192 lb 10/4/2007 United Kingdom
Primary
Concomitant
Weight Decreased Hospitalization 4/15/2007 Male 132 lb 10/17/2007 Physician United Kingdom
Primary
Concomitant
Infection Other Serious 9/17/2007 Female 159 lb 10/17/2007 Czech Republic
Primary
Concomitant
Meningitis Aseptic Hospitalization 62 Male 10/25/2007
Primary
Secondary
Concomitant
Nodal Marginal Zone B-cell Lymphoma Other Serious 10/15/2007 Female 152 lb 11/7/2007 United States
Primary
Concomitant
Spinal Laminectomy Other Serious 1/1/1999 Male 180 lb 11/14/2007 Consumer United States
Primary
Concomitant
Surgery Other Serious Female 11/16/2007 Other Health Professional United Kingdom
Primary
Concomitant
Rheumatoid Arthritis Hospitalization 8/15/2007 Male 196 lb 11/21/2007 United Kingdom
Primary
Concomitant
Pneumonia Legionella Other Serious 11/8/2007 85 143 lb 11/21/2007 Physician Israel
Primary
Concomitant
Pericarditis Other Serious 46 Female 11/28/2007 Other Health Professional United Kingdom
Primary
Concomitant
Tachycardia Hospitalization 8/14/2007 Female 159 lb 11/28/2007 Germany
Primary
Concomitant
Rectal Cancer Hospitalization 3/14/2007 Female 198 lb 11/30/2007 United Kingdom
Primary
Concomitant
Myocardial Ischaemia Death 11/19/2007 Female 183 lb 11/30/2007 Consumer United Kingdom
Primary
Secondary
Concomitant

Drug Data