Methotrexate combined with Rituximab

Reports:

Reaction Outcome Event Date Age Sex Weight Reported Reporter Country Treatment
Role Name
Tongue Disorder Other Serious 12/5/2005 Male 216 lb 12/27/2005 United States
Primary
Secondary
Palpitations Hospitalization 8/4/2005 Female 1/20/2006 Other Health Professional Sweden
Primary
Concomitant
Limb Injury Hospitalization 1/9/2006 77 Female 207 lb 1/17/2006 Physician United States
Primary
Concomitant
Vomiting Other Serious 1/19/2006 Female 125 lb 1/26/2006 United States
Primary
Secondary
Transaminases Increased Other Serious 1/11/2006 Male 141 lb 1/30/2006 United States
Primary
Secondary
Ovarian Cancer Metastatic Life Threatening 3/15/2004 Female 143 lb 3/2/2006 Physician United Kingdom
Primary
Concomitant
Staphylococcal Infection Hospitalization 11/23/2005 Male 3/1/2006 Other Health Professional United States
Primary
Secondary
Concomitant
Deep Vein Thrombosis Hospitalization 8/27/2005 63 Female 3/22/2006 Physician France
Primary
Secondary
Concomitant
Sigmoiditis Hospitalization 3/27/2006 70 Male 146 lb 4/11/2006 Physician France
Primary
Secondary
Concomitant
T-cell Lymphoma Death 66 Male 5/12/2006 Consumer United States
Primary
Secondary
Concomitant
Stomach Discomfort Required Intervention 1/1/2005 40 Female 136 lb 1/3/2006 Physician United States
Primary
Secondary
Concomitant
Stem Cell Transplant Other Serious 2/13/2005 66 Female 5/15/2006 Physician Germany
Primary
Concomitant
Ovarian Cancer Metastatic Life Threatening 3/15/2004 Female 143 lb 5/31/2006 Physician United Kingdom
Primary
Concomitant
Tongue Disorder Hospitalization 6/1/2006 Male 212 lb 7/18/2006 Physician Germany
Primary
Secondary
Concomitant
Pancytopenia Other Serious 5/18/2006 49 Male 146 lb 7/28/2006 Physician France
Primary
Secondary
Concomitant
White Blood Cell Count Decreased Life Threatening 3/6/2006 64 Male 182 lb 8/3/2006 Other Health Professional United States
Primary
Concomitant
Peripheral Sensory Neuropathy Hospitalization 11/9/2004 68 Female 8/11/2006 Consumer United States
Primary
Secondary
Respiratory Tract Infection Hospitalization 1/1/2005 Female 132 lb 8/17/2006 Physician Germany
Primary
Secondary
Concomitant
Malignant Melanoma In Situ Other Serious 5/24/2006 57 Female 8/17/2006 Physician United States
Primary
Secondary
Concomitant
Transient Ischaemic Attack Other Serious 7/30/2004 Female 8/25/2006 Other Health Professional Sweden
Primary
Concomitant
Refusal Of Treatment By Patient Hospitalization 58 Female 9/1/2006 United States
Primary
Secondary
Transient Ischaemic Attack Other Serious 7/30/2004 Female 9/8/2006 Other Health Professional Sweden
Primary
Concomitant
Transient Ischaemic Attack Other Serious 7/30/2004 Female 9/8/2006 Other Health Professional Sweden
Primary
Concomitant
Liver Disorder Hospitalization 10/1/2005 66 Male 10/18/2006 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Sigmoiditis Hospitalization 3/27/2006 70 Male 146 lb 10/20/2006 Other Health Professional France
Primary
Secondary
Concomitant
Venous Thrombosis Limb Other Serious 58 Female 10/26/2006 Physician United States
Primary
Secondary
Lymphoma Other Serious 10/1/2003 Female 11/8/2006 Physician United States
Primary
Secondary
Concomitant
Muscular Weakness Disability 3/1/2006 47 Male 150 lb 11/20/2006 Physician Switzerland
Primary
Secondary
Concomitant
Muscular Weakness Disability 3/1/2006 47 Male 150 lb 11/30/2006 Physician Switzerland
Primary
Secondary
Concomitant
Hepatotoxicity Other Serious 52 Male 1/19/2007 Other Health Professional Israel
Primary
Secondary
Concomitant
Hepatotoxicity Other Serious 47 Female 1/19/2007 Other Health Professional Israel
Primary
Secondary
Concomitant
Vith Nerve Paralysis Other Serious 10/22/2006 23 Male 172 lb 1/10/2007 Physician Finland
Primary
Secondary
Concomitant
Jaundice Cholestatic 52 Male 1/26/2007 Israel
Primary
Secondary
Concomitant
Hepatotoxicity 47 Female 1/26/2007 Israel
Primary
Secondary
Concomitant
Pneumonia Hospitalization 1/3/2007 53 Male 179 lb 2/12/2007 Physician Israel
Primary
Secondary
Concomitant
Febrile Neutropenia Life Threatening 70 Female 2/12/2007 Consumer Israel
Primary
Secondary
Concomitant
Neutropenic Sepsis Death 2/20/2007 Consumer Australia
Primary
Secondary
Thrombocytopenia Other Serious 2/20/2007 Consumer Australia
Primary
Secondary
Headache Life Threatening 12/20/2006 49 Male 3/6/2007 Other Health Professional France
Primary
Secondary
Concomitant
Transient Ischaemic Attack Other Serious 7/30/2004 Female 3/8/2007 Other Health Professional Sweden
Primary
Concomitant
Staphylococcal Sepsis Other Serious 31 Male 4/4/2007 Other Health Professional United States
Primary
Secondary
Status Epilepticus Hospitalization Male 4/20/2007 Physician France
Primary
Concomitant
Staphylococcal Sepsis Hospitalization 2/21/2007 Female 159 lb 5/2/2007 Germany
Primary
Secondary
Concomitant
Transient Ischaemic Attack Other Serious 7/30/2004 Female 5/4/2007 Other Health Professional Sweden
Primary
Concomitant
T-cell Lymphoma Other Serious 7/1/2005 66 Male 5/10/2007 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Staphylococcal Sepsis Other Serious 4/2/2007 Female 165 lb 5/16/2007 Physician Germany
Primary
Secondary
Concomitant
Status Epilepticus Life Threatening Male 5/18/2007 Other Health Professional France
Primary
Secondary
Concomitant
Cryptogenic Organising Pneumonia Other Serious Female 150 lb 5/18/2007 Physician United Kingdom
Primary
Concomitant
Neoplasm Skin Hospitalization 2/28/2006 Female 5/18/2007 Other Health Professional France
Primary
Secondary
Concomitant
Rheumatoid Arthritis Other Serious 9/13/2006 Female 205 lb 5/25/2007 Other Health Professional United States
Primary
Secondary
Concomitant
Pleural Effusion Other Serious 12/1/2003 Female 121 lb 5/29/2007 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Pneumonia Cytomegaloviral Other Serious 65 Female 5/25/2007 Other Health Professional United States
Primary
Secondary
Concomitant
Neurotoxicity Death 54 Male 5/25/2007 Physician United States
Primary
Secondary
Concomitant
Staphylococcal Sepsis Hospitalization 2/21/2007 56 Female 6/12/2007 Physician Germany
Primary
Secondary
Concomitant
Lymphadenopathy Hospitalization 4/23/2007 Female 115 lb 6/15/2007 Physician United Kingdom
Primary
Concomitant
Cryptogenic Organising Pneumonia Hospitalization 4/1/2007 Female 150 lb 6/15/2007 Physician United Kingdom
Primary
Concomitant
Mastoiditis Hospitalization 10/22/2006 Male 6/17/2007 Physician Germany
Primary
Secondary
Concomitant
Pyrexia Hospitalization 5/9/2006 57 Male 6/19/2007 Consumer Japan
Primary
Secondary
Psychomotor Skills Impaired Life Threatening 1/1/2007 1 Male 15 lb 6/14/2007 Physician United States
Primary
Concomitant
Staphylococcal Sepsis Other Serious 2/21/2007 Female 165 lb 6/20/2007 Physician Germany
Primary
Secondary
Concomitant
Gastrointestinal Disorder Hospitalization 4/21/2006 Male 6/20/2007 Consumer Belgium
Primary
Secondary
Concomitant
Drug Toxicity Death 64 Male 6/16/2007 Italy
Primary
Secondary
Concomitant
Dyspnoea Hospitalization 12/24/2006 67 Male 198 lb 6/16/2007 Consumer United Kingdom
Primary
Secondary
Concomitant
Lymphadenopathy Hospitalization 4/23/2007 Female 115 lb 6/22/2007 Physician United Kingdom
Primary
Concomitant
Pulmonary Fibrosis Other Serious 5/7/2007 39 Male 6/25/2007 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Breast Cancer Other Serious 6/21/2005 Female 6/26/2007 Physician United States
Primary
Secondary
Concomitant
Deep Vein Thrombosis Other Serious 6/14/2007 Female 123 lb 6/29/2007 Physician United Kingdom
Primary
Secondary
Concomitant
Tenosynovitis Hospitalization 1/16/2007 Female 108 lb 6/29/2007 Physician United Kingdom
Primary
Secondary
Concomitant
Pneumonia Other Serious 2/21/2007 Female 165 lb 7/9/2007 Physician Germany
Primary
Secondary
Concomitant
Diabetes Mellitus Hospitalization 7/2/2007 Female 176 lb 7/12/2007 Consumer United Kingdom
Primary
Secondary
Concomitant
Pulmonary Fibrosis Hospitalization 5/7/2007 39 Male 7/17/2007 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Vertigo Other Serious 2/9/2007 Female 166 lb 7/17/2007 Consumer United Kingdom
Primary
Concomitant
Bradycardia Hospitalization 7/5/2007 Female 176 lb 7/18/2007 Other Health Professional United States
Primary
Concomitant
Lymphadenopathy Hospitalization 4/23/2007 Female 115 lb 7/18/2007 Physician United Kingdom
Primary
Concomitant
Deep Vein Thrombosis Other Serious 6/14/2007 Female 123 lb 7/19/2007 Consumer United Kingdom
Primary
Secondary
Concomitant
Upper Gastrointestinal Haemorrhage Hospitalization 7/9/2007 Female 123 lb 7/19/2007 Consumer United Kingdom
Primary
Secondary
Concomitant
Sinusitis Hospitalization 9/20/2006 Female 198 lb 7/26/2007 Consumer Australia
Primary
Secondary
Concomitant
Rash Pruritic Other Serious 7/7/2006 37 Female 7/27/2007 Germany
Primary
Secondary
Concomitant
Pulmonary Fibrosis Other Serious 5/7/2007 39 Male 8/16/2007 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Staphylococcal Sepsis Hospitalization 2/21/2007 56 Female 8/18/2007 Physician Germany
Primary
Secondary
Concomitant
Transient Ischaemic Attack Other Serious 7/30/2004 Female 8/27/2007 Other Health Professional Sweden
Primary
Concomitant
Interstitial Lung Disease Death 7/25/2007 Male 176 lb 8/30/2007 Consumer Mexico
Primary
Concomitant
Gastric Ulcer Death 8/1/2007 Male 205 lb 9/4/2007 Physician Poland
Primary
Concomitant
Osteonecrosis Other Serious 8/2/2006 Female 202 lb 9/7/2007 Physician United States
Primary
Concomitant
Rash Maculo-papular Hospitalization 10/1/2006 Male 9/7/2007 Other Health Professional France
Primary
Concomitant
Polyneuropathy Death 1/5/2007 Female 130 lb 9/10/2007 Consumer France
Primary
Secondary
Escherichia Sepsis Hospitalization 7/14/2007 Male 123 lb 9/12/2007 Physician United Kingdom
Primary
Secondary
Drug Exposure During Pregnancy Other Serious 6/14/2007 Female 195 lb 9/14/2007 Physician United States
Primary
Secondary
Concomitant
Skin Lesion Hospitalization 10/1/2006 Male 9/14/2007 Other Health Professional France
Primary
Concomitant
Non-hodgkin's Lymphoma Other Serious 46 Female 9/17/2007 Other Health Professional Spain
Primary
Concomitant
Polyneuropathy Death 1/5/2007 Female 130 lb 9/21/2007 Consumer France
Primary
Secondary
Atrioventricular Block Second Degree Hospitalization 7/5/2007 Female 176 lb 9/21/2007 Other Health Professional United States
Primary
Concomitant
Anaemia Hospitalization 8/29/2007 47 Female 119 lb 9/20/2007 Physician United States
Primary
Concomitant
Rectal Perforation Hospitalization 7/14/2007 Male 123 lb 9/26/2007 Physician United Kingdom
Primary
Secondary
Anaemia Hospitalization 8/29/2007 47 Female 119 lb 9/28/2007 Physician United States
Primary
Concomitant
Myelodysplastic Syndrome Death 54 9/27/2007 Physician United States
Primary
Secondary
Concomitant
Myelodysplastic Syndrome Death 61 9/27/2007 Physician United States
Primary
Secondary
Concomitant
Myelodysplastic Syndrome Death 79 9/27/2007 Physician United States
Primary
Secondary
Concomitant
Escherichia Sepsis Hospitalization 7/14/2007 Male 123 lb 10/1/2007 Consumer United Kingdom
Primary
Secondary
Gastric Ulcer Death 8/1/2007 Male 205 lb 10/4/2007 Physician Poland
Primary
Concomitant
Tongue Disorder Hospitalization 6/1/2006 Male 212 lb 10/5/2007 Physician Germany
Primary
Secondary
Concomitant
Atrioventricular Block Second Degree Hospitalization 7/5/2007 Female 176 lb 10/5/2007 Other Health Professional United States
Primary
Concomitant
Uveitis Other Serious 25 Female 10/8/2007
Primary
Secondary
Asthma Hospitalization 8/16/2007 Female 198 lb 10/9/2007 Consumer Australia
Primary
Secondary
Concomitant
Renal Failure Acute Other Serious 28 Male 10/15/2007 Consumer Switzerland
Primary
Secondary
Ureaplasma Infection Other Serious 28 Male 10/15/2007 Switzerland
Primary
Secondary
Concomitant
Renal Failure Acute Other Serious 28 Male 10/17/2007
Primary
Secondary
Concomitant
Pulmonary Fibrosis Other Serious 5/7/2007 39 Male 10/18/2007 Other Health Professional United States
Primary
Secondary
Concomitant
Urinary Incontinence Other Serious 11/12/1993 60 Female 10/19/2007 Taiwan, Province Of China
Primary
Secondary
Concomitant
Pulmonary Fibrosis Other Serious 5/7/2007 39 Male 10/22/2007 Other Health Professional United States
Primary
Secondary
Concomitant
Ureaplasma Infection Hospitalization 28 Male 10/11/2007 Switzerland
Primary
Secondary
Atrioventricular Block Second Degree Hospitalization 7/2/2007 Female 176 lb 10/26/2007 Other Health Professional United States
Primary
Concomitant
Squamous Cell Carcinoma Hospitalization 6/1/2007 Male 10/30/2007 Physician Norway
Primary
Secondary
Concomitant
Tongue Neoplasm Malignant Stage Unspecified Hospitalization 6/1/2007 Male 11/2/2007 Physician Norway
Primary
Secondary
Concomitant
Leukocytosis Hospitalization 4/26/2007 Female 115 lb 11/7/2007 Physician United Kingdom
Primary
Concomitant
Tumour Lysis Syndrome Other Serious 1/1/2004 Male 11/8/2007 Other Health Professional Portugal
Primary
Secondary
Concomitant
Myelopathy Other Serious 11/12/2004 60 Female 11/8/2007 Taiwan, Province Of China
Primary
Secondary
Concomitant
Squamous Cell Carcinoma Hospitalization 6/1/2007 Male 11/9/2007 Other Health Professional Norway
Primary
Secondary
Concomitant
Anaemia Hospitalization 8/29/2007 47 Female 119 lb 11/12/2007 Physician United States
Primary
Concomitant
Type 1 Diabetes Mellitus Hospitalization 7/2/2007 Female 176 lb 11/14/2007 Consumer United Kingdom
Primary
Secondary
Concomitant
Respiratory Rate Increased Life Threatening 1/1/2007 1 Male 15 lb 11/16/2007 Physician United States
Primary
Concomitant
Adenocarcinoma Death 9/6/2007 Female 11/21/2007 Physician Denmark
Primary
Secondary
Concomitant
Ureaplasma Infection Other Serious 28 Male 11/23/2007 Physician Switzerland
Primary
Secondary
Concomitant
Pyrexia Other Serious 12/20/2006 Female 137 lb 11/29/2007 Consumer France
Primary
Secondary
Concomitant
Myocardial Ischaemia Death 11/19/2007 Female 183 lb 11/30/2007 Consumer United Kingdom
Primary
Secondary
Concomitant
Basal Cell Carcinoma Other Serious Female 176 lb 12/4/2007 Physician United Kingdom
Primary
Secondary
Concomitant
Breast Cancer Other Serious 8/14/2007 Female 132 lb 12/4/2007 Physician Germany
Primary
Secondary
Drug Ineffective Death 10/13/2005 Female 185 lb 12/4/2007 Physician Denmark
Primary
Secondary
Concomitant
Respiratory Failure Hospitalization 8/1/2007 1 Male 11/29/2007 Physician United States
Primary
Concomitant
Brain Neoplasm Life Threatening 9/15/2007 62 Male 12/5/2007 Other Health Professional France
Primary
Concomitant
Pyrexia Other Serious 12/20/2006 Female 137 lb 12/8/2007 Consumer France
Primary
Secondary
Concomitant
Pulmonary Embolism Death 11/21/2007 Female 143 lb 12/10/2007 Physician United Kingdom
Primary
Concomitant
Asthma Hospitalization 9/20/2006 Female 198 lb 12/12/2007 Consumer Australia
Primary
Secondary
Concomitant
Myocardial Ischaemia Death 10/31/2007 Female 183 lb 12/12/2007 Consumer United Kingdom
Primary
Secondary
Concomitant
Respiratory Disorder Hospitalization 11/25/2007 1 Male 23 lb 12/10/2007 Pharmacist United States
Primary
Concomitant
Pyelonephritis Hospitalization 7/2/2007 Female 176 lb 12/14/2007 Consumer United Kingdom
Primary
Secondary
Concomitant
Basal Cell Carcinoma Other Serious 6/21/2007 Female 176 lb 12/14/2007 Physician United Kingdom
Primary
Secondary
Concomitant
Malignant Melanoma Other Serious 11/6/2007 Male 160 lb 12/17/2007 Physician United Kingdom
Primary
Secondary
Concomitant
Weight Bearing Difficulty Hospitalization 8/1/2007 1 Male 22 lb 12/11/2007 Physician United States
Primary
Concomitant
Weaning Failure Hospitalization 3/19/2007 1 Male 12 lb 12/13/2007 Other Health Professional United States
Primary
Concomitant
Weaning Failure Life Threatening 4/1/2007 1 Male 15 lb 12/13/2007 Physician United States
Primary
Concomitant
Leukocytosis Hospitalization 4/23/2007 Female 115 lb 12/20/2007 Physician United Kingdom
Primary
Concomitant
Pyrexia Other Serious 17 Male 12/28/2007 Other Health Professional France
Primary
Secondary
Diverticulitis Hospitalization 8/22/2007 Female 226 lb 12/28/2007 Other Health Professional United Kingdom
Primary
Concomitant
Staphylococcal Infection Hospitalization 8/22/2007 Female 226 lb 1/2/2008 Other Health Professional United Kingdom
Primary
Concomitant
Pulmonary Embolism Death 11/21/2007 Female 143 lb 1/8/2008 Physician United Kingdom
Primary
Concomitant
Metastases To Peritoneum Death 10/13/2005 Female 185 lb 1/11/2008 Physician Denmark
Primary
Secondary
Concomitant
Lower Respiratory Tract Infection Viral Hospitalization 9/20/2006 Female 198 lb 1/23/2008 Consumer Australia
Primary
Secondary
Concomitant
Renal Failure Hospitalization 2/7/2007 Male 1/25/2008 Physician France
Primary
Secondary
Epistaxis Hospitalization 2/7/2007 Male 1/25/2008 Physician France
Primary
Secondary

Drug Data