Methotrexate combined with Rituxan

Reports:

Reaction Outcome Event Date Age Sex Weight Reported Reporter Country Treatment
Role Name
White Blood Cell Count Decreased Hospitalization 5/30/2005 65 Male 137 lb 2/1/2006 Japan
Primary
Concomitant
White Blood Cell Count Decreased Hospitalization 5/30/2005 65 Male 137 lb 2/8/2006 Physician Japan
Primary
Concomitant
Anaphylactic Shock Required Intervention 2/1/2006 27 Female 160 lb 2/23/2006 United States
Primary
Concomitant
White Blood Cell Count Decreased Hospitalization 5/30/2005 65 Male 137 lb 2/27/2006 Physician Japan
Primary
Concomitant
Pericardial Haemorrhage Death 1/9/2006 47 Male 2/27/2006 Physician Japan
Primary
Concomitant
White Blood Cell Count Decreased Hospitalization 5/30/2005 65 Male 137 lb 3/2/2006 Physician Japan
Primary
Concomitant
Prostration Hospitalization 12/1/2005 Male 168 lb 3/9/2006 Physician Portugal
Primary
Secondary
Concomitant
White Blood Cell Count Decreased Other Serious 11/10/2004 68 Male 152 lb 3/7/2006 Physician Japan
Primary
Secondary
Concomitant
Rheumatoid Arthritis Other Serious 8/1/2005 Female 171 lb 4/11/2006 Physician United States
Primary
Concomitant
Pericardial Haemorrhage Death 1/9/2006 47 Male 4/7/2006 Physician Japan
Primary
Concomitant
White Blood Cell Count Decreased Other Serious 11/3/2004 30 Female 99 lb 4/11/2006 Physician Japan
Primary
Secondary
Concomitant
Pneumonia Death 2/13/2004 63 Male 4/14/2006 Physician Japan
Primary
Secondary
Concomitant
Prostration Hospitalization 12/1/2005 Male 168 lb 5/9/2006 Physician Portugal
Primary
Secondary
Concomitant
Rheumatoid Arthritis Other Serious 8/1/2005 Female 171 lb 5/9/2006 Physician United States
Primary
Concomitant
Infusion Related Reaction Other Serious 3/16/2006 62 Female 5/15/2006 Physician Norway
Primary
Concomitant
Nausea 6/2/2006 Female 166 lb 6/26/2006 Other Health Professional United States
Primary
Concomitant
Thrombosis Death 6/12/2006 51 Female 164 lb 7/5/2006 Other Health Professional United States
Primary
Concomitant
Therapy Non-responder Death 7/11/2006 46 Female 7/31/2006 Physician United States
Primary
Concomitant
Rheumatoid Arthritis Hospitalization 8/10/2006 Female 8/29/2006 Other Health Professional United States
Primary
Concomitant
Hypotension Required Intervention 4/12/2006 60 Female 207 lb 6/6/2006 Physician United States
Primary
Concomitant
Weight Loss Diet Hospitalization 1/1/2006 46 Female 248 lb 8/29/2006 Consumer United States
Primary
Concomitant
Rhinalgia Other Serious 9/7/2006 48 Female 9/15/2006 Consumer United States
Primary
Secondary
White Blood Cell Count Decreased Hospitalization 7/1/2006 46 Female 9/20/2006 Physician United States
Primary
Concomitant
Neoplasm Malignant Other Serious 60 Male 167 lb 10/20/2006 Other Health Professional United States
Primary
Concomitant
Hepatitis B Death 7 Male 10/24/2006 Physician Japan
Primary
Concomitant
Dysphasia Life Threatening 10/7/2006 82 Female 99 lb 10/30/2006 Other Health Professional Canada
Primary
Concomitant
Pleural Effusion Hospitalization 11/26/2003 61 Male 168 lb 11/6/2006 Physician United States
Primary
Secondary
Stomatitis Other Serious 10/1/2006 48 Female 191 lb 11/14/2006 Consumer United States
Primary
Secondary
Oedema Peripheral Other Serious 10/1/2006 48 Female 140 lb 12/11/2006 United States
Primary
Concomitant
Sepsis Hospitalization 56 Female 12/13/2006 Consumer United States
Primary
Concomitant
Hyperammonaemia Death 9/15/2005 60 Male 12/18/2006 Physician Japan
Primary
Concomitant
Oedema Peripheral Other Serious 10/1/2006 48 Female 140 lb 1/9/2007 United States
Primary
Concomitant
Toxic Shock Syndrome Hospitalization 56 Female 1/10/2007 Consumer United States
Primary
Concomitant
Thrombosis Death 6/12/2006 51 Female 164 lb 2/21/2007 Other Health Professional United States
Primary
Concomitant
Musculoskeletal Chest Pain Hospitalization 12/8/2006 56 Female 2/28/2007 Physician United Kingdom
Primary
Secondary
Concomitant
Progesterone Receptor Assay Positive Other Serious 12/12/2005 54 Female 125 lb 3/6/2007 Physician United States
Primary
Secondary
Concomitant
Coronary Artery Occlusion Life Threatening 1/12/2007 72 Female 226 lb 3/8/2007 Physician United States
Primary
Concomitant
White Blood Cell Count Increased Death 9/21/2006 41 Female 123 lb 3/13/2007 Other Health Professional United States
Primary
Secondary
Concomitant
Tachycardia Hospitalization 12/8/2006 56 Female 3/19/2007 Physician United Kingdom
Primary
Secondary
Concomitant
Skin Cancer Other Serious 6/1/2006 Female 3/27/2007 Physician United States
Primary
Concomitant
White Blood Cell Count Decreased Death 3/20/2007 Physician United States
Primary
Concomitant
Coronary Artery Occlusion Life Threatening 1/12/2007 72 Female 226 lb 3/21/2007 Other Health Professional United States
Primary
Concomitant
Weight Increased Other Serious 67 Male 3/23/2007 United States
Primary
Secondary
Concomitant
Cholelithiasis Hospitalization 1/21/2007 60 Unknown 3/22/2007 Other Health Professional United States
Primary
Concomitant
Toxic Shock Syndrome Hospitalization 56 Female 3/30/2007 Consumer United States
Primary
Concomitant
Neutropenic Sepsis Hospitalization 2/22/2007 62 Male 4/18/2007 Consumer United States
Primary
Concomitant
Weight Increased Hospitalization 6/11/2006 Male 198 lb 4/18/2007 Other Health Professional United States
Primary
Secondary
Concomitant
Subcutaneous Nodule Other Serious 2/1/2007 Female 5/7/2007 Consumer United States
Primary
Secondary
Concomitant
Acute Respiratory Distress Syndrome Other Serious 11/23/2006 Female 190 lb 5/7/2007 Consumer United States
Primary
Secondary
Concomitant
Sepsis Death 5/18/2007 Consumer United States
Primary
Concomitant
Myelodysplastic Syndrome Other Serious 1/15/2007 59 Male 234 lb 5/24/2007 Other Health Professional United States
Primary
Secondary
Concomitant
Weight Increased Other Serious 67 Male 6/11/2007 Consumer United States
Primary
Secondary
Concomitant
Respiratory Syncytial Virus Infection Hospitalization 5/13/2007 Female 6/12/2007 Consumer United States
Primary
Concomitant
Vith Nerve Paralysis Other Serious 10/22/2006 23 Male 172 lb 7/9/2007 United Kingdom
Primary
Concomitant
Female Genital Tract Fistula Hospitalization 5/1/2007 Female 7/25/2007 Physician United Kingdom
Primary
Concomitant
Asthma Hospitalization 9/20/2006 Female 198 lb 8/2/2007 Consumer Australia
Primary
Secondary
Concomitant
Liver Function Test Abnormal Other Serious Female 8/3/2007 Pharmacist United Kingdom
Primary
Secondary
Atrioventricular Block Second Degree Hospitalization 7/5/2007 Female 176 lb 8/3/2007 Other Health Professional United States
Primary
Concomitant
Female Genital Tract Fistula Hospitalization 5/1/2007 Female 8/3/2007 Physician United Kingdom
Primary
Concomitant
Drug Exposure During Pregnancy Other Serious 6/14/2007 Female 195 lb 8/7/2007 Physician United States
Primary
Concomitant
Fatigue Other Serious Male 200 lb 8/9/2007 Consumer United States
Primary
Concomitant
Lacunar Infarction Other Serious 12/30/2005 Female 166 lb 8/10/2007 Physician United States
Primary
Secondary
Concomitant
Renal Impairment Death 5/31/2007 Male 8/10/2007 Other Health Professional Italy
Primary
Concomitant
Interstitial Lung Disease Hospitalization 8/2/2007 Female 218 lb 8/13/2007 Other Health Professional United States
Primary
Secondary
Renal Impairment Death 5/31/2007 Male 8/15/2007 Other Health Professional Italy
Primary
Concomitant
Polyp Hospitalization 5/1/2007 Female 8/17/2007 Physician United Kingdom
Primary
Concomitant
Arthritis Other Serious 12/9/2006 Female 195 lb 8/17/2007 Other Health Professional Netherlands
Primary
Concomitant
Regurgitation Other Serious 7/20/2007 Male 175 lb 8/31/2007 Consumer United States
Primary
Concomitant
Urinary Tract Infection Other Serious 12/13/2006 55 Female 6/8/2007 Consumer United States
Primary
Concomitant
Hypertension Other Serious 12/4/2006 48 Female 193 lb 6/8/2007 Consumer United States
Primary
Concomitant
White Blood Cell Count Decreased Other Serious 12/1/2006 60 Female 6/8/2007 Consumer United States
Primary
Secondary
Concomitant
Infection Other Serious 2/1/2007 51 Female 6/8/2007 Consumer United States
Primary
Concomitant
Staphylococcal Infection Other Serious 67 Female 108 lb 6/8/2007 Consumer United States
Primary
Concomitant
Hypersensitivity Other Serious 11/23/2006 64 Female 190 lb 6/8/2007 Consumer United States
Primary
Secondary
Concomitant
Polyp Hospitalization 5/1/2007 Female 9/6/2007 Physician United Kingdom
Primary
Concomitant
Thrombocytopenia Hospitalization 7/1/2007 25 Female 9/6/2007 Physician Colombia
Primary
Concomitant
Hepatitis B Death 3/1/2006 54 Male 9/11/2007 Japan
Primary
Secondary
Concomitant
Red Blood Cell Sedimentation Rate Increased Other Serious 4/27/2007 Female 190 lb 9/11/2007 Physician United States
Primary
Concomitant
Mutism Female 126 lb 9/11/2007 Physician Jordan
Primary
Concomitant
Paranoia Other Serious Male 9/12/2007 Physician United Kingdom
Primary
Secondary
Mutism Other Serious 8/21/2007 Female 126 lb 9/14/2007 Physician Jordan
Primary
Concomitant
Rash Generalised Hospitalization 9/7/2007 Female 9/18/2007 Physician Singapore
Primary
Concomitant
Hepatitis Fulminant Death 2/1/2006 54 Male 9/18/2007 Japan
Primary
Secondary
Concomitant
Psoriatic Arthropathy Other Serious Female 176 lb 9/25/2007 Physician Australia
Primary
Concomitant
Hepatitis B Death 54 Male 9/25/2007 Physician Japan
Primary
Concomitant
Vomiting Hospitalization 9/11/2007 Male 9/26/2007 Consumer Italy
Primary
Concomitant
Red Blood Cell Sedimentation Rate Increased Other Serious 4/27/2007 Female 190 lb 9/27/2007 Physician United States
Primary
Concomitant
Pharyngitis Streptococcal Hospitalization 9/17/2007 50 Male 9/27/2007 Physician France
Primary
Secondary
Concomitant
Hepatitis Fulminant Death 2/1/2006 54 Male 10/2/2007 Japan
Primary
Secondary
Concomitant
Rash Generalised Hospitalization 9/7/2007 Female 10/2/2007 Physician Singapore
Primary
Concomitant
Tendon Rupture Hospitalization 70 Male 10/2/2007 Physician France
Primary
Concomitant
Tendon Rupture Hospitalization 70 Male 10/5/2007 Physician France
Primary
Concomitant
Loss Of Consciousness Hospitalization 9/12/2007 70 Male 196 lb 10/1/2007 Physician United States
Primary
Secondary
Concomitant
Therapeutic Agent Toxicity Hospitalization 8/30/2007 43 Male 233 lb 10/4/2007 Pharmacist United States
Primary
Concomitant
Weight Increased Other Serious 55 Female 10/24/2007 Other Health Professional United Kingdom
Primary
Concomitant
Pulmonary Fibrosis Life Threatening 5/7/2007 39 Male 10/25/2007 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
White Blood Cell Disorder Hospitalization Female 10/26/2007 Physician Greece
Primary
Concomitant
Deep Vein Thrombosis Other Serious 9/26/2007 Male 10/26/2007 Physician Australia
Primary
Concomitant
Regurgitation Other Serious 7/20/2007 Male 175 lb 10/26/2007 Consumer United States
Primary
Concomitant
Pancytopenia Life Threatening 10/4/2007 66 Female 99 lb 10/27/2007 Physician Portugal
Primary
Secondary
Concomitant
Liver Function Test Abnormal Other Serious 66 Female 99 lb 10/27/2007 Physician Portugal
Primary
Secondary
Concomitant
Pancytopenia Life Threatening 10/4/2007 66 Female 99 lb 10/29/2007 Physician Portugal
Primary
Secondary
Concomitant
Respiratory Distress Hospitalization 9/2/2007 28 Female 10/30/2007 Consumer United States
Primary
Secondary
Concomitant
Squamous Cell Carcinoma Hospitalization 6/1/2007 Male 10/30/2007 Physician Norway
Primary
Secondary
Concomitant
Hepatitis B Death 54 Male 10/31/2007 Physician Japan
Primary
Concomitant
Hepatitis B Death 54 Male 11/8/2007 Physician Japan
Primary
Concomitant
Post Procedural Haemorrhage Disability 47 Male 11/7/2007 Physician United States
Primary
Concomitant
Bladder Cancer Other Serious 6/7/2007 Female 11/15/2007 Physician United States
Primary
Concomitant
Breast Cancer Other Serious Female 131 lb 11/16/2007 Physician United States
Primary
Concomitant
Red Blood Cells Csf Positive Disability 47 Male 11/29/2007 United States
Primary
Concomitant
Vascular Graft Hospitalization Male 175 lb 12/7/2007 Consumer United States
Primary
Concomitant
Erythema Hospitalization 7/25/2007 65 Female 12/4/2007 Pharmacist United States
Primary
Concomitant
Bladder Cancer Other Serious 6/7/2007 Female 12/12/2007 Physician United States
Primary
Concomitant
Encephalopathy Hospitalization 10/6/2007 Female 12/22/2007 Physician United States
Primary
Concomitant
Large Intestinal Haemorrhage Hospitalization 45 Male 12/28/2007 Consumer United Kingdom
Primary
Concomitant
Optic Ischaemic Neuropathy Other Serious 12/20/2007 1/9/2008 Consumer United States
Primary
Concomitant
Optic Ischaemic Neuropathy Other Serious 12/20/2007 1/17/2008 Consumer United States
Primary
Concomitant
Altered State Of Consciousness Disability 11/20/2007 Female 104 lb 1/17/2008 Physician Japan
Primary
Concomitant
Septic Shock Death 12/31/2007 65 Male 239 lb 1/16/2008 Physician United States
Primary
Secondary
Concomitant
Myocardial Infarction Death 1/1/2008 Male 1/25/2008 Physician United Kingdom
Primary
Concomitant
Optic Ischaemic Neuropathy Other Serious 12/20/2007 1/26/2008 Consumer United States
Primary
Concomitant
Altered State Of Consciousness Disability 11/20/2007 Female 104 lb 2/4/2008 Physician Japan
Primary
Concomitant
Sepsis Death 12/31/2007 65 Male 239 lb 1/31/2008 Physician United States
Primary
Secondary
Concomitant
Large Intestinal Haemorrhage Hospitalization Male 150 lb 2/8/2008 Consumer United Kingdom
Primary
Concomitant
Febrile Neutropenia Hospitalization 2/11/2008 Female 2/29/2008 Consumer United Kingdom
Primary
Secondary
Concomitant
Large Intestinal Haemorrhage Hospitalization Male 150 lb 2/29/2008 Consumer United Kingdom
Primary
Concomitant
Pulmonary Alveolar Haemorrhage Other Serious 39 Female 3/6/2008 Other Health Professional Japan
Primary
Concomitant
Infectious Mononucleosis Hospitalization 1/1/2008 Female 3/7/2008 Consumer Canada
Primary
Concomitant
Encephalopathy Death 6 Male 3/8/2008 United States
Primary
Concomitant
Altered State Of Consciousness Disability 11/20/2007 Female 104 lb 3/13/2008 Physician Japan
Primary
Concomitant
Pulmonary Alveolar Haemorrhage Other Serious 39 Female 3/17/2008 Japan
Primary
Concomitant
Gastrointestinal Haemorrhage Hospitalization 34 Female 3/18/2008 Physician Canada
Primary
Secondary
Concomitant
Vomiting Other Serious 6 Male 3/15/2008 Physician United States
Primary
Secondary
Concomitant
Subcutaneous Abscess Hospitalization 1/1/2008 Female 210 lb 3/25/2008 Consumer Canada
Primary
Concomitant
Large Intestinal Haemorrhage Hospitalization Male 150 lb 3/26/2008 Consumer United Kingdom
Primary
Concomitant
Sepsis Death 12/12/2007 Female 189 lb 4/3/2008 Physician United States
Primary
Concomitant
Neck Pain Other Serious 3/26/2008 55 Female 119 lb 4/7/2008 Consumer United States
Primary
Concomitant
Transient Ischaemic Attack Other Serious 9/22/2007 Male 147 lb 4/10/2008 Consumer United States
Primary
Concomitant
Haemorrhage Intracranial Death 1/1/2008 Male 4/15/2008 Physician Canada
Primary
Concomitant
Subcutaneous Abscess Hospitalization 1/1/2008 Female 210 lb 5/1/2008 Consumer Canada
Primary
Concomitant
Interstitial Lung Disease Hospitalization 8/2/2007 Female 218 lb 6/4/2008 Other Health Professional United States
Primary
Secondary
Oedema Peripheral Hospitalization Female 6/6/2008 Physician United States
Primary
Concomitant
Kaposi's Sarcoma Other Serious 49 Male 6/10/2008 Physician United States
Primary
Secondary
Concomitant
Oedema Peripheral Other Serious 5/22/2008 Female 133 lb 6/17/2008 Physician United States
Primary
Concomitant
Skin Hypertrophy Other Serious 49 Male 6/13/2008 United States
Primary
Secondary
Concomitant
Kaposi's Sarcoma Other Serious 49 Male 6/13/2008 Physician United States
Primary
Secondary
Concomitant
Oedema Peripheral Other Serious 5/22/2008 Female 133 lb 6/26/2008 Physician United States
Primary
Concomitant
Neck Pain Other Serious 3/26/2008 55 Female 119 lb 7/2/2008 Consumer United States
Primary
Concomitant
Hepatotoxicity Other Serious 7/2/2008 Consumer United Kingdom
Primary
Secondary
Concomitant
Mycobacterial Infection Life Threatening 4/22/2008 Female 185 lb 7/15/2008 Other Health Professional United States
Primary
Concomitant

Drug Data